Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs

Conclusions
BMP4 acts downstream of HIF-1 and mediates hypoxia-induced up-regulation of TRPC, leading to increased basal [Ca2+]i in PASMCs, promoting CHPH pathogenesis.

Source: Cardiovascular Research - June 22, 2015 Category: Cardiology Authors: Wang, J., Fu, X., Yang, K., Jiang, Q., Chen, Y., Jia, J., Duan, X., Wang, E. W., He, J., Ran, P., Zhong, N., Semenza, G. L., Lu, W. Tags: Vascular biology Source Type: research