TiO2 nanotubes promote osteogenic differentiation of mesenchymal stem cells via regulation of lncRNA CCL3-AS
This study supplied a comprehensive understanding for further study using lncRNA modulators to surface design of titanium for enhancing osseointegration.Graphical Abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - May 21, 2019 Category: Biochemistry Source Type: research

Surface Properties and Foamability of Saponin and Saponin-Chitosan Systems
Publication date: Available online 19 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Eva Santini, Ewelina Jarek, Francesca Ravera, Libero Liggieri, Piotr Warszynski, Marcel KrzanAbstractIn this work we investigate the surface properties and foamability of saponin and mixed saponin-chitosan solutions. These natural compounds are widely used in various cosmetic, pharmaceutical and food technologies because of their efficiency as bio-active components and their biodegradability.These compounds and their mixture were investigated versus the composition by surface tension and dilational rheology measurements a...
Source: Colloids and Surfaces B: Biointerfaces - May 21, 2019 Category: Biochemistry Source Type: research

Biologically safe colloidal suspensions of naked iron oxide nanoparticles for in situ antibiotic suppression
Publication date: Available online 17 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Massimiliano Magro, Davide Baratella, Simone Molinari, Andrea Venerando, Gabriella Salviulo, Giulia Chemello, Ike Olivotto, Giorgio Zoppellaro, Juri Ugolotti, Claudia Aparicio, Jiri Tucek, Anna P. Fifi, Giuseppe Radaelli, Radek Zboril, Fabio VianelloAbstractA category of naked maghemite nanoparticles (γ-Fe2O3), named surface active maghemite nanoparticles (SAMNs), is characterized by biological safety, high water colloidal stability and a surface chemistry permitting the binding of ligands. In the present study, the...
Source: Colloids and Surfaces B: Biointerfaces - May 18, 2019 Category: Biochemistry Source Type: research

Complement proteins regulating macrophage polarisation on biomaterials
Publication date: Available online 17 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): N. Araújo-Gomes, F. Romero-Gavilán, Y. Zhang, C. Martinez-Ramos, F. Elortza, M. Azkargorta, J.J. Martín de Llano, M. Gurruchaga, I. Goñi, J.J.J.P. van den Beucken, J. SuayAbstractOne of the events occurring when a biomaterial is implanted in an host is the protein deposition onto its surface, which might regulate cell responses. When a biomaterial displays a compromised biocompatibility, distinct complement pathways can be activated to produce a foreign body reaction. In this article, we have d...
Source: Colloids and Surfaces B: Biointerfaces - May 18, 2019 Category: Biochemistry Source Type: research

Film-nanoparticle composite for enhanced oral delivery of alpha-casozepine
Publication date: Available online 18 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Pedro M. Castro, Patrícia Baptista, Giampaolo Zuccheri, Ana Raquel Madureira, Bruno Sarmento, Manuela E. PintadoAbstractWhey-derived alpha-casozepine bioactive peptide (YLGYLEQLLR) was associated with previously optimized guar-gum film-PLGA nanoparticles, aiming to increase both stability across gastrointestinal tract and permeability across absorptive epithelia. Oral films associated with nanoparticles (FNp) enhance buccal absorption along with protection of carried bioactive molecules that are swallowed, with inh...
Source: Colloids and Surfaces B: Biointerfaces - May 18, 2019 Category: Biochemistry Source Type: research

Rhamnolipids functionalized with basic amino acids: synthesis, aggregation behavior, antibacterial activity and biodegradation studies
Publication date: Available online 18 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Anderson Ramos da Silva, M. Ángeles Manresa, Aurora Pinazo, M. Teresa García, Lourdes PérezAbstractRhamnolipids have been intensively studied due to their remarkable properties; however, the biosynthesis of RLs cannot compete commercially with the production of synthetic surfactants. Here, novel cationic rhamnolipids (RLs) derivatives containing arginine and lysine were prepared for the first time using a straightforward synthetic procedure. The RLs used to prepare these new cationic derivatives were ...
Source: Colloids and Surfaces B: Biointerfaces - May 18, 2019 Category: Biochemistry Source Type: research

Mesoporous electromagnetic composite particles: electric current responsive release of biologically active molecules and antibacterial properties
Publication date: Available online 18 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Mohammad K. Hossain, Hideto Minami, Sheikh M. Hoque, Mohammad M. Rahman, Mostafa K. Sharafat, Mosammat F. Begum, Mohammad E. Islam, Hasan AhmadAbstractElectric current responsive magnetic composite particles are prepared in three steps. In the first step, spherical and mesoporous submicrometer-sized magnetic iron oxide (Fe3O4) core particles are prepared by solvothermal method. Then magnetic Fe3O4 particles are functionalized with amine groups using glycine, where the COO- group of glycine formed a bridging bidentate inte...
Source: Colloids and Surfaces B: Biointerfaces - May 18, 2019 Category: Biochemistry Source Type: research

Chitosan Based Self-Assembled Nanocapsules as Antibacterial Agent
Publication date: Available online 18 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Sabrina Belbekhouche, Noureddine Bousserrhine, Vanessa Alphonse, Fannie Le Floch, Youcef Charif Mechiche, Ilyes Menidjel, Benjamin CarbonnierAbstractCreating an appropriate antibacterial disinfection system without forming any harmful compounds is still a major challenge and calls for new technologies for efficient disinfection and microbial control. Towards this aim, we report on the elaboration of biodegradable and biocompatible polymeric nanocapsules, also called hollow nanoparticles, for potential applications in anti...
Source: Colloids and Surfaces B: Biointerfaces - May 18, 2019 Category: Biochemistry Source Type: research

One-step preparation of reduction-responsive cross-linked gemcitabine prodrug micelles for intracellular drug Delivery
Publication date: Available online 16 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Xiaohui Chen, Wenzhuo Teng, Qiao Jin, Jian JiAbstractA cross-linkable gemcitabine (GEM)-containing reduction-sensitive polymeric micelles based on the copolymer poly(PEG-co-CMA-co-GEM) was successfully fabricated. The copolymer which synthesized by one-step radical copolymerization of poly(ethylene glycol) methacrylate (PEGMA), 7-(2-Methylacryloylethoxy)-4-methylcoumarin (CMA), and 2-((2-hydroxyethyl)disulfanyl)ethyl acrylate (HSEA-GEM), endowed the micelles with “stealth” surface in circulation, photo cross-l...
Source: Colloids and Surfaces B: Biointerfaces - May 18, 2019 Category: Biochemistry Source Type: research

Persulfated Flavonoids Accelerated Re-endothelialization and Improved Blood Compatibility for Vascular Medical Implants
In conclusion, it is believed that the persulfates flavonoids have a great potential in the field of drug-eluting stents and blood contacting medical implants to improve blood compatibility, suppress SMCs, and get rapid re-endothelialization.Graphical Abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - May 18, 2019 Category: Biochemistry Source Type: research

A new silanizing agent tailored to surface bio-functionalization
Publication date: Available online 17 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): L. Lunelli, F. Caradonna, C. Potrich, C. Piotto, P. Bettotti, L. Vanzetti, C. Pederzolli, G. GuellaAbstractAmino-terminated surfaces can be effectively obtained by means of silanizing agents, realizing surfaces suitable for the purification of biomarkers of several pathologies. Since the level of biomarkers, such as microRNAs and cell-free DNA, into circulation may be extremely low, new and ameliorated capturing molecules and protocols are highly required. In this work, a new silane, acetone-imine propyl trimethoxysilane ...
Source: Colloids and Surfaces B: Biointerfaces - May 18, 2019 Category: Biochemistry Source Type: research

Acetylcysteine-Decorated Prussian Blue Nanoparticles for Strong Photothermal Sterilization and Focal Infection Treatment
Publication date: Available online 7 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Suya Cai, Jun Qian, Sen Yang, Liangju Kuang, Daoben HuaAbstractThe major challenge in bacterial infection in clinical settings is the development of antimicrobial materials in the treatment of drug-resistant bacteria. Herein, we report a new strategy for efficient near-infrared radiation (NIR) photothermal sterilization and focal infection treatment by acetylcysteine-modified Prussian blue nanoparticles (AC-PB). Specifically, AC-PB is fabricated as a multifunctional therapeutic agent via a co-precipitation approach, where ...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Poloxamer-407 thickened lipid colloidal system of agomelatine for brain targeting: Characterization, brain pharmacokinetic study and behavioral study on Wistar rats
Publication date: Available online 8 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Shakeeb Ahmed, Azka Gull, Mohd. Aqil, Mohd Danish Ansari, Yasmin SultanaAbstractThe current study was designed to enhance the brain bioavailability and to extract maximum therapeutic benefit from a novel antidepressant drug, agomelatine. For this purpose, a thermoresponsive in situ gel was prepared by dissolving 20% w/v of Poloxamer-407 in agomelatine containing nanoemulsion. To impart mucoadhesive property, 0.5% w/v concentration of chitosan was ensured in the final formulation, named as Ago-NE-gel+0.5%chitosan. The gelli...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Use of Electrospun Threads in Immobilized Cell Reactors for Continuous Ethanol Production
This study shows that the use of electrospinning is a promising method for continuous ethanol production through immobilized cell-based continuous flow reactors.Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Nanocomposite multifunctional polyelectrolyte thin films with copper nanoparticles as the antimicrobial coatings
Publication date: Available online 9 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): T. Kruk, M. Gołda-Cępa, K. Szczepanowicz, L. Szyk-Warszyńska, M. Brzychczy-Włoch, A. Kotarba, P. WarszyńskiAbstractThe work presents the formation and physicochemical characterization of polyelectrolyte-copper nanocomposite coatings using: poly(diallyldimethylammonium chloride) (PDADMAC) as a polycation, poly(sodium 4-styrenesulfonate)(PSS) as a polyanion and negatively charged copper nanoparticles (CuNPs) to obtain biocompatible surfaces with an antibacterial functionality. The mass and thickness of composite films w...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Colloids or Powders: Which Nanoparticle Formulations Do Cells Like More?
In this study we compared a set of biological effects of colloidal and powder formulations of composite nanoparticles comprising superparamagnetic iron oxide cores and silicate/carbon shells. Magnetic dipole interaction between adjacent nanoparticles was more pronounced in their powders than in their colloidal formulations. Nanoparticles delivered as powders were thus more responsive to the magnetic field, but exhibited reduced uptake in bone and brain cancer cells, including K7M2 osteosarcoma line and U87 and E297 glioblastoma lines. Specifically, while the alternate magnetic field elicited a more rapid heat generation in...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Facile immobilization of Trametes versicolor laccase on highly monodisperse superparamagnetic iron oxide nanoparticles
Publication date: Available online 10 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Claudia Iriarte-Mesa, Sergio Díaz-Castañón, Darío G. AbradeloAbstractHypothesisThe development of enzymatic conjugates with industrial applications require approaches with good scalability and batch-to-batch reproducibility. Hereof, nearly monodisperse iron oxide nanoparticles can be synthesized by thermal decomposition with high yields. A mixture of gallic and polyacrylic acid is used for the direct water transfer and later immobilization of laccase (Trametes versicolor).ExperimentsNanoparticl...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Effect of dehydrocholic acid conjugated with a hydrocarbon on a lipid bilayer composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine
Publication date: Available online 10 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Keita Hayashi, Kazutoshi Morimoto, Toshiyuki Kamei, Eiko Mieda, Sosaku Ichikawa, Takashi Kuroiwa, Sakiko Fujita, Hidemi Nakamura, Hiroshi UmakoshiAbstractThe effects of bile acids, dehydrocholic acid (DHA) and DHA conjugated with a hydrocarbon (6-aminohexanoate; 6A-DHA) were evaluated using a lipid bilayer composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC). DOPC formed a homogenous thin membrane in presence or absence of theDHA, while 20 mol% 6A-DHA induced phase separation on the DOPC thin membrane. It wa...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Spray-drying microencapsulation of nisin by complexation with exopolysaccharides produced by probiotic Bacillus tequilensis-GM and Leuconostoc citreum-BMS
Publication date: Available online 11 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Yousra ABID, Adem GHARSALLAOUI, Emilie DUMAS, Sami GHNIMI, Hamadi ATTIA, Samia AZABOUAbstractThis work aims to encapsulate nisin by complexation with exopolysaccharides (EPS), produced by Bacillus tequilensis-GM and Leuconostoc citreum-BMS, namely EPS-GM and EPS-BMS, respectively, using spray-drying technique, and to evaluate the effect of this encapsulation on the structure of nisin. Results related to suspensions turbidity showed that EPS/nisin complexes were formed through electrostatic attractions. These interactions ...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Multifunctional PEG-b-polypeptide-decorated gold nanorod for targeted combined chemo-photothermal therapy of breast cancer
In this study, a multifunctional nanoplatform based on gold nanorod (GNR) decorated with folate-conjugated poly(ethylene glycol)-b-poly(L-γ-glutamylhydrazine) (FEGGH) containing disulfide linker and dihydroxyphenyl groups was developed for targeted combined chemo-photothermal therapy of breast cancer. FEGGH was synthesized by ring-opening polymerization of γ-benzyl-L-glutamate-N-carboxyanhydride using folate/cystamine-heterobifunctionalized poly(ethylene glycol) as an initiator, following by hydrazinolysis and carbodiimide reactions. FEGGH was decorated onto GNR through Au-catechol bonds. Chemotherapeutic drug ...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Bioinspired EVAL membrane modified with cilia-like structures showing simultaneously enhanced permeability and antifouling properties
Publication date: Available online 13 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Sisi Ma, Ligang Lin, Qi Wang, Yuhui Zhang, Honglei Zhang, Yixin Gao, Lin Xu, Fusheng Pan, Yuzhong ZhangAbstractA simple and effective strategy to simultaneously enhance the permeability and antifouling properties of ethylene vinyl alcohol (EVAL) membrane was developed based on the bioinspired natural cleaner, cilia. Taking clue from the self-cleaning effect of cilia, supramolecular polyrotaxanes (PRs) with sliding and rotating cyclic molecules along linear chains were synthesized using azide-alkyne click chemistry. Cilia-...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Effects of carbon dots surface functionalities on cellular behaviors – Mechanistic exploration for opportunities in manipulating uptake and translocation
Publication date: Available online 14 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Gui-Hua Yan, Zheng-Mei Song, Yuan-Yuan Liu, Qianqian Su, Weixiong Liang, Aoneng Cao, Ya-Ping Sun, Haifang WangAbstractCarbon dots (CDots) for their excellent optical and other properties have been widely pursued for potential biomedical applications, in which a more comprehensive understanding on the cellular behaviors and mechanisms of CDots is required. For such a purpose, two kinds of CDots with surface passivation by 3-ethoxypropylamine (EPA-CDots) and oligomeric polyethylenimine (PEI-CDots) were selected for evaluati...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Dual-antibody Modified PLGA Nanofibers for Specific Capture of Epithelial and Mesenchymal CTCs
Publication date: Available online 15 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Hui Liu, Zhili Wang, Changchong Chen, Ding Pi, Sun Na, Renjun PeiAbstractCTC detection has great potential to provide crucial clinical information for early cancer diagnosis, patient prognosis, personalized therapy, and cancer progress monitoring etc. It has been proved that the disease progress is associated with an increase in mesenchymal CTCs, while most mature techniques have been developed based on epithelial CTC detection. In present work, a dual-antibody nanointerface against EpCAM and N-Cadherin was developed to c...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

An ultrasensitive electrochemical anti-Lysozyme aptasensor with biorecognition Surface based on aptamer/amino-rGO/ionic liquid/amino-mesosilica nanoparticles
Publication date: Available online 15 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Hamid Reza Jamei, Behzad Rezaei, Ali Asghar EnsafiAbstractIn this work, a novel method based on aptamers is proposed for electrochemical measurement of lysozyme. To this end, screen-printed carbon electrode (SPCE) was modified with a nanocomposite made from amino-reduced graphene oxide (Amino-rGO) synthesized from natural graphite powder, an ionic liquid (IL), and amino-mesosilica nanoparticles (Amino-MSNs). The composition of the nanocomposite (Amino-rGO/IL/Amino-MSNs) results in high thermal and chemical stability, cond...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Application of biosurfactants and chitosan in toothpaste formulation
Publication date: Available online 15 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Ana Helena M. Resende, Juliana M. Farias, Dhanilo D.B. Silva, Raquel D. Rufino, Juliana M. Luna, Thayza Christina M. Stamford, Leonie A. SarubboAbstractThe aim of the present study was to formulate toothpastes containing biosurfactants and either fungal chitosan or sodium fluoride and evaluate the cytotoxicity, antimicrobial action and inhibition potential against biofilm formed by Streptococcus mutans. Chitosan was extracted from the biomass of the fungus Mucorales. We tested biosurfactants produced by Pseudomonas aerugi...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Combination of active behaviors and passive structures contributes to the cleanliness of housefly wing surfaces: A new insight for the design of cleaning materials
In this study, we explored the relationship between these micro/nanostructures and wettability as well as the role of the housefly cleaning behaviors in keeping their wings clean. Hierarchical structures consisting of microscale macrotrichias with nanoscale grooves on the wings were observed under scanning electron microscope. The wings were hydrophobic (CA = 133.3°) but with high adhesion to water (CAH = 87.5°), indicating that they were non-self-cleaning surfaces. Macroscale droplets standing on the wings could be best described as being in a transitional wetting state between Wenzel a...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Carbon@polypyrrole nanotubes as a photosensitizer in laser phototherapy of Pseudomonas aeruginosa
This study evaluated the antibacterial and phototherapy effects of carbon nanotubes with a polypyrrole coating in a core@shell structure (CNTs@PPy) on Pseudomonas aeruginosa (P. aeruginosa). P. aeruginosa was treated with CNTs@PPy at different concentrations (50–500 μg mL−1) in dark or laser light irradiation with a wavelength of 808 nm, a power density of 1000 mW cm−2 for 20 min. Temperature increment, cell viability, formation of reactive oxygen species (ROS) and protein/nucleic acid leakage subsequent the P. aeruginosa treatment were evaluated. The results showed that nea...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Micro-characterization of modified microemulsions loaded with gossypol, pure and extracted from cottonseed
In this study, modified ME nanodroplets (nano-sized self-assembled liquids, NSSLs) were employed as extraction medium of gossypol, a toxic component of cottonseed. Loading was performed using both pure gossypol, and gossypol obtained by extraction from cottonseed. We achieved two goals: i) remove gossypol from cottonseed to obtain cotton-oil free of gossypol; and ii) extract gossypol directly into a nano-delivery vehicle for biomedical purposes. Structural and dynamical information on the unloaded and gossypol-loaded NSSL systems were obtained by self-diffusion nuclear magnetic resonance, SD-NMR, and spin-probe electron pa...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

PLGA based particles as “drug reservoir” for antitumor drug delivery: characterization and cytotoxicity studies
In this study we developed and characterized biodegradable and stable poly(D,L-lactic-co-glycolic) acid (PLGA) submicrocarriers employing an osmosis-based patented methodology, which allowed to optimize the drug loading efficiency up to 99%.Proceeding from this, we evaluated on MCF-7, a human breast cancer cell line, the ability of PLGA to promote the internalization of DOX and to improve its cytotoxicity in vitro. We found that the in vitro uptake efficiency is dramatically increased when DOX is loaded within PLGA colloidal carriers, which adhere to the cell membrane behaving as an efficient drug reservoir. In fact, the p...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Development of antibiotic loaded biodegradable matrices to prevent superficial infections associated to total knee arthroplasty
Publication date: 1 September 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 181Author(s): Javier Martínez-Moreno, Silvia Mir-Palomo, Virginia Merino, Amparo Nácher, Matilde Merino-SanjuánAbstractDevelopment of a pharmaceutical form for the superficial infections related with arthroplasties would be helpful for clinical practice. In this context, we set out to evaluate ciprofloxacin and gentamicin elution from systems based on chitosan. Films and semisolid hydrogels containing chitosan alone (2%) or in combination with gelatin (6%) or different proportions (from 12% to 36%) of tetrakis-(hyd...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Graphene oxide exhibits differential mechanistic action towards Gram-positive and Gram-negative bacteria
The objective of the study was to elucidate the difference in the interactions of GO towards Gram-positive and Gram-negative bacteria. The synthesized GO was characterized by Ultraviolet–visible spectroscopy (UV–vis), Raman and Attenuated Total Reflectance-Fourier-transform infrared spectroscopy (ATR-FTIR). Viability, time-kill and Lactose Dehydrogenase (LDH) release assays were carried out along with FESEM, TEM and ATR-FTIR analysis of GO treated bacterial cells. Characterizations of synthesized GO confirmed the transition of graphene to GO and the antibacterial activity of GO was concentration and time-depend...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2019 Category: Biochemistry Source Type: research

Homogeneously alloyed nanoparticles of immiscible Ag–Cu with ultrahigh antibacterial activity
Publication date: 1 August 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 180Author(s): Lingyan Yang, Liliang Chen, Yi-Chun Chen, Lei Kang, Jiantao Yu, Yuhang Wang, Chengjia Lu, Tsutomu Mashimo, Akira Yoshiasa, Chia-Hua LinAbstractImmiscible bimetallic Ag–Cu system has been synthesized by the pulsed plasma in liquid method with a graph of one pulse duration. Herein, by combining X-ray power diffraction, K-edge X-ray absorption near edge structure and high-resolution transmission electron microscopy, our results indicate that homogeneously alloyed Ag–Cu nanoparticles (Ag–Cu NAs) have the averag...
Source: Colloids and Surfaces B: Biointerfaces - May 16, 2019 Category: Biochemistry Source Type: research

Nuclear-targeted of TAT peptide-conjugated carbon dots for both one-and two-photon fluorescence imaging
In this study, we reported a strategy for the design of peptide-conjugated CDs for cellular nuclear-targeted imaging. The CDs were prepared from amino acid and formic acid via an one-step hydrothermal synthesis method, and then modified with trans-activator of transcription (TAT) peptide for both one- and two- photon nuclear-targeted fluorescence imaging. The CDs derived from tryptophan (Trp) and formic acid showed the highest fluorescence quantum yield of 58.4% with an average size about 1.7 nm in diameter. The maximum excitation and emission wavelengths of the Trp/formic acid CDs were 360 and 442 nm, respec...
Source: Colloids and Surfaces B: Biointerfaces - May 15, 2019 Category: Biochemistry Source Type: research

PVA Cryogel as model hydrogel for iontophoretic transdermal drug delivery investigations. Comparison with PAA/PVA and PAA/PVP interpenetrating networks
Publication date: 1 August 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 180Author(s): Vladislav Rac, Steva Lević, Bojana Balanč, Beatriz Olalde Graells, Goran BijelićAbstractThe use of polyvinyl alcohol (PVA) cryogel as a model hydrogel for iontophoretic transdermal investigations is proposed. Due to the excellent combination of its properties, it could be used for evaluating iontophoretic transdermal delivery of variety of drugs, regardless of pKa, pH or presence of auxiliary ions. Applicability of PVA Cryogel for drug delivery purposes was compared to those of polyacrylic acid/polyvinyl alcohol (PAA/PVA)...
Source: Colloids and Surfaces B: Biointerfaces - May 15, 2019 Category: Biochemistry Source Type: research

Amphipathic β-cyclodextrin nanocarriers serve as intelligent delivery platform for anticancer drug
Publication date: 1 August 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 180Author(s): Hui Liu, Jian Chen, Xiufang Li, Zhiwei Deng, Peiru Gao, Jianbin Li, Tao Ren, Ling Huang, Yanjing Yang, Shian ZhongAbstractA novel glutathione-responsive (GSH-responsive) star-like amphiphilic polymer (C12H25)14-β-CD-(S-S-mPEG)7 (denoted as CCSP) was designed for efficient antitumor drug delivery. The amphiphilic β-cyclodextrin (β-CD) self-polymerize in water to form a sphere with a diameter of 40–50 nm. The secondary hydroxyl groups of β-CD were modified by dodecyl to form a hydrophobic core ...
Source: Colloids and Surfaces B: Biointerfaces - May 13, 2019 Category: Biochemistry Source Type: research

Cobalt nanowire-based multifunctional platform for targeted chemo-photothermal synergistic cancer therapy
Publication date: 1 August 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 180Author(s): Huang Zhu, Jiuhong Deng, Yuanyi Yang, Yunfei Li, Jiacheng Shi, Jiankui Zhao, Yi Deng, Xianchun Chen, Weizhong YangAbstractCobalt nanowires (CoNWs) simultaneously possessing advantages in photothermal effect, targeting drug delivery and photoacoustic imaging property are hopefully promising strategies to further improve the treatment efficiency and reduce the side effects of cancer chemotherapy. Herein, a unique cobalt-based structure decorated with graphene oxide (GO) and polyethylene glycol (PEG) is fabricated through a fac...
Source: Colloids and Surfaces B: Biointerfaces - May 11, 2019 Category: Biochemistry Source Type: research

High density gold nanostructure composites for precise electrochemical detection of human embryonic stem cells in cell mixture
Publication date: 1 August 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 180Author(s): Intan Rosalina Suhito, Ee-Seul Kang, Da-Seul Kim, Seungho Baek, Soon-Jung Park, Sung-Hwan Moon, Zhengtang Luo, Donghyun Lee, Junhong Min, Tae-Hyung KimAbstractPrecise detection of undifferentiated human pluripotent stem cells (hPSCs) and their entire subsequent elimination are incredibly important in preventing teratoma formations after transplantation. Recently, electrochemical sensing platforms have demonstrated immense potential as a new tool to detect remaining hPSCs in label-free and non-destructive manner. Nevertheless...
Source: Colloids and Surfaces B: Biointerfaces - May 11, 2019 Category: Biochemistry Source Type: research

Therapeutic and diagnostic potential of nanomaterials for enhanced biomedical applications
Publication date: 1 August 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 180Author(s): M. Abd Elkodous, Gharieb S. El-Sayyad, Ibrahim Y. Abdelrahman, Hanan S. El-Bastawisy, Abd Elrahman Mohamed, Farag M. Mosallam, Hebatallah A. Nasser, Mohamed Gobara, Ahmad Baraka, Mohamed A. Elsayed, Ahmed I. El-BatalAbstractBiomedical applications of nanomaterials have received considerable attention and interest from many researchers over the past decade due to the key role they can play in enhancing public health. Different types of nanomaterials possess both diagnostic and therapeutic potential owing to their outstanding ...
Source: Colloids and Surfaces B: Biointerfaces - May 11, 2019 Category: Biochemistry Source Type: research

pH/near infrared dual-triggered drug delivery system based black phosphorus nanosheets for targeted cancer chemo-photothermal therapy
In conclusion, pH/NIR dual-triggered drug delivery system based BP NSs would be a prospective strategy in the chemo-photothermal medical fields through our preliminary assessments.Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - May 10, 2019 Category: Biochemistry Source Type: research

Glucose-responsive complex micelles for self-regulated delivery of insulin with effective protection of insulin and enhanced hypoglycemic activity in vivo
In this study, we fabricated a new type of insulin-loaded glucose-responsive complex micelles (CMs), which were self-assembled by a phenylboronic acid (PBA)-modified block copolymer PEG-b-P(Asp-co-AspPBA) and a glucosamine (GA)/nitrilotriacetic acid (NTA)-functionalized block copolymer PNIPAM-b-P(Asp-co-AspGA-co-AspNTA), for self-regulated delivery of insulin with effective protection of insulin and enhanced hypoglycemic activity in vivo. The CMs possessed mixed shell of PEG/PNIPAM and cross-linked core of PBA/GA complex, which could be disintegrated under the condition of high glucose concentration (5 g/L) while ma...
Source: Colloids and Surfaces B: Biointerfaces - May 7, 2019 Category: Biochemistry Source Type: research

Resveratrol-delivery vehicle with anti-VEGF activity carried to human retinal pigmented epithelial cells exposed to high-glucose induced conditions
Publication date: Available online 7 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Dumitrita Ruginǎ, Raluca Ghiman, Monica Focşan, Flaviu Tăbăran, Florina Copaciu, Maria Suciu, Adela Pintea, Simion AştileanAbstractAs an integrated approach to defeat diabetic retinopathy, a common complication of diabetes leading to vision loss, a delivery vehicle able to transport resveratrol (Rv) directly into retina pigmented epithelial D407 cells was designed. Rv, a molecule with known therapeutic potential, was successfully inserted into a microcapsule based on porous CaCO3 templates revealing an encapsulation e...
Source: Colloids and Surfaces B: Biointerfaces - May 7, 2019 Category: Biochemistry Source Type: research

Effect of casein on pure lecithin liposome: Mixed biomacromolecular system for providing superior stabilization to hydrophobic molecules
Publication date: 1 August 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 180Author(s): Sudipta Panja, Deb Kumar Khatua, Mintu HalderAbstractFormulation of new liposoma-based systems can always be in the spotlight for their unique utilization as carriers. Some changes in the composition of lipids may give rise to new mixed liposomes exhibiting modified size and physico-chemical characteristics. Consequently, these display different encapsulating properties toward various molecules. In this work, we have explored the variations in the model lecithin liposomes with casein additive from their size, shape, microenv...
Source: Colloids and Surfaces B: Biointerfaces - May 7, 2019 Category: Biochemistry Source Type: research

Fractal analysis and mathematical models for the investigation of photothermal inactivation of Candida albicans using carbon nanotubes
Publication date: Available online 6 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Kevin F. dos Santos, Marcos S. Sousa, João V.P. Valverde, Clarissa A. Olivati, Paula C.S Souto, Josmary R. Silva, Nara C. de SouzaABSTRACTCandida albicans is responsible for the majority of nosocomial infections affecting immunocompromised patients. Systemic antifungals may promote microbial resistance, which has led to the search for alternative treatments, such as photothermal therapy (PTT). PTT assumes that the interaction of electromagnetic radiation with a photothermal agent generates heat that can lead to the ...
Source: Colloids and Surfaces B: Biointerfaces - May 7, 2019 Category: Biochemistry Source Type: research

Engineering Functional Hydrogel Microparticle Interfaces by Controlled Oxygen-Inhibited Photopolymerization
Publication date: Available online 3 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Daniel Debroy, Katie Dongmei Li-Oakey, John OakeyAbstractFunctional poly(ethylene glycol) diacrylate (PEGDA) hydrogel microparticles for the detection of bioactive macromolecules were fabricated via oxygen-inhibited photopolymerization in a droplet microfluidic device. Hydrogel network functionalization and architecture were characterized using a biotin-avidin binding assay, which revealed radial network inhomogeneities dependent on exposure conditions. Empirical results were corroborated using a reaction-diffusion model, ...
Source: Colloids and Surfaces B: Biointerfaces - May 4, 2019 Category: Biochemistry Source Type: research

Adsorption of chia proteins at interfaces: Kinetics of foam and emulsion formation and destabilization
Publication date: Available online 3 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Débora N. López, Valeria Boeris, Darío Spelzini, Carla Bonifacino, Luis A. Panizzolo, Cecilia AbirachedAbstractChia proteins were extracted by solubilisation at pH 10 or 12 and precipitated at pH 4.5. Isolates were named as CPI10 and CPI12, according to their extraction pH, 10 or 12, respectively. The surface properties of both isolates were studied at neutral conditions. Foams were formed by air bubbling and both the formation and destabilization processes were analysed by conductimetry. The extractio...
Source: Colloids and Surfaces B: Biointerfaces - May 4, 2019 Category: Biochemistry Source Type: research

Green synthesis of Ag nanoflowers using Kalanchoe Daigremontiana extract for enhanced photocatalytic and antibacterial activities
Publication date: 1 August 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 180Author(s): Gustavo A. Molina, Rodrigo Esparza, J. Luis López-Miranda, Angel R. Hernández-Martínez, Beatriz L. España-Sánchez, Eduardo A. Elizalde-Peña, Miriam EstevezAbstractThe synthesis and applications of anisotropic nanostructures have attracted much attention in the last decade. The nanoflower-type structures are one of the nanomaterials with anisotropic structures most investigated because of owing to high densities of edges, corners, and stepped atoms present on their nano-petals. Here, ...
Source: Colloids and Surfaces B: Biointerfaces - May 4, 2019 Category: Biochemistry Source Type: research

Towards biocompatible NIR-II nanoprobes - transfer of hydrophobic Ag2S quantum dots to aqueous solutions using phase transfer catalysed hydrolysis of poly(maleic anhydride-alt-1-octadecene)
Publication date: Available online 2 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Rotko Grzegorz, Cichos Jakub, Wysokińska Edyta, Karbowiak Mirosław, Kałas WojciechAbstractDevelopment of protocols for transferring of hydrophobic quantum dots (QDs) into aqueous solution is of special importance for their biomedical applications. Particularly, hydrophilization of Ag2S without quenching of photoluminescence is a great challenge. Application of standard protocol for amphiphilic polymer coating of hydrophobic Ag2S nanocrystals failed, whereas ligand exchange and direct synthesis of Ag2S in aqueous solutio...
Source: Colloids and Surfaces B: Biointerfaces - May 4, 2019 Category: Biochemistry Source Type: research

Modulating Conformational Stability of Human Serum Albumin and Implications for Surface Passivation Applications
Publication date: Available online 2 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Jae Hyeon Park, Abdul Rahim Ferhan, Joshua A. Jackman, Nam-Joon ChoAbstractHuman serum albumin (HSA) is one of the most abundant proteins in the human body and also used as a biomaterial coating. While there is significant interest in modifying the properties of solid supports to control HSA adsorption, there is an outstanding need to investigate whether modulating the conformational properties of HSA proteins can influence adsorption properties, especially in the context of surface passivation applications. Herein, we inv...
Source: Colloids and Surfaces B: Biointerfaces - May 4, 2019 Category: Biochemistry Source Type: research

Novel propyl karaya gum nanogels for bosentan: in vitro and in vivo drug delivery performance
Publication date: Available online 1 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Bibek Laha, Sanjib Das, Sabyasachi Maiti, Kalyan Kumar SenAbstractThe amphiphilic propyl Karaya gum (KG) with a degree of propyl group substitution of 3.24 was synthesized to design self-assembled nanogels as carriers for bosentan monohydrate, a poorly soluble antihypertensive drug. The drug was physically hosted into the hydrophobic core of the micellar nanogels by solvent evaporation method. TEM images revealed spherical shape and core-shell morphology of the nanogels. Depending upon polymer: drug weight ratio, the drug ...
Source: Colloids and Surfaces B: Biointerfaces - May 2, 2019 Category: Biochemistry Source Type: research

Probing Phospholipid-Microbubbles by Atomic Force Microscopy to Quantify Bubble Mechanics and Nanostructural Shell Properties
Publication date: Available online 1 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Adeel S Shafi, Jake McClements, Ibrahim Al-Baijan, Radwa H. Abou-Saleh, Carmel Moran, Vasileios KoutsosAbstractMicrobubbles (MBs), which are used as ultrasonic contrast agents, have distinct acoustic signatures which enable them to significantly enhance visualisation of the vasculature. Research is progressing to develop MBs which act as drug/gene delivery vehicles for site-specific therapeutics. In order to manufacture effective theranostic vehicles, it is imperative to understand the mechanical and nanostructural propert...
Source: Colloids and Surfaces B: Biointerfaces - May 2, 2019 Category: Biochemistry Source Type: research