Curcumin-loaded PLA-PEG copolymer nanoparticles for treatment of liver inflammation in streptozotocin-induced diabetic rats
This report focused on loading curcumin (CUR) drug into biodegradable Polylactide-poly(ethylene glycol) (PLA-PEG) copolymer nanoparticles as an effective anti-inflammatory agent in vivo to overcome the limitations resulted from the free CUR. By a simple nano-emulsification technique, hydrophobic CUR was loaded into hydrophobic polymer’s segments and stabilized by cationic surfactant. They were then characterized by DLS, TEM, and SEM techniques providing monodispersed and spherical nanoparticles with an average diameter of 117 nm and high surface charge of +35 mV. Thereafter, they were orally administrated into five g...
Source: Colloids and Surfaces B: Biointerfaces - February 20, 2019 Category: Biochemistry Source Type: research

Gold nanoparticle-carboxymethyl cellulose nanocolloids for detection of human immunodeficiency virus type-1 (HIV-1) using laser light scattering immunoassay
Publication date: 1 May 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 177Author(s): A.J. Caires, H.S. Mansur, A.A.P. Mansur, S.M. Carvalho, Z.I.P. Lobato, J.K.P. dos ReisAbstractIt is estimated that over 100 million people have been infected with human immunodeficiency virus (HIV-1) resulting in approximately 30 million deaths globally. Herein, we designed and developed novel nano-immunoconjugates using gold nanoparticles (AuNPs) and carboxymethylcellulose (CMC) biopolymer, which performed simultaneously as an eco-friendly in situ reducing agent and surface stabilizing ligand for the aqueous colloidal process....
Source: Colloids and Surfaces B: Biointerfaces - February 20, 2019 Category: Biochemistry Source Type: research

In situ reduction of silver nanoparticles in the lignin based hydrogel for enhanced antibacterial application
In this study, we designed a new lignin based antimicrobial hydrogel for antimicrobial application. First, we grafted the amino group onto sodium lignin sulfonate through Mannich reaction to obtain lignin amine (LA), which can cross-link with poly(vinyl alcohol) (PVA) to form hydrogel. Then, silver nitrate solution is added to the formed gel pre-solution to be in situ reduced to silver nanoparticles. The enhanced effect of antibacterial properties due to lignin and silver nanoparticles endows the hydrogel enhanced antibacterial properties. The modification of sodium lignosulfonate and the crosslinking reaction between LA a...
Source: Colloids and Surfaces B: Biointerfaces - February 20, 2019 Category: Biochemistry Source Type: research

Chondroitin sulfate-functionalized polymeric nanoparticles for colon cancer-targeted chemotherapy
Publication date: 1 May 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 177Author(s): Menghang Zu, Lijun Ma, Xueqing Zhang, Dengchao Xie, Yuejun Kang, Bo XiaoAbstractTargeted delivery of chemotherapeutic drugs to tumors is a major challenge in colon cancer chemotherapy. To overcome this bottleneck, we loaded camptothecin (CPT) into polymeric nanoparticles (NPs), and further functionalized their surface with chondroitin sulfate (CS). The resulting CS-CPT-NPs had a desirable hydrodynamic diameter (289 nm), narrow particle size distribution (polydispersity index = 0.192) and neutral surface cha...
Source: Colloids and Surfaces B: Biointerfaces - February 20, 2019 Category: Biochemistry Source Type: research

Electrochemical behavior of flufenamic acid at amberlite XAD-4 resin and silver-doped titanium dioxide/ amberlite XAD-4 resin modified carbon electrodes
Publication date: Available online 12 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Nagaraj P. Shetti, Deepti S. Nayak, Shweta J. Malode, Raghava R. Kakarla, Shyam S. Shukla, Tejraj M. AminabhaviABSTRACTNovel sensors based on carbon paste assorted with amberlite XAD-4 resin and silver-doped titanium dioxide/amberlite XAD-4 resin (AgTiO2/XAD) were designed and employed for sensitive detection of flufenamic acid (FFA). The main objective of this study is to develop novel electrochemical sensors for more sensitive and selective detection of FFA and to propose its oxidation mechanism. In this perspectiv...
Source: Colloids and Surfaces B: Biointerfaces - February 13, 2019 Category: Biochemistry Source Type: research

Role of Surface Charges on Interaction of Rod-Shaped Magnetic Hydroxyapatite Nanoparticles with Protein
Publication date: Available online 12 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Kavita Kadu, Goutam Ghosh, Lata Panicker, Meenal Kowshik, Sutapa Roy RamananAbstractMagnetic hydroxyapatite (MHAp) exhibits excellent biocompatibility, making it an ideal candidate as a biomaterial. Recent investigations have shown that the combined effect of magnetite and hydroxyapatite nanostructures provide efficient means for diagnostic and therapeutic applications which can be controlled with an external magnetic field. For these applications an important aspect to be considered is the interaction of the MHAp na...
Source: Colloids and Surfaces B: Biointerfaces - February 13, 2019 Category: Biochemistry Source Type: research

Impact of soy proteins, hydrolysates and monoglycerides at the oil/water interface in emulsions on interfacial properties and emulsion stability
This study provided the foundation for the preparation and application of soy protein isolate with different emulsion stability requirements paired with selected enzyme treatments.Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - February 13, 2019 Category: Biochemistry Source Type: research

Corrigendum to “PEGylated ofloxacin nanoparticles render strong antibacterial activity against many clinically important human pathogens” [Colloids Surf. B: Biointerfaces 132 (2015) 62–70]
Publication date: 1 May 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 177Author(s): Gregory Marslin, Ann Mary Revina, Vinoth Kumar Megraj Khandelwal, Krishnamoorthy Balakumar, Caroline J. Sheeba, Gregory Franklin (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - February 13, 2019 Category: Biochemistry Source Type: research

Site-specific, covalent immobilization of an engineered enterokinase onto magnetic nanoparticles through transglutaminase-catalyzed bioconjugation
Publication date: Available online 10 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Jing-Hong Wang, Ming-Ze Tang, Xiao-Tian Yu, Chong-Mei Xu, Hong-Ming Yang, Jin-Bao TangAbstractEnterokinase (EK) is one of the most popular enzymes for the in vitro cleavage of fusion proteins due to its high degree of specificity for the amino-acid sequence (Asp)4-Lys. Enzyme reusability is desirable for reducing operating costs and facilitating the industrial application of EK. In this work, we report the controlled, site-specific and covalent cross-linking of an engineered EKLC on amine-modified magnetic nanopartic...
Source: Colloids and Surfaces B: Biointerfaces - February 11, 2019 Category: Biochemistry Source Type: research

Cellulose nanocrystals/fluorinated polyacrylate soap-free emulsion prepared via RAFT-assisted Pickering emulsion polymerization
Publication date: Available online 10 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Jianhua Zhou, Yannan Li, Hong Li, Hongtao YaoAbstractCellulose nanocrystals/fluorinated polyacrylate soap-free emulsion was successfully synthesized via RAFT-assisted Pickering emulsion process using modified cellulose nanocrystals as particle stabilizers. The cellulose nanocrystals were organically modified by linear triblock copolymer poly(2-(dimethylamino) ethyl methacrylate)-b-poly(glycidyl methacrylate)-b-poly(2,2,3,4,4,4-Hexafluorobutyl acrylate) (PDMAEMA-b-PGMA-b-PHFBA) with reactive trithiocarbonate group. Tr...
Source: Colloids and Surfaces B: Biointerfaces - February 11, 2019 Category: Biochemistry Source Type: research

INCREASED ANTIBACTERIAL ACTIVITY OF ZnO NANOPARTICLES: INFLUENCE OF SIZE AND SURFACE MODIFICATION
Publication date: Available online 11 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Bruna Lallo da Silva, Bruno Leonardo Caetano, Bruna Galdorfini Chiari-Andréo, Rosemeire Cristina Linhari Rodrigues Pietro, Leila Aparecida ChiavacciAbstractIn the current study, the size and surface of ZnO nanoparticle (ZnO NP) suspensions and powders were finely controlled to evaluate their influence on the ZnO antibacterial activity against Staphylococcus aureus and Escherichia coli. The ZnO NP were prepared by the sol-gel method with different reaction times for NP size control and followed by the addition ...
Source: Colloids and Surfaces B: Biointerfaces - February 11, 2019 Category: Biochemistry Source Type: research

Fabrication of novel casein gel with controlled release property via acidification, spray drying and tableting approach
Publication date: Available online 11 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Songwen Tan, Koentadi Hadinoto, Amirali Ebrahimi, Timothy LangrishAbstractIn this work, casein has been acidified at a pH of 1.0, forming a shampoo/lotion-like gel. It has been further processed by spray drying and tableting for controlled-release applications. The engineered casein gel shows higher moisture contents and lower Tg/dehydration temperatures compared with the non-gelled casein, based on the DSC and FTIR analysis. Casein is sensitive to thermal exposure (DSC), and no significant change in the casein was o...
Source: Colloids and Surfaces B: Biointerfaces - February 11, 2019 Category: Biochemistry Source Type: research

One-pot synthesis of polypyrrole nanoparticles with tunable photothermal conversion and drug loading capacity
Publication date: Available online 8 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Bingqian Guo, Jiulong Zhao, Chenyao Wu, Yuting Zheng, Changqing Ye, Mingxian Huang, Shige WangAbstractWith an excellent near-infrared (NIR) light-responsive property, polypyrrole (PPy) nanoparticle has emerged as a promising NIR photothermal transducing agent for tumor photothermal therapy (PTT). However, the physicochemical characteristics of PPy can be affected by its morphology. Therefore, it is important to seek optimal processing parameter to optimize the application property of PPy-PVP NPs. Herein, we reported t...
Source: Colloids and Surfaces B: Biointerfaces - February 9, 2019 Category: Biochemistry Source Type: research

Biocompatibility and effectiveness of paclitaxel-encapsulated micelle using phosphoester compounds as a carrier for cancer treatment
In this study, paclitaxel (PTX)–encapsulated micelles were prepared using four kinds of alkyl di(MePEG-lactate) phosphates. From the results of the determination of critical micelle concentrations and an in vitro stability test, it was shown that a compound to which 1-eicosanol was introduced as a side chain was desirable in the preparation of PTX-encapsulated micelles (PTX-micelles). The mean volume diameter and PTX content of the micelles were 135.7 ± 52.2 nm and 3.9% ± 0.2%, respectively. In vitro release tests of the micelles were performed at different pH levels. Twenty-four ho...
Source: Colloids and Surfaces B: Biointerfaces - February 9, 2019 Category: Biochemistry Source Type: research

Glucose-Sensitive Capsules Based on Hydrogen-bonded (Polyvinylpyrrolidone / Phenylboronic –modified Alginate) System
Publication date: Available online 7 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Sabrina Belbekhouche, Saddam Charaabi, Benjamin CarbonnierAbstractGlucose-responsive multilayer capsules have been produced through the layer-by-layer deposition of biodegradable polymers based on hydrogen bonding. The used polymers are alginate derivative and polyvinylpyrolidone (PVPON). Concentration-dependent glucose responsiveness was reached through chemical modification of alginate, selected as polyanion, with phenylboronic acid moieties (known to enable complexes with diols derivative). demonstrated that the al...
Source: Colloids and Surfaces B: Biointerfaces - February 8, 2019 Category: Biochemistry Source Type: research

Mesoporous, Degradable Hyaluronic Acid Microparticles for Sustainable Drug Delivery Application
Publication date: Available online 8 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Nurettin Sahiner, Selin Sagbas, Ramesh S. AyyalaAbstract*Porous and degradable hyaluronic acid (HA) microparticles was synthesized in a single step using different ratio of crosslinker, divinylsulfone (DVS) ranging between 2.5 and 100% mole ratio of HA repeating unit. HA particles less than 25% (≤10%) crosslinker ratio were found to be mesoporous and provided the highest surface area, calculated as 21.54±10.31 m2/g for 2.5% crosslinked HA particles via BET analysis. Hydrolytic degradation of 2.5% crosslinked...
Source: Colloids and Surfaces B: Biointerfaces - February 8, 2019 Category: Biochemistry Source Type: research

One-Step Preparation of Gold Nanovectors Using Folate Modified Polyethylenimine and Their Use in Target-Specific Gene Transfection
Publication date: Available online 6 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Zhenhua Li, Yuping Liu, Xuejin Huang, Changming Hu, Hongwei Wang, Lin Yuan, John L. Brash, Hong ChenABSTRACTGene transfection, as an effective treatment for inherited and acquired life threatening diseases caused by genetic deficiencies and abnormalities, has evolved as a promising therapeutic strategy for cancer and other intractable diseases. Non-target-specific vectors will affect normal cells as well as pathogenic cells, resulting in a relative decrease in transfection efficiency and unnecessary cytotoxicity. In t...
Source: Colloids and Surfaces B: Biointerfaces - February 7, 2019 Category: Biochemistry Source Type: research

Synthesis and Colloidal Characterization of Folic Acid-modified PEG-b-PCL Micelles for Methotrexate Delivery
Publication date: Available online 6 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): João Victor Brandt, Rodolfo Debone Piazza, Caio Carvalho dos Santos, Jaime Vega-Chacón, Bruno Estevam Amantéa, Gabriel Cardoso Pinto, Marina Magnani, Henrique Luís Piva, Antonio Claudio Tedesco, Fernando Lucas Primo, Miguel Jafelicci, Rodrigo Fernando Costa MarquesAbstractHydrophobic drugs, such as methotrexate, are not easily delivered into the human body. Therefore, the use of amphiphilic nanoplatforms to the transport of these drugs through the bloodstream is a challenge. While the hydro...
Source: Colloids and Surfaces B: Biointerfaces - February 7, 2019 Category: Biochemistry Source Type: research

Development and characterization of nanostructured lipid carrier-based gels for the transdermal delivery of donepezil
Publication date: Available online 6 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): I.T. Mendes, A.L.M. Ruela, F.C. Carvalho, J.T.J. Freitas, R. Bonfilio, G.R. PereiraAbstractDonepezil is one of the main compounds used in the therapy of Alzheimer’s disease. Oral administration of this drug presents many drawbacks, resulting in treatment non-adherence among patients. Thus, the development of transdermal formulations for donepezil delivery is important. The aim of this study was to prepare and to evaluate nanostructured lipid carrier-based gels (NLC gel) able to improve the skin delivery of donep...
Source: Colloids and Surfaces B: Biointerfaces - February 7, 2019 Category: Biochemistry Source Type: research

An evaluation of the gliding performance of solid oral dosage form film coatings using an artificial mucous layer
Publication date: Available online 6 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Nélio Drumond, Sven StegemannABSTRACTOral drug delivery technology is mainly provided in the form of solid oral dosage forms (SODF) that have to be swallowed intact and move throughout the oro-esophageal system to release the drug content in the stomach or intestine. As there is growing evidence for an increasing prevalence of impaired swallowing functions in certain diseases, multimorbidity and advanced age, predictive in vitro methods for the oro-esophageal gliding behavior of SODF would be very useful. The g...
Source: Colloids and Surfaces B: Biointerfaces - February 7, 2019 Category: Biochemistry Source Type: research

BMP2-loaded titania nanotubes coating with pH-responsive multilayers for bacterial infections inhibition and osteogenic activity improvement
This study thus provides a promising strategy to develop pH-responsive antibacterial and enhance bone integrative Ti-based implants for potential orthopedic application.Graphical abstractSchematic illustration the fabrication process of TNT-BMP2-LBLg and use for preventing bacterial infections and enhancing osteogenic activity. (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - February 7, 2019 Category: Biochemistry Source Type: research

Single-vesicle measurement of protein-induced membrane tethering
Publication date: Available online 5 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Bin Cai, Luning Yu, Savanna R. Sharum, Kai Zhang, Jiajie DiaoAbstractFunctions of the proteins involved in membrane tethering, a crucial step in membrane trafficking, remain elusive due to the lack of effective tools to investigate protein-lipid interaction. To address this challenge, we introduce a method to study protein-induced membrane tethering via in vitro reconstitution of lipid vesicles, including detailed steps from the preparation of the PEGylated slides to the imaging of single vesicles. Furthermore, we dem...
Source: Colloids and Surfaces B: Biointerfaces - February 6, 2019 Category: Biochemistry Source Type: research

Polymeric prodrug microspheres with tumor intracellular microenvironment bioreducible degradation, pH-triggered “off-on” fluorescence and drug release for precise imaging-guided diagnosis and chemotherapy
Publication date: Available online 4 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Mingliang Pei, Guoping Li, Kangwei Ma, Jianan Li, Yuanfan Wang, Peng LiuAbstractTheranostic nanoplatforms have been recognized for imaging-guided diagnosis and chemotherapy of cancer by integrating imaging function into the drug delivery systems (DDSs). Here, a facile approach was developed for the fabrication of polymeric prodrug microspheres by introducing pH sensitive “off-on” fluorochrome Rhodamine 6 G into bioreducible cleavable bisulfide crosslinked PEGylated poly(glycidyl methacrylate) (PEG-P...
Source: Colloids and Surfaces B: Biointerfaces - February 5, 2019 Category: Biochemistry Source Type: research

High-efficiency bacteriostatic material modified by nano zinc oxide and polyelectrolyte diallyl dimethylammonium chloride based on red mud
Publication date: Available online 5 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Jian Li, Qi Zhu, Yingying Su, Dongdong Wang, Zipeng Xing, Lei FangAbstractAfter depositing nano zinc oxide on the surface of red mud granule material by one-step hydrothermal method, a layer of cationic polyelectrolyte diallyldimethylammonium chloride is coated to obtain nano zinc oxide-cation polyelectrolyte diallyl dimethylammonium chloride (PDDA) modified red mud granule material. The modified granule material were characterized and tested. The results showed that the modified granule material has significant antib...
Source: Colloids and Surfaces B: Biointerfaces - February 5, 2019 Category: Biochemistry Source Type: research

Indocyanine Green/Doxorubicin-Encapsulated Functionalized Nanoparticles for Effective Combination Therapy against Human MDR Breast Cancer
Publication date: Available online 5 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Hsin-Hung Chen, I.-Lin Lu, Te-I Liu, Yuan-Chung Tsai, Wen-Hsuan Chiang, Sung-Chyr Lin, Hsin-Cheng ChiuAbstractTo overcome low therapeutic efficacy of chemotherapy against multidrug resistance (MDR) breast cancer, a combination therapy system based upon functionalized polymer nanoparticles comprising poly(γ-glutamic acid)-g-poly(lactic-co-glycolic acid) (γ-PGA-g-PLGA) as the major component was developed. The NPs were loaded with doxorubicin (DOX) and indocyanine green (ICG) for dual modality cancer treatme...
Source: Colloids and Surfaces B: Biointerfaces - February 5, 2019 Category: Biochemistry Source Type: research

Comprehensive Toxicity Assessment of PEGylated Magnetic Nanoparticles for in vivo applications
Publication date: Available online 3 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Carlos Caro, David Egea-Benavente, Rocio Polvillo, Jose Luis Royo, Manuel Pernia Leal, María Luisa García-MartínAbstractMagnetic nanoparticles (MNPs) represent one of the greatest promises for the development of a new generation of diagnostic agents for magnetic resonance imaging, with improved specificity and safety. Indeed, during the last decade the number of studies published in this field has grown exponentially. However, the clinical translation achieved so far has been very limited. This si...
Source: Colloids and Surfaces B: Biointerfaces - February 4, 2019 Category: Biochemistry Source Type: research

Fluorescent protein nanoparticles: Synthesis and recognition of cellular oxidation damage
Publication date: Available online 1 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Bing-Qiong Yu, Jian-Cheng Jin, Han-Feng Zou, Bei-Bei Wang, Huan He, Peng Jiang, Feng-Lei Jiang, Yi LiuAbstractIntracellular reactive oxygen species (ROS) generation are associated with many diseases. Lots of studies focus on the detection of intracellular ROS by small fluorescent molecules. However, ROS recognized by biocompatible nanoparticles are relatively less reported. It is widely known that albumin-based nanomaterials possess unique advantages in biomedical applications because they are biodegradable and biocom...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2019 Category: Biochemistry Source Type: research

Nano-silver Hydroxyapatite Based Antibacterial 3D Scaffolds of Gelatin/Alginate/Poly (vinyl alcohol) for Bone Tissue Engineering Applications
Publication date: Available online 31 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Rajesh Kumar Saini, Laxami Prasad Bagri, A.K. BajpaiAbstractIn the present study macroporous three dimensional spongy scaffolds composed of gelatin, alginate, and poly (vinyl alcohol) were prepared by cryogelation technique and silver hydroxyapatite was reinforced into the 3 D matrix. The polymer nanocomposite materials were characterized by analytical techniques such as Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and x-ray diffraction (XRD) analysis. The nanocomposite scaffolds...
Source: Colloids and Surfaces B: Biointerfaces - February 1, 2019 Category: Biochemistry Source Type: research

Effect of deuteration on the phase behaviour and structure of lamellar phases of phosphatidylcholines – deuterated lipids as proxies for the physical properties of native bilayers
Publication date: Available online 31 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Gary Bryant, Matthew B. Taylor, Tamim A. Darwish, Anwen M. Krause-Heuer, Ben Kent, Christopher J. GarveyAbstractDeuteration of phospholipids is a common practice to elucidate membrane structure, dynamics and function, by providing selective visualisation in neutron scattering, nuclear magnetic resonance and vibrational spectroscopy. It is generally assumed that the properties of the deuterated lipids are identical to those of the protiated lipids, and while a number of papers have compared the properties of different ...
Source: Colloids and Surfaces B: Biointerfaces - February 1, 2019 Category: Biochemistry Source Type: research

Physiological neutral pH drives a gradual lamellar-to-reverse cubic-to-reverse hexagonal phase transition in phytantriol-based nanoparticles
Publication date: Available online 31 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Iris R. Ribeiro, Maira F. Immich, Dan Lundberg, Fernanda Poletto, Watson LohAbstractDispersed systems of bicontinuous cubic phases, called cubosomes, show a drug release rate faster than those obtained using other liquid-crystalline phases. To minimize side effects associated with the accelerated release of incorporated drugs, compounds may be added in the dispersions to produce systems of slow initial release and then fast release only in the desired action region. This paper addresses the addition of 10.0 % (w/w) of...
Source: Colloids and Surfaces B: Biointerfaces - February 1, 2019 Category: Biochemistry Source Type: research

Interactions of Gold and Silica Nanoparticles with Plasma Membranes Get Distinguished by the van der Waals Forces: Implications for Drug Delivery, Imaging, and Theranostics
Publication date: Available online 1 February 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Haoyuan Jing, Shayandev Sinha, Harnoor Singh Sachar, Siddhartha DasAbstractMaking a nanoparticle (NP) approach and interact with a plasma membrane (PM) through the receptor-ligand interaction is key for applications like targeted drug delivery, cellular imaging, and theranostics. In this paper, we show that the van der Waals (vdW) interactions dominate the electrostatics ensuring that a gold NP approached the PM more spontaneously as compared to a silica NP. The negative σ (charge density) of a PM induces a nega...
Source: Colloids and Surfaces B: Biointerfaces - February 1, 2019 Category: Biochemistry Source Type: research

The construction and effect of physical properties on intracellular drug delivery of poly(amino acid) capsules
Publication date: Available online 31 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Wenjuan Huang, Tinghong Zhang, Pengzhong Shi, Dejun Yang, Shan Luo, Brigitte Voit, Dietmar Appelhans, Xingjie Zan, Hao ChenAbstractConstructing intracellular degradable drug delivery vehicles is critical to fully exert the function of loaded drugs. Considering the poly (amino acid) is sensitively degradable to acid and enzyme which indwell in the mature lysosome, we here presented the poly(amino acid) capsules constructed by the synthetic poly(amino acid), (poly-glutamic acid, PGA and poly-ornithine, POR). The fabrica...
Source: Colloids and Surfaces B: Biointerfaces - January 31, 2019 Category: Biochemistry Source Type: research

“Solvent/non-solvent” treatment as a method for non-covalent immobilization of gelatin on the surface of poly(L-lactic acid) electrospun scaffolds
Publication date: Available online 29 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): S.I. Goreninskii, R.O. Guliaev, K.S. Stankevich, N.V. Danilenko, E.N. Bolbasov, A.S. Golovkin, A.I. Mishanin, V.D. Filimonov, S.I. TverdokhlebovAbstractIn the present study, we report a simple and efficient method of gelatin immobilization on the surface of PLA electrospun fibers using pre-treatment with a mixture of toluene and ethanol allowing to form swelled surface layer followed by gelatin adsorption from its solution in PBS. Our results demonstrate that gelatin immobilization leads to a decrease in the water con...
Source: Colloids and Surfaces B: Biointerfaces - January 30, 2019 Category: Biochemistry Source Type: research

Poly(N-isopropylacrylamide)/Polydopamine/Clay Nanocomposite Hydrogels with Stretchability, Conductivity, and Light/Thermo Dual Responsive Bending and Adhesive Properties
Publication date: Available online 29 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Xiang Di, Yanke Kang, Feifan Li, Rui Yao, Qin Chen, Chen Hang, Yue Xu, Yanming Wang, Pingchuan Sun, Guolin WuAbstractConducting hydrogels have attracted attention as a special functional class of smart soft materials and have found applications in various advanced fields. However, acquiring all the characteristics such as conductivity, adequate adhesiveness, self-healing ability, stretchability, biocompatibility, and stimulating deformation responsiveness still remains a challenge. Inspired by the mechanism of bioadhe...
Source: Colloids and Surfaces B: Biointerfaces - January 30, 2019 Category: Biochemistry Source Type: research

Proteomic analysis of the bio-corona formed on the surface of (Au, Ag, Pt)-nanoparticles in human serum
Publication date: Available online 29 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): María del Pilar Chantada-Vázquez, Antonio Castro López, Susana B. Bravo, Sergio Vázquez-Estévez, Benigno Acea-Nebril, Cristina NúñezAbstractAdsorption of biomolecules onto nanoparticles surface in biological samples led to the formation of a bio-corona, it could modified the “identity” of nanoparticles, contributing to the determination of their toxicity and biocompatibility.Gel electrophoresis in combination with liquid chromatography-tandem mass spectromet...
Source: Colloids and Surfaces B: Biointerfaces - January 30, 2019 Category: Biochemistry Source Type: research

Poly-L/DL-lactic acid films functionalized with collagen IV as carrier substrata for corneal epithelial stem cells
Publication date: Available online 28 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Ana de la Mata, Miguel A Mateos-Timoneda, Teresa Nieto-Miguel, Sara Galindo, Marina López-Paniagua, Josep A Planell, Elisabeth Engel, Margarita CalongeAbstractLimbal epithelial stem cells (LESCs) are responsible for the renewal of corneal epithelium. Cultivated limbal epithelial transplantation is the current treatment of choice for restoring the loss or dysfunction of LESCs. To perform this procedure, a substratum is necessary for in vitro culturing of limbal epithelial cells and their subsequent transplantati...
Source: Colloids and Surfaces B: Biointerfaces - January 29, 2019 Category: Biochemistry Source Type: research

Fe3O4@PDA immune probe-based signal amplification in surface plasmon resonance (SPR) biosensing of human cardiac troponin I
Publication date: Available online 28 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Fangfang Chen, Qiong Wu, Daqian Song, Xinghua Wang, Pinyi Ma, Ying SunAbstractThis work reports immunomagnetic separation technology-assisted surface plasmon resonance (SPR) biosensing for human cardiac troponin-I (cTnI), a well-known diagnostic marker for myocardial damage. Au film modified by Au nanoparticles (AuNPs) and polydopamine (PDA) was employed as the platforms for immobilizing capture antibody (cAb) and SPR sensing. Magnetic immune probe was prepared by attaching detection antibody (dAb) on the surface of F...
Source: Colloids and Surfaces B: Biointerfaces - January 29, 2019 Category: Biochemistry Source Type: research

Antimicrobial Alumina Nanobiostructures of Disulfide- and Triazole-Linked Peptides: synthesis, characterization, membrane interactions and biological activity
In this study we present two novel synthesis approaches to obtain fibrous type alumina nanoparticles covalently bound to antimicrobial peptides. In the first strategy, thiol functionalized alumina nanoparticles were linked via disulfide bond formation to a cysteine residue of an analog of the peptide BP100 containing a four amino acid spacer (Cys-Ala-Ala-Ala). In the second strategy, alumina nanoparticles were functionalized with azide groups and then bound to alkyne-decorated analogs of the peptides BP100 and DD K through a triazole linkage obtained via a copper(I)-catalyzed cycloaddition reaction. The complete physical-c...
Source: Colloids and Surfaces B: Biointerfaces - January 29, 2019 Category: Biochemistry Source Type: research

Entrapment of bacterial cellulose nanocrystals stabilized Pickering emulsions droplets in alginate beads for hydrophobic drug delivery
Publication date: Available online 29 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Huiqiong Yan, Xiuqiong Chen, Meixi Feng, Zaifeng Shi, Wei Zhang, Yue Wang, Chaoran Ke, Qiang LinAbstractIn this work, the interfacial assembly of amphiphilic bacterial cellulose nanocrystals (BCNs) by Pickering emulsion method was proposed to improve the compatibility between the alginate and hydrophobic drug. BCNs prepared by sulfuric acid hydrolysis of biosynthesized bacterial cellulose was used as the particulate emulsifiers, whereas the model drug, alfacalcidol, dissolved in CH2Cl2 was used as the oil phase. The o...
Source: Colloids and Surfaces B: Biointerfaces - January 29, 2019 Category: Biochemistry Source Type: research

Nanocrystalline diamond-based impedance sensors for real-time monitoring of adipose tissue-derived stem cells
Publication date: Available online 28 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Václav Procházka, Roman Matějka, Tibor Ižák, Ondrej Szabó, Jana Štěpanovská, Elena Filová, Lucie Bačáková, Vít Jirásek, Alexander KromkaAbstractCell-based impedance spectroscopy is a promising label-free method for electrical monitoring of cell activity. Here we present a diamond-based impedance sensor with built-in gold interdigitated electrodes (IDT) as a promising platform for simultaneous electrical and optical monitoring of adipose t...
Source: Colloids and Surfaces B: Biointerfaces - January 28, 2019 Category: Biochemistry Source Type: research

Preparation, Microstructure and Function of Liposome with Light Responsive Switch
Publication date: Available online 26 October 2018Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Yangyang Liu, Xueqin AnAbstractA novel liposome with photo-responsiveness was prepared by a combined method of thin film hydration and supercritical carbon dioxide technique. In liposomes, curcumin and 4-butylazobenzene-4-hexyloxy-trimethyl-ammoniumtrifluoro-acetate (BHA) were used as model drug and photo-responsive reversible switch, respectively. Optimum incubation temperature of drug was determined by using phase transition temperature of the liposomes. Morphology and size of liposomes were obtained by transmissio...
Source: Colloids and Surfaces B: Biointerfaces - January 26, 2019 Category: Biochemistry Source Type: research

Short Fluorocarbon Chains Containing Hydrophobic Nanofibrous Membranes with Improved Hemocompatibility, Anticoagulation and Anti-fouling Performance
Publication date: Available online 14 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Ying Wang, Yuqing Liu, Menglong Liu, Wei Qian, Daijun Zhou, Tengfei Liu, Gaoxing Luo, Malcolm XingAbstractThromboembolic diseases have become one of the most hazardous and mortal diseases to human life. In this paper, a highly hydrophobic nanofibrous membrane was prepared via electrospinning of PCL-b-PHFBA (polycaprolactone -b- poly (heptafluoro butyl acrylate)) block copolymers. The nanofibrous membranes showed high hydrophobicity with a water contact angle of ˜136° due to their rough nanofibrous surface mo...
Source: Colloids and Surfaces B: Biointerfaces - January 26, 2019 Category: Biochemistry Source Type: research

In silico search, chemical characterization and immunogenic evaluation of amino-terminated G4-PAMAM-HIV peptide complexes using three-dimensional models of the HIV-1 gp120 protein
Publication date: Available online 18 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Rolando Alberto Rodríguez-Fonseca, Martiniano Bello, María Ángeles de los Muñoz-Fernández, José Luis Jiménez, Saúl Rojas-Hernández, MJ Fragoso-Vázquez, M Gutiérrez-Sánchez, João Rodrigues, N Cayetano-Castro, R Borja-Urby, Octavio Rodríguez-Cortés, Jazmín García-Machorro, José Correa-BasurtoAbstractPeptide epitopes have been widely used to develop synthetic vaccines and immunotherapies. However,...
Source: Colloids and Surfaces B: Biointerfaces - January 26, 2019 Category: Biochemistry Source Type: research

PEO-b-PCL grafted niosomes: the cooperativilty of amphiphilic components and their properties in vitro and in vivo
In this study, we designed and developed systems composed of non-ionic surfactants i.e. Tween 80, Span 80 and cholesterol with and without poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) block copolymer, using different molar ratios of the above components. The nanosystems were formed by the thin-film hydration method with purified water as dispersion medium. Several physicochemical techniques were utilized in order to study the physicochemical and morphological characteristics of the prepared assemblies. The results showed that the presence of the block copolymer alters significantly the size and morpholog...
Source: Colloids and Surfaces B: Biointerfaces - January 26, 2019 Category: Biochemistry Source Type: research

Nano polydopamine crosslinked thiol-functionalized hyaluronic acid hydrogel for angiogenic drug delivery
Publication date: Available online 22 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Ramanathan Yegappan, Vignesh Selvaprithiviraj, Annapoorna Mohandas, Rangasamy JayakumarAbstractCrosslinking of polymeric network using nanoparticles via physical or chemical method to obtain hydrogel is an emerging approach. Herein, we synthesized polydopamine (PDA) nanoparticles via oxidative self-polymerization of dopamine in water-ethanol mixture. Thiol-functionalized hyaluronic acid was developed using cysteamine and hyaluronic acid (HA-Cys) via 1-Ethyl-3-(3-Dimethylaminopropyl) Carbodiimide - N-hydroxysuccinimide...
Source: Colloids and Surfaces B: Biointerfaces - January 26, 2019 Category: Biochemistry Source Type: research

Effect of blue light irradiation on the stability of phospholipid molecules in the presence of epigallocatechin-3-gallate
Publication date: Available online 23 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Filipa Pires, Vananelia P.N. Geraldo, Andrea Antunes, Alexandre Marletta, Osvaldo N. Oliveira, Maria RaposoAbstractIn this paper, we report on the effects from epigallocatechin-3-gallate (EGCG), a phytochemical flavonoid present in green tea, on Langmuir monolayers of 1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol) (sodium salt) (DPPG), including experiments with blue light irradiation. EGCG was found to interact with both the DPPG headgroups and hydrophobic tails, thus affecting the lipid packing according to ...
Source: Colloids and Surfaces B: Biointerfaces - January 26, 2019 Category: Biochemistry Source Type: research

Development and characterization of benznidazole nano- and microparticles: A new tool for pediatric treatment of Chagas disease?
Publication date: Available online 23 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Katia P. Seremeta, Eva C. Arrúa, Nora B. Okulik, Claudio J. SalomonAbstractBenznidazole (BNZ) is the drug of choice for the treatment of Chagas disease in many countries. However, its low water solubility produces low and/or variable oral bioavailability. Thus, the aim of this work was to formulate micro- and nanoparticles based on Eudragit® RS PO and Eudragit® RL PO as a convenient approach to increase the dissolution rate of BNZ. The microparticles were obtained by means of spray-drying process while ...
Source: Colloids and Surfaces B: Biointerfaces - January 26, 2019 Category: Biochemistry Source Type: research

Propolis nanoparticles prevent structural changes in human hemoglobin during glycation and fructation
Publication date: Available online 23 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Fatemeh Kazemi, Adeleh Divsalar, Ali Akbar Saboury, Arefeh SeyedarabiAbstractNowadays diabetes, as a metabolic disorder, is increasing at an alarming rate. Glycation and production of advanced glycation end products (AGEs) is the most important factor involved in diabetic complications. Due to the side effects of synthetic drugs, the demand for natural anti-diabetic herbal medicines has increased. Propolis is a natural and resinous material, which iscollected by honeybees. Due to the impact of nanotechnology in medici...
Source: Colloids and Surfaces B: Biointerfaces - January 26, 2019 Category: Biochemistry Source Type: research

Biodegradable zein film composites reinforced with chitosan nanoparticles and cinnamon essential oil: physical, mechanical, structural and antimicrobial attributes
Publication date: Available online 23 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Nooshin Vahedikia, Farhad Garavand, Behjat Tajeddin, Ilaria Cacciotti, Seid Mahdi Jafari, Tayebeh Omidi, Zahra ZahediAbstractNatural bio-based zein films were prepared by incorporating cinnamon essential oil (CEO) and chitosan nanoparticles (CNPs) at 2% and 4% (w/w) amounts, respectively, in order to provide mechanical and antimicrobial functionalities. The physical, mechanical, structural and antibacterial properties of the enriched zein films were also scrutinized. The results showed that the combination of CEO-CNPs...
Source: Colloids and Surfaces B: Biointerfaces - January 26, 2019 Category: Biochemistry Source Type: research

Submicron amino acid particles reinforced 100% keratin biomedical films with enhanced wet properties via interfacial strengthening
Publication date: Available online 24 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Xiang Mi, Helan Xu, Yiqi YangAbstractKeratin films with wet stability and strength suitable for biomedical applications were developed via reinforcement with submicron cysteine particles for improved interfaces. Keratin products regenerated from wool or human hair were widely investigated as wound dressing and tissue engineering scaffolds for their satisfactory biomedical properties. However, regenerated keratin scaffolds usually did not have good mechanical properties, and also could not stand humid or wet biological...
Source: Colloids and Surfaces B: Biointerfaces - January 26, 2019 Category: Biochemistry Source Type: research