Molecular imaging of atherosclerotic plaque with lipid nanobubbles as targeted ultrasound contrast agents
Publication date: May 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 189Author(s): Xiangyu Zhang, Mingcong Wu, Yu Zhang, Jie Zhang, Jin Su, Chunrong YangAbstractMolecularly-targeted nanobubbles (NBs) offer opportunities to improve the ability of ultrasound imaging to identify specific pathological tissue from healthy tissue. In this work, we aimed to design ligands-conjugated, nanosized, lipid ultrasound contrast agents (UCAs) and apply the agents in the ultrasound imaging of atherosclerotic plaque. Anti-VEGFR-2 ligands were conjugated to UCAs using the noncovalent biotin-avidin linker method. Several investiga...
Source: Colloids and Surfaces B: Biointerfaces - February 15, 2020 Category: Biochemistry Source Type: research

Pharmaceutical excipient salts effect on micellization and drug solubilization of PEO-PPO-ph-PPO-PEO block copolymer
Publication date: Available online 10 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Yaoyao Zhu, Mengran Chu, Zixiao Wang, Yutao Xue, Bo Liu, Jie Sun, Teng LiuABSTRACTHydrophobic modification PEO-PPO copolymer BP123 was synthesized, with two aromatic rings in the centre linked to PEO-PPO blocks, and the identical PEO and PPO block numbers were possessed with commercial copolymer P123. The influence of three common pharmaceutical excipient salts sodium chloride (NaCl), sodium citrate (NaCA) and sodium benzoate (NaBZ) on self-assembly behaviors of BP123 and P123 was investigated via cloud point, surfa...
Source: Colloids and Surfaces B: Biointerfaces - February 11, 2020 Category: Biochemistry Source Type: research

Atmospheric pressure cold plasma versus classical chemical treatments for carboxyl functionalization of PLA surfaces: A first step toward covalent grafting of bioactive molecules
Publication date: Available online 8 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Stéphanie Vanslambrouck, Iván Rodríguez Durán, Pascale Chevallier, Corinne Hoesli, Gaétan LarocheAbstractThe use of polylactic acid (PLA) has attracted growing interest, particularly in recent years, for biomedical applications because of its mechanical properties, biocompatibility, and biodegradability. Despite this, features such as surface hydrophobicity and the absence of suitable functional groups for covalent immobilization of bioactive molecules, make it challenging to endow P...
Source: Colloids and Surfaces B: Biointerfaces - February 10, 2020 Category: Biochemistry Source Type: research

Optimization of the collagen extraction from Nile tilapia skin (Oreochromis niloticus) and its hydrogel with hyaluronic acid
Publication date: Available online 8 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Maria do L.L.R. Menezes, Hálisson L. Ribeiro, Flávia de Oliveira M.S. Abreu, Judith P.A. Feitosa, Men de Sá Moreira de S. FilhoAbstractNile tilapia skin, an abundant waste from fish processing, can be used for collagen extraction, which has a high aggregated value for biomedical applications. Collagen extraction was conducted under different reaction conditions (time, temperature, and concentration of acetic acid) in order to optimize the yield without compromising the integrity of the collagen. T...
Source: Colloids and Surfaces B: Biointerfaces - February 10, 2020 Category: Biochemistry Source Type: research

A surface convertible nanoplatform with enhanced mitochondria targeted delivery for tumor photothermal therapy
In this study, a targeted photothermal delivery nanoplatform (P-D-CS-CNTs) was facilely fabricated by decoration of an acidity-labile polyethylene glycol (PEG) derivative onto chitosan nanoparticles encapsulating single-walled carbon nanotubes. P-D-CS-CNTs displayed a good stability in serum at normal physiological pH and convertibility of surface charges upon exposure to tumoral acidic pH, which was attributed to the acidity-triggered dePEGylation. The confocal laser scanning microscopic observations suggested that such surface-convertibility of nanoparticles facilitated tumor cell uptake, endo/lyososomal escape, and enha...
Source: Colloids and Surfaces B: Biointerfaces - February 8, 2020 Category: Biochemistry Source Type: research

Silicon-hydroxyapatite‒glycerohydrogel as a promising biomaterial for dental applications
Publication date: Available online 7 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): T.G. Khonina, O.N. Chupakhin, V.Ya. Shur, A.P. Turygin, V.V. Sadovsky, Yu.V. Mandra, E.A. Sementsova, A.Yu Kotikova, A.V. Legkikh, E.Yu Nikitina, E.A. Bogdanova, N.A. SabirzyanovAbstractNanocomposite silicon-hydroxyapatite‒glycerohydrogel (Si-HA‒glycerohydrogel) with different hydroxyapatite (HA) contents of 0.75 and 1.75 wt.% and the same Si content (2.04 wt.%) was obtained by the sol‒gel method. Silicon tetraglycerolate in the form of glycerol solution was used as a biocompatible precursor and H...
Source: Colloids and Surfaces B: Biointerfaces - February 8, 2020 Category: Biochemistry Source Type: research

Hydrogen molecules can modulate enzymatic activity and structural properties of pepsin in vitro
Publication date: Available online 7 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Jie Cheng, Chao Tang, Xueling Li, Jun Hu, Junhong LüAbstractHydrogen gas therapy has been recognized as the promising application merit. However, the underlying mechanism on the biological effects remains far from being understood. In this work, pepsin used as a research model, the effects of hydrogen-rich water on the protein activities and structural properties were investigated by enzymatic assay, atomic force microscopy-based peakforce quantitative nanomechanical mapping (PF-QNM) and terahertz time-domain spe...
Source: Colloids and Surfaces B: Biointerfaces - February 8, 2020 Category: Biochemistry Source Type: research

Antimicrobial activity of bioactive glass S53P4 against representative microorganisms causing osteomyelitis – real-time assessment by isothermal microcalorimetry
Publication date: Available online 7 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Mercedes Gonzalez Moreno, Maria Eugenia Butini, Elena Maryka Maiolo, Laura Sessa, Andrej TrampuzAbstractBioactive glass (BAG) is a synthetic bone substitute with intrinsic antimicrobial properties, used for bone defect filling. We evaluated the antimicrobial activity of two formulations of BAG S53P4 against representative pathogens of osteomyelitis: Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli and Candida albicans. Antimicrobial activity of BAG S53P4 was assessed by isothe...
Source: Colloids and Surfaces B: Biointerfaces - February 8, 2020 Category: Biochemistry Source Type: research

Absorptive and expansive behaviors of poly(methyl methacrylate-co-acrylic acid) bone cement
In this study, a homogeneous distribution of poly (methyl methacrylate-co-acrylic acid) [P(MMA-AA)] microspheres led to the formation of microchannels that favored the delivery of SBF to the interior, causing an increased absorption capacity and enhanced expansion behavior before solidification of the bone cement, with the maximum equilibrium absorption ratio and the expansion ratio reaching 27.3% and 26.3%, respectively, at an AA content of 50%. In addition, the expansion stress induced by the expansion behavior experienced a gradual increase from the 0 s to 2590s, followed by a sharp climbed in a short period rang...
Source: Colloids and Surfaces B: Biointerfaces - February 8, 2020 Category: Biochemistry Source Type: research

Study on phase transition and contrast-enhanced imaging of ultrasound-responsive nanodroplets with polymer shells
This study provides a better understanding of phase transition and contrast-enhanced imaging for ultrasound-responsive nanodroplets with polymer shells.Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - February 8, 2020 Category: Biochemistry Source Type: research

Imiquimod-loaded nanoarchaeosomes as a promising immunotherapy against Trypanosoma cruzi infection
Publication date: Available online 6 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Federico L. Parra, Fernanda M. Frank, Bruno F. Alliani, Eder L. Romero, Patricia B. PetrayAbstractThe purpose of this study was to evaluate the efficacy of imiquimod-containing nanovesicles prepared with lipids extracted from the hyperhalophile archaebacterium Halorubrum tebenquichense (nanoARC-IMQ) to induce protection against Trypanosoma cruzi infection. The therapeutic efficacy of archaeolipid nanovesicles was assessed in an experimental murine model of acute infection with T. cruzi. The administration of nanoARQ-I...
Source: Colloids and Surfaces B: Biointerfaces - February 8, 2020 Category: Biochemistry Source Type: research

Biogenic Ag/CaO nanocomposites kill Staphylococcus aureus with reduced toxicity towards mammalian cells
Publication date: Available online 4 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Md. Imran Khan, Ankit Mazumdar, Soumitra Pathak, Prajita Paul, Susanta Kumar Behera, Ashok J. Tamhankar, Suraj K. Tripathy, Cecilia Stålsby Lundborg, Amrita MishraAbstractRapid increase in the case of bacterial infections is considered as a major public health concern and hence exploration of alternative treatment procedures including development of nanomaterials based therapeutic strategies is receiving much attention. In this aspect, here we investigated the antibacterial efficacy of a simple and potential met...
Source: Colloids and Surfaces B: Biointerfaces - February 5, 2020 Category: Biochemistry Source Type: research

Multiscale simulations of drug distributions in polymer dissolvable microneedles
In this study, Hyaluronic acid (HA) and Polyvinyl alcohol (PVA) were used to fabricate the MNs and sulfonhodamine B (SRB) was selected as the model drug. Firstly, from the quantum chemical calculations, the global electronegativity of HA (3.786 eV) is stronger than that of PVA (2.435 eV), which means that HA owns stronger electronegativity. The Flory-Huggins parameter of HA-SRB is -1.16 which is lower than that of PVA-SRB (53.51), indicating that HA has better compatibility with SRB molecules than PVA. From molecular dynamic simulations, the binding energy of HA-SRB is 93.52 kcal/mol which is much high...
Source: Colloids and Surfaces B: Biointerfaces - February 5, 2020 Category: Biochemistry Source Type: research

Influence of graphene oxide nanoparticles on the transport and cotransport of biocolloids in saturated porous media
This study examines the effect of graphene oxide (GO) nanoparticles (NPs) on the transport (individual species) and cotransport (simultaneous transport) of three biocolloids (Escherichia (E.) coli, Enterococcus (E.) faecalis and Staphylococcus (S.) aureus) in water saturated porous media. Flowthrough experiments were performed in 30-cm long laboratory columns packed with quartz sand. All of the experiments were conducted at room temperature (22 °C), pH = 7, and ionic strength Is = 2 mM. The results from the cotransport experiments indicated that the mass recovery values for all...
Source: Colloids and Surfaces B: Biointerfaces - February 5, 2020 Category: Biochemistry Source Type: research

Bioinspired red blood cell membrane-encapsulated biomimetic nanoconstructs for synergistic and efficacious chemo-photothermal therapy
Publication date: Available online 3 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Pei Wang, Fuquan Jiang, Biaoqi Chen, Hanxiao Tang, Xiaojiao Zeng, Duanhua Cai, Mingzhi Zhu, Ruimin Long, Dayun Yang, Ranjith Kumar Kankala, Shibin Wang, Yuangang LiuAbstractRecently, the fabrication of nanotechnology-based co-delivery systems has garnered enormous interest for efficacious cancer therapy. However, these systems still face certain challenges such as codelivery of drugs with different chemistries, inadequate loading efficiency, immune rejection resulting in rapid clearance and substantially poor bioavail...
Source: Colloids and Surfaces B: Biointerfaces - February 5, 2020 Category: Biochemistry Source Type: research

Peptide 18-4/chlorin e6-conjugated polyhedral oligomeric silsesquioxane nanoparticles for targeted photodynamic therapy of breast cancer
Publication date: Available online 3 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Ye-Ji Kim, Hye-In Lee, Jin-Kyung Kim, Chun-Ho Kim, Young-Jin KimAbstractChlorin e6 (Ce6), with its high phototoxic potential, has wide applications in photodynamic therapy (PDT) for many human diseases. However, poor cancer cell localization of Ce6 has limited its direct application for PDT. Here, we developed cancer-targeting peptide p 18-4/chlorin e6 (Ce6)-conjugated polyhedral oligomeric silsesquioxane (PPC) nanoparticles for improving the targeting ability of Ce6 to breast cancer cells, thereby enhancing PD...
Source: Colloids and Surfaces B: Biointerfaces - February 5, 2020 Category: Biochemistry Source Type: research

Sustained release of TGF-β3 from polysaccharide nanoparticles induces chondrogenic differentiation of human mesenchymal stromal cells
Publication date: Available online 3 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Roger Y., Sydow S., Burmeister L., Menzel H., Hoffmann A.AbstractMedical treatment of certain diseases and biomedical implants are tending to use delivery systems on the nanoscale basis for biologically active factors including drugs (e. g. antibiotics) or growth factors. Nanoparticles are a useful tool to deliver bioactive substances of different chemical nature directly to the site where it is required in the patient. Here we developed three innovative delivery systems based on different polysaccharides in order to ...
Source: Colloids and Surfaces B: Biointerfaces - February 5, 2020 Category: Biochemistry Source Type: research

An ultrasensitive Cystatin C renal failure immunosensor based on a PPy/CNT electrochemical capacitor grafted on interdigitated electrode
Publication date: Available online 1 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Paula A.B. Ferreira, Maria C.M. de Araujo, Cecília M. Prado, Ricardo A. de Lima, Blanca A.G. Rodríguez, Rosa F. DutraAbstractAn interdigitated immunosensor for Cystatin C detection based on polypyrrole/carbon nanotube electrochemical capacitor is described. Cystatin C (CysC) is powerful biomarker for early acute renal failure and one predictive for cardiovascular risk, sepsis, cancer and death. Recently, electrochemical immunosensors based on interdigitated electrodes (IDE) have been successfully focused...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Interface crosslinked mPEG-b-PAGE-b-PCL triblock copolymer micelles with high stability for anticancer drug delivery
In this study, a novel amphiphilic triblock copolymer, methoxy poly(ethylene glycol)-b-poly(allyl glycidyl ether)-b-poly(ε-caprolactone) (mPEG-b-PAGE-b-PCL), with different hydrophobic lengths was designed and synthesized using the combination of two successive ring-opening polymerizations. The products were characterized using 1H NMR and gel permeation chromatography (GPC). The triblock copolymers could self-assemble into micelles to encapsulate doxorubicin (DOX). The diameter of the DOX-loaded micelles increased from 63 to 92 nm with increasing PCL block length in the copolymer composition. The interface o...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Synergistic action of doxorubicin and 7-Ethyl-10-hydroxycamptothecin polyphosphorylcholine polymer prodrug
Publication date: Available online 1 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Zhengzhong Wu, Shuai Li, Yuanyuan Cai, Fan chen, Yuanwei Chen, Xianglin LuoAbstractThere are opportunities for improvements to the efficiency and toxicity of widely used cancer chemotherapy agents such as doxorubicin (DOX·HCl) and 7-Ethyl-10-hydroxycamptothecin (SN38). We developed a safe and effective combination therapy by encapsulating DOX into micelles of a zwitterionic polymer prodrug, SN38 conjugate of poly (α-azide caprolactone-co-caprolactone)-b-poly (2-methacryloyloxyethyl phosphorylcholine [P(CL...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Direct Incorporation of Nano Graphene Oxide (nGO) into Hydrophobic Drug Crystals for Enhanced Aqueous Dissolution
Publication date: Available online 1 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Mohammad Saiful Islam, Faradae Renner, Samar Azizighannad, Somenath MitraAbstractThis paper reports the development of a successful anti-solvent method that incorporates colloidal nano scale graphene oxide (nGO) directly into hydrophobic drug crystals. The nGO dispersed in solution acted as nucleating sites for crystallization and were embedded into the drug crystals without altering its structure or physical properties such as melting point. Several composites of drugs Sulfamethoxazole and Griseofulvin were synthesiz...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Camel α−lactalbumin at the oil−water interface: Effect of protein concentration and pH change on surface characteristics and emulsifying properties
Publication date: Available online 20 January 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Maroua Ellouze, Roua Lajnaf, Ahmed Zouari, Hamadi Attia, Mohamed Ali Ayadi, Christophe VialAbstractCamel α−lactalbumin (Ala−C), the main whey protein of camel milk, was purified by membrane filtration. Surface hydrophobicity as well as interfacial tension were examined at different levels of pH (3.0, 6.0, 9.0) and protein concentration (0.1%, 0.2%, 0.4% w/w), and compared to bovine α−lactalbumin (Ala−B). The emulsifying properties (EAI and ESI) of oil-in-water emulsions (20%/80%) we...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Bis-quaternary ammonium gemini surfactants for gene therapy: Effects of the spacer hydrophobicity on the DNA complexation and biological activity
Publication date: Available online 21 January 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Delvis R. Acosta-Martínez, Eustolia Rodríguez-Velázquez, Fernanda Araiza-Verduzco, Pablo Taboada, Gerardo Prieto, Ignacio A. Rivero, Georgina Pina-Luis, Manuel Alatorre-MedaABSTRACTGemini surfactants (GS) have been highlighted as attractive gene carriers for a few years now; however, key aspects of the role of the GS chemical structure on the DNA-GS complexation and subsequent biological activity remain to be determined. Aiming to elucidate the effects of the GS spacer hydrophobicity, this work wa...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Incorporation of molybdenum disulfide into polyetheretherketone creating biocomposites with improved mechanical, tribological performances and cytocompatibility for artificial joints applications
Publication date: Available online 21 January 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Xinke Lv, Xuehong Wang, Songchao Tang, Dongliang Wang, Lili Yang, Axiang He, Tingting Tang, Jie WeiAbstractTo improve mechanical, tribological and biological performances of polyetheretherketone (PEEK) for artificial joints applications, molybdenum disulfide (MoS2, MS) nanosheets were incorporated into PEEK to fabricate MS/PEEK biocomposites (MPC) with MS content of 4 w% (MPC4) and 8 w% (MPC8). The results revealed that the MS nanosheets with the size of about 400 nm and sheet thickness of about 7...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Encapsulation of Escherichia coli strain Nissle 1917 in a chitosan―alginate matrix by combining layer-by-layer assembly with CaCl2 cross-linking for an effective treatment of inflammatory bowel diseases
Publication date: Available online 21 January 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Xiaoming Luo, Haixing Song, Jing Yang, Bin Han, Ye Feng, Yanbing Leng, Zhaoqiong ChenAbstractEscherichia coli strain Nissle 1917 (EcN) has been widely shown to effectively treat inflammatory bowel diseases (IBDs). Unfortunately, after oral administration, EcN viability dramatically decreases due to severe environmental factors, including low gastric pH, temperature and osmotic pressure. To address these challenges and improve oral bio-availability, this study utilized layer-by-layer assembly (LbL) and ionic cross-link...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Responsive Functionalized MoSe2 Nanosystem for Highly Efficient Synergistic Therapy of Breast Cancer
This study presented a nanosystem that could improve the photostability of optical materials and enhance the photothermal/photodynamic synergy effect, providing a new idea for finding a way to effectively treat breast cancer.Graphical AbstractDiagram of the synthesis of MoSe2@ICG-PDA-HA. (B) Schematic illustration of the targeted photothermal/photodynamic synergistic therapy in tumor. (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Development of Microemulsion Based Topical Ivermectin Formulations: Pre-Formulation and Formulation Studies
Publication date: Available online 23 January 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Surajit Das, Lee Sie Huey, Vernissa Dilys Chia Chye Ting, Pui Shan Chow, Calum Macbeath, Yuanjie Liu, George ShlieoutAbstractThe aim of this work was to develop microemulsions and microemulsion gels which can be used as vehicles for the topical delivery of ivermectin. Tea tree oil and ethyl butanoate were found to be suitable for ivermectin-loaded microemulsion formulations due to the higher solubility of ivermectin in these two oils than other tested oils. The pseudo-ternary phase diagrams were constructed based on t...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Synthesis of Lactoferrin Mesoporous Silica Nanoparticles for Pemetrexed/Ellagic Acid Synergistic Breast Cancer Therapy
Publication date: Available online 24 January 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Omnia M. Ali, Adnan A. Bekhit, Sherine N. Khattab, Maged W. Helmy, Yasser S. Abdel-Ghany, Mohamed Teleb, Ahmed O. ElzoghbyAbstractDespite the clinical approval of few nanomedicines for cancer therapy, some drawbacks still impede their improved efficiency including low drug loading, off-target toxicity and development of multi-drug resistance. Herein, lactoferrin (Lf)-coupled mesoporous silica nanoparticles (MSNPs) were developed for combined delivery of the cytotoxic drug pemetrexed (PMT) and the phytomedicine ellagic...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Zn-HA/Bi-HA biphasic coatings on Titanium: fabrication, characterization, antibacterial and biological activity
Publication date: Available online 25 January 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Qing Bi, Xian Song, Yujia Chen, Yaping Zheng, Ping Yin, Ting LeiAbstractHydroxyapatite (HA) coatings have been of important as biocompatible coatings for dental and bone tissue engineering application. However, the poor antibacterial performance and weak biological activity of HA coatings limited their clinical applications. As a strategy to improve the antibacterial performance and biological activity of HA, Zinc and bismuth ions were incorporated into HA lattice by substituting Ca2+ ions, respectively, and thus zinc...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Evaluation of Chlorine Substituted Hydroxyapatite (ClHAP)/Polydopamine Composite Coatings on Ti64
Publication date: Available online 28 January 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Chin-Shih Hsu, Stephanie L. Haag, Matthew T. Bernards, Qizhen LiAbstractTitanium (Ti) and its alloys (especially Ti-6Al-4 V or Ti64) are commonly used as load-bearing implants because of their biocompatibility and resistance to fatigue and corrosion. However, Ti/alloys are bio-inert metals and not prone to osseointegration. In order to further improve the bioactivity and osseointegration of Ti64, this study evaluated the modification of the Ti64 surface with a deposited chlorine substituted hydroxyapatite (ClHA...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Roughened Graphite Biointerfaced with P450 Liver Microsomes: Surface and Electrochemical Characterizations
In this study, we have designed biointerfaces of human liver microsomes with various roughened, high-purity graphite disk electrodes to study electrochemical and electrocatalytic properties. Successful spectral and microscopic characterizations, direct bioelectronic communication, direct electron-transfer rates from the electrode to liver microsomal enzymes, microsomal heme-enzyme specific oxygen reduction currents, and voltage-driven diclofenac hydroxylation (chosen as the probe reaction) are presented.Graphical Abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Poly(amidoamine)-Modified Mesoporous Silica Nanoparticles as a Mucoadhesive Drug Delivery System for Potential Bladder Cancer Therapy
In this study, poly(amidoamine) (PAMAM) dendrimers were modified onto the surface of mesoporous silica nanoparticles (MSNPs) through a layer-by-layer grafting method. A series of PAMAM-modified MSNPs were prepared and compared for their mucoadhesive capabilities on pig bladder wall and controlled drug release properties. Results demonstrated an increase in the mucoadhesive capacity of PAMAM-modified MSNPs upon an increase in the number of PAMAM amino groups, and the maximum nanoparticle mucoadhesivity was observed after two-generation PAMAM were grafted on the surface of MSNPs. An antineoplastic, doxorubicin, was encapsula...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Effect of surface chemistry on hMSC growth under xeno-free conditions
Publication date: Available online 30 January 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Maura Cimino, Paula Parreira, Sílvia Bidarra, Raquel M. Gonçalves, Cristina C. Barrias, M. Cristina L. MartinsAbstractHuman mesenchymal stem/stromal cells (hMSC) are promising therapeutic agents for regenerative medicine. However, therapeutic doses necessary for clinical application require in vitro expansion, ideally under Xeno-Free conditions (XF) to avoid the use of foetal bovine serum (FBS). We previously reported that hMSCs could be expanded using a pharmaceutical-grade human plasma-derived suppleme...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Microgels and hydrogels as delivery systems for antimicrobial peptides
Publication date: Available online 30 January 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Bruno C. Borro, Randi Nordström, Martin MalmstenAbstractDue to rapid development of bacterial resistance against antibiotics, an emerging health crisis is underway, where ‘simple’ infections may no longer be treatable. Antimicrobial peptides (AMPs) constitute a class of substances attracting interest in this context. So far, research on AMPs has primarily focused on the identification of potent and selective peptides, as well as on the action mode of such peptides. More recently, there has been an inc...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

One-step microwave synthesis of N,S co-doped carbon dots from 1,6-hexanediamine dihydrochloride for cell imaging and ion detection
Publication date: Available online 30 January 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Caihe Ding, Zhiqin Deng, Jiucun Chen, Yanzi JinAbstractAs a new member of the fluorescent carbon nanomaterial family, carbondots (CDs) not only have outstanding photoluminescence properties and small size characteristics, but also contain favourable low cytotoxicity and biocompatibility, which could be the best choice to detect of ions to replace quantum dots for ions detection. Here, the N,S co-doped carbon dots (N/S-CDs) was synthesized by one-step microwave using 1,6-hexanediamine dihydrochloride and dimethyl sulfo...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Fabrication of a novel drug-resin combination device for controlled release of dextromethorphan hydrobromide
This study confirmed the novel DRC could control the release of drug. It concluded that DRC woul be a promising and alternative approach for the development of controlled release dosage form.Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Mitochondria-targeting zeolitic imidazole frameworks to overcome platinum-resistant ovarian cancer
Publication date: Available online 30 January 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Yan Xing, Zhenqi Jiang, Ozioma Udochukwu Akakuru, Yan He, Aiguo Li, Juan Li, Aiguo WuABSTRACTEpithelial ovarian cancer is still the leading cause of death in gynecology due to its resistance to platinum-based first-line chemotherapeutic drugs. The utilization of mitochondria-targeted drugs has become an important direction in anti-tumor drug research and development. In this work, cisplatin (DDP)-loaded ZIF-90with mitochondrial-targeting was synthesized at room temperature with a high drug loading (11.7 %, calculated ...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Tailoring of cardiovascular stent material surface by immobilizing exosomes for better pro-endothelialization function
In this study, we developed a pro-endothelial-functionalization surface by immobilizing a natural factors-loaded nanoparticle, exosome, onto the poly-dopamine (PDA) coated materials via electrostatic binding. (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Focused Characteristics and Effects of Light Reflected from Spherical Lipid Membrane of Giant Unilamellar Vesicles
Publication date: Available online 31 January 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Hai Qiao, Zixin Wei, Yiting Wang, Na Hu, Sineng Sun, Jin Bai, Liaoqiong Fang, Zhibiao WangAbstractLipid vesicle is spherical membranous structure with a concave surface on the inside. When a beam of light illuminates a lipid vesicle, the light reflected from the vesicular concave membrane can be focused to have higher intensity and generate enhanced effects. By observing and simulating light reflected from giant unilamellar vesicles (GUVs), the intensity distribution of the light reflected from a spherical concave lip...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Dual enzyme-like properties of silver nanoparticles decorated Ag2WO4 nanorods and its application for H2O2 and glucose sensing
Publication date: Available online 31 January 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Aneesh Koyappayil, Sheela Berchmans, Min-Ho LeeAbstractThe facile one-pot hydrothermal synthesis of silver nanoparticles decorated silver tungstate nanorods (Ag@Ag2WO4 NRs) and their catalytic activities similar to those of natural enzymes catalase and peroxidase were reported. The Ag@Ag2WO4 NRs could catalyze the decomposition reaction of H2O2 into water and oxygen besides catalyzing the reduction of H2O2 into water in the presence of peroxidase substrates. Spectrophotometric and electrochemical methods were used to ...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

Au nanozyme-driven antioxidation for preventing frailty
Publication date: Available online 31 January 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Jeonghyo Kim, Sangjin Oh, Yong Cheol Shin, Caifeng Wang, Moon Sung Kang, Jong Ho Lee, Woobin Yun, Jin Ah Cho, Dae Youn Hwang, Dong-Wook Han, Jaebeom LeeAbstractFrom senescence and frailty that may result from various biological, mechanical, nutritional, and metabolic processes, the human body has its own antioxidant defense enzymes to remove by-products of oxygen metabolism, and if unregulated, can cause several types of cell damage. Herein, an antioxidant, artificial nanoscale enzyme, called nanozyme (NZs), is introd...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

A novel versatile yolk-shell nanosystem based on NIR-elevated drug release and GSH depletion-enhanced Fenton-like reaction for synergistic cancer therapy
In this study, a versatile doxorubicin (DOX)-loaded yolk-shell nano-particles (HMCMD) assembled with manganese dioxide (MnO2) as the core and copper sulfide (HMCuS) as the mesoporous (∼ 6.4 nm) shell, was designed and synthesized. The resulting HMCMD possess excellent photothermal conversion efficiency. The DOX release from the yolk-shell nanoparticles could be promoted by laser irradiation, which increased the chemotherapy of DOX. Meanwhile, Mn2+ could be released from the HMCMD through a redox reaction between MnO2 and abundant glutathione (GSH) in tumor cells. The released Mn2+ could promote the decomposition of t...
Source: Colloids and Surfaces B: Biointerfaces - February 2, 2020 Category: Biochemistry Source Type: research

pH dependent degradation properties of lactide based 3D microchamber arrays for sustained cargo release
Publication date: April 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 188Author(s): Yuechi Liu, Meiyu Gai, Dusita Sukvanitvichai, Johannes Frueh, Gleb B. SukhorukovAbstractEncapsulation of small water soluble molecules is important in a large variety of applications, ranging from medical substance releasing implants in the field of medicine over release of catalytically active substances in the field of chemical processing to anti-corrosion agents in industry. In this work polylactic acid (PLA) based hollow-structured microchamber (MC) arrays are fabricated via one-step dip coating of a silicone rubber stamp i...
Source: Colloids and Surfaces B: Biointerfaces - February 1, 2020 Category: Biochemistry Source Type: research

Polyvinyl alcohol based hydrogels as new tunable materials for application in the cultural heritage field
Publication date: April 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 188Author(s): Claudia Mazzuca, Leonardo Severini, Fabio Domenici, Yosra Toumia, Francesca Mazzotta, Laura Micheli, Mattia Titubante, Benedetta Di Napoli, Gaio Paradossi, Antonio PalleschiAbstractHydrogel-based cleaning of paper artworks is an increasingly widespread process in the cultural heritage field. However, the search for tuned (compatible, highly retentive and not perishable) hydrogels is a challenging open question. In this paper, a complete characterization of chemical hydrogels based on polyvinyl alcohol (PVA) crosslinked with tel...
Source: Colloids and Surfaces B: Biointerfaces - January 30, 2020 Category: Biochemistry Source Type: research

Antibacterial and photocatalytic activities of 5-nitroindole capped bimetal nanoparticles against multidrug resistant bacteria
In this study, MBR1 was isolated from a membrane bioreactor used in wastewater treatment plants, and the resistance profile was explored. 5-Nitroindole (5 N)-capped CuO/ZnO bimetal nanoparticles (5 NNP) were synthesized using a one pot method to improve the antibacterial and antibiofilm activities of 5 N against Gram-negative (Escherichia coli ATCC700376 and Pseudomonas aeruginosa PA01) and positive (Staphylococcus aureus ATCC6538) human pathogens. 5 NNP containing 1 mM of 5 N exhibited strong antibacterial and antibiofilm properties to most MDR bacteria. In addition, the photocatalytic activity of CuO/ZnO redu...
Source: Colloids and Surfaces B: Biointerfaces - January 30, 2020 Category: Biochemistry Source Type: research

Green synthesis of poly-L-lysine-coated sericin nanoparticles and their molecular size-dependent antibacterial activity
In this study, crude silk sericin protein of Antheraea mylitta cocoon was fractionated into three different molecular size-ranges fractions such as fraction-1 (50−300 kDa), fraction-2 (30−50 kDa) and fraction-3 (10−30 kDa), and used to prepare crude sericin nanoparticles (CRSNPs), as well as fraction specific negative surface potential nanoparticles : n-SNP1, n-SNP2 and n-SNP3, respectively. SNPs were coated with poly-l-lysine to make the surface potential positive (p-SNPs) and confirmed through UV–vis spectroscopy, FTIR, zeta sizer and zeta potential measurement. The shape and ...
Source: Colloids and Surfaces B: Biointerfaces - January 30, 2020 Category: Biochemistry Source Type: research

Thermally induced structural metamorphosis of ZnO:Rb nanostructures for antibacterial impacts
Publication date: April 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 188Author(s): Gajendra Kumar Inwati, Promod Kumar, WD Roos, HC SwartAbstractIn this work, we report on the synthesis of pure and Rb doped ZnO (ZnO:Rb) nanoparticles by a simple combustion technique followed by thermal treatment in an open-air atmosphere. The prepared samples were characterized using UV–vis spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), photoluminescence, Raman spectroscopy and scanning electron microscopy. The wurtzite hexagonal phase structure ...
Source: Colloids and Surfaces B: Biointerfaces - January 29, 2020 Category: Biochemistry Source Type: research

Poly(ethylene glycol) shell-sheddable TAT-modified core cross-linked nano-micelles: TAT-enhanced cellular uptake and lysosomal pH-triggered doxorubicin release
This study aimed to develop sheddable polyethylene glycol (PEG) shells with TAT-modified core cross-linked nanomicelles as drug-delivery carriers of doxorubicin (DOX) to establish a programmed response against the tumor microenvironment, enhanced endocytosis, and lysosomal pH-triggered DOX release. First, poly(L-succinimide) (PSI) underwent a ring-opening reaction with ethylenediamine to generate poly(N-(2-aminoethyl)-l-aspartamide) (P(ae-Asp)). Next, the thiolytic cleavable PEG, 3,4-dihydroxyphenylacetic acid, and TAT were grafted onto P(ae-Asp) to synthesize the amphiphilic graft copolymer of mPEG-SS-g-P(ae-Asp)-MCA-DA-T...
Source: Colloids and Surfaces B: Biointerfaces - January 29, 2020 Category: Biochemistry Source Type: research

A comparative study on EpCAM antibody immobilization on gold surfaces and microfluidic channels for the detection of circulating tumor cells
Publication date: April 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 188Author(s): Didem Cetin, Meltem Okan, Erhan Bat, Haluk KulahAbstractDetection of circulating tumor cells (CTCs) from the bloodstream holds great importance to diagnose cancer at early stages. However, CTCs being extremely rare in blood makes them difficult to reach. In this paper, we introduced different surface modification techniques for the enrichment and detection of MCF-7 in microfluidic biosensor applications using gold surface and EpCAM antibody. Mainly, two different mechanisms were employed to immobilize the antibodies; covalent b...
Source: Colloids and Surfaces B: Biointerfaces - January 27, 2020 Category: Biochemistry Source Type: research

Comparative whole corona fingerprinting and protein adsorption thermodynamics of PLGA and PCL nanoparticles in human serum
Publication date: April 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 188Author(s): Myolisi Ndumiso, Nela Buchtová, Lizex Husselmann, Gadija Mohamed, Ashwil Klein, Marique Aucamp, David Canevet, Sarah D’Souza, Retsepile E. Maphasa, Frank Boury, Admire DubeAbstractNanoparticles (NPs) based on biocompatible and biodegradable polymers such as poly(lactic-co-glycolic acid) (PLGA) and polycaprolactone (PCL) represent effective systems for systemic drug delivery. Upon injection into the blood circuit, the NP surface is rapidly modified due to adsorption of proteins that form a ‘protein corona&rsqu...
Source: Colloids and Surfaces B: Biointerfaces - January 27, 2020 Category: Biochemistry Source Type: research