Mesoporous bioactive glass-polyurethane nanocomposites as reservoirs for sustained drug delivery
Publication date: 1 December 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 172Author(s): Muhammad Shoaib, Muhammad Saif ur Rahman, Aamer Saeed, Muhammad Moazzam NaseerAbstractThe materials capable of sustained drug release are highly desired in the biomedical field, and for this purpose, mesoporous bioactive glass (MBG) and polyurethanes (PUs) are being used along with various other materials. However, MBG is highly brittle and PUs suffer from the lower tensile strength value. Therefore, to overcome these shortcomings, bioactive nanocomposites were designed and fabricated by using MBG and biodegradable PUs. MB...
Source: Colloids and Surfaces B: Biointerfaces - October 21, 2018 Category: Biochemistry Source Type: research

Enhanced osteogenic activity of phosphorylated polyetheretherketone via surface-initiated grafting polymerization of vinylphosphonic acid
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Yanyan Zheng, Lvhua Liu, Li Xiao, Qianyu Zhang, Ying LiuAbstractPolyetheretherketone (PEEK) is considered to be a prime candidate with the potential to replace biomedical metallic materials as an orthopedic and dental implant on account of its elastic modulus similar to that of human cortical bone. Unfortunately, its biomedical application is impeded by the bioinert surface property and inferior osteogenic activity. In this work, phosphate groups were incorporated onto the PEEK surface through a single-step UV-initiated gra...
Source: Colloids and Surfaces B: Biointerfaces - October 21, 2018 Category: Biochemistry Source Type: research

Near-infrared light triggered liposomes combining photodynamic and chemotherapy for synergistic breast tumor therapy
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Ying Yang, Xue Yang, Huipeng Li, Chenzi Li, Huaqian Ding, Mengting Zhang, Yuxin Guo, Minjie SunAbstractPhotodynamic therapy (PDT) as a promising noninvasive and effective treatment modality has been clinically approved for cancer therapy. However, the poor selectivity of tumor and hypoxia-induced resistance constrain PDT efficacy immensely. To further enhance PDT’s potency, we developed a drug delivery system based on liposome combining PDT and chemotherapeutics. The lipophilic IR780 was loaded into the lipid bilayer ...
Source: Colloids and Surfaces B: Biointerfaces - October 20, 2018 Category: Biochemistry Source Type: research

Folate receptor-targeted liposomal nanocomplex for effective synergistic photothermal-chemotherapy of breast cancer in vivo
This study explores the breast tumor regression in vivo by synergistic photothermal-chemotherapy based on liposomal nanocomplex (folic acid-gold nanorods-anticancer drug-liposome). The proposed liposomal nanocomplex can enhance the tumor targeting by functionalizing folic acid (FA) molecules on the surface of liposome that encapsulates both gold nanorods (AuNRs) and the doxorubicin (DOX) to combine the photothermal therapy and the chemotherapy, respectively. Herein, 7-nm gold nanorods were fabricated and co-encapsulated with DOX into nanoliposomes functionalized with FA, with an average diameter of 154 nm, for activ...
Source: Colloids and Surfaces B: Biointerfaces - October 20, 2018 Category: Biochemistry Source Type: research

Impact of sphingomyelin acyl chain (16:0 vs 24:1) on the interfacial properties of Langmuir monolayers: A PM-IRRAS study
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Romina F. Vázquez, M. Antonieta Daza Millone, Felippe J. Pavinatto, María L. Fanani, Osvaldo N. Oliveira, María E. Vela, Sabina M. MatéAbstractMembrane structure is a key factor for the cell`s physiology, pathology, and therapy. Evaluating the importance of lipid species such as N-nervonoyl sphingomyelin (24:1-SM) —able to prevent phase separation— to membrane structuring remains a formidable challenge. This is the first report in which polarization-modulated infrared reflection-absor...
Source: Colloids and Surfaces B: Biointerfaces - October 20, 2018 Category: Biochemistry Source Type: research

Adsorption of proteins on gold nanoparticles: One or more layers?
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Dmitriy V. Sotnikov, Anna N. Berlina, Vladislav S. Ivanov, Anatoly V. Zherdev, Boris B. DzantievAbstractAdsorption of proteins on nanoparticles is a complex and poorly studied process. The mechanisms of protein layer formation can fundamentally differ depending on the composition of the medium, the nanoparticles’ structure, the protein’s nature, and other factors. In particular, monolayer or multilayer immobilization may occur. In the present work, the composition of conjugates of bovine serum albumin and immuno...
Source: Colloids and Surfaces B: Biointerfaces - October 20, 2018 Category: Biochemistry Source Type: research

Quantifying the interactions between biomimetic biomaterials – collagen I, collagen IV, laminin 521 and cellulose nanofibrils – by colloidal probe microscopy
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Robertus Wahyu N. Nugroho, Riina Harjumäki, Xue Zhang, Yan-Ru Lou, Marjo Yliperttula, Juan José Valle-Delgado, Monika ÖsterbergAbstractBiomaterials of different nature have been and are widely studied for various biomedical applications. In many cases, biomaterial assemblies are designed to mimic biological systems. Although biomaterials have been thoroughly characterized in many aspects, not much quantitative information on the molecular level interactions between different biomaterials is available. That ...
Source: Colloids and Surfaces B: Biointerfaces - October 20, 2018 Category: Biochemistry Source Type: research

Mechanical properties of P-selectin PSGL-1 bonds
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Bahman Farzi, Dylan Young, Jan Scrimgeour, Cetin CetinkayaAbstractThe accurate determination of the mechanical properties of P-selectin and PSGL-1 is crucial for design and optimization of applications utilizing such bonds, e.g. biosensors and targeted drug delivery systems, as adhesion and mechanical interactions play a critical role in several key functions of biological cells. In current work, the spring constant and rupture force of a single P-selectin PSGL-1 ligand receptor bond and the Young’s modulus of a layer...
Source: Colloids and Surfaces B: Biointerfaces - October 19, 2018 Category: Biochemistry Source Type: research

Stable perfluorocarbon emulsions for the delivery of halogenated ether anesthetics
ConclusionsThese formulations showed stability, safety and efficacy. In addition to induction and general anesthesia, these emulsions could have utility in global health or in military applications where equipment and resources are limited.Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - October 18, 2018 Category: Biochemistry Source Type: research

Polylactic acid sealed polyelectrolyte complex microcontainers for controlled encapsulation and NIR-Laser based release of cargo
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Meiyu Gai, Wenhao Li, Johannes Frueh, Gleb B. SukhorukovAbstractSurface mediated drug delivery is important for a large variety of applications, especially in medicine to control cell growth, prevent blood platelet activation on implants or for self-disinfecting devices (e.g. catheters). In industrial applications, controlled release of substances from surfaces is needed in a broad range of applications from anti-corrosion systems to anti-biofouling. Polyelectrolyte multilayers (PEM) based microcontainers (MCs) require seve...
Source: Colloids and Surfaces B: Biointerfaces - October 17, 2018 Category: Biochemistry Source Type: research

One-pot synthesis of thermosensitive glycopolymers grafted gold nanoparticles and their lectin recognition
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Fa-Wei Shen, Kai-Chun Zhou, Hao Cai, Yi-Na Zhang, Yong-Li Zheng, Jing QuanAbstractThermosensitive glucose-functionalized glycopolymers grafted gold nanoparticles (Glyco@GNPs) with good colloidal stability and thermosensitive in aqueous solution were fabricated by reversible addition-fragmentation chain transfer (RAFT) mediated one-pot synthesis. The formation of core-shell morphology with about a 60 nm gold core in diameter and a glycopolymer shell of about 80 nm in thickness was indicated by transmission elec...
Source: Colloids and Surfaces B: Biointerfaces - October 16, 2018 Category: Biochemistry Source Type: research

Development of rosemary essential oil nanoemulsions using a wheat biomass-derived surfactant
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): M. José Martin-Piñero, Pablo Ramirez, José Muñoz, M. Carmen AlfaroAbstractIn the present work aqueous-based emulsions formulated with bio-based solvents and surfactants were studied. The droplet size distribution, rheology and physical stability of rosemary essential oil/water emulsions formulated with an emulsifier derived from wheat waste (alkyl polypentoside) were investigated as a function of the dispersed phase concentration (10–50 wt%) by means of laser diffraction, multiple li...
Source: Colloids and Surfaces B: Biointerfaces - October 16, 2018 Category: Biochemistry Source Type: research

Directional affinity of a spherical Gold nanoparticle for the adsorption of DNA bases
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Hossein Farrokhpour, Soraya Abedi, Hamidreza JouypazadehAbstractIn this work, the adsorption activities of different facets of a spherical gold nanoparticle (Au(111), Au(100) and Au(110)) for adenine (ADE) and cytosine (CYT) in two different environments including gas phase and in the presence of solvent (water) have been investigated, separately. It has been found that the adsorption energy (Ead) and geometry of the DNA bases depend strongly on the kind of nanoparticle facet. The Au (110) facet showed the highest adsorptio...
Source: Colloids and Surfaces B: Biointerfaces - October 16, 2018 Category: Biochemistry Source Type: research

Fabrication of hydroxyapatite/hydrophilic graphene composites and their modulation to cell behavior toward bone reconstruction engineering
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Pengjun Wang, Tengbo Yu, Qiulan Lv, Shaoke Li, Xuexiao Ma, Guanpin Yang, Daxing Xu, Xiu Liu, Guangtao Wang, Zeqing Chen, Shi-chao XingAbstractCell adhesion was the first step of bone reconstruction. While hydroxyapatite (HA)/graphene composites had been utilized for improving the cell adhesion and bone osteogenesis, the impact of cell adhesion and HA/graphene composites, especially HA/hydrophilic graphene (HG) composites, on internal interaction force and external surface properties remained poorly understood. Here, higher ...
Source: Colloids and Surfaces B: Biointerfaces - October 16, 2018 Category: Biochemistry Source Type: research

Hemocompatibility and anti-fouling behavior of multilayer biopolymers immobilized on gold-thiolized drug-eluting cardiovascular stents
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Li-Ying Huang, Ming-Chien Yang, Hui-Ming Tsou, Ting-Yu LiuAbstractTo solve the thrombosis and restenosis problem in cardiovascular stent implantation for cardiovascular artery disease, chondroitin 6-sulfate (ChS) with heparin (HEP) have been used as drug carrier layers and alternatively covalently bonded on gold (Au)-dimercaptosuccinic acid (DMSA)-thiolized cardiovascular metallic (SUS316 L stainless steel, SS) stents. Sirolimus, a model drug, was encapsulated in the ChS-HEP alternative layers. The behavior of the dr...
Source: Colloids and Surfaces B: Biointerfaces - October 15, 2018 Category: Biochemistry Source Type: research

Time-dependent mucoadhesion of conjugated bioadhesive polymers
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Kenneth M. Estrellas, Mark Fiecas, Aharon Azagury, Bryan Laulicht, Daniel Y. Cho, Alexis Mancini, Joshua Reineke, Stacia Furtado, Edith MathiowitzAbstractThe time-dependent bioadhesive performance of various polymers was evaluated using a texture analyzer apparatus and freshly excised rat small intestinal tissue. A series of novel bioadhesive polymers were prepared by conjugating L-phenylalanine, L-tyrosine, and L-DOPA to either a low molecular weight poly (butadiene-maleic anhydride) or a high molecular weight poly (ethyle...
Source: Colloids and Surfaces B: Biointerfaces - October 15, 2018 Category: Biochemistry Source Type: research

A gold nanocluster chemical tongue sensor array for Alzheimer’s disease diagnosis
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Xiaojuan Han, Zhentao Man, Shenghao Xu, Lin Cong, Yongxiang Wang, Xiang Wang, Yifeng Du, Qinghua Zhang, Shi Tang, Zengfa Liu, Wei LiAbstractAlzheimer's disease (AD) is a common neurodegenerative disorder in elderly people, and is associated with a heavy financial burden on our society. The use of serologic biomarkers is an attractive method to diagnose AD. Although the determination of blood-based biomarkers for AD has been explored in many studies, few practical diagnosis methods have been used in the clinic. In this work,...
Source: Colloids and Surfaces B: Biointerfaces - October 15, 2018 Category: Biochemistry Source Type: research

Enhancement of bone formation on LBL-coated Mg alloy depending on the different concentration of BMP-2
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Seo-Young Kim, Yu-Kyoung Kim, Kyung-Seon Kim, Kwang-Bok Lee, Min-Ho LeeAbstractTo control the bio-absorption rate of Mg alloy and improve its biocompatibility, a BMP-2 of various concentrations (20, 50, and 100 ng/mL) was immobilized in the carrier layer formed by micro-arc oxidation + hydrothermal treatment on the surface of Mg alloy. Their morphological and chemical properties were evaluated by FE-SEM with EDS and XRD. The electrochemical corrosion behavior was examined, and the cytotoxicity was asses...
Source: Colloids and Surfaces B: Biointerfaces - October 13, 2018 Category: Biochemistry Source Type: research

Insights on the ultra high antibacterial activity of positionally substituted 2′-O-hydroxypropyl trimethyl ammonium chloride chitosan: A joint interaction of -NH2 and -N+(CH3)3 with bacterial cell wall
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Jianhui Li, Liqing Zhao, Yiguang Wu, Muhammad Shahid Riaz RajokaAbstractThe positionally substituted 2′-O-hydroxypropyl trimethyl ammonium chloride chitin (2′-O-HTACCT) with different substitution degree of quaternary ammonium salt were synthesized directly from β-chitin, after that these 2′-O-HTACCT were then deacetylated to obtain corresponding 2′-O-hydroxypropyl trimethyl ammonium chloride chitosan (2′-O-HTACCS) with different deacetylation degree. The antibacterial activity and mechani...
Source: Colloids and Surfaces B: Biointerfaces - October 13, 2018 Category: Biochemistry Source Type: research

Polydimethylsiloxanes biocompatibility in PC12 neuronal cell line
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Edi Simoni, Erica Gentilin, Mariarita Candito, Alessandro Martini, Laura AstolfiAbstractCochlear implants, the only way to recover from severe/profound hearing loss, may cause adverse effects, among which reactions to silicone materials coating implant electrodes, leading to apoptosis and necrosis of spiral ganglion cells. Our aim was to evaluate whether three polydimethylsiloxane (PDMS) compounds (hexadimethylsiloxane, octamethyltrisiloxane, decamethylcyclopentasiloxane) used in silicone rods could exert toxic effects on a...
Source: Colloids and Surfaces B: Biointerfaces - October 13, 2018 Category: Biochemistry Source Type: research

Fabrication of porous FePt microcapsules for immunosensing techniques
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Kumiko Miyajima, Yuki Miwa, Yoshitaka KitamotoAbstractPorous FePt microcapsules are fabricated for use in bead-based immunoassay technologies, that generally use magnetic spheres to immobilize biomolecules on their surface. The magnetic capsules can be used to carry assay reagents to reduce the time required to perform immunoassay processes, and microsize capsules are easier to manipulate magnetically than nanosize ones. Silica particles of approximately 2.5 μm diameter are used as templates and modified with poly...
Source: Colloids and Surfaces B: Biointerfaces - October 13, 2018 Category: Biochemistry Source Type: research

Layer-by-layer films of polysaccharides modified with polyethylene glycol and dextran
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Tatsiana G. Shutava, Kanstantsin S. Livanovich, Anastasiya A. SharametAbstractLayer-by-layer (LbL) films with enhanced resistance to protein adsorption were obtained on the basis of N-grafted copolymers of chitosan with polyethylene glycol (PEG) or dextran (DEX). The copolymers with the backbone molecular weight of 18 and 450 kDa, side chains of PEG of 5.0 and 0.9 kDa, DEX of 6.0 kDa and the degree of amine groups substitution χSub as high as ∼0.25 were alternated with dextran sulfate (DS) to assemble up to 10 bilay...
Source: Colloids and Surfaces B: Biointerfaces - October 13, 2018 Category: Biochemistry Source Type: research

Functionalized graphene nanosheets with improved dispersion stability and superior paclitaxel loading capacity
This study reports our attempt of improving dispersibility of reduced graphene oxide (rGO) through differential functionalization of carboxyl moieties with ethylene diamine (EDA) and folic acid (FA) using carbodimide chemistry. Successful covalent linkage was demonstrated through FT-IR, Raman and energy dispersive X-ray spectroscopy. Functionalized nanosheets (GNs) produced a stable dispersion up to 0.1 wt% which remained unaffected against salt- and protein-induced aggregation. Hemolysis test showed negligible toxicity of GNs in murine erythrocytes up to 100 μg/ml. Non-covalent hydrophobic and п–п...
Source: Colloids and Surfaces B: Biointerfaces - October 13, 2018 Category: Biochemistry Source Type: research

QCM-D and XPS study of protein adsorption on plasma polymers with sulfonate and phosphonate surface groups
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Kim S. Siow, Leanne Britcher, Sunil Kumar, Hans J. GriesserAbstractAs some proteins are known to interact with sulfated and phosphated biomolecules such as specific glycosaminoglycans, this study derives from the hypothesis that sulfonate and phosphonate groups on solid polymer surfaces might cause specific interfacial interactions. Such surfaces were prepared by plasma polymerization of heptylamine (HA) and subsequent grafting of sulfonate or phosphonate groups via Michael-type addition of vinylic compounds. Adsorption of ...
Source: Colloids and Surfaces B: Biointerfaces - October 13, 2018 Category: Biochemistry Source Type: research

Incorporation of functionalized carbon nanotubes into hydrophobic drug crystals for enhancing aqueous dissolution
We present for the first time the direct incorporation of carboxylated carbon nanotubes (f-CNTs) into hydrophobic drug particles during their formation via anti-solvent precipitation. The approach was tested using two drugs namely antifungal agent Griseofulvin (GF) and antibiotic Sulfamethoxazole (SMZ) that had very different aqueous solubility. It was observed that the f-CNTs dispersed in the water served as nucleating sites for crystallization and were readily incorporated into the drug particles without altering crystal structure or other properties. The results showed that the hydrophilic f-CNTs dramatically enhanced d...
Source: Colloids and Surfaces B: Biointerfaces - October 12, 2018 Category: Biochemistry Source Type: research

Based on reduced graphene oxide-copper sulfide-carbon nitride nanosheets composite electrochemiluminescence sensor for determination of gatifloxacin in mouse plasma
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Lihua Jiang, Guichun Mo, Chunhe Yu, Dongmei Ya, Xinxin He, Weiming Mo, Biyang DengAbstractA new method for determination of gatifloxacin hydrochloride (GAT) by reduced graphene oxide-copper sulfide (rGO-CuS) composite coupled with graphite-like carbon nitride nanosheets (g-C3N4 NSs) modified glassy carbon electrode was developed. In this work, rGO-CuS composite was synthesized by one-pot hydrothermal method and used for enhancing sensitivity of GAT. g-C3N4 NSs were synthesized as radiant agent. The sensor characteristics of...
Source: Colloids and Surfaces B: Biointerfaces - October 12, 2018 Category: Biochemistry Source Type: research

Diminishing biofilm resistance to antimicrobial nanomaterials through electrolyte screening of electrostatic interactions
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Robert A. Harper, Guy H. Carpenter, Gordon B. Proctor, Richard D. Harvey, Robert J. Gambogi, Anthony R. Geonnotti, Robert Hider, Stuart A. JonesAbstractThe extracellular polymer substances (EPS) generated by biofilms confers resistance to antimicrobial agents through electrostatic and steric interactions that hinder molecular diffusion. This resistance mechanism is particularly evident for antibacterial nanomaterials, which inherently diffuse more slowly compared to small organic antibacterial agents. The aim of this study ...
Source: Colloids and Surfaces B: Biointerfaces - October 12, 2018 Category: Biochemistry Source Type: research

Molecular imprinted S-nitrosothiols nanoparticles for nitric oxide control release as cancer target chemotherapy
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Tuanwei Liu, Zhenyun Qiao, Jilan Wang, Ping Zhang, Zhide Zhang, Dian-Shun Guo, Xinlin YangAbstractIt is the goal for the development of cancer target chemotherapy with specific recognition, efficient killing the tumor cells and tissues to avoid the intolerable side effects. Molecular imprinted polymer (MIPs) nanoparticles could introduce kinds of specific bio-markers (template molecules) into the nanoparticles with the subsequent removal, leaving special holes in the structure with predictable recognition specificity with c...
Source: Colloids and Surfaces B: Biointerfaces - October 11, 2018 Category: Biochemistry Source Type: research

A pH-sensitive prodrug strategy to co-deliver DOX and TOS in TPGS nanomicelles for tumor therapy
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Shujuan Xiong, Zhe Wang, Juan Liu, Xiangping Deng, Runde Xiong, Xuan Cao, Zhizhong Xie, Xiaoyong Lei, Yanming Chen, Guotao TangAbstractThis work has presented a novel strategy for designing pH-sensitive TOS-H-DOX prodrug-loaded TPGS nanomicelles for co-delivery TOS and DOX to enhance tumor therapy and reduce the toxic side effects. DOX was covalently conjugated to the vitamin E succinate through hydrazone bond to produce an pH-sensitive prodrug TOS-H-DOX (amido bond as a control, TOS-A-DOX), which was responsive to the acid...
Source: Colloids and Surfaces B: Biointerfaces - October 11, 2018 Category: Biochemistry Source Type: research

Trastuzumab decorated TPGS-g-chitosan nanoparticles for targeted breast cancer therapy
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Abhishesh Kumar Mehata, Shreekant Bharti, Priya Singh, Matte Kasi Viswanadh, Lakshmi Kumari, Poornima Agrawal, Sanjay Singh, Biplob Koch, Madaswamy S. MuthuAbstractBreast cancer, up-regulated with human epidermal growth factor receptor type-2 (HER-2) has led to the concept of developing HER-2 targeted anticancer therapeutics. Docetaxel-loaded D-α-tocopherol polyethylene glycol 1000 succinate conjugated chitosan (TPGS-g-chitosan) nanoparticles were prepared with or without Trastuzumab decoration. The particle size and ...
Source: Colloids and Surfaces B: Biointerfaces - October 11, 2018 Category: Biochemistry Source Type: research

Effect of hyaluronic acid on phospholipid model membranes
In this study, we set out to investigate the interaction between HA and representative lipid model membranes, bilayers as well as monolayers, in detail using a variety of calorimetric, spectroscopic, scattering and microscopic techniques, to explore their role in lubrication of articular cartridge. We also cover a wide range of pressures to mimic pressures occurring upon joint movement, aiming at elucidating a possible mechanism for the low friction forces in synovial joints. Effects of HA on lipid bilayer membranes, encompassing significant adsorption at the membrane, penetration of the hydrophobic regions of the HA betwe...
Source: Colloids and Surfaces B: Biointerfaces - October 10, 2018 Category: Biochemistry Source Type: research

Effects of phospholipid and polyethylene glycol monostearate (100) on the in vitro and in vivo physico-chemical characterization of poly(n-butyl cyanoacrylate) nanoparticles
In this study, poly(n-butyl cyanoacrylate) nanoparticles (PBCA-NPs) modified with various amounts of soybean phospholipid (PC) and polyethylene glycol monostearate (S100) were prepared in order to investigate the effects of PC and S100 on the nanoparticles’ physico-chemical properties, cytological properties and in vivo gastrointestinal absorption. Coumarin-6 (C6) was used as a fluorescent probe; C6-loaded PBCA-NPs modified with both PC and S100 (C6-PS-PBCA-NPs) were prepared using miniemulsion polymerization, and C6-loaded PBCA-NPs modified with either S100 (C6-S-PBCA-NPs) or PC (C6-P-PBCA-NPs) were used as referenc...
Source: Colloids and Surfaces B: Biointerfaces - October 10, 2018 Category: Biochemistry Source Type: research

A new drug carrier with oxygen generation function for modulating tumor hypoxia microenvironment in cancer chemotherapy
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Zhe Zhang, Na Niu, Xi Gao, Fuqin Han, Zhijun Chen, Shujun Li, Jian LiAbstractHypoxia is the main characteristic of tumor microenvironment, and the one of the key factors that cause the drug resistance of cancer cells for chemotherapy. Anticancer drug such as DOX cannot react with sufficient oxygen to produce reactive oxygen species (ROS) in hypoxic environment, which affects the therapeutic efficiency of the drug. In this work, we constructed a multi-functional nano-carrier (named as FeSiAuO) containing Fe3O4, mesoporous Si...
Source: Colloids and Surfaces B: Biointerfaces - October 10, 2018 Category: Biochemistry Source Type: research

The effects of blood conditioning films on the antimicrobial and retention properties of zirconium-nitride silver surfaces
This study suggests that the presence of a pre-defined blood conditioning film may result in surfaces with anti-adhesive properties, potentially leading to a reduction in bacterial retention. This, combined with the antimicrobial efficacy of the coatings, could reduce the risk of infection on biomaterial surfaces.Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - October 9, 2018 Category: Biochemistry Source Type: research

Interaction of surfactant and protein at the O/W interface and its effect on colloidal and biological properties of polymeric nanocarriers
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Teresa del Castillo-Santaella, José Manuel Peula-García, Julia Maldonado-Valderrama, Ana Belén Jódar-ReyesAbstractHypothesisThe use of polymer-based surfactants in the double-emulsion (water/oil/water, W/O/W) solvent-evaporation technique is becoming a widespread strategy for preparing biocompatible and biodegradable polymeric nanoparticles (NPs) loaded with biomolecules of interest in biomedicine, or biotechnology. This approach enhances the stability of the NPs, reduces their size and recogniti...
Source: Colloids and Surfaces B: Biointerfaces - October 9, 2018 Category: Biochemistry Source Type: research

Quantitative detection of acyclovir by surface enhanced Raman spectroscopy using a portable Raman spectrometer coupled with multivariate data analysis
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Binge Deng, Xia Luo, Meng Zhang, Liming Ye, Yu ChenAbstractAcyclovir (ACV) is a synthetic antiviral agent with serious side effect, particularly its nephrotoxicity, so this study was to explore the ultrasensitive detection of ACV by surface-enhanced Raman scattering (SERS). The enhancement capability of nanoparticles prepared by different chemical reduction were compared, and Ag nanoparticles reduced by citrate are the most propriate enhanced substrate for acyclovir. In addition, comparison between prominent SERS-enhanced b...
Source: Colloids and Surfaces B: Biointerfaces - October 9, 2018 Category: Biochemistry Source Type: research

On the role of epigallocatechin-3-gallate in protecting phospholipid molecules against UV irradiation
In this study, we confirmed the protective role of EGCG against UV of 1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol) (sodium salt) (DPPG) in liposomes and cast films. The incorporation of EGCG increased the stability of DPPG liposomes as indicated by UV–vis absorption spectra. Using 2D correlation spectroscopy to analyse the spectra, we found that DPPG and EGCG are co-helpers and complement each other against degradation induced by UV. At the molecular level, UV irradiation affects the phosphate and carbonyl groups of DPPG, in addition to triggering the oxidation and opening of the pyrogallol ring of EGCG. Si...
Source: Colloids and Surfaces B: Biointerfaces - October 9, 2018 Category: Biochemistry Source Type: research

Biocompatible graphene-based nanoagent with NIR and magnetism dual-responses for effective bacterial killing and removal
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Fan Yang, Yiting Feng, Xin Fan, Man Zhang, Chen Wang, Weifeng Zhao, Changsheng ZhaoAbstractAntibiotics have been widely used in clinical applications to treat pathogenic infections at present, but the problem of drug-resistance associated with the abuse of antibiotics has become a large threat to human beings. Herein, we developed an antibacterial nanoagent by coating quaternized chitosan (QCS) on the surface of Fe3O4 nanoparticles-anchored graphene oxide (GO), which enabled QCS and GO to achieve synergistic effects on kill...
Source: Colloids and Surfaces B: Biointerfaces - October 7, 2018 Category: Biochemistry Source Type: research

Poly(d,l-lactic-co-glycolic acid) (PLGA) hollow fiber with segmental switchability of its chains sensitive to NIR light for synergistic cancer therapy
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Ji Hyun Choi, Hojun Seo, Ju Hyang Park, Jin Ho Son, Da In Kim, Jongbok Kim, Geon Dae Moon, Dong Choon HyunAbstractThis work introduces a new fibrous system for synergistic cancer therapy. The system consists of poly(d,l-lactic-co-glycolic acid) (PLGA) fibers with a core encapsulating an anticancer drug and a shell entrapping gold nanorods (AuNRs) as a photothermal agent. On exposure to NIR light, the photothermal agent generates heat to raise the local temperature of the fibers. If the temperature is above a glass transitio...
Source: Colloids and Surfaces B: Biointerfaces - October 7, 2018 Category: Biochemistry Source Type: research

Potentiality of microemulsion systems in treatment of ophthalmic disorders: Keratoconus and dry eye syndrome – In vivo study
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Nina Lidich, Sharon Garti-Levy, Abraham Aserin, Nissim GartiAbstractMicroemulsions are widely studied as potential ocular drug delivery vehicles. In the present study we show the versatility of possible use microemulsions as ocular delivery vehicle. The ME is loaded with a hydrophilic drug, riboflavin phosphate (RFP) and a lipophilic, docosahexaenoic acid in triglyceride form (TG-DHA), each separately. These drugs treat keratoconus and dry eye syndrome, respectively. The advantage of using ME loaded with RFP is in overcomin...
Source: Colloids and Surfaces B: Biointerfaces - October 7, 2018 Category: Biochemistry Source Type: research

Entrapment and growth of Chlamydomonas reinhardtii in biocompatible silica hydrogels
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Sarah Vanessa Homburg, Deepak Venkanna, Konstantin Kraushaar, Olaf Kruse, Edwin Kroke, Anant V. PatelAbstractIn this work, we aimed at improved viability and growth of the microalga Chlamydomonas reinhardtii in transparent silica hydrogels based on low-ethanol, low-sodium and low-propylamine synthesis. Investigation into replacement of conventional base KOH by buffers dipotassium phosphate and tris(hydroxymethyl)aminomethane along with increased precursor concentrations yielded an aqueous synthesis route which provided a ge...
Source: Colloids and Surfaces B: Biointerfaces - October 7, 2018 Category: Biochemistry Source Type: research

Preparation of antimicrobial gold and silver nanoparticles from tea leaf extracts
This study provides a means of utilizing used tea leaves, which would otherwise be considered waste products.Graphical abstract (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - October 7, 2018 Category: Biochemistry Source Type: research

Synthesis of ultra-small Rh nanoparticles congregated over DNA for catalysis and SERS applications
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): K. Sangeetha, S. Sam Sankar, K. Karthick, S. Anantharaj, S.R. Ede, Shilpa Wilson T., Subrata KunduAbstractExploration of rare earth metals for the Surface Enhanced Raman Scattering (SERS) is greatly preferred to identify probe molecules even at nano molar level. Highly stable Rh nanoparticles (NPs) which are ultra-small size have been prepared within 20 min of reaction time as a colloidal solution using a bio-molecular scaffold DNA and NaBH4 as a reducing agent under room temperature. While keeping metal ion concentr...
Source: Colloids and Surfaces B: Biointerfaces - October 7, 2018 Category: Biochemistry Source Type: research

An investigation into the release behavior of solid lipid microparticles in different simulated gastrointestinal fluids
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Beatrice Albertini, Serena Bertoni, Beatrice Perissutti, Nadia PasseriniAbstractIn recent years there has been a growing interest in solid lipid-based systems, particularly in solid lipid microparticles (SLMs); however, only very few studies deeply investigated the dissolution behaviour of orally delivered-SLMs. The present study provides new insights about the release performance in different gastrointestinal fluids of SLMs containing a freely water soluble drug (caffeine, as BCS class I drug). Three different formulations...
Source: Colloids and Surfaces B: Biointerfaces - October 7, 2018 Category: Biochemistry Source Type: research

A comparison among β-caseins purified from milk of different species: Self-assembling behaviour and immunogenicity potential
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Diego Romano Perinelli, Giulia Bonacucina, Marco Cespi, Francesca Bonazza, Giovanni Filippo Palmieri, Stefania Pucciarelli, Valeria Polzonetti, Loucine Attarian, Paolo Polidori, Silvia VincenzettiAbstractCaseins are a family of proteins constituted by α-caseins (αs-1 and αs-2 caseins), β-caseins and κ-caseins. β-caseins, in particular, show a temperature and concentration-dependent self-assembling behaviour. Recently, β-casein micelles have been proposed as natural nanocarriers for the...
Source: Colloids and Surfaces B: Biointerfaces - October 6, 2018 Category: Biochemistry Source Type: research

In situ phase transition of microemulsions for parenteral injection yielding lyotropic liquid crystalline carriers of the antitumor drug bufalin
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Yawen Li, Angelina Angelova, Jianwen Liu, Vasil M. Garamus, Na Li, Markus Drechsler, Yabin Gong, Aihua ZouAbstractIn this work, we used the small angle X-ray scattering (SAXS) method for controlled preparation of in situ forming sustained-release carriers for the antitumor drug bufalin (BUF), which has very poor solubility and a considerable cardiotoxicity in a non-encapsulated state. To that aim, we exploited the pseudo-ternary phase diagram of an oil(O)/surfactant(S)/water(W) system containing medium chain capric/caprylic...
Source: Colloids and Surfaces B: Biointerfaces - October 6, 2018 Category: Biochemistry Source Type: research

Substrate topography interacts with substrate stiffness and culture time to regulate mechanical properties and smooth muscle differentiation of mesenchymal stem cells
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Azim Parandakh, Azadeh Anbarlou, Mohammad Tafazzoli-Shadpour, Abdolreza Ardeshirylajimi, Mohammad-Mehdi KhaniAbstractSubstrate stiffness and topography are two powerful means by which mesenchymal stem cells (MSCs) activities can be modulated. The effects of substrate stiffness on the MSCs mechanical properties were investigated previously, however, the role of substrate topography in this regard is not yet well understood. Moreover, in vessel wall, these two physical cues act simultaneously to regulate cellular function, he...
Source: Colloids and Surfaces B: Biointerfaces - October 5, 2018 Category: Biochemistry Source Type: research

Hepatocyte culture on 3D porous scaffolds of PCL/PMCL
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Yan Xiao, Miaomiao Zhou, Mi Zhang, Wei Liu, Yan Zhou, Meidong LangAbstractThe development of three-dimensional (3D) porous scaffolds for soft tissue engineering mainly focused on manipulation of scaffold properties with cell behaviors. By emulsion freeze-drying method, four types of porous scaffolds were prepared from amorphous poly(4-methy-ε-caprolactone) (PMCL) and semi-crystalline poly(ε-caprolactone) (PCL) at different weight ratios, named as PMCL0, PMCL30, PMCL50 and PMCL70, respectively. Visual observa...
Source: Colloids and Surfaces B: Biointerfaces - October 5, 2018 Category: Biochemistry Source Type: research

Liquid crystals-based sensor for the detection of lithocholic acid coupled with competitive host-guest inclusion
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Hui Ma, Qi Kang, Tao Wang, Jianhong Xiao, Li YuAbstractA simple, low-cost and label-free strategy for detecting lithocholic acid (LCA) was designed at the liquid crystals (LCs)/aqueous interface via competitive host-guest inclusion. In this method, sodium dodecyl sulfate (SDS) was initially adsorbed on the fluid interface and induced LCs to adopt the homeotropic ordering. Inclusion complexation of SDS and β-cyclodextrin (β-CD) disturbed interaction between LCs and SDS and evoked LCs to keep a tilted alignment. Whe...
Source: Colloids and Surfaces B: Biointerfaces - October 5, 2018 Category: Biochemistry Source Type: research

Towards biomimics of cell membranes: Structural effect of phosphatidylinositol triphosphate (PIP3) on a lipid bilayer
Publication date: 1 January 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 173Author(s): Alessandra Luchini, Achebe N.O. Nzulumike, Tania K. Lind, Tommy Nylander, Robert Barker, Lise Arleth, Kell Mortensen, Marité CárdenasAbstractPhosphoinositide (PIP) lipids are anionic phospholipids playing a fundamental role for the activity of several transmembrane and soluble proteins. Among all, phosphoinositol-3′,4′,5′-trisphosphate (PIP3) is a secondary signaling messenger that regulates the function of proteins involved in cell growth and gene transcription. The present study aims to rev...
Source: Colloids and Surfaces B: Biointerfaces - October 5, 2018 Category: Biochemistry Source Type: research