Patient ‐reported outcomes for NAFLD/NASH: rational for expanded use
This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 25, 2018 Category: Internal Medicine Authors: Patrizia Carrieri, Martin Duracinsky, Fabienne Marcellin, Jeffrey V Lazarus Tags: Correspondence Source Type: research

Diagnosis and treatment of alcohol use disorder in patients with end ‐stage alcoholic liver disease
This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 24, 2018 Category: Internal Medicine Authors: Fabio Caputo, Marco Domenicali, Mauro Bernardi Tags: Concise Review Source Type: research

New strategies for the management of decompensated cirrosis: long ‐term albumin administration for everyone?
This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 23, 2018 Category: Internal Medicine Authors: Elsa Sol à, Cristina Solé, Pere Ginès Tags: Hepatology Elsewhere Source Type: research

Sexual dysfunction and sex hormone abnormalities in patients with cirrhosis: Review of pathogenesis and management
This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 23, 2018 Category: Internal Medicine Authors: Shuet Fong Neong, Emma O. Billington, Stephen E. Congly Tags: Review Source Type: research

New strategies for the management of decompensated cirrosis: long ‐term albumin administration for everyone?
This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 23, 2018 Category: Internal Medicine Authors: Elsa Sol à, Cristina Solé, Pere Ginès Tags: Hepatology Elsewhere Source Type: research

Sexual dysfunction and sex hormone abnormalities in patients with cirrhosis: Review of pathogenesis and management
This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 23, 2018 Category: Internal Medicine Authors: Shuet Fong Neong, Emma O. Billington, Stephen E. Congly Tags: Review Source Type: research

Short ‐Duration AL‐335, Odalasvir, With or Without Simeprevir, in Patients With HCV GT1 or 3 Infection Without Cirrhosis
Conclusions: In treatment ‐naïve subjects without cirrhosis, AL‐335 + odalasvir + simeprevir for 6‐8 weeks was generally safe and highly efficacious against HCV GT1. However, inadequate efficacy was observed for the 2‐DAA regimen in GT1‐infected subjects and the 3‐DAA regimen in GT3‐infected subjects. (Source: Hepatology)
Source: Hepatology - November 19, 2018 Category: Internal Medicine Authors: Edward J. Gane, Catherine A. Stedman, Christian Schwabe, Leen Vijgen, Sushmita Chanda, Thomas N. Kakuda, John Fry, Lawrence M. Blatt, Matthew W. McClure Tags: Original Article Source Type: research

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood
Conclusion: Bile microinfarcts occur in the acute phase after BDL in a limited number of dispersed hepatocytes followed by larger infarcts involving neighboring hepatocytes, and they allow leakage of bile from the BS ‐overloaded biliary tract into blood, thereby protecting the liver from BS toxicity; in the chronic phase after BDL, reduced sinusoidal BS uptake is a dominant protective factor, and the kidney contributes to the elimination of BS until cholemic nephropathy sets in. (Source: Hepatology)
Source: Hepatology - November 19, 2018 Category: Internal Medicine Authors: Ahmed Ghallab, Ute Hofmann, Selahaddin Sezgin, Nachiket Vartak, Reham Hassan, Ayham Zaza, Patricio Godoy, Kai Markus Schneider, Georgia Guenther, Yasser A. Ahmed, Aya A. Abbas, Verena Keitel, Lars Kuepfer, Steven Dooley, Frank Lammert, Chri Tags: Original Article Source Type: research

Short ‐Duration AL‐335, Odalasvir, With or Without Simeprevir, in Patients With HCV GT1 or 3 Infection Without Cirrhosis
Conclusions: In treatment ‐naïve subjects without cirrhosis, AL‐335 + odalasvir + simeprevir for 6‐8 weeks was generally safe and highly efficacious against HCV GT1. However, inadequate efficacy was observed for the 2‐DAA regimen in GT1‐infected subjects and the 3‐DAA regimen in GT3‐infected subjects. (Source: Hepatology)
Source: Hepatology - November 19, 2018 Category: Internal Medicine Authors: Edward J. Gane, Catherine A. Stedman, Christian Schwabe, Leen Vijgen, Sushmita Chanda, Thomas N. Kakuda, John Fry, Lawrence M. Blatt, Matthew W. McClure Tags: Original Article Source Type: research

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood
Conclusion: Bile microinfarcts occur in the acute phase after BDL in a limited number of dispersed hepatocytes followed by larger infarcts involving neighboring hepatocytes, and they allow leakage of bile from the BS ‐overloaded biliary tract into blood, thereby protecting the liver from BS toxicity; in the chronic phase after BDL, reduced sinusoidal BS uptake is a dominant protective factor, and the kidney contributes to the elimination of BS until cholemic nephropathy sets in. (Source: Hepatology)
Source: Hepatology - November 19, 2018 Category: Internal Medicine Authors: Ahmed Ghallab, Ute Hofmann, Selahaddin Sezgin, Nachiket Vartak, Reham Hassan, Ayham Zaza, Patricio Godoy, Kai Markus Schneider, Georgia Guenther, Yasser A. Ahmed, Aya A. Abbas, Verena Keitel, Lars Kuepfer, Steven Dooley, Frank Lammert, Chri Tags: Original Article Source Type: research

Safety and Efficacy of Ledipasvir –Sofosbuvir With or Without Ribavirin for Chronic Hepatitis C in Children Ages 6‐11
Currently, there are no interferon ‐free treatments available for hepatitis C virus (HCV)–infected patients younger than 12 years. We evaluated the safety and effectiveness of the all‐oral regimen ledipasvir–sofosbuvir ± ribavirin in HCV‐infected children aged 6 to
Source: Hepatology - November 17, 2018 Category: Internal Medicine Authors: Karen F. Murray, William F. Balistreri, Sanjay Bansal, Suzanne Whitworth, Helen M. Evans, Regino P. Gonzalez ‐Peralta, Jessica Wen, Benedetta Massetto, Kathryn Kersey, Jiang Shao, Kimberly L. Garrison, Bandita Parhy, Diana M. Brainard, Rone Tags: Original Article Source Type: research

MicroRNA Sequencing Identifies a Serum MicroRNA Panel, Which Combined With Aspartate Aminotransferase to Platelet Ratio Index Can Detect and Monitor Liver Disease in Pediatric Cystic Fibrosis
Cystic fibrosis (CF) ‐associated liver disease (CFLD) is a hepatobiliary complication of CF. Current diagnostic modalities rely on nonspecific assessments, whereas liver biopsy is the gold standard to assess severity of fibrosis. MicroRNAs (miRNAs) regulate liver disease pathogenesis and are proposed as diagnostic bio markers. We investigated the combined use of serum miRNAs and aspartate aminotransferase (AST) to platelet ratio (APRI) to diagnose and assess CFLD severity. This was a cross‐sectional cohort study of the circulatory miRNA signature of 124 children grouped by clinical, biochemical, and imaging ass essment...
Source: Hepatology - November 15, 2018 Category: Internal Medicine Authors: Diego A. Calvopina, Mark D. Chatfield, Anna Weis, Miranda A. Coleman, Manuel A. Fernandez ‐Rojo, Charlton Noble, Louise E. Ramm, Daniel H. Leung, Peter J. Lewindon, Grant A. Ramm Tags: Original Article Source Type: research

Successful Treatment With Ledipasvir/Sofosbuvir in an Infant With Severe Combined Immunodeficiency Caused by Adenosine Deaminase Deficiency With HCV Allowed Gene Therapy with Strimvelis
Hepatology, EarlyView. (Source: Hepatology)
Source: Hepatology - November 13, 2018 Category: Internal Medicine Authors: Francesca Tucci, Valeria Calbi, Federica Barzaghi, Maddalena Migliavacca, Francesca Ferrua, Maria Ester Bernardo, Daniele Canarutto, Giulia Consiglieri, Salvatore Recupero, Francesco Calzatini, Michela Gabaldo, Caterina Lucano, Miriam Casiragh Tags: Clinical Observations in Hepatology Source Type: research

Of Mice and Men and Nonalcoholic Steatohepatitis
Hepatology, EarlyView. (Source: Hepatology)
Source: Hepatology - November 13, 2018 Category: Internal Medicine Authors: David A. Brenner Tags: EDITORIAL Source Type: research

Revisiting the paradox of interferon ‐stimulated gene expression as a predictor of hepatitis C virus treatment response, a decade later
Hepatology, EarlyView. (Source: Hepatology)
Source: Hepatology - November 13, 2018 Category: Internal Medicine Authors: Lucy Golden ‐Mason, Hugo R. Rosen Tags: Editorial Source Type: research

Successful Treatment With Ledipasvir/Sofosbuvir in an Infant With Severe Combined Immunodeficiency Caused by Adenosine Deaminase Deficiency With HCV Allowed Gene Therapy with Strimvelis
Hepatology, EarlyView. (Source: Hepatology)
Source: Hepatology - November 13, 2018 Category: Internal Medicine Authors: Francesca Tucci, Valeria Calbi, Federica Barzaghi, Maddalena Migliavacca, Francesca Ferrua, Maria Ester Bernardo, Daniele Canarutto, Giulia Consiglieri, Salvatore Recupero, Francesco Calzatini, Michela Gabaldo, Caterina Lucano, Miriam Casiragh Tags: Clinical Observations in Hepatology Source Type: research

Of Mice and Men and Nonalcoholic Steatohepatitis
Hepatology, EarlyView. (Source: Hepatology)
Source: Hepatology - November 13, 2018 Category: Internal Medicine Authors: David A. Brenner Tags: EDITORIAL Source Type: research

Revisiting the paradox of interferon ‐stimulated gene expression as a predictor of hepatitis C virus treatment response, a decade later
Hepatology, EarlyView. (Source: Hepatology)
Source: Hepatology - November 13, 2018 Category: Internal Medicine Authors: Lucy Golden ‐Mason, Hugo R. Rosen Tags: Editorial Source Type: research

Liver Stiffness Measurements in Patients with Noncirrhotic Portal Hypertension —The Devil Is in the Details
Noncirrhotic portal hypertension (NCPH) is often a diagnostic challenge due to signs and symptoms of portal hypertension that overlap with cirrhosis. The etiology of NCPH is broadly classified as prehepatic, hepatic (presinusoidal and sinusoidal) and posthepatic.#hep30167-bib-0001 Some common etiologies of NCPH encountered in clinical practice include portal vein thrombosis (prehepatic) and nodular regenerative hyperplasia (hepatic). Liver histology, although considered gold standard to exclude cirrhosis in individuals with suspected NCPH, is often limited by subtle histologic features or inadequate sampling. Liver stiffne...
Source: Hepatology - November 12, 2018 Category: Internal Medicine Authors: Raj Vuppalanchi, Karan Mathur, Maximillian Pyko, Niharika Samala, Naga Chalasani Tags: Clinical Observations in Hepatology Source Type: research

Prospective Intraindividual Comparison of Magnetic Resonance Imaging With Gadoxetic Acid and Extracellular Contrast for Diagnosis of Hepatocellular Carcinomas Using the Liver Imaging Reporting and Data System
We intraindividually compared the efficacy of magnetic resonance imaging (MRI) with extracellular contrast agents (ECA ‐MRI) and MRI with hepatobiliary agents (HBA‐MRI) for the diagnosis of hepatocellular carcinoma (HCC) using the Liver Imaging Reporting and Data System (LI‐RADS). Between November 2016 and November 2017, we enrolled 91 patients with chronic liver disease who underwent both ECA‐MRI and HBA‐ MRI within a 1‐month interval for a first detected hepatic nodule on ultrasound. In total, 117 observations (95 HCCs, 19 benign lesions, and 3 other malignancies; median size, 18 mm) were identified with surg...
Source: Hepatology - November 12, 2018 Category: Internal Medicine Authors: Ji Hye Min, Jong Man Kim, Young Kon Kim, Tae Wook Kang, Soon Jin Lee, Gyu Seong Choi, Seo ‐Youn Choi, Soohyun Ahn Tags: Original Article Source Type: research

Liver Stiffness Measurements in Patients with Noncirrhotic Portal Hypertension —The Devil Is in the Details
Noncirrhotic portal hypertension (NCPH) is often a diagnostic challenge due to signs and symptoms of portal hypertension that overlap with cirrhosis. The etiology of NCPH is broadly classified as prehepatic, hepatic (presinusoidal and sinusoidal) and posthepatic.#hep30167-bib-0001 Some common etiologies of NCPH encountered in clinical practice include portal vein thrombosis (prehepatic) and nodular regenerative hyperplasia (hepatic). Liver histology, although considered gold standard to exclude cirrhosis in individuals with suspected NCPH, is often limited by subtle histologic features or inadequate sampling. Liver stiffne...
Source: Hepatology - November 12, 2018 Category: Internal Medicine Authors: Raj Vuppalanchi, Karan Mathur, Maximillian Pyko, Niharika Samala, Naga Chalasani Tags: Clinical Observations in Hepatology Source Type: research

Prospective Intraindividual Comparison of Magnetic Resonance Imaging With Gadoxetic Acid and Extracellular Contrast for Diagnosis of Hepatocellular Carcinomas Using the Liver Imaging Reporting and Data System
We intraindividually compared the efficacy of magnetic resonance imaging (MRI) with extracellular contrast agents (ECA ‐MRI) and MRI with hepatobiliary agents (HBA‐MRI) for the diagnosis of hepatocellular carcinoma (HCC) using the Liver Imaging Reporting and Data System (LI‐RADS). Between November 2016 and November 2017, we enrolled 91 patients with chronic liver disease who underwent both ECA‐MRI and HBA‐ MRI within a 1‐month interval for a first detected hepatic nodule on ultrasound. In total, 117 observations (95 HCCs, 19 benign lesions, and 3 other malignancies; median size, 18 mm) were identified with surg...
Source: Hepatology - November 12, 2018 Category: Internal Medicine Authors: Ji Hye Min, Jong Man Kim, Young Kon Kim, Tae Wook Kang, Soon Jin Lee, Gyu Seong Choi, Seo ‐Youn Choi, Soohyun Ahn Tags: Original Article Source Type: research

HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non ‐Alcoholic Fatty Liver Disease
In conclusion, we demonstrate the association of variants inHSD17B13 with specific features of NAFLD histology, and identify the enzyme as a lipid droplet ‐associated RDH. Our data suggest that HSD17B13 plays a role in NAFLD through its enzymatic activity.This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 11, 2018 Category: Internal Medicine Authors: Yanling Ma, Olga V. Belyaeva, Philip M. Brown, Koji Fujita, Katherine Valles, Suman Karki, Ynto S. de Boer, Christopher Koh, Yanhua Chen, Xiaomeng Du, Samuel K. Handelman, Vincent Chen, Elizabeth K. Speliotes, Cara Nestlerode, Emmanuel Thoma Tags: Original Source Type: research

Intestinal immune dysregulation driven by dysbiosis promotes barrier disruption and bacterial translocation in rats with cirrhosis
This study correlates immune system dysregulation in the intestines of rats at different stages of CCl4‐induced cirrhosis with barrier function and pathogenic microbiota. The following variables were addressed in the small intestine: intraepithelial and lamina propria lymphocyte (IEL, LPL) activation status and cytokine production (flow cytometry), cytokine mRNA and protein expression (real‐time quantitative PCR (qPCR) and immunofluorescence), microbiota composition of ileum content (16SrDNA massive sequencing), permeability (fecal albumin loss) and epithelial junctions (immunohistochemistry and immunofluorescence). Th...
Source: Hepatology - November 10, 2018 Category: Internal Medicine Authors: Leticia Mu ñoz, María‐José Borrero, María Úbeda, Elisa Conde, Rosa del Campo, Macarena Rodríguez‐Serrano, Margaret Lario, Ana‐María Sánchez‐Díaz, Oscar Pastor, David Díaz, Laura García‐Bermejo, Jorge Monserrat, Melchor Ál Tags: Original Source Type: research

Coagulation Failure in Patients With Acute ‐on‐Chronic Liver Failure and Decompensated Cirrhosis: Beyond the International Normalized Ratio
Conclusion: Patients with ACLF frequently show hypocoagulable features with prolonged time to initial fibrin formation and clot formation time and reduced clot firmness; these alterations worsen after admission, correlate with systemic inflammation, and translate into higher short ‐term mortality; hypofibrinolysis could contribute to organ failure in ACLF. (Source: Hepatology)
Source: Hepatology - November 9, 2018 Category: Internal Medicine Authors: Annabel Blasi, Andrea Calvo, Ver ónica Prado, Enric Reverter, Juan Carlos Reverter, María Hernández‐Tejero, Fátima Aziz, Alex Amoros, Andres Cardenas, Javier Fernández Tags: Original Article Source Type: research

Human Leukocyte Antigen F Locus Adjacent Transcript 10 Overexpression Disturbs WISP1 Protein and mRNA Expression to Promote Hepatocellular Carcinoma Progression
Conclusion: Our study demonstrated that overexpression of FAT10 results in expression discordance between WISP1 protein and mRNA, thereby promoting HCC progression by down ‐regulating WISP1 protein expression. (Hepatology 2018; 00:000 ‐000). (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Jinlong Yan, Jun Lei, Leifeng Chen, Huan Deng, Dingxiang Dong, Tao Jin, Xiuxia Liu, Rongfa Yuan, Yumin Qiu, Jin Ge, Xiaogang Peng, Jianghua Shao Tags: Original Article Source Type: research

PI3K δ Is a Therapeutic Target in Hepatocellular Carcinoma
Conclusion: Our data identify PI3K δ inhibition, recently approved for the treatment of human B‐cell malignancies, as a potential treatment for HCC. (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Eunkyong Ko, Hyun ‐Wook Seo, Eun Sun Jung, Soomi Ju, Baek‐hui Kim, Hyeki Cho, Yoon Jun Kim, Young Min Park, Jong‐Seo Kim, Guhung Jung Tags: Original Article Source Type: research

Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma
Conclusion: these findings indicate that human intratumoral CD 96+ NK cells are functionally exhausted and patients with higher intratumoral CD96 expression exhibit poorer clinical outcomes. Blocking CD96 ‐CD155 interaction or TGF‐β1 restores NK cell immunity against tumors by reversing NK cell exhaustion, suggesting a possible therapeutic role of CD96 in fighting liver cancer.This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Haoyu Sun, Qiang Huang, Mei Huang, Hao Wen, Renyong Lin, Meijuan Zheng, Kun Qu, Kun Li, Haiming Wei, Weihua Xiao, Rui Sun, Zhigang Tian, Cheng Sun Tags: Original Article Source Type: research

The epidermal growth factor receptor ligand amphiregulin protects from cholestatic liver injury and regulates bile acids synthesis
Conclusion: AREG ‐EGFR signaling protects from cholestatic injury and participates in the physiological regulation of BA synthesis.This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Eva Santamar ía, Carlos M Rodríguez‐Ortigosa, Iker Uriarte, Maria U Latasa, Raquel Urtasun, Gloria Alvarez‐Sola, Marina Bárcena‐Varela, Leticia Colyn, Sara Arcelus, Maddalen Jiménez, Kathleen Deutschmann, Ana Peleteiro‐Vigil, Julia Tags: Original Article Source Type: research

Human Leukocyte Antigen F Locus Adjacent Transcript 10 Overexpression Disturbs WISP1 Protein and mRNA Expression to Promote Hepatocellular Carcinoma Progression
Conclusion: Our study demonstrated that overexpression of FAT10 results in expression discordance between WISP1 protein and mRNA, thereby promoting HCC progression by down ‐regulating WISP1 protein expression. (Hepatology 2018; 00:000 ‐000). (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Jinlong Yan, Jun Lei, Leifeng Chen, Huan Deng, Dingxiang Dong, Tao Jin, Xiuxia Liu, Rongfa Yuan, Yumin Qiu, Jin Ge, Xiaogang Peng, Jianghua Shao Tags: Original Article Source Type: research

PI3K δ Is a Therapeutic Target in Hepatocellular Carcinoma
Conclusion: Our data identify PI3K δ inhibition, recently approved for the treatment of human B‐cell malignancies, as a potential treatment for HCC. (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Eunkyong Ko, Hyun ‐Wook Seo, Eun Sun Jung, Soomi Ju, Baek‐hui Kim, Hyeki Cho, Yoon Jun Kim, Young Min Park, Jong‐Seo Kim, Guhung Jung Tags: Original Article Source Type: research

Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma
Conclusion: these findings indicate that human intratumoral CD 96+ NK cells are functionally exhausted and patients with higher intratumoral CD96 expression exhibit poorer clinical outcomes. Blocking CD96 ‐CD155 interaction or TGF‐β1 restores NK cell immunity against tumors by reversing NK cell exhaustion, suggesting a possible therapeutic role of CD96 in fighting liver cancer.This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Haoyu Sun, Qiang Huang, Mei Huang, Hao Wen, Renyong Lin, Meijuan Zheng, Kun Qu, Kun Li, Haiming Wei, Weihua Xiao, Rui Sun, Zhigang Tian, Cheng Sun Tags: Original Article Source Type: research

The epidermal growth factor receptor ligand amphiregulin protects from cholestatic liver injury and regulates bile acids synthesis
Conclusion: AREG ‐EGFR signaling protects from cholestatic injury and participates in the physiological regulation of BA synthesis.This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Eva Santamar ía, Carlos M Rodríguez‐Ortigosa, Iker Uriarte, Maria U Latasa, Raquel Urtasun, Gloria Alvarez‐Sola, Marina Bárcena‐Varela, Leticia Colyn, Sara Arcelus, Maddalen Jiménez, Kathleen Deutschmann, Ana Peleteiro‐Vigil, Julia Tags: Original Article Source Type: research

Estimating Prevalence of Hepatitis C Virus Infection in the United States, 2013 ‐2016
Conclusion: Over 2 million people in the United States had current HCV infection during 2013 ‐2016; compared to past estimates based on similar methodology, HCV antibody prevalence may have increased, while RNA prevalence may have decreased, likely reflecting the combination of the opioid crisis, curative treatment for HCV infection, and mortality among the HCV‐infected population; effo rts on multiple fronts are needed to combat the evolving HCV epidemic, including increasing capacity for and access to HCV testing, linkage to care, and cure. (Source: Hepatology)
Source: Hepatology - November 6, 2018 Category: Internal Medicine Authors: Megan G. Hofmeister, Elizabeth M. Rosenthal, Laurie K. Barker, Eli S. Rosenberg, Meredith A. Barranco, Eric W. Hall, Brian R. Edlin, Jonathan Mermin, John W. Ward, A. Blythe Ryerson Tags: Original Article Source Type: research

Immunosuppression minimization trials in liver transplantation: can we predict humoral response to asses eligibility?
This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 5, 2018 Category: Internal Medicine Authors: Magdalena Meszaros, Jose Ursic ‐Bedoya, Stéphanie Faure, Georges‐Philippe Pageaux Tags: Correspondence Source Type: research

A Novel Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of NAFLD and HCC
Conclusion AATF drives NAFLD and hepatocarcinogenesis, offering a potential target for therapeutic intervention.This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 5, 2018 Category: Internal Medicine Authors: Divya P. Kumar, Prasanna K. Santhekadur, Mulugeta Seneshaw, Faridoddin Mirshahi, Cora Uram Tuculescu, Arun J. Sanyal Tags: Original Article Source Type: research

B Cell ‐Mediated Maintenance of Cluster of Differentiation 169–Positive Cells Is Critical for Liver Regeneration
Conclusion: We identified CD169+ cells to be a central trigger for liver regeneration, by inducing key signaling pathways important for liver regeneration. (Source: Hepatology)
Source: Hepatology - November 5, 2018 Category: Internal Medicine Authors: Kristina Behnke, Yuan Zhuang, Haifeng C. Xu, Balamurugan Sundaram, Maria Reich, Prashant V. Shinde, Jun Huang, Nastaran Fazel Modares, Alexei V. Tumanov, Robin Polz, J ürgen Scheller, Carl F. Ware, Klaus Pfeffer, Verena Keitel, Dieter Häus Tags: Original Article Source Type: research

Immunosuppression minimization trials in liver transplantation: can we predict humoral response to asses eligibility?
Hepatology,Volume 0, Issue ja, -Not available-. (Source: Hepatology)
Source: Hepatology - November 5, 2018 Category: Internal Medicine Authors: Magdalena Meszaros, Jose Ursic ‐Bedoya, Stéphanie Faure, Georges‐Philippe Pageaux Source Type: research

A Novel Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of NAFLD and HCC
Hepatology,Volume 0, Issue ja, -Not available-. (Source: Hepatology)
Source: Hepatology - November 5, 2018 Category: Internal Medicine Authors: Divya P. Kumar, Prasanna K. Santhekadur, Mulugeta Seneshaw, Faridoddin Mirshahi, Cora Uram Tuculescu, Arun J. Sanyal Source Type: research

B Cell ‐Mediated Maintenance of Cluster of Differentiation 169–Positive Cells Is Critical for Liver Regeneration
Hepatology, EarlyView. (Source: Hepatology)
Source: Hepatology - November 5, 2018 Category: Internal Medicine Authors: Kristina Behnke, Yuan Zhuang, Haifeng C. Xu, Balamurugan Sundaram, Maria Reich, Prashant V. Shinde, Jun Huang, Nastaran Fazel Modares, Alexei V. Tumanov, Robin Polz, J ürgen Scheller, Carl F. Ware, Klaus Pfeffer, Verena Keitel, Dieter Häus Source Type: research

Confirmation of the optimization to prevent the first oesophageal variceal bleeding?
Hepatology,Volume 0, Issue ja, -Not available-. (Source: Hepatology)
Source: Hepatology - November 5, 2018 Category: Internal Medicine Authors: Xinwen Yan, Ziyuan Zou, Xiaolong Qi Source Type: research

Confirmation of the optimization to prevent the first oesophageal variceal bleeding?
This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 4, 2018 Category: Internal Medicine Authors: Xinwen Yan, Ziyuan Zou, Xiaolong Qi Tags: Correspondence Source Type: research