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Condition: Hypertension

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Total 587 results found since Jan 2013.

BOLA3 Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.
CONCLUSIONS: BOLA3 acts as a crucial lynchpin connecting Fe-S-dependent oxidative respiration and glycine homeostasis with endothelial metabolic re-programming critical to PH pathogenesis. These results provide a molecular explanation for the clinical associations linking PH with hyperglycinemic syndromes and mitochondrial disorders. These findings also identify novel metabolic targets, including those involved in epigenetics, iron-sulfur biogenesis, and glycine biology, for diagnostic and therapeutic development. PMID: 30759996 [PubMed - as supplied by publisher]
Source: Circulation - February 14, 2019 Category: Cardiology Authors: Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, Saggar R, Saggar R, Wallace WD, Ross DJ, Waxman AB, Wendell SG, Mullett SJ, Sembrat J, Rojas M, Khan OF, Dahlman JE, Sugahara M, Kagiyama N, Satoh T, Zhang M, Feng N, Gorc Tags: Circulation Source Type: research

Nox1/Ref-1-Mediated Activation of CREB Promotes Gremlin1-Driven Endothelial Cell Proliferation & Migration
Publication date: Available online 8 February 2019Source: Redox BiologyAuthor(s): Daniel S. de Jesus, Evan DeVallance, Yao Li, Micol Falabella, Danielle Guimaraes, Sruti Shiva, Brett Kaufman, Mark T. Gladwin, Patrick J. PaganoAbstractPulmonary arterial hypertension (PAH) is a complex degenerative disorder marked by aberrant vascular remodeling associated with hyperproliferation and migration of endothelial cells (ECs). Previous reports implicated bone morphogenetic protein antagonist Gremlin 1 in this process; however, little is known of the molecular mechanisms involved. The current study was designed to test whether redo...
Source: Redox Biology - February 9, 2019 Category: Biology Source Type: research

Altered hypoxia ‐inducible factor–1α (HIF‐1α) signaling contributes to impaired angiogenesis in fetal lambs with persistent pulmonary hypertension of the newborn (PPHN)
We examined HIF ‐1α expression and promoter activity in the isolated pulmonary artery endothelial cells (PAEC) from fetal lambs with or without PPHN induced by prenatal ductus arteriosus constriction. We measured the levels of HIF ‐1α downstream targets, vascular endothelial growth factor (VEGF) and glycolytic protein, hexokinase 2 (Hek ‐2) in PAEC from PPHN, and control lambs. We examined the effect of small interfering‐RNA (siRNA) mediated knockdown of native HIF‐1α on VEGF expression and in  vitro angiogenesis function of PPHN‐PAEC. HIF‐1α protein levels were higher in the isolated PAEC from PPHN ‐l...
Source: Physiological Reports - January 31, 2019 Category: Physiology Authors: Kartikeya Makker, Adeleye J. Afolayan, Ru ‐Jeng Teng, Girija G. Konduri Tags: Original Research Source Type: research

AT1 Receptors in the Subfornical Organ Modulate Arterial Pressure and the Baroreflex In Two-kidney One-clip Hypertensive Rats.
Abstract The subfornical organ (SFO), a forebrain circumventricular organ that lies outside the blood brain barrier, has been implicated in arterial pressure and baroreflex responses to angiotensin II (Ang II). We tested whether pharmacologic inhibition or selective silencing of SFO AT1 receptors (AT1R) of two-kidney one-clip rats with elevated plasma Ang II decreases resting arterial pressure and renal sympathetic nerve activity (RSNA) and/or modulates arterial baroreflex responses of heart rate and RSNA. Male Sprague Dawley rats underwent renal artery clipping (2K-1C) or sham-clipping (Sham). Six weeks later, co...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - January 9, 2019 Category: Physiology Authors: Rossi NF, Zenner Z, Rishi AK, Levi E, Maliszewska-Scislo M Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Functional interaction between PDGF and GluN2B-containing NMDA receptors in smooth muscle cell proliferation and migration in pulmonary arterial hypertension.
In this study, we explored the complex interactions between platelet-derived growth factor (PDGF) and N-methyl D-aspartate receptor (NMDAR), and their effect on the excessive proliferation and migration of smooth muscle cells leading to obstructed arteries in Pulmonary Arterial Hypertension (PAH). We report lower expression of GluN2B, a subunit composing NMDARs expected to affect cell survival/proliferation of pulmonary artery smooth muscle cells (PASMCs), in PAH patients' lungs. PASMCs exposure to PDGF-BB, stimulated immediate increased levels of phosphorylated Src family kinases (SFKs) together with increased phosphoryla...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - December 13, 2018 Category: Cytology Authors: Quatredeniers M, Nakhleh MK, Dumas SJ, Courboulin A, Vinhas MC, Antigny F, Phan C, Guignabert C, Bendifallah I, Vocelle M, Fadel E, Dorfmüller P, Humbert M, Cohen-Kaminsky S Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Sulfatase 2 mediates, partially, the expression of endothelin-1 and the additive effect of Ang II-induced endothelin-1 expression by CXCL8 in vascular smooth muscle cells from spontaneously hypertensive rats.
In this study, we investigated the effect of Sulfs on the expression of CXCL8-induced endothelin (ET)-1, a hypertensive mediator, in VSMCs from spontaneously hypertensive rats (SHR). Expression of ET-1 and elevation of angiotensin (Ang) II-induced ET-1 expression by CXCL8 were reduced in Sulf2 small interfering RNA (siRNA)-transfected SHR VSMCs. But, downregulation of Sulf1 did not affect the expression of CXCL8-induced ET-1 and additive effect of CXCL8 on Ang II-induced ET-1 expression in SHR VSMCs. CXCL8-induced ET-1 expression and the additive effect of CXCL8 on Ang II-induced ET-1 expression were dependent on the Ang I...
Source: Cytokine - November 20, 2018 Category: Molecular Biology Authors: Kim HY, Jeong DW, Kim HS Tags: Cytokine Source Type: research

SphK1/S1P Mediates PDGF-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation via miR-21/BMPRII/Id1 Signaling Pathway
Conclusion: Our study indicates that SphK1/S1P pathway plays an important role in PDGF-induced PASMC proliferation via miR-21/BMPRII/Id1 axis and targeting against SphK1/S1P axis might be a novel strategy in the prevention and treatment of pulmonary arterial hypertension (PAH).Cell Physiol Biochem 2018;51:487 –500
Source: Cellular Physiology and Biochemistry - November 19, 2018 Category: Cytology Source Type: research

Alternative Polyadenylation(APA) modulates extracellular matrix deposition in pulmonary hypertension
Cleavage and polyadenylation is an important and regulated step in the maturation of mRNAs. Alternative polyadenylation (APA) is typically a shortening of the 3’UTR of affected gene by using a second polyadenylation signal. This shortening can remove regulation and can lead to increased expression of these mRNAs. APA induced by the depletion of the 25kDa subunit of cleavage factor I (CFIm25) has been shown to affect transcripts encoding for extracellular matrix (ECM) Proteins. This leads to the hypothesis that APA due to reduced CFIm25 expression could play a role in modulating ECM production of pulmonary vasculature...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Collum, S., Weng, T., Hernandez, A., Mertens, T., Chen, N., Guha, A., Youker, K., Wagner, E., Han, L., Blackburn, M., Karmouty-Quintana, H. Tags: Pulmonary Hypertension Source Type: research

Late Breaking Abstract - NGF induces pulmonary arterial hyperreactivity through increased connexin-43 expression: potential role in pulmonary hypertension
Conclusions: Our results show that NGF increases Cx43 expression in human and rat PA through a TrkA/PI3K/ERK-dependent signalling pathway. This mechanism contributes to NGF-induced PA hyperreactivity and may thus participate in PH pathophysiology.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Douard, M., Robillard, P., Deweirdt, J., Baudrimont, I., Dubois, M., Marthan, R., Savineau, J.-P., Muller, B., Guibert, C., Freund-Michel, V. Tags: Pulmonary hypertension Source Type: research

Late Breaking Abstract - Chronic Hypoxia Promotes Pulmonary Venous Smooth Muscle Cells Proliferation by Upregulating Calcium Sensing Receptor
Conclusions: CaSR mediating excessive PVSMC proliferation is a new pathogenic mechanism involved in the initiation and progression of hypoxic PVSMC proliferation.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Peng, G., Li, S., Hong, W., Xu, J., Liu, R., Li, B., Ran, P. Tags: Pulmonary hypertension Source Type: research

The BRD4-PLK1 Axis Drives Vascular Remodeling in PAH
Conclusion: We demonstrate that the BRD4/PLK1 axis is increased in human PAH and represents a promising therapeutic target.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Boucherat, O., Tremblay, E., Martineau, S., Jahagirdar, R., Kulikowski, E., Provencher, S., Bonnet, S. Tags: Pulmonary hypertension Source Type: research

The involvement of miR-155 in blood pressure regulation in pregnant hypertension rat via targeting FOXO3a.
CONCLUSIONS: The inhibition of miR-155 improves the damage of pregnant hypertension via the upregulation of FOXO3a, which provides academic leads for the future therapy of pregnant hypertension. PMID: 30402830 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - November 9, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Angiotensin II Type I Receptor Agonistic Autoantibody Induces Podocyte Injury via Activation of the TRPC6- Calcium/Calcineurin Pathway in Pre-Eclampsia
Conclusion: AT1-AA induced podocyte damage in a dose-dependent manner. The underlying mechanism might involve activation of the TRPC6 –calcium/calcineurin pathway. This study provides new details regarding podocyte injury and the mechanism underlying the generation of proteinuria in pre-eclampsia.Kidney Blood Press Res 2018;43:1666 –1676
Source: Kidney and Blood Pressure Research - October 31, 2018 Category: Urology & Nephrology Source Type: research

Calcitonin gene-related peptide inhibits the cardiac fibroblasts senescence in cardiac fibrosis via up-regulating klotho expression.
Abstract It has been documented cardiac fibroblasts as the predominant cell population undergoing senescence in heart. Calcitonin gene-related peptide (CGRP) exhibits a wide range of cardiovascular protective effects. Whether CGRP protects against cardiac fibroblasts senescence in cardiac fibrosis remains unknown. Here, we detected the down-regulation of CGRP concomitant with senescence in fibrotic myocardium, both hypertension- induced left ventricular fibrosis in SHR rats and hypoxia-induced right ventricular fibrosis in pulmonary artery hypertension rats. Exogenous CGRP inhibited the cardiac fibroblasts senesce...
Source: European Journal of Pharmacology - October 20, 2018 Category: Drugs & Pharmacology Authors: Li WQ, Tan SL, Li XH, Sun TL, Li D, Du J, Wei SS, Li YJ, Zhang BK Tags: Eur J Pharmacol Source Type: research