Filtered By:
Condition: Hypertension
This page shows you your search results in order of date. This is page number 15.
Order by Relevance | Date
Total 587 results found since Jan 2013.
Activation of AMPK inhibits Galectin-3-induced pulmonary artery smooth muscle cells proliferation by upregulating hippo signaling effector YAP
Mol Cell Biochem. 2021 Apr 2. doi: 10.1007/s11010-021-04131-3. Online ahead of print.ABSTRACTGalectin-3(Gal-3) is an effective regulator in the pathological process of pulmonary arterial hypertension (PAH). However, the detailed mechanisms underlying Gal-3 contribution to PAH are not yet entirely clear. The aim of the present study was to explore these issues. Proliferation of rat pulmonary arterial smooth muscle cells (PASMCs) was determined using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Small interfering RNA (siRNA) was applied to silence the expression of yes-associated protein (YAP) a...
Source: Molecular and Cellular Biochemistry - April 2, 2021 Category: Biochemistry Authors: Qianqian Zhang Wenge Li Yanting Zhu Qingting Wang Cui Zhai Wenhua Shi Wei Feng Jian Wang Xin Yan Limin Chai Yuqian Chen Cong Li Pengtao Liu Manxiang Li Source Type: research
Serotonin and chronic hypoxic pulmonary hypertension activate a NADPH oxidase 4 and TRPM2 dependent pathway for pulmonary arterial smooth muscle cell proliferation and migration
Vascul Pharmacol. 2021 Mar 29:106860. doi: 10.1016/j.vph.2021.106860. Online ahead of print.ABSTRACT5-Hydroxytryptamine (5-HT)-dependent signaling mediated through its transporter and receptors plays important roles in chronic hypoxic pulmonary hypertension (CHPH), which is associated with aberrant reactive oxygen species (ROS) production. NADPH oxidase 4 (NOX4) is one of the major sources of ROS in pulmonary vasculature, and has been implicated in the development of PH. NOX4 generates H2O2, which can activate the transient receptor potential melastatin 2 (TRPM2) channels, providing Ca2+ signals for cell proliferation and ...
Source: Vascular Pharmacology - April 1, 2021 Category: Drugs & Pharmacology Authors: Jia-Lin Song Si-Yi Zheng Rui-Lan He Long-Xin Gui Mo-Jun Lin James S K Sham Source Type: research
Up-regulation of nPKC contributes to proliferation of mice pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension
This study is designed to investigate the role of novel protein kinases C (nPKC) in mediating pulmonary artery smooth muscle cells (PASMCs) proliferation in pulmonary hypertension (PH) and the underlying mechanisms. Mouse PASMCs was isolated using magnetic separation technology. The PASMCs were divided into 24 h group, 48 h group and 72 h group according to different hypoxia treatment time, then detected cell proliferation rate and nPKC expression level in each group. We treated PASMCs with agonists or inhibitors of PKCdelta (PKCδ) and PKCepsilon (PKCε) and exposed them to hypoxia or normoxia for 72 h, then measured the ...
Source: European Journal of Pharmacology - March 22, 2021 Category: Drugs & Pharmacology Authors: Yiwei Shi Rui Jiang Xiaojiang Qin Anqi Gao Xiaomin Hou Liangjing Chen Xinrong Xu Yunting Guo Lina Chai Liangyuan Zhao Xuefeng Du Furong Wu Source Type: research
17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin
Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV) function and survival than men; however, the underlying mechanisms are unknown. We hypothesized that 17β-estradiol (E2), through estrogen receptor α (ER-α), attenuates PAH-induced RV failure (RVF) by upregulating the procontractile and prosurvival peptide apelin via a BMPR2-dependent mechanism. We found that ER-α and apelin expression were decreased in RV homogenates from patients with RVF and from rats with maladaptive (but not adaptive) RV remodeling. RV cardiomyocyte apelin abundance increased in vivo or in vitro after treatment w...
Source: Journal of Clinical Investigation - March 15, 2021 Category: Biomedical Science Authors: Andrea L. Frump, Marjorie Albrecht, Bakhtiyor Yakubov, Sandra Breuils-Bonnet, Valérie Nadeau, Eve Tremblay, Francois Potus, Junichi Omura, Todd Cook, Amanda Fisher, Brooke Rodriguez, R. Dale Brown, Kurt R. Stenmark, C. Dustin Rubinstein, Kathy Krentz, Di Source Type: research
Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension
Transl Res. 2021 Mar 7:S1931-5244(21)00054-2. doi: 10.1016/j.trsl.2021.03.004. Online ahead of print.ABSTRACTOphiocordyceps sinensis (OCS), an entomopathogenic fungus, is known to exert anti-proliferative and anti-tissue remodeling effects. Vascular remodeling and vasoconstriction play critical roles in the development of pulmonary hypertension (PH). The therapeutic potential of OCS for PH was investigated using rodent PH models, and cultured pulmonary artery endothelial and smooth muscle cells (PAECs and PASMCs), with a focus on the involvement of TRPM7. OCS ameliorated the development of PH, right ventricular hypertrophy...
Source: Translational Research : the journal of laboratory and clinical medicine - March 10, 2021 Category: Laboratory Medicine Authors: Keizo Hiraishi Lin Hai Kurahara Jianlin Feng Aya Yamamura Yuanyuan Cui Eiji Yahiro Hiroyasu Yokomise Tetsuhiko Go Kaori Ishikawa Naoya Yokota Atsushi Fujiwara Miki Onitsuka Kohtaro Abe Shoji Ohga Toru Satoh Yasumasa Okada Lixia Yue Ryuji Inoue Katsuya Hir Source Type: research
Selective deletion of Connective Tissue Growth Factor attenuates experimentally -induced pulmonary fibrosis and pulmonary arterial hypertension
In this study, genetic manipulation of the CCN2 gene was employed to investigate the role of CCN2 expression in vitro and in experimentally-induced models of pulmonary fibrosis and pulmonary arterial hypertension (PAH). Knocking down CCN2 using siRNA, reduced expression of pro-fibrotic markers (fibronectin p < 0.01, collagen type I p < 0.05, α-SMA p < 0.0001, TIMP-1 p < 0.05 and IL-6 p < 0.05) in TGF-β-treated lung fibroblasts derived from systemic sclerosis patients. In vivo studies were performed in mice using a conditional gene deletion strategy targeting CCN2 in a fibroblast-specific and time-dependent...
Source: The International Journal of Biochemistry and Cell Biology - March 4, 2021 Category: Biochemistry Authors: Angela Y Y Tam Amy L Horwell Sarah L Trinder Korsa Khan Shiwen Xu Voon Ong Christopher P Denton Jill T Norman Alan M Holmes George Bou-Gharios David J Abraham Source Type: research
Tetrahydroxystilbene glycoside improves endothelial dysfunction and hypertension in obese rats: the role of omentin-1
CONCLUSIONS: Down-regulation of omentin-1 induces endothelial dysfunction and hypertension in obesity. TSG treatment (at least partially) increases omentin-1 via promoting binding of PPAR-γ and Itln-1 promoter in adipose tissues, subsequently exerts protective effects on endothelial function via activating Akt/eNOS/NO signaling and attenuating oxidative/nitrative stress. These results suggest that TSG could be developed as a promising anti-hypertension agent that protects against endothelial dysfunction and obesity-associated cardiovascular diseases.PMID:33647262 | DOI:10.1016/j.bcp.2021.114489
Source: Biochemical Pharmacology - March 1, 2021 Category: Drugs & Pharmacology Authors: Qianqian Dong Wenjuan Xing Kaifeng Li Xuanxuan Zhou Siwang Wang Haifeng Zhang Source Type: research
