Negative regulation of eNOS-NO signaling by over-SUMOylation of PPAR γ contributes to insulin resistance and dysfunction of vascular endothelium in rats.
Negative regulation of eNOS-NO signaling by over-SUMOylation of PPARγ contributes to insulin resistance and dysfunction of vascular endothelium in rats. Vascul Pharmacol. 2019 Aug 31;:106597 Authors: Yuan W, Ma C, Zhou Y, Wang M, Zeng G, Huang Q Abstract SUMOylation of peroxisome proliferator-activated receptor gamma (PPAR γ) plays important regulatory role in its transcriptional activity. Our recent studies in vitro found that over-SUMOylation of PPARγ, like high glucose and high fat (HG/HF), induced endothelial insulin resistance (IR). However, whether such an event occurs in rats ...
Source: Vascular Pharmacology - August 31, 2019 Category: Drugs & Pharmacology Authors: Yuan W, Ma C, Zhou Y, Wang M, Zeng G, Huang Q Tags: Vascul Pharmacol Source Type: research

Elevated luteinizing hormone contributes to atherosclerosis formation by inhibiting nitric oxide synthesis via PI3K/Akt pathway.
CONCLUSIONS: Elevated LH promotes atherosclerosis formation in OVX ApoE-/- female mice. This effect may be mediated by inhibiting endothelial NO synthesis via PI3K/Akt signaling pathway. PMID: 31437529 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - August 19, 2019 Category: Drugs & Pharmacology Authors: Meng X, Li X, Xu X, Li P, Chen Y, Fu X, Xu X Tags: Vascul Pharmacol Source Type: research

SNF472, a novel anti-crystallization agent, inhibits induced calcification in an in vitro model of human aortic valve calcification.
acute; J, Vaage J Abstract The purpose of the present study was to investigate whether SNF472, the hexasodium salt of myo-inositol hexaphosphate (IP6 or phytate): 1. Inhibits induced calcification in cultured aortic valve interstitial cells (VIC) as an in vitro model of aortic valve stenosis and 2. Whether inhibition is different in VIC obtained from healthy and calcified aortic valves. VIC from healthy (n = 5) and calcified (n = 7) human aortic valves were seeded in basic growth medium, osteogenic differentiation medium alone, or in osteogenic medium with SNF472 (3, 10, and 30 μM) and cultivated for ...
Source: Vascular Pharmacology - August 19, 2019 Category: Drugs & Pharmacology Authors: Zabirnyk A, Ferrer MD, Bogdanova M, Pérez MM, Salcedo C, Kaljusto ML, Kvitting JE, Stensløkken KO, Perelló J, Vaage J Tags: Vascul Pharmacol Source Type: research

Vitamin K2-MK-7 improves nitric oxide-dependent endothelial function in ApoE/LDLR-/- mice.
In conclusion, K2-MK-7 improves NO-dependent endothelial function in ApoE/LDLR-/- mice. This study, identifies the endothelial profile of the pharmacological activity of vitamin K2, which had not been previously described. PMID: 31421222 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - August 14, 2019 Category: Drugs & Pharmacology Authors: Bar A, Kuś K, Manterys A, Proniewski B, Sternak M, Przyborowski K, Moorlag M, Sitek B, Marczyk B, Jasztal A, Skórka T, Franczyk-Żarów M, Kostogrys R, Chlopicki S Tags: Vascul Pharmacol Source Type: research

Modulation of vascular responses of guinea-pig aorta by non-endothelial nitric oxide: A minor role for the endothelium.
Abstract Acetylcholine (Ach) causes vasodilatation by nitric oxide (NO) release from the vascular endothelium. Vasoconstrictors such as α-adrenoceptor agonists (phenylephrine) or thromboxane TxA2 mimetics (U46619) also release endothelial NO. Inhibition of nitric oxide synthase (NOS) with Nω-nitro-L-arginine (L-NAME) potentiates vasoconstriction by phenylephrine and the trace amine, β-phenylethylamine (PEA), indicating underlying opposing vasodilatation. However, the roles of the endothelium and NO in vasodilator and constrictor responses of guinea-pig aorta have not been examined and are the subj...
Source: Vascular Pharmacology - July 23, 2019 Category: Drugs & Pharmacology Authors: Broadley KJ, Broadley HD Tags: Vascul Pharmacol Source Type: research

FNDC5 inhibits foam cell formation and monocyte adhesion in vascular smooth muscle cells via suppressing NF κB-mediated NLRP3 upregulation.
FNDC5 inhibits foam cell formation and monocyte adhesion in vascular smooth muscle cells via suppressing NFκB-mediated NLRP3 upregulation. Vascul Pharmacol. 2019 Jul 15;:106579 Authors: Zang YH, Chen D, Zhou B, Chen AD, Wang JJ, Gao XY, Chen Q, Li YH, Kang YM, Zhu GQ Abstract Foam cell formation and monocytes adhesion are key events in pathogenesis of atherosclerosis. Vascular smooth muscle cells (VSMCs) are an important origin of foam cells besides macrophages. Fibronectin type III domain containing protein 5 (FNDC5) is a protein, which induces browning of fat and attenuates glucose/lipid metab...
Source: Vascular Pharmacology - July 15, 2019 Category: Drugs & Pharmacology Authors: Zang YH, Chen D, Zhou B, Chen AD, Wang JJ, Gao XY, Chen Q, Li YH, Kang YM, Zhu GQ Tags: Vascul Pharmacol Source Type: research

Antiretroviral drug-induced endothelial dysfunction is improved by dual PPAR α/γ stimulation in obesity.
Antiretroviral drug-induced endothelial dysfunction is improved by dual PPARα/γ stimulation in obesity. Vascul Pharmacol. 2019 Jul 05;:106577 Authors: Kamau F, Strijdom H, Mwangi P, Blackhurst D, Imperial E, Salie R Abstract Obesity rates are rising in HIV-infected populations; however, the putative role of highly active antiretroviral therapy (HAART) in the development of endothelial and cardiovascular derangements in the presence of pre-existing overweight/obesity is unclear. Although dual peroxisome proliferator-activated receptors-alpha/gamma (PPARα/γ) stimulation mitigates...
Source: Vascular Pharmacology - July 5, 2019 Category: Drugs & Pharmacology Authors: Kamau F, Strijdom H, Mwangi P, Blackhurst D, Imperial E, Salie R Tags: Vascul Pharmacol Source Type: research

Benzo[a]pyrene alters vascular function in rat aortas ex vivo and in vivo.
Abstract Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon found in tobacco smoke and air pollution products. BaP exposure has been recently suggested to be a risk factor for hypertension in coke oven workers. The mechanisms of BaP on vascular smooth muscle function remain unclear. Here, we examined the influence and possible mechanism of BaP on vasoconstriction in rat thoracic aortas ex vivo and in vivo. In vivo exposure of rats to BaP (20 mg/kg) for 8 weeks caused a significant enhancement in the systolic blood pressure and enhanced aortic hyperreactivity to α1-adrenoceptor selective agonist ph...
Source: Vascular Pharmacology - July 4, 2019 Category: Drugs & Pharmacology Authors: Tzeng HP, Yang TH, Wu CT, Chiu HC, Liu SH, Lan KC Tags: Vascul Pharmacol Source Type: research

Hemodynamic and autonomic effects of low-dose glyceryl trinitrate used to test endothelium-independent vasodilation of the brachial artery.
This study compared the hemodynamic and autonomic effects of the two most often used GTN dosages. In 80 essential hypertensive patients (HT) and 60 normotensive subjects (NT), FMD of the brachial artery and endothelium-independent response to sublingual GTN (25 μg and 400 μg) were evaluated by high-resolution ultrasound and automated image analysis. In 10 HT, muscle sympathetic nerve activity (MSNA) was also assessed by microneurography. HT showed significantly (p 
Source: Vascular Pharmacology - July 3, 2019 Category: Drugs & Pharmacology Authors: Ghiadoni L, Francesconi M, Taddei S, Bruno RM Tags: Vascul Pharmacol Source Type: research

Cost effectiveness of lifelong therapy with PCSK9 inhibitors for lowering cardiovascular events in patients with stable coronary artery disease: Insights from the Ludwigshafen Risk and Cardiovascular Health cohort.
z W Abstract Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) reduce cardiovascular events in coronary artery disease (CAD). Their costs exceed that of established oral lipid-lowering agents. Previous cost-effectiveness assessments have been inconsistent. Markov cohort state transitions models for stable CAD patients were calculated using information from 1530 participants of the Ludwigshafen Risk and Cardiovascular Health Study (LURIC) with known causes of deaths. Non-fatal to fatal event rates, drug prices, direct treatment costs, and utility weights were from public sources. At an assumed relat...
Source: Vascular Pharmacology - June 14, 2019 Category: Drugs & Pharmacology Authors: Dressel A, Schmidt B, Schmidt N, Laufs U, Fath F, Chapman MJ, Grammer TB, März W Tags: Vascul Pharmacol Source Type: research

Stox1 induced the proliferation and cell cycle arrest in pulmonary artery smooth muscle cells via AKT signaling pathway.
CONCLUSION: These findings indicated that Stox1 induced proliferation of PASMCs and the effect is, at least in part, mediated through AKT signaling pathway. PMID: 31207359 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - June 14, 2019 Category: Drugs & Pharmacology Authors: Xu Y, Sun Z, Wang Q, Wang T, Liu Y, Yu F Tags: Vascul Pharmacol Source Type: research

Vitamin D levels and platelet reactivity in diabetic patients receiving dual antiplatelet therapy.
Abstract BACKGROUND: Hypovitaminosis D represents an emerging cardiovascular risk factor, and especially among higher-risk subsets of patients, such as in those with diabetes mellitus. The anti-inflammatory and anti-thrombotic properties of vitamin D, in fact, could be even more beneficial among diabetics, where platelet hyperreactivity and suboptimal response to antiplatelet drugs has been associated with poorer outcomes. However, no study has so far evaluated the impact of vitamin D levels on platelet reactivity and high-on treatment platelet reactivity (HRPR) among diabetic patients receiving dial antiplatelet ...
Source: Vascular Pharmacology - June 6, 2019 Category: Drugs & Pharmacology Authors: Verdoia M, Pergolini P, Nardin M, Rolla R, Negro F, Kedhi E, Suryapranata H, Marcolongo M, Carriero A, De Luca G, Novara Atherosclerosis Study Group (NAS) Tags: Vascul Pharmacol Source Type: research

Extended treatment with non-vitamin K antagonist oral anticoagulants versus low-molecular-weight heparins in cancer patients following venous thromboembolism. A pilot study.
CONCLUSIONS: In patients following CAT, extended treatment with NOAC, compared with LMWH, appears to be associated with similar effectiveness and safety. PMID: 31158568 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - May 31, 2019 Category: Drugs & Pharmacology Authors: Stepien K, Nowak K, Zalewski J, Pac A, Undas A Tags: Vascul Pharmacol Source Type: research

Uric acid: from a biological advantage to a potential danger. A focus on cardiovascular effects.
Abstract Non-communicable diseases represent nowadays the most common cause of death worldwide, having largely overcome infectious diseases. Among them, cardiovascular diseases constitute the majority. Given these premise, great efforts have been made by scientific societies to emphasize the fundamental role of cardiovascular prevention and risk factors control. In addition to classical cardiovascular risk factors such as smoking, arterial hypertension, hypercholesterolemia and male gender, new risk factors are emerging from international literature. Among them, uric acid is the protagonist. Several evidences show...
Source: Vascular Pharmacology - May 29, 2019 Category: Drugs & Pharmacology Authors: Cortese F, Giordano P, Scicchitano P, Faienza MF, De Pergola G, Calculli G, Meliota G, Ciccone MM Tags: Vascul Pharmacol Source Type: research

Effects of sildenafil on maximum walking time in patients with arterial claudication: The ARTERIOFIL study.
te; G Abstract BACKGROUND: Patients with lower extremity peripheral artery disease (PAD) frequently experience claudication, a clinical symptom indicative of reduced walking capacity. Recommended care consists of exercise rehabilitation combined with optimal medical treatment and surgery. The effects of a single oral dose of sildenafil, a phosphodiesterase type-5 inhibitor, on patients with claudication are discussed. The aim of this study was to test the efficacy of a single 100 mg dose of sildenafil compared to placebo in terms of maximal walking time (MWT) in patients with claudication. METHODS: The ARTE...
Source: Vascular Pharmacology - May 29, 2019 Category: Drugs & Pharmacology Authors: Omarjee L, Le Pabic E, Custaud MA, Fontaine C, Locher C, Renault A, Jaquinandi V, Azzola V, Barbeau-Terrier C, Laporte I, Ripoche M, Onillon Y, Chretien JM, Daniel V, de la Barca JC, Homedan C, Reynier P, Abraham P, Mahé G Tags: Vascul Pharmacol Source Type: research

Inflammation in pulmonary artery hypertension.
PMID: 31112745 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - May 18, 2019 Category: Drugs & Pharmacology Authors: Sakuma M, Toyoda S, Inoue T, Node K Tags: Vascul Pharmacol Source Type: research

Nitric oxide donor molsidomine favors features of atherosclerotic plaque stability and reduces myocardial infarction in mice.
Abstract Nitric oxide (NO) donors are commonly used for the prevention and treatment of ischemic heart disease. Besides their effects on the heart, NO donors may also prevent hypoxic brain damage and exert beneficial effects on atherosclerosis by favoring features of plaque stability. We recently described that apolipoprotein E (ApoE) deficient mice with a mutation in the fibrillin-1 (Fbn1) gene (ApoE-/-Fbn1C1039G+/-) develop accelerated atherosclerosis, plaque rupture, myocardial infarction, cerebral hypoxia and sudden death. In the present study, we evaluated the effects of chronic treatment with the NO donor mo...
Source: Vascular Pharmacology - May 11, 2019 Category: Drugs & Pharmacology Authors: Roth L, der Donckt CV, Veseli BE, Van Dam D, De Deyn PP, Martinet W, Herman AG, De Meyer GRY Tags: Vascul Pharmacol Source Type: research

Compromised cardiovascular function in aged rats corresponds with increased expression and activity of calcium/calmodulin dependent protein kinase II δ in aortic endothelium.
Compromised cardiovascular function in aged rats corresponds with increased expression and activity of calcium/calmodulin dependent protein kinase IIδ in aortic endothelium. Vascul Pharmacol. 2019 Apr 30;: Authors: McCluskey C, Mooney L, Paul A, Currie S Abstract Ageing is the greatest risk factor for cardiovascular disease. Calcium/calmodulin dependent protein kinase IIδ (CaMKIIδ) plays a fundamental role in the pathology of heart disease yet a potential role for CaMKIIδ in cardiovascular pathology associated with ageing remains unclear. Taking a combined in vivo and in vitro ...
Source: Vascular Pharmacology - April 30, 2019 Category: Drugs & Pharmacology Authors: McCluskey C, Mooney L, Paul A, Currie S Tags: Vascul Pharmacol Source Type: research

Metabolomics as a tool to improve decision making for the vascular surgeon - wishful thinking or a dream come true?
PMID: 30959115 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - April 5, 2019 Category: Drugs & Pharmacology Authors: Kirlikaya B, Langridge B, Davies AH, Onida S Tags: Vascul Pharmacol Source Type: research

HMGB1 enhances AGE-mediated VSMC proliferation via an increase in 5-LO-linked RAGE expression.
Abstract Receptors for advanced glycation end-product (RAGE) play a pivotal role in the progression of proliferative vascular diseases. However, the precise mechanisms regulating RAGE expression in vascular smooth muscle cells (VSMCs) of the injured vasculatures is unclear. Given the potential importance of 5-lipoxygenase (5-LO) derived mediators in cellular responses mediated by RAGE, this study aimed to evaluate in VSMCs treated with high mobility group box 1 (HMGB1): 1) the RAGE expression; 2) the AGE-induced VSMC proliferation; 3) the role of 5-LO signaling in HMGB1-induced RAGE expression. In cultured human V...
Source: Vascular Pharmacology - April 4, 2019 Category: Drugs & Pharmacology Authors: Jang EJ, Baek SE, Kim EJ, Park SY, Kim CD Tags: Vascul Pharmacol Source Type: research

Oxidative stress and vascular stiffness in hypertension: A renewed interest for antioxidant therapies?
Abstract Since the first successful launch of the Veterans Administration(VA) cooperative studies in the late 1960s, the increasing access to blood pressure lowering medications has significantly contributed to improving longevity and quality of life in hypertensive patients. Since then, insights into the pathogenesis of hypertension have shown a mechanistic role for reactive oxygen species (ROS) in all phases of disease progression, suggesting the potential utility of antioxidant therapies to counteract symptoms and, at the same time, treat a fundamental mechanism of the disease. Despite these progresses, hyperte...
Source: Vascular Pharmacology - April 1, 2019 Category: Drugs & Pharmacology Authors: Massaro M, Scoditti E, Carluccio MA, Caterina R Tags: Vascul Pharmacol Source Type: research

GLP-1-based therapies to boost autophagy in cardiometabolic patients: From experimental evidence to clinical trials.
Abstract Obesity has many deleterious effects on the cardiovascular system, mediated by changes in insulin sensitivity, dyslipidaemia, oxidative stress and inflammation. Current therapies mainly focus on caloric intake suppression and bariatric surgery, however the efficacy of these approaches remains elusive as most patients regain their body weight within the next 5 years. A better understanding of the pathophysiology of obesity is of paramount importance for the development of new therapeutic strategies to prevent vascular complications. Autophagy has emerged as key self-degrading process responsible for the ...
Source: Vascular Pharmacology - March 26, 2019 Category: Drugs & Pharmacology Authors: Costantino S, Paneni F Tags: Vascul Pharmacol Source Type: research

Treatment with PCSK9 inhibitors reduces atherogenic VLDL remnants in a real-world study.
, Kassner U Abstract BACKGROUND: Proprotein convertase subtilisin-kexin type 9 inhibitors (PCSK9-I) reduce low-density lipoprotein (LDL) cholesterol in human studies. Previous studies suggest that PCSK9-I may also affect very-low-density lipoproteins (VLDL). We therefore studied VLDL size and composition in a "real-world" study population with the use of β-quantification. SUBJECTS AND METHODS: 350 patients (62 ± 11 years old, 58% men, 22% with diabetes mellitus) with different concomitant lipid lowering therapies, and in whom PCSK9-I treatment was indicated, received either alirocu...
Source: Vascular Pharmacology - March 22, 2019 Category: Drugs & Pharmacology Authors: Hollstein T, Vogt A, Grenkowitz T, Stojakovic T, März W, Laufs U, Bölükbasi B, Steinhagen-Thiessen E, Scharnagl H, Kassner U Tags: Vascul Pharmacol Source Type: research

Switching between P2Y12 inhibitors: Rationale, methods, and expected consequences.
Abstract The pharmacological and clinical differences of the three oral P2Y12 inhibitors (clopidogrel, prasugrel, ticagrelor) enable physicians to switch from one agent to another that it is considered more appropriate in the specific clinical setting. Moreover, the recent availability of cangrelor, the only intravenous P2Y12 inhibitor with a rapid onset and offset of its antiplatelet action, makes it necessary to switch from this agent to an oral P2Y12 inhibitor for a continued platelet inhibition after percutaneous coronary intervention. Several pharmacodynamic studies have provided information on how to change ...
Source: Vascular Pharmacology - March 12, 2019 Category: Drugs & Pharmacology Authors: Capranzano P, Capodanno D Tags: Vascul Pharmacol Source Type: research

Drug-induced hypertension: Know the problem to know how to deal with it.
Abstract Arterial hypertension remains the world's leading mortality risk factor and despite overwhelming evidence that blood pressure-lowering strategies greatly reduce the cardiovascular risk, a substantial proportion of hypertensive individuals worldwide fail to achieve an optimal blood pressure control under treatment. Among the causes responsible for the gap existing between blood pressure lowering potential of the different antihypertensive treatments and real-life practice is the presence of drug-induced hypertension. Many therapeutic agents or substances may directly favour an increment of blood pressure v...
Source: Vascular Pharmacology - February 26, 2019 Category: Drugs & Pharmacology Authors: Masi S, Uliana M, Gesi M, Taddei S, Virdis A Tags: Vascul Pharmacol Source Type: research

CRISPR links to long noncoding RNA function in mice: A practical approach.
Abstract Next generation sequencing has uncovered a trove of short noncoding RNAs (e.g., microRNAs) and long noncoding RNAs (lncRNAs) that act as molecular rheostats in the control of diverse homeostatic processes. Meanwhile, the tsunamic emergence of clustered regularly interspaced short palindromic repeats (CRISPR) editing has transformed our influence over all DNA-carrying entities, heralding global CRISPRization. This is evident in biomedical research where the ease and low-cost of CRISPR editing has made it the preferred method of manipulating the mouse genome, facilitating rapid discovery of genome function ...
Source: Vascular Pharmacology - February 26, 2019 Category: Drugs & Pharmacology Authors: Miano JM, Long X, Lyu Q Tags: Vascul Pharmacol Source Type: research

Long non-coding RNA-SRA promotes neointimal hyperplasia and vascular smooth muscle cells proliferation via MEK-ERK-CREB pathway.
Abstract Long noncoding RNA-steroid receptor RNA activator (LncRNA-SRA) is transcribed from a class of noncoding genes, and plays a critical role in regulating cell proliferation. However, the effect of lncRNA-SRA remains unclear in vascular proliferative diseases. In the present study, we overexpressed lncRNA-SRA in vitro, then investigated the biological consequences. A vascular damage mice model was constructed by performing femoral artery wire injury. LncRNA-SRA was overexpressed in the injured arteries, and significantly promoted the expression of ki67, thereby caused an overall increase in neointima formatio...
Source: Vascular Pharmacology - February 26, 2019 Category: Drugs & Pharmacology Authors: Zhang CJ, Liu C, Wang YX, Zhu N, Hu ZY, Liao DF, Qin L Tags: Vascul Pharmacol Source Type: research

Lipid core nanoparticles as vehicle for docetaxel reduces atherosclerotic lesion, inflammation, cell death and proliferation in an atherosclerosis rabbit model.
In conclusion, LDE-DTX showed a wide array of strong effects on pro-inflammatory and proliferation-promoting factors that drive the lesion development. These findings and the lack of observable toxicity indicate that LDE-DTX can be a candidate for future clinical trials. PMID: 30797043 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - February 20, 2019 Category: Drugs & Pharmacology Authors: Meneghini BC, Tavares ER, Guido MC, Tavoni TM, Stefani HA, Kalil-Filho R, Maranhão RC Tags: Vascul Pharmacol Source Type: research

Maternal high ‑sodium intake affects the offspring' vascular renin-angiotensin system promoting endothelial dysfunction in rats.
Maternal high‑sodium intake affects the offspring' vascular renin-angiotensin system promoting endothelial dysfunction in rats. Vascul Pharmacol. 2019 Feb 18;: Authors: Santos-Rocha J, Lima-Leal GA, Moreira HS, Ramos-Alves FE, de Sá FG, Duarte GP, Xavier FE Abstract Perinatal sodium overload induces endothelial dysfunction in adult offspring, but the underlying mechanisms are not fully known. The involvement of tissue renin-angiotensin system on high sodium-programmed endothelial dysfunction was examined. Acetylcholine and angiotensin I and II responses were analyzed in aorta and mesenteric r...
Source: Vascular Pharmacology - February 18, 2019 Category: Drugs & Pharmacology Authors: Santos-Rocha J, Lima-Leal GA, Moreira HS, Ramos-Alves FE, de Sá FG, Duarte GP, Xavier FE Tags: Vascul Pharmacol Source Type: research

Angiotensin II and vascular damage in hypertension: Role of oxidative stress and sympathetic activation.
Abstract Reactive oxygen species (ROS) are oxygen derivates and play an active role in vascular biology. These compounds are generated within the vascular wall, at the level of endothelial and vascular smooth muscle cells, as well as by adventitial fibroblasts. Physiologically, ROS generation is counteracted effectively by the rate of elimination. In hypertension, a ROS excess occurs, which is not counterbalanced by the endogenous antioxidant mechanisms, leading to a state of oxidative stress. Angiotensin II, the active peptide of the renin-angiotensin-system (RAS), is a significant stimulus for ROS generation wit...
Source: Vascular Pharmacology - January 29, 2019 Category: Drugs & Pharmacology Authors: Masi S, Uliana M, Virdis A Tags: Vascul Pharmacol Source Type: research

Amorphous nano-selenium quantum dots improve endothelial dysfunction in rats and prevent atherosclerosis in mice through Na+/H+ exchanger 1 inhibition.
CONCLUSION: A-SeQDs prevents endothelial dysfunction and the growth of atherosclerotic plaque through NHE1 inhibition and subsequent inactivation of Ca2+/calpain signaling. Clinically, the administration of A-SeQDs is an effective approach to treat atherosclerosis. PMID: 30695730 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - January 26, 2019 Category: Drugs & Pharmacology Authors: Zhu ML, Wang G, Wang H, Guo YM, Song P, Xu J, Li P, Wang SX, Yang L Tags: Vascul Pharmacol Source Type: research

Switching between P2Y12 antagonists - From bench to bedside.
Abstract Platelet P2Y12 receptors play a key role in platelet activation and thrombus formation. Accordingly, P2Y12 receptor antagonists are the cornerstone of secondary prevention of atherothrombotic events in patients undergoing percutaneous coronary intervention (PCI). The availability of different oral P2Y12 antagonists (clopidogrel, prasugrel, ticagrelor) along with the introduction of the first intravenous P2Y12 antagonist cangrelor offer an opportunity to individualize antiplatelet therapy according to the changing clinical setting. The recent International Expert Consensus provided the first recommendation...
Source: Vascular Pharmacology - January 24, 2019 Category: Drugs & Pharmacology Authors: Gasecka A, Konwerski M, Pordzik J, Soplińska A, Filipiak KJ, Siller-Matula JM, Postuła M Tags: Vascul Pharmacol Source Type: research

Didymin by suppressing NF- κB activation prevents VEGF-induced angiogenesis in vitro and in vivo.
In this study, we examined the effect of didymin on VEGF-induced angiogenesis in vitro and in vivo models. Our results suggest that treatment of human umbilical vein endothelial cell (HUVECs) with didymin significantly prevented the VEGF-induced cell proliferation, migration, and invasion. Further, didymin significantly prevented the VEGF-induced endothelial tube formation in culture. Didymin also attenuated the VEGF-induced generation of ROS, activation of NF-κB and the expression of adhesion molecules such as VCAM-1, ICAM-1, and E-selectin in HUVECs. Further, didymin also prevented the VEGF-induced microvessel spro...
Source: Vascular Pharmacology - January 8, 2019 Category: Drugs & Pharmacology Authors: Shukla K, Sonowal H, Saxena A, Ramana KV Tags: Vascul Pharmacol Source Type: research

HMGB1/TLR4 promotes hypoxic pulmonary hypertension via suppressing BMPR2 signaling.
Abstract High mobility group box 1 (HMGB1), a critical nonclassical inflammatory cytokine, has been found up-regulated in patients with idiopathic pulmonary arterial hypertension (IPAH), but its role in vascular remodeling of pulmonary hypertension (pH) is still unknown. In present study, we demonstrated that the plasma level of inflammatory cytokine including HMGB1, interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) were elevated in hypoxia-induced pulmonary hypertension rats model. Moreover, expressions of HMGB1 and Toll like receptor-4 (TLR4) in pulmonary art...
Source: Vascular Pharmacology - January 2, 2019 Category: Drugs & Pharmacology Authors: Wang J, Tian XT, Peng Z, Li WQ, Cao YY, Li Y, Li XH Tags: Vascul Pharmacol Source Type: research

Nox4 and soluble epoxide hydrolase synergistically mediate homocysteine-induced inflammation in vascular smooth muscle cells.
CONCLUSIONS: The inflammatory response induced by homocysteine in VSMCs was accompanied by Nox4 and sEH upregulation. Nox4 and soluble epoxide hydrolase synergistically contribute to homocysteine-induced inflammation. PMID: 30610956 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - January 2, 2019 Category: Drugs & Pharmacology Authors: Liu X, Qin Z, Liu C, Song M, Luo X, Zhao H, Qian D, Chen J, Huang L Tags: Vascul Pharmacol Source Type: research

Extracorporeal shock wave-assisted adipose-derived fresh stromal vascular fraction restores the blood flow of critical limb ischemia in rat.
Abstract We tested the hypothesis that extracorporeal-shock-wave (ECSW)-assisted adipose-derived stromal vascular fraction (SVF) therapy was better than either one for restoring the blood flow in critical limb ischemia (CLI). Adult male-SD rats were categorized into group 1 (sham-operated-control), group 2 (CLI), group 3 [CLI + ECSW (280 impulses/0.10 mJ/mm2) applied to left inguinal area at 3 h after CLI], group 4 [CLI + SVF (1.2 × 106) implanted into CLI area at 3 h after CLI], group 5 (CLI + ECSW-SVF). In vitro studies showed that ECSW significantly enhanced angiogenesis in human umb...
Source: Vascular Pharmacology - December 28, 2018 Category: Drugs & Pharmacology Authors: Yin TC, Sung PH, Chen KH, Li YC, Luo CW, Huang CR, Sheu JJ, Chiang JY, Lee MS, Yip HK Tags: Vascul Pharmacol Source Type: research

The endothelial status reflected by circulating endothelial cells, circulating endothelial progenitor cells and soluble thrombomodulin in patients with mild and resistant hypertension.
CONCLUSIONS: The results of the present study suggest that an endothelial alteration accompanies hypertension. The number of CECs reflecting the extent of endothelial damage does not appear to be related to the severity of disease. The drastically decreased ratio between CEPCs and CECs observed in both groups of patients suggests an inadequate process of endothelial regeneration. Among analyzed factors inflammation and lipid abnormalities may have significant contribution in endothelial pathology in hypertension. PMID: 30590133 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - December 24, 2018 Category: Drugs & Pharmacology Authors: Budzyń M, Gryszczyńka B, Boruczkowski M, Kaczmarek M, Begier-Krasińska B, Osińska A, Bukowska A, Iskra M, Kasprzak MP Tags: Vascul Pharmacol Source Type: research

Everolimus depletes plaque macrophages, abolishes intraplaque neovascularization and improves survival in mice with advanced atherosclerosis.
CONCLUSIONS: Everolimus enhances features of plaque stability and counters cardiovascular complications in ApoE-/-Fbn1C1039G+/- mice, even when administered at a later stage of the disease. PMID: 30590134 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - December 24, 2018 Category: Drugs & Pharmacology Authors: Kurdi A, Roth L, Van der Veken B, Van Dam D, De Deyn PP, De Doncker M, Neels H, De Meyer GRY, Martinet W Tags: Vascul Pharmacol Source Type: research

Variety matters: Diverse functions of monocyte subtypes in vascular inflammation and atherogenesis.
Abstract Monocytes are important mediators of the innate immunity by recognizing and attacking especially bacterial pathogens but also play crucial roles in various inflammatory diseases, including vascular inflammation and atherosclerosis. Maturation, differentiation and function of monocytes have been intensively explored for a long time in innumerable experimental and clinical studies. Monocytes do not represent a uniform cell type but could be further subdivided into subpopulations with distinct features and functions. Those subpopulations have been identified in experimental mouse models as well as in humans,...
Source: Vascular Pharmacology - December 12, 2018 Category: Drugs & Pharmacology Authors: Vlacil AK, Schuett J, Schieffer B, Grote K Tags: Vascul Pharmacol Source Type: research

Pioneering updates in vascular biology.
PMID: 30529641 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - December 7, 2018 Category: Drugs & Pharmacology Authors: Yvonne Alexander M, Bussolati B, Banfi A Tags: Vascul Pharmacol Source Type: research

The function of miR-143, miR-145 and the MiR-143 host gene in cardiovascular development and disease.
Abstract Noncoding RNAs (long noncoding RNAs and small RNAs) are emerging as critical modulators of phenotypic changes associated with physiological and pathological contexts in a variety of cardiovascular diseases (CVDs). Although it has been well established that hereditable genetic alterations and exposure to risk factors are crucial in the development of CVDs, other critical regulators of cell function impact on disease processes. Here we discuss noncoding RNAs have only recently been identified as key players involved in the progression of disease. In particular, we discuss micro RNA (miR)-143/145 since they ...
Source: Vascular Pharmacology - November 28, 2018 Category: Drugs & Pharmacology Authors: Vacante F, Denby L, Sluimer JC, Baker AH Tags: Vascul Pharmacol Source Type: research

Adenosine receptor agonists deepen the inhibition of platelet aggregation by P2Y12 antagonists.
Abstract Several adenosine receptor (AR) agonists have been shown in the past to possess anti-platelet potential; however, the adjunctive role of AR agonists in anti-platelet therapy with the use of P2Y12 receptor inhibitors has not been elucidated so far. This in vitro aggregation-based study investigates whether the inhibition of platelet function mediated by cangrelor or prasugrel metabolite can be potentiated by AR agonists. It evaluates the effect of non-selective (2-chloroadenosine), A2A-selective (UK 432097, MRE 0094, PSB 0777) and A2B-selective AR agonists (BAY 60-6583) on platelet function in relation to ...
Source: Vascular Pharmacology - November 21, 2018 Category: Drugs & Pharmacology Authors: Boncler M, Wzorek J, Wolska N, Polak D, Watala C, Rozalski M Tags: Vascul Pharmacol Source Type: research

Inhibition of endoplasmic reticulum stress protected DOCA-salt hypertension-induced vascular dysfunction.
Abstract Hypertension has complex vascular pathogenesis and therefore the molecular etiology remains poorly elucidated. Endoplasmic reticulum stress (ERS), which is a condition of the unfolded/misfolded protein accumulation in the endoplasmic reticulum, has been defined as a potential target for cardiovascular disease. In the present study, the effects of ERS inhibition on hypertension-induced alterations in the vessels were investigated. In male Wistar albino rats, hypertension was induced through unilateral nephrectomy, deoxycorticosterone-acetate (DOCA) injection (20 mg/kg, twice a week) and 1% NaCl with 0.2%...
Source: Vascular Pharmacology - November 17, 2018 Category: Drugs & Pharmacology Authors: Han S, Bal NB, Sadi G, Usanmaz SE, Tuglu MM, Uludag MO, Demirel-Yilmaz E Tags: Vascul Pharmacol Source Type: research

Alogliptin improves endothelial function by promoting autophagy in perivascular adipose tissue of obese mice through a GLP-1-dependent mechanism.
CONCLUSIONS: These results revealed that promoting autophagy in PVAT improved endothelial function in response to alogliptin intervention. Additionally, the beneficial effect of alogliptin intervention on PVAT was GLP-1 dependent. PMID: 30447331 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - November 14, 2018 Category: Drugs & Pharmacology Authors: Zhu B, Li Y, Mei W, He M, Ding Y, Meng B, Zhao H, Xiang G Tags: Vascul Pharmacol Source Type: research

Sprouting and anastomosis in the Drosophila trachea and the vertebrate vasculature: Similarities and differences in cell behaviour.
We describe the similarities and the differences and discuss them in the context of their possible developmental significance. We finish by highlighting some old and new data, which suggest that live imaging of the development of capillary beds in adult animals might reveal yet unexplored endothelial behaviour of endothelial cells. PMID: 30423447 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Kotini MP, Mäe MA, Belting HG, Betsholtz C, Affolter M Tags: Vascul Pharmacol Source Type: research

Role of amino acid metabolism in angiogenesis.
Abstract The role of endothelial metabolism has now been taken into consideration as a crucial element governing formation and the differentiation of blood vessels, termed angiogenesis. Besides glycolysis and fatty acid oxidation, endothelial cells rely on specific amino acids to proliferate, migrate, and survive. In this review we focus on the metabolism of those amino acids and the intermediates that hold an established function within angiogenesis and endothelial pathophysiology. We also discuss recent work which provides a rationale for specific amino acid-restricted diets and its beneficial effects on vascula...
Source: Vascular Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Oberkersch RE, Santoro MM Tags: Vascul Pharmacol Source Type: research

The first 3500  years of aspirin history from its roots - A concise summary.
The first 3500 years of aspirin history from its roots - A concise summary. Vascul Pharmacol. 2018 Nov 01;: Authors: Montinari MR, Minelli S, De Caterina R Abstract Aspirin is currently the most widely used drug worldwide, and has been clearly one of the most important pharmacological achievements of the twentieth century. Historians of medicine have traced its birth in 1897, but the fascinating history of aspirin actually dates back>3500 years, when willow bark was used as a painkiller and antipyretic by Sumerians and Egyptians, and then by great physicians from ancient Greece and Rome. The mo...
Source: Vascular Pharmacology - November 1, 2018 Category: Drugs & Pharmacology Authors: Montinari MR, Minelli S, De Caterina R Tags: Vascul Pharmacol Source Type: research

Elucidating the contributory role of microRNA to cardiovascular diseases (a review).
Abstract Cardiovascular diseases encompassing atherosclerosis, aortic aneurysms, restenosis, and pulmonary arterial hypertension, remain the leading cause of morbidity and mortality worldwide. In response to a range of stimuli, the dynamic interplay between biochemical and biomechanical mechanisms affect the behaviour and function of multiple cell types, driving the development and progression of cardiovascular diseases. Accumulating evidence has highlighted microRNAs (miRs) as significant regulators and micro-managers of key cellular and molecular pathophysiological processes involved in predominant cardiovascula...
Source: Vascular Pharmacology - October 31, 2018 Category: Drugs & Pharmacology Authors: Johnson JL Tags: Vascul Pharmacol Source Type: research

Protection of dilator function of coronary arteries from homocysteine by tetramethylpyrazine: Role of ER stress in modulation of BKCa channels.
CONCLUSIONS: Reversal of BKCa channel inhibition via suppressing ER stress-mediated loss of β1 subunits contributes to the protective effect of TMP against homocysteine on coronary dilator function. Inhibition of FoxO3a-dependent ubiquitin ligases is involved in TMP-conferred normalization of BKCa β1 protein level. These results provide new mechanistic insights into the cardiovascular benefits of TMP. PMID: 30389615 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - October 30, 2018 Category: Drugs & Pharmacology Authors: Sun WT, Wang XC, Novakovic A, Wang J, He GW, Yang Q Tags: Vascul Pharmacol Source Type: research

Non-coding RNAs in vascular remodeling and restenosis.
Abstract Vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) are crucial in vascular remodeling. They exert pivotal roles in the development and progression of atherosclerosis, vascular response to injury, and restenosis after transcatheter angioplasty. As a witness of their importance in the cardiovascular system, a large body of evidence has accumulated about the role played by micro RNAs (miRNA) in modulating both VSMCs and ECs. More recently, a growing number of long noncoding RNA (lncRNAs) came beneath the spotlights in this research field. Several mechanisms have been revealed by which lncRNAs a...
Source: Vascular Pharmacology - October 24, 2018 Category: Drugs & Pharmacology Authors: Indolfi C, Iaconetti C, Gareri C, Polimeni A, De Rosa S Tags: Vascul Pharmacol Source Type: research