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Condition: Hypertension
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Total 587 results found since Jan 2013.
Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension
Conclusions: We define a previously unrecognized interaction of human endothelial cells and monocytes that promote formation of AS DCs in hypertension and show a critical role of GAS6 and Axl signaling in both immune cells and endothelial cells. This pathway is potentially a novel therapeutic target to reduce inflammation and end organ damage in hypertension.PMID:34565181 | DOI:10.1161/CIRCRESAHA.121.319643
Source: Circulation Research - September 27, 2021 Category: Cardiology Authors: Justin Pieter Van Beusecum Natalia Ruggeri Barbaro Charles Duncan Smart David M Patrick Roxana Loperena Shilin Zhao Nestor de la Visitacion Mingfang Ao Liang Xiao Cyndya A Shibao David G Harrison Source Type: research
MicroRNA-137 Inhibited Hypoxia-Induced Proliferation of Pulmonary Artery Smooth Muscle Cells by Targeting Calpain-2
In this study, male Sprague-Dawley rats were subjected to 10% O2 for 3 weeks to establish PH, and rat primary PASMCs were treated with hypoxia (3% O2) for 48 h to induce cell proliferation. The effect of miR-137 on PASMC proliferation and calpain-2 expression was assessed by transfecting miR-137 mimic and inhibitor. The effect of calpain-2 on PASMC proliferation was assessed by transfecting calpain-2 siRNA. The present study found for the first time that miR-137 was downregulated in pulmonary arteries of hypoxic PH rats and in hypoxia-treated PASMCs. miR-137 mimic inhibited hypoxia-induced PASMC proliferation and upregulat...
Source: Biomed Res - September 13, 2021 Category: Research Authors: Xiao-Yue Ge Tian-Tian Zhu Mao-Zhong Yao Hong Liu Qian Wu Jie Qiao Wei-Fang Zhang Chang-Ping Hu Source Type: research
Central role of c-Src in NOX5- mediated redox signaling in vascular smooth muscle cells in human hypertension
CONCLUSIONS: We define NOX5/ROS/c-Src as a novel feedforward signaling network in human VSMCs. Amplification of this system in hypertension contributes to VSMC dysfunction. Dampening the NOX5/ROS/c-Src pathway may ameliorate hypertension-associated vascular injury.TRANSLATIONAL PERSPECTIVE: Oxidative stress is a major factor contributing to vascular damage in hypertension. We corroborate experimental evidence that NOX-derived ROS generation is increased in human vascular smooth muscle cells (VSMC) and demonstrate that in human hypertension NOX5 upregulation is a major trigger of VSMC dysfunction. We uncover new regulatory ...
Source: Cell Research - July 28, 2021 Category: Cytology Authors: Livia L Camargo Augusto C Montezano Misbah Hussain Yu Wang Zhiguo Zou Francisco J Rios Karla B Neves Rheure Alves-Lopes Fazli R Awan Tomasz J Guzik Thomas Jensen Richard C Hartley Rhian M Touyz Source Type: research
Angiotensin II -induced overexpression of Sirtuin-1 contributes to enhanced expression of Gi α proteins and hyperproliferation of vascular smooth muscle cells
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00898.2020. Online ahead of print.ABSTRACTAngiotensin II (Ang II) plays an important role in the regulation of various physiological functions including proliferation, hypertrophy of vascular smooth muscle cells (VSMC) through the overexpression of Giα proteins. Sirtuin1 (Sirt1), a class III histone deacetylase and epigenetic regulator is implicated in a wide range of cellular functions, including migration and growth of VSMC as well as in Ang II-induced hypertension. The present study was undertaken to examine the role of Sirt1 in Ang II-induced overexpr...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Ekhtear Hossain Yuan Li Madhu B Anand-Srivastava Source Type: research
Regulation of The Methylation and Expression Levels of the BMPR2 Gene by SIN3a As A Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension
Conclusions: Altogether, our study unveiled the protective/beneficial role of SIN3a in pulmonary hypertension. We also identified a novel and distinct molecular mechanism by which SIN3a regulates BMPR2 in hPASMC. Our study also identified lung-targeted SIN3a gene therapy using AAV1 as a new promising therapeutic strategy for treating patients with PAH.PMID:34078089 | DOI:10.1161/CIRCULATIONAHA.120.047978
Source: Circulation - June 3, 2021 Category: Cardiology Authors: Malik Bisserier Prabhu Mathiyalagan Shihong Zhang Firas Elmastour Peter Dorfm üller Marc Humbert Gregory David Sima Tarzami Thomas Weber Fr édéric Perros Yassine Sassi Susmita Sahoo Lahouaria Hadri Source Type: research
Azilsartan ameliorates ox-LDL-induced endothelial dysfunction via promoting the expression of KLF2
CONCLUSION: Azilsartan might ameliorate ox-LDL-induced endothelial damage via elevating the expression of KLF2.PMID:33946046 | DOI:10.18632/aging.202973
Source: Aging - May 4, 2021 Category: Biomedical Science Authors: Wenfeng Li Chenggao Wang Dandan Zhang Kanghua Zeng Shihui Xiao Feng Chen Jun Luo Source Type: research
Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis
In conclusion, we identified a novel role for the cardiogenic transcription factors GATA-4 and GATA-6 in heart fibroblasts, where both proteins act in concert to promote myocardial capillarization and heart function by directing intercellular crosstalk.
Source: Basic Research in Cardiology - April 19, 2021 Category: Cardiology Source Type: research
