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Condition: Hypertension
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Total 587 results found since Jan 2013.
SKF96365 activates calcium-sensing receptors in pulmonary arterial smooth muscle cells
Biochem Biophys Res Commun. 2022 Mar 25;607:44-48. doi: 10.1016/j.bbrc.2022.03.121. Online ahead of print.ABSTRACTIn pulmonary arterial smooth muscle cells (PASMCs), an increase in the cytosolic Ca2+ concentration ([Ca2+]cyt) is involved in many physiological processes such as cell contraction and proliferation. However, chronic [Ca2+]cyt increases cause pulmonary vasoconstriction and vascular remodeling, resulting in pulmonary arterial hypertension (PAH). Therefore, [Ca2+]cyt signaling plays a substantial role in the regulation of physiological and pathological functions in PASMCs. In the present study, the effects of SKF...
Source: Cell Research - April 2, 2022 Category: Cytology Authors: Riko Miyaki Aya Yamamura Akiko Kawade Moe Fujiwara Rubii Kondo Yoshiaki Suzuki Hisao Yamamura Source Type: research
Adeno-associated virus-mediated in vivo suppression of expression of EPHX2 gene modulates the activity of paraventricular nucleus neurons in spontaneously hypertensive rats
CONCLUSIONS: The elevation of EET levels by EPHX2 downregulation reduced presympathetic neuronal activity in the PVN of SHRs, leading to a reduced sympathetic outflow in hypertension rats. The ATP/SR/D-serine pathway of astrocytes is involved in EET-mediated neuroprotection.PMID:35344709 | DOI:10.1016/j.bbrc.2022.03.084
Source: Biochemical and Biophysical Research communications - March 28, 2022 Category: Biochemistry Authors: Xiaoming Zhu Kuibao Li Yuanfeng Gao Source Type: research
Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation
Am J Physiol Lung Cell Mol Physiol. 2022 Mar 23. doi: 10.1152/ajplung.00447.2021. Online ahead of print.ABSTRACTConcentric pulmonary vascular wall thickening due partially to increased PASMC proliferation contributes to elevating PVR in patients with pulmonary hypertension (PH). While pulmonary vasoconstriction may be an early contributor to increasing PVR, the transition of contractile PASMCs to proliferative PASMCs may play an important role in the development and progression of pulmonary vascular remodeling in PH. A rise in cytosolic Ca2+ concentration ([Ca2+]cyt) is a trigger for PASMC contraction and proliferation. He...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 23, 2022 Category: Cytology Authors: Jiyuan Chen Marisela Rodriguez Jinrui Miao Jing Liao Pritesh Prakash Jain Manjia Zhao Tengteng Zhao Aleksandra Babicheva Ziyi Wang Sophia Parmisano Ryan Powers Moreen Matti Cole Paquin Zahra Soroureddin John Y-J Shyy Patricia A Thistlethwaite Ayako Makino Source Type: research
