New Updates in Sarcoidosis Research: Defining and Renewing the Quest
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 15. doi: 10.1152/ajplung.00082.2024. Online ahead of print.NO ABSTRACTPMID:38487816 | DOI:10.1152/ajplung.00082.2024 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 15, 2024 Category: Cytology Authors: Catherine A Bonham Michelle Sharp Source Type: research

New Updates in Sarcoidosis Research: Defining and Renewing the Quest
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 15. doi: 10.1152/ajplung.00082.2024. Online ahead of print.NO ABSTRACTPMID:38487816 | DOI:10.1152/ajplung.00082.2024 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 15, 2024 Category: Cytology Authors: Catherine A Bonham Michelle Sharp Source Type: research

Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 12. doi: 10.1152/ajplung.00392.2022. Online ahead of print.ABSTRACTAcute respiratory distress syndrome (ARDS) is characterized by dysregulated inflammation and increased permeability of lung microvascular cells. CD26/Dipeptidyl peptidase-4 (DPP4) is a type II membrane protein that is expressed in several cell types and mediates multiple pleiotropic effects. We previously reported that DPP4 inhibition by sitagliptin attenuates lipopolysaccharide (LPS)-induced lung injury in mice. The current study characterized the functional role of CD26/DPP4 expression in LPS-induced lung injur...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 12, 2024 Category: Cytology Authors: Shun Sato Takeshi Kawasaki Ryo Hatano Yu Koyanagi Yukiko Takahashi Kei Ohnuma Chikao Morimoto Steven M Dudek Koichiro Tatsumi Takuji Suzuki Source Type: research

Endoplasmic reticulum stress enhances the expression of TLR3-induced TSLP by airway epithelium
In conclusion, these results suggest that ER stress primes TSLP which is then enhanced further upon TLR3 activation, which may induce severe asthma exacerbations. Targeting ER stress using pharmacological interventions may provide novel therapeutics for severe uncontrolled asthma.PMID:38469627 | DOI:10.1152/ajplung.00378.2023 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 12, 2024 Category: Cytology Authors: Prabuddha S Pathinayake Alan C-Y Hsu Kristy S Nichol Jay C Horvat Philip M Hansbro Peter A Wark Source Type: research

The Emerging Role of Extracellular Vesicles in Bronchopulmonary Dysplasia
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 12. doi: 10.1152/ajplung.00244.2023. Online ahead of print.ABSTRACTExtracellular vesicle (EV) biology in neonatal lung development and disease is a rapidly growing area of investigation. While EV research in the neonatal population lags behind EV research in adult lung diseases, recent discoveries demonstrate promise in furthering our understanding of the pathophysiology of bronchopulmonary dysplasia and the potential use of EVs in the clinical setting, as both biomarkers and therapeutic agents. This mini-review article explores some of the recent advances in this field and our ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 12, 2024 Category: Cytology Authors: Meaghan A Ransom Alexander M Blatt Heather H Pua Jennifer M S Sucre Source Type: research

Metabolic signatures of acute respiratory distress syndrome: COVID VS non-COVID
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 12. doi: 10.1152/ajplung.00266.2023. Online ahead of print.ABSTRACTAcute respiratory distress syndrome (ARDS) is a fatal pulmonary disorder characterized by severe hypoxia and inflammation. Systemic and pulmonary infections are a leading cause of ARDS. The common respiratory pathogens include bacteria and virus, including Pseudomonas aeruginosa, Streptococcus aureus, Enterobacter species, coronavirus, influenza, and herpesviruses. COVID-19-associated ARDS is a new etiologic phenotype of the disease. The pathogenesis of ARDS caused by bacteria and viruses differs in host immune r...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 12, 2024 Category: Cytology Authors: Xiangming Ji Hong-Long Ji Source Type: research

Mucopolysaccharidosis (MPS IIIA) mice have increased lung compliance and airways resistance, decreased diaphragm strength and no change in alveolar structure
In conclusion, the increased storage of HS which leads to biochemical and biophysical changes in pulmonary surfactant, also affects lung and diaphragm function, but has no impact on lung or diaphragm structure at this stage of the disease.PMID:38469649 | DOI:10.1152/ajplung.00445.2022 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 12, 2024 Category: Cytology Authors: Tamara L Paget Alexander N Larcombe Gavin J Pinniger Irene Tsioutsias Jan Philipp Schneider Emma J Parkinson-Lawrence Sandra Orgeig Source Type: research

Philanthropy Pushes Sarcoidosis Forward
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 12. doi: 10.1152/ajplung.00084.2024. Online ahead of print.NO ABSTRACTPMID:38471073 | DOI:10.1152/ajplung.00084.2024 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 12, 2024 Category: Cytology Authors: Quinton Banks Source Type: research

Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 12. doi: 10.1152/ajplung.00392.2022. Online ahead of print.ABSTRACTAcute respiratory distress syndrome (ARDS) is characterized by dysregulated inflammation and increased permeability of lung microvascular cells. CD26/Dipeptidyl peptidase-4 (DPP4) is a type II membrane protein that is expressed in several cell types and mediates multiple pleiotropic effects. We previously reported that DPP4 inhibition by sitagliptin attenuates lipopolysaccharide (LPS)-induced lung injury in mice. The current study characterized the functional role of CD26/DPP4 expression in LPS-induced lung injur...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 12, 2024 Category: Cytology Authors: Shun Sato Takeshi Kawasaki Ryo Hatano Yu Koyanagi Yukiko Takahashi Kei Ohnuma Chikao Morimoto Steven M Dudek Koichiro Tatsumi Takuji Suzuki Source Type: research

Endoplasmic reticulum stress enhances the expression of TLR3-induced TSLP by airway epithelium
In conclusion, these results suggest that ER stress primes TSLP which is then enhanced further upon TLR3 activation, which may induce severe asthma exacerbations. Targeting ER stress using pharmacological interventions may provide novel therapeutics for severe uncontrolled asthma.PMID:38469627 | DOI:10.1152/ajplung.00378.2023 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 12, 2024 Category: Cytology Authors: Prabuddha S Pathinayake Alan C-Y Hsu Kristy S Nichol Jay C Horvat Philip M Hansbro Peter A Wark Source Type: research

The Emerging Role of Extracellular Vesicles in Bronchopulmonary Dysplasia
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 12. doi: 10.1152/ajplung.00244.2023. Online ahead of print.ABSTRACTExtracellular vesicle (EV) biology in neonatal lung development and disease is a rapidly growing area of investigation. While EV research in the neonatal population lags behind EV research in adult lung diseases, recent discoveries demonstrate promise in furthering our understanding of the pathophysiology of bronchopulmonary dysplasia and the potential use of EVs in the clinical setting, as both biomarkers and therapeutic agents. This mini-review article explores some of the recent advances in this field and our ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 12, 2024 Category: Cytology Authors: Meaghan A Ransom Alexander M Blatt Heather H Pua Jennifer M S Sucre Source Type: research

Metabolic signatures of acute respiratory distress syndrome: COVID VS non-COVID
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 12. doi: 10.1152/ajplung.00266.2023. Online ahead of print.ABSTRACTAcute respiratory distress syndrome (ARDS) is a fatal pulmonary disorder characterized by severe hypoxia and inflammation. Systemic and pulmonary infections are a leading cause of ARDS. The common respiratory pathogens include bacteria and virus, including Pseudomonas aeruginosa, Streptococcus aureus, Enterobacter species, coronavirus, influenza, and herpesviruses. COVID-19-associated ARDS is a new etiologic phenotype of the disease. The pathogenesis of ARDS caused by bacteria and viruses differs in host immune r...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 12, 2024 Category: Cytology Authors: Xiangming Ji Hong-Long Ji Source Type: research

Mucopolysaccharidosis (MPS IIIA) mice have increased lung compliance and airways resistance, decreased diaphragm strength and no change in alveolar structure
In conclusion, the increased storage of HS which leads to biochemical and biophysical changes in pulmonary surfactant, also affects lung and diaphragm function, but has no impact on lung or diaphragm structure at this stage of the disease.PMID:38469649 | DOI:10.1152/ajplung.00445.2022 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 12, 2024 Category: Cytology Authors: Tamara L Paget Alexander N Larcombe Gavin J Pinniger Irene Tsioutsias Jan Philipp Schneider Emma J Parkinson-Lawrence Sandra Orgeig Source Type: research

Philanthropy Pushes Sarcoidosis Forward
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 12. doi: 10.1152/ajplung.00084.2024. Online ahead of print.NO ABSTRACTPMID:38471073 | DOI:10.1152/ajplung.00084.2024 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 12, 2024 Category: Cytology Authors: Quinton Banks Source Type: research

Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 12. doi: 10.1152/ajplung.00392.2022. Online ahead of print.ABSTRACTAcute respiratory distress syndrome (ARDS) is characterized by dysregulated inflammation and increased permeability of lung microvascular cells. CD26/Dipeptidyl peptidase-4 (DPP4) is a type II membrane protein that is expressed in several cell types and mediates multiple pleiotropic effects. We previously reported that DPP4 inhibition by sitagliptin attenuates lipopolysaccharide (LPS)-induced lung injury in mice. The current study characterized the functional role of CD26/DPP4 expression in LPS-induced lung injur...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 12, 2024 Category: Cytology Authors: Shun Sato Takeshi Kawasaki Ryo Hatano Yu Koyanagi Yukiko Takahashi Kei Ohnuma Chikao Morimoto Steven M Dudek Koichiro Tatsumi Takuji Suzuki Source Type: research