American Journal of Physiology. Lung Cellular and Molecular Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Red Blood Cells Function as Reservoirs of Tumor DNA
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 26. doi: 10.1152/ajplung.00049.2024. Online ahead of print.ABSTRACTNovel screening techniques for early detection of lung cancer are urgently needed. Profiling circulating tumor cell-free DNA (ctDNA) has emerged as a promising tool for biopsy-free tumor genotyping. However, both the scarcity and short half-life of ctDNA substantially limit the sensitivity and clinical utility of ctDNA detection methodologies. Our discovery that Red Blood Cells (RBCs) sequester mitochondrial DNA opens a new avenue for detecting circulating nucleic acids, as RBCs represent an unrecognized reservoi...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 26, 2024 Category: Cytology Authors: Jeffrey C Thompson Sue Li Joshua S Jose Jarrod Predina Aasha Gupta Evgeniy Eruslanov Sunil Singhal Steven M Albelda Nilam S Mangalmurti Source Type: research

Downregulation of protein phosphatase 2A α in asthmatic airway smooth muscle
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 26. doi: 10.1152/ajplung.00050.2024. Online ahead of print.ABSTRACTAirway smooth muscle cell (ASM) is renowned for its involvement in airway hyperresponsiveness through impaired ASM relaxation and bronchoconstriction in asthma which poses a significant challenge in the field. Recent studies have explored different targets in ASM to alleviate airway hyperresponsiveness, however, a sizeable portion of asthmatics still experience poor control. In our study, we explored protein phosphatase 2A (PP2A) in ASM as it has been reported to regulate cellular contractility by controlling int...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 26, 2024 Category: Cytology Authors: Mohammad Irshad Reza Ashish Kumar Christina M Pabelick Rodney D Britt Y S Prakash Venkatachalem Sathish Source Type: research

Identification of Siglec-1-negative alveolar macrophages with pro-inflammatory phenotypes in chronic obstructive pulmonary disease
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 26. doi: 10.1152/ajplung.00303.2023. Online ahead of print.ABSTRACTAlveolar macrophages (AMs) in patients with chronic obstructive pulmonary disease (COPD) orchestrate persistent inflammation in the airway. However, sub-populations of AMs participating in the chronic inflammation have been poorly characterized. We previously reported that Siglec-1 expression on AMs, which is important for bacteria engulfment, was decreased in COPD. Here, we show that Siglec-1-negative AMs isolated from COPD lung tissues exhibit a pro-inflammatory phenotype and is associated with poor clinical ou...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 26, 2024 Category: Cytology Authors: Takuya Saito Naoya Fujino Yorihiko Kyogoku Mitsuhiro Yamada Koji Okutomo Yoshinao Ono Shuichi Konno Takuto Endo Koji Itakura Shuichiro Matsumoto Hirohito Sano Hiroyuki Aizawa Tadahisa Numakura Katsuhiro Onodera Yoshinori Okada Tracy Hussell Masakazu Ichin Source Type: research

Bi-phasic regulation of miR-17~92 transcription during hypoxia: Roles of HIF1 and p53 hyperphosphorylation at ser15
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 19. doi: 10.1152/ajplung.00127.2023. Online ahead of print.ABSTRACTWe have reported previously that during hypoxia exposure, the expression of mature miR-17~92 was first upregulated and then downregulated in pulmonary artery smooth muscle cells (PASMC) and in mouse lungs in vitro and in vivo. Here we investigated the mechanisms regulating this bi-phasic expression of miR-17~92 in PASMC in hypoxia. We measured the level of primary miR-17~92 in PASMC during hypoxia exposure and found that short-term hypoxia exposure (3%O2, 6 hours) induced the level of primary miR-17~92, while lon...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - March 19, 2024 Category: Cytology Authors: Miranda R Sun Susana Gonzalez Jason B Huang Qiyuan Zhou Arjun Cherukuri Rohan Adavadkar Hong-Li Yan Shu-Han Sun Guofei Zhou J Usha Raj Tianji Chen Source Type: research