Nicotine Affects Mitochondrial Structure and Function in Human Airway Smooth Muscle Cells
Am J Physiol Lung Cell Mol Physiol. 2023 Nov 7. doi: 10.1152/ajplung.00158.2023. Online ahead of print.ABSTRACTExposure to cigarette smoke and e-cigarettes, with nicotine as the active constituent, contributes to increased health risks associated with asthma. Nicotine exerts its functional activity via nicotinic acetylcholine receptors (nAChRs) and the alpha7 subtype (α7nAChR) has recently been shown to adversely affect airway dynamics. The mechanisms of α7nAChR action in airways, particularly in the context of airway smooth muscle (ASM), a key cell type in asthma, are still under investigation. Mitochondria have garnere...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 7, 2023 Category: Cytology Authors: Niyati A Borkar Michael A Thompson Colleen M Bartman Venkatachalem Sathish Y S Prakash Christina M Pabelick Source Type: research

The alveolar fibroproliferative response in moderate to severe COVID-19-related acute respiratory distress syndrome and one-year follow up
CONCLUSION: In COVID-19-ARDS patients, alveolar FPR during hospitalization was associated with higher mortality but not with the presence of long-term fibrotic lung sequelae within survivors.PMID:37933449 | DOI:10.1152/ajplung.00156.2023 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 7, 2023 Category: Cytology Authors: Shiqi Zhang Leonoor S Boers Justin de Brabander Laura B van den Heuvel Siebe G Blok Robert F J Kullberg Barbara S Smids-Dierdorp Tamara Dekker Hella L Aberson Lilian J Meijboom Alexander P J Vlaar Leo Heunks Esther J Nossent Tom van der Poll Lieuwe D J Bo Source Type: research

Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx
Am J Physiol Lung Cell Mol Physiol. 2023 Nov 7. doi: 10.1152/ajplung.00045.2023. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is marked by unremitting matrix deposition and architectural distortion. Multiple pro-fibrotic pathways contribute to the persistent activation of mesenchymal cells (MCs) in fibrosis, highlighting the need to identify and target common signaling pathways. The transcription factor NFAT1 (nuclear factor of activated T cells 1) lies downstream of second messenger calcium signaling and has been recently shown to regulate key pro-fibrotic mediator autotaxin (ATX) in lung MCs. Herein,...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 7, 2023 Category: Cytology Authors: Ragini Vittal Natalie M Walker A Patrick McLinden Russell R Braeuer Fang Ke Fatemeh Fattahi Michael P Combs Keizo Misumi Yoshiro Aoki David S Wheeler Carol A Wilke Steven K Huang Bethany B Moore Pengxiu Cao Vibha N Lama Source Type: research

Changes in respiratory mechanics in response to crystalloid infusions in extremely premature infants
Am J Physiol Lung Cell Mol Physiol. 2023 Nov 7. doi: 10.1152/ajplung.00179.2023. Online ahead of print.ABSTRACTExtremely premature infants are at a higher risk of developing respiratory distress syndrome and circulatory impairments in the first few weeks of life. Administration of normal saline bolus is a common practice to manage hypotension in preterm infants. As a crystalloid, a substantial proportion might leak into the interstitium; most consequently the lungs in the preterm cohorts, putatively affecting ventilation. We downloaded and analysed ventilator mechanics data in infants managed by conventional mechanical ven...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 7, 2023 Category: Cytology Authors: Arvind Sehgal Bishal Gauli Source Type: research

Nicotine Affects Mitochondrial Structure and Function in Human Airway Smooth Muscle Cells
Am J Physiol Lung Cell Mol Physiol. 2023 Nov 7. doi: 10.1152/ajplung.00158.2023. Online ahead of print.ABSTRACTExposure to cigarette smoke and e-cigarettes, with nicotine as the active constituent, contributes to increased health risks associated with asthma. Nicotine exerts its functional activity via nicotinic acetylcholine receptors (nAChRs) and the alpha7 subtype (α7nAChR) has recently been shown to adversely affect airway dynamics. The mechanisms of α7nAChR action in airways, particularly in the context of airway smooth muscle (ASM), a key cell type in asthma, are still under investigation. Mitochondria have garnere...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 7, 2023 Category: Cytology Authors: Niyati A Borkar Michael A Thompson Colleen M Bartman Venkatachalem Sathish Y S Prakash Christina M Pabelick Source Type: research

The alveolar fibroproliferative response in moderate to severe COVID-19-related acute respiratory distress syndrome and one-year follow up
CONCLUSION: In COVID-19-ARDS patients, alveolar FPR during hospitalization was associated with higher mortality but not with the presence of long-term fibrotic lung sequelae within survivors.PMID:37933449 | DOI:10.1152/ajplung.00156.2023 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 7, 2023 Category: Cytology Authors: Shiqi Zhang Leonoor S Boers Justin de Brabander Laura B van den Heuvel Siebe G Blok Robert F J Kullberg Barbara S Smids-Dierdorp Tamara Dekker Hella L Aberson Lilian J Meijboom Alexander P J Vlaar Leo Heunks Esther J Nossent Tom van der Poll Lieuwe D J Bo Source Type: research

Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx
Am J Physiol Lung Cell Mol Physiol. 2023 Nov 7. doi: 10.1152/ajplung.00045.2023. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is marked by unremitting matrix deposition and architectural distortion. Multiple pro-fibrotic pathways contribute to the persistent activation of mesenchymal cells (MCs) in fibrosis, highlighting the need to identify and target common signaling pathways. The transcription factor NFAT1 (nuclear factor of activated T cells 1) lies downstream of second messenger calcium signaling and has been recently shown to regulate key pro-fibrotic mediator autotaxin (ATX) in lung MCs. Herein,...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 7, 2023 Category: Cytology Authors: Ragini Vittal Natalie M Walker A Patrick McLinden Russell R Braeuer Fang Ke Fatemeh Fattahi Michael P Combs Keizo Misumi Yoshiro Aoki David S Wheeler Carol A Wilke Steven K Huang Bethany B Moore Pengxiu Cao Vibha N Lama Source Type: research

Changes in respiratory mechanics in response to crystalloid infusions in extremely premature infants
Am J Physiol Lung Cell Mol Physiol. 2023 Nov 7. doi: 10.1152/ajplung.00179.2023. Online ahead of print.ABSTRACTExtremely premature infants are at a higher risk of developing respiratory distress syndrome and circulatory impairments in the first few weeks of life. Administration of normal saline bolus is a common practice to manage hypotension in preterm infants. As a crystalloid, a substantial proportion might leak into the interstitium; most consequently the lungs in the preterm cohorts, putatively affecting ventilation. We downloaded and analysed ventilator mechanics data in infants managed by conventional mechanical ven...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 7, 2023 Category: Cytology Authors: Arvind Sehgal Bishal Gauli Source Type: research

Nicotine Affects Mitochondrial Structure and Function in Human Airway Smooth Muscle Cells
Am J Physiol Lung Cell Mol Physiol. 2023 Nov 7. doi: 10.1152/ajplung.00158.2023. Online ahead of print.ABSTRACTExposure to cigarette smoke and e-cigarettes, with nicotine as the active constituent, contributes to increased health risks associated with asthma. Nicotine exerts its functional activity via nicotinic acetylcholine receptors (nAChRs) and the alpha7 subtype (α7nAChR) has recently been shown to adversely affect airway dynamics. The mechanisms of α7nAChR action in airways, particularly in the context of airway smooth muscle (ASM), a key cell type in asthma, are still under investigation. Mitochondria have garnere...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 7, 2023 Category: Cytology Authors: Niyati A Borkar Michael A Thompson Colleen M Bartman Venkatachalem Sathish Y S Prakash Christina M Pabelick Source Type: research

The alveolar fibroproliferative response in moderate to severe COVID-19-related acute respiratory distress syndrome and one-year follow up
CONCLUSION: In COVID-19-ARDS patients, alveolar FPR during hospitalization was associated with higher mortality but not with the presence of long-term fibrotic lung sequelae within survivors.PMID:37933449 | DOI:10.1152/ajplung.00156.2023 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 7, 2023 Category: Cytology Authors: Shiqi Zhang Leonoor S Boers Justin de Brabander Laura B van den Heuvel Siebe G Blok Robert F J Kullberg Barbara S Smids-Dierdorp Tamara Dekker Hella L Aberson Lilian J Meijboom Alexander P J Vlaar Leo Heunks Esther J Nossent Tom van der Poll Lieuwe D J Bo Source Type: research

Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx
Am J Physiol Lung Cell Mol Physiol. 2023 Nov 7. doi: 10.1152/ajplung.00045.2023. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is marked by unremitting matrix deposition and architectural distortion. Multiple pro-fibrotic pathways contribute to the persistent activation of mesenchymal cells (MCs) in fibrosis, highlighting the need to identify and target common signaling pathways. The transcription factor NFAT1 (nuclear factor of activated T cells 1) lies downstream of second messenger calcium signaling and has been recently shown to regulate key pro-fibrotic mediator autotaxin (ATX) in lung MCs. Herein,...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 7, 2023 Category: Cytology Authors: Ragini Vittal Natalie M Walker A Patrick Patrick McLinden Russell R Braeuer Fang Ke Fatemeh Fattahi Michael P Combs Keizo Misumi Yoshiro Aoki David S Wheeler Carol A Wilke Steven K Huang Bethany B Moore Pengxiu Cao Vibha N Lama Source Type: research

Changes in respiratory mechanics in response to crystalloid infusions in extremely premature infants
Am J Physiol Lung Cell Mol Physiol. 2023 Nov 7. doi: 10.1152/ajplung.00179.2023. Online ahead of print.ABSTRACTExtremely premature infants are at a higher risk of developing respiratory distress syndrome and circulatory impairments in the first few weeks of life. Administration of normal saline bolus is a common practice to manage hypotension in preterm infants. As a crystalloid, a substantial proportion might leak into the interstitium; most consequently the lungs in the preterm cohorts, putatively affecting ventilation. We downloaded and analysed ventilator mechanics data in infants managed by conventional mechanical ven...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 7, 2023 Category: Cytology Authors: Arvind Sehgal Bishal Gauli Source Type: research

Nicotine Affects Mitochondrial Structure and Function in Human Airway Smooth Muscle Cells
Am J Physiol Lung Cell Mol Physiol. 2023 Nov 7. doi: 10.1152/ajplung.00158.2023. Online ahead of print.ABSTRACTExposure to cigarette smoke and e-cigarettes, with nicotine as the active constituent, contributes to increased health risks associated with asthma. Nicotine exerts its functional activity via nicotinic acetylcholine receptors (nAChRs) and the alpha7 subtype (α7nAChR) has recently been shown to adversely affect airway dynamics. The mechanisms of α7nAChR action in airways, particularly in the context of airway smooth muscle (ASM), a key cell type in asthma, are still under investigation. Mitochondria have garnere...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 7, 2023 Category: Cytology Authors: Niyati A Borkar Michael A Thompson Colleen M Bartman Venkatachalem Sathish Y S Prakash Christina M Pabelick Source Type: research

The alveolar fibroproliferative response in moderate to severe COVID-19-related acute respiratory distress syndrome and one-year follow up
CONCLUSION: In COVID-19-ARDS patients, alveolar FPR during hospitalization was associated with higher mortality but not with the presence of long-term fibrotic lung sequelae within survivors.PMID:37933449 | DOI:10.1152/ajplung.00156.2023 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 7, 2023 Category: Cytology Authors: Shiqi Zhang Leonoor S Boers Justin de Brabander Laura B van den Heuvel Siebe G Blok Robert F J Kullberg Barbara S Smids-Dierdorp Tamara Dekker Hella L Aberson Lilian J Meijboom Alexander P J Vlaar Leo Heunks Esther J Nossent Tom van der Poll Lieuwe D J Bo Source Type: research

Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx
Am J Physiol Lung Cell Mol Physiol. 2023 Nov 7. doi: 10.1152/ajplung.00045.2023. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is marked by unremitting matrix deposition and architectural distortion. Multiple pro-fibrotic pathways contribute to the persistent activation of mesenchymal cells (MCs) in fibrosis, highlighting the need to identify and target common signaling pathways. The transcription factor NFAT1 (nuclear factor of activated T cells 1) lies downstream of second messenger calcium signaling and has been recently shown to regulate key pro-fibrotic mediator autotaxin (ATX) in lung MCs. Herein,...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 7, 2023 Category: Cytology Authors: Ragini Vittal Natalie M Walker A Patrick Patrick McLinden Russell R Braeuer Fang Ke Fatemeh Fattahi Michael P Combs Keizo Misumi Yoshiro Aoki David S Wheeler Carol A Wilke Steven K Huang Bethany B Moore Pengxiu Cao Vibha N Lama Source Type: research