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Condition: Hypertension

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Total 587 results found since Jan 2013.

Tetrahydroxystilbene glycoside improves endothelial dysfunction and hypertension in obese rats: the role of omentin-1
CONCLUSIONS: Down-regulation of omentin-1 induces endothelial dysfunction and hypertension in obesity. TSG treatment (at least partially) increases omentin-1 via promoting binding of PPAR-γ and Itln-1 promoter in adipose tissues, subsequently exerts protective effects on endothelial function via activating Akt/eNOS/NO signaling and attenuating oxidative/nitrative stress. These results suggest that TSG could be developed as a promising anti-hypertension agent that protects against endothelial dysfunction and obesity-associated cardiovascular diseases.PMID:33647262 | DOI:10.1016/j.bcp.2021.114489
Source: Biochemical Pharmacology - March 1, 2021 Category: Drugs & Pharmacology Authors: Qianqian Dong Wenjuan Xing Kaifeng Li Xuanxuan Zhou Siwang Wang Haifeng Zhang Source Type: research

GSE138991 Caveolin1 Deficiency: A Type I Endothelial Interferonopathy Associated with Pulmonary Arterial Hypertension
Contributors : Salina Gairhe ; Gabriela A Ferreyra ; Jason M Elinoff ; Cumhur Y Demirkale ; Robert L DannerSeries Type : Expression profiling by arrayOrganism : Homo sapiensCAV1 loss-of-function mutations have been associated with the development of pulmonary arterial hypertension (PAH). CAV1 is an integral component of endothelial caveolae, specialized lipid rafts that attach to the actin cytoskeleton and modulate receptor/signal transduction coupling. CAV1 loss in pulmonary artery endothelial cells produced a proliferative, hypermigratory cellular phenotype with a disrupted cytoskeletal architecture, mirroring known feat...
Source: GEO: Gene Expression Omnibus - February 24, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Recombinant Thrombomodulin Attenuates Preeclamptic Symptoms by Inhibiting High Mobility Group Box 1 in Mice.
Abstract Preeclampsia (PE) is a common gestational complication that involves systemic endothelial dysfunction and inflammatory responses primarily due to placental damage. Recombinant thrombomodulin (rTM), a novel anti-coagulant clinically used for disseminated intravascular coagulation, is reported to have a unique anti-inflammatory endothelial repair function by inhibiting proinflammatory mediator high mobility group box 1 (HMGB1). Despite the severe patient outcomes, there are currently no effective therapeutic to treat PE. Here, we verified the efficacy of rTM as a novel therapeutic agent for PE using a murin...
Source: Endocrinology - January 6, 2021 Category: Endocrinology Authors: Oda H, Nagamatsu T, Schust DJ, Cabral H, Miyazaki T, Iriyama T, Kawana K, Osuga Y, Fujii T Tags: Endocrinology Source Type: research

Protective effects of dioscin on vascular remodeling in pulmonary arterial hypertension via adjusting GRB2/ERK/PI3K-AKT signal.
In this study, effect of dioscin on vascular remodeling in PAH was assessed in hypoxia-induced PASMCs, hypoxia-induced and monocrotaline (MCT)-induced rats. Western blot, Real-time PCR and siRNA transfection tests were applied to evaluate the possible mechanisms of dioscin. In vitro experiments, results showed dioscin markedly inhibited the proliferation and migration, and promoted apoptosis of hypoxic PASMCs. In vivo, dioscin significantly decreased the right ventricular systolic pressure (RVSP) and right ventricular hypertrophy index (RVHI), and improved pulmonary vascular stenosis in rats induced by hypoxia or MCT. Mole...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 1, 2021 Category: Drugs & Pharmacology Authors: Yang Y, Yin L, Zhu M, Song S, Sun C, Han X, Xu Y, Zhao Y, Qi Y, Xu L, Peng JY Tags: Biomed Pharmacother Source Type: research

TMEM16A Regulates Pulmonary Arterial Smooth Muscle Cells Proliferation via p38MAPK/ERK Pathway in High Pulmonary Blood Flow-Induced Pulmonary Arterial Hypertension
Conclusion: TMEM16A regulates PASMCs proliferation in high pulmonary blood flow-induced PAH, and the p38MAPK/ERK signaling pathway is probably involved.J Vasc Res
Source: Journal of Vascular Research - December 11, 2020 Category: Research Source Type: research

Involvement of TRPC1 and Cyclin D1 in Human Pulmonary Artery Smooth Muscle Cells Proliferation Induced by Cigarette Smoke Extract
SummaryCigarette smoking contributes to the development of pulmonary artery hypertension (PAH). As the basic pathological change of PAH, pulmonary vascular remodeling is considered to be related to the abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs). However, the molecular mechanism underlying this process remains not exactly clear. The aim of this research was to study the molecular mechanism of PASMCs proliferation induced by smoking. Human PASMCs (HPASMCs) were divided into 6 groups: 0% (control group), cigarette smoking extract (CSE)-treated groups at concentrations of 0.5%, 1%, 2%, 5%, 10% CSE ...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - December 1, 2020 Category: Research Source Type: research

Haploid genetic screening identifies a novel regulator of BMPR2
Pulmonary arterial hypertension (PAH), is characterised by profound remodelling of small pulmonary arteries, leading to increased pulmonary arterial pressures and premature death by right heart failure. Heterozygous germ-line mutations in the bone morphogenetic protein type II receptor (BMPR2) cause ~70% of familial PAH and ~20% of idiopathic PAH cases. The majority of mutations lead to haploinsufficiency but crucially, regardless of the presence of mutation, lung BMPR2 expression is reduced in all forms of PAH. Therefore, restoration of BMPR2 levels is an important therapeutic target. We previously showed that BMPR2 ubiqu...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Dunmore, B., Burr, S., Upton, P., Nathan, J., Morrell, N. Tags: Pulmonary hypertension Source Type: research

Protein truncating mutations in ATP13A3 promote pulmonary arterial hypertension
Conclusions: Our initial findings provide further evidence that loss of function mutations in ATP13A3 are directly involved in causation of PAH and the mechanism involves alterations in cellular polyamine levels.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Legchenko, E., Liu, B., West, J., Vangheluwe, P., Upton, P., Morrell, N. Tags: Pulmonary hypertension Source Type: research

GCN2 regulates BMP signaling: consequence for PVOD pathobiology and therapeutic management
Conclusion: GCN2 loss-of-function negatively regulates SMAD1/5/9 phosphorylation. Despite this dampened BMP signaling, exogenous BMP9 was still able to reverse GCN2 inhibition-induced hPMEC proliferation. BMP9 may hence be considered as potential therapeutic options for PVOD
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Manaud, G., Lambert, M., Soilih, B., Girerd, B., Soubrier, F., Bignard, J., Claude, O., Lecerf, F., Florio, M., Sun, B., Nadaud, S., Verleden, S., Remy, S., Anegon, I., Mercier, O., Fadel, E., Simmoneau, G., Humbert, M., Montani, D., Antigny, F., Perros, Tags: Pulmonary hypertension Source Type: research

Regulation of Type I cytokine receptors as a target for pulmonary arterial hypertension treatment?
Conclusions: TypeIR intracellular trafficking regulation is altered in PAH patients compared to controls, due to a shift in USP8/RNF41 ratio. Restoring USP8/RNF41 ratio in PA-SMCs may represent a potential target in PAH.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Jutant, E.-M., Tu, L., Le Vely, B., Thuillet, R., Humbert, M., Guignabert, C., Huertas, A. Tags: Pulmonary hypertension Source Type: research

Role of c-Abelson in the loss of genome integrity in endothelial cells in pulmonary arterial hypertension
Conclusions: Our results demonstrate a central role of c-Abl in the loss of DNA integrity in iPAH P-ECs.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Le Vely, B., Berrebeh, N., Phan, C., Thuillet, R., Humbert, M., Huertas, A., Guignabert, C., Tu, L. Tags: Pulmonary hypertension Source Type: research

NGF induces pulmonary arterial hyperreactivity through connexin 43 increased expression
In conclusion, NGF pathway is upregulated in IPAH cells. NGF increases Cx43 PA expression through TrkA receptor. Cx43 increased expression at plasma membrane upregulates GAP junction activity, thus promoting PA hyperreactivity.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Cardouat, g., Douard, M., Roubenne, L., Kmecova, Z., Robillard, P., Guignabert, C., Tu, L., Delcambre, F., Marthan, R., Muller, B., Guibert, C., Freund-Michel, V. Tags: Pulmonary hypertension Source Type: research

The protective effects of MSC-EXO against pulmonary hypertension through regulating Wnt5a/BMP signalling pathway.
Abstract The aim of the study was to explore the mechanism of mesenchymal stem cell-derived exosomes (MSC-EXO) to protect against experimentally induced pulmonary hypertension (PH). Monocrotaline (MCT)-induced rat model of PH was successfully established by a single intraperitoneal injection of 50 mg/kg MCT, 3 weeks later the animals were treated with MSC-EXO via tail vein injection. Post-operation, our results showed that MSC-EXO could significantly reduce right ventricular systolic pressure (RVSP) and the right ventricular hypertrophy index, attenuate pulmonary vascular remodelling and lung fibrosis in vivo. I...
Source: J Cell Mol Med - October 22, 2020 Category: Molecular Biology Authors: Zhang Z, Ge L, Zhang S, Wang J, Jiang W, Xin Q, Luan Y Tags: J Cell Mol Med Source Type: research