Correction to: "The Role of GLP-1 in the Metabolic Success of Bariatric Surgery"
Endocrinology. 2024 Mar 29;165(5):bqae042. doi: 10.1210/endocr/bqae042.NO ABSTRACTPMID:38651299 | DOI:10.1210/endocr/bqae042 (Source: Endocrinology)
Source: Endocrinology - April 23, 2024 Category: Endocrinology Source Type: research
Correction to: "The Role of GLP-1 in the Metabolic Success of Bariatric Surgery"
Endocrinology. 2024 Mar 29;165(5):bqae042. doi: 10.1210/endocr/bqae042.NO ABSTRACTPMID:38651299 | DOI:10.1210/endocr/bqae042 (Source: Endocrinology)
Source: Endocrinology - April 23, 2024 Category: Endocrinology Source Type: research
Correction to: "The Role of GLP-1 in the Metabolic Success of Bariatric Surgery"
Endocrinology. 2024 Mar 29;165(5):bqae042. doi: 10.1210/endocr/bqae042.NO ABSTRACTPMID:38651299 | DOI:10.1210/endocr/bqae042 (Source: Endocrinology)
Source: Endocrinology - April 23, 2024 Category: Endocrinology Source Type: research
Molecular Assessment of Pro-Adipogenic Effects for Common-Use Contraceptives and their Mixtures
In conclusion, this research provides valuable insights into the complex interactions between hormonal contraceptives and adipocyte development. The results suggest that both progestins and estrogens within these contraceptives can influence adipogenesis, and the specific effects may vary based on the receptor activation profiles. Further research is warranted to establish translation of these findings to in vivo models and to further assess causal mechanisms underlying these effects.PMID:38648498 | DOI:10.1210/endocr/bqae050 (Source: Endocrinology)
Source: Endocrinology - April 22, 2024 Category: Endocrinology Authors: Yu-Ting Tiffany Chiang Christopher D Kassotis Source Type: research
Estrogen receptor alpha mutations, truncations, heterodimers, and therapies
Endocrinology. 2024 Apr 21:bqae051. doi: 10.1210/endocr/bqae051. Online ahead of print.ABSTRACTAnnual breast cancer (BCa) deaths have declined since its apex in 1989 concomitant with widespread adoption of hormone therapies that target estrogen receptor alpha (ERα), the prominent nuclear receptor expressed in ∼80% of BCa. However, up to ∼50% of ER + patients with high-risk disease experience post endocrine therapy relapse and metastasis to distant organs. The vast majority of BCa mortality occurs in this setting, highlighting the inadequacy of current therapies. Genomic abnormalities to ESR1, the gene encoding ERα, e...
Source: Endocrinology - April 21, 2024 Category: Endocrinology Authors: Govinda R Hancock Jason Gertz Rinath Jeselsohn Sean W Fanning Source Type: research
Impact of ghrelin on islet size in non-pregnant and pregnant female mice
Endocrinology. 2024 Apr 16:bqae048. doi: 10.1210/endocr/bqae048. Online ahead of print.ABSTRACTReducing ghrelin by ghrelin gene knockout (GKO), ghrelin-cell ablation, or high-fat diet feeding increases islet size and β-cell mass in male mice. Here, we determined if reducing ghrelin also enlarges islets in females, and if pregnancy-associated changes in islet size are related to reduced ghrelin. Islet size and β-cell mass were larger (P=0.057 for β-cell mass) in female GKO mice. Pregnancy was associated with reduced ghrelin and increased LEAP2 [a ghrelin receptor (GHSR) antagonist] in WT mice. Ghrelin deletion and pregna...
Source: Endocrinology - April 16, 2024 Category: Endocrinology Authors: Deepali Gupta Avi W Burstein Kripa Shankar Salil Varshney Omprakash Singh Sherri Osborne-Lawrence Corine P Richard Jeffrey M Zigman Source Type: research
Impact of ghrelin on islet size in non-pregnant and pregnant female mice
Endocrinology. 2024 Apr 16:bqae048. doi: 10.1210/endocr/bqae048. Online ahead of print.ABSTRACTReducing ghrelin by ghrelin gene knockout (GKO), ghrelin-cell ablation, or high-fat diet feeding increases islet size and β-cell mass in male mice. Here, we determined if reducing ghrelin also enlarges islets in females, and if pregnancy-associated changes in islet size are related to reduced ghrelin. Islet size and β-cell mass were larger (P=0.057 for β-cell mass) in female GKO mice. Pregnancy was associated with reduced ghrelin and increased LEAP2 [a ghrelin receptor (GHSR) antagonist] in WT mice. Ghrelin deletion and pregna...
Source: Endocrinology - April 16, 2024 Category: Endocrinology Authors: Deepali Gupta Avi W Burstein Kripa Shankar Salil Varshney Omprakash Singh Sherri Osborne-Lawrence Corine P Richard Jeffrey M Zigman Source Type: research
Impact of ghrelin on islet size in non-pregnant and pregnant female mice
Endocrinology. 2024 Apr 16:bqae048. doi: 10.1210/endocr/bqae048. Online ahead of print.ABSTRACTReducing ghrelin by ghrelin gene knockout (GKO), ghrelin-cell ablation, or high-fat diet feeding increases islet size and β-cell mass in male mice. Here, we determined if reducing ghrelin also enlarges islets in females, and if pregnancy-associated changes in islet size are related to reduced ghrelin. Islet size and β-cell mass were larger (P=0.057 for β-cell mass) in female GKO mice. Pregnancy was associated with reduced ghrelin and increased LEAP2 [a ghrelin receptor (GHSR) antagonist] in WT mice. Ghrelin deletion and pregna...
Source: Endocrinology - April 16, 2024 Category: Endocrinology Authors: Deepali Gupta Avi W Burstein Kripa Shankar Salil Varshney Omprakash Singh Sherri Osborne-Lawrence Corine P Richard Jeffrey M Zigman Source Type: research
Clomiphene citrate administered in peri-conception phase causes fetal loss and developmental impairment in mice
Endocrinology. 2024 Apr 12:bqae047. doi: 10.1210/endocr/bqae047. Online ahead of print.ABSTRACTClomiphene citrate is a common treatment for ovulation induction in subfertile women, but its use is associated with elevated risk of adverse perinatal outcomes and birth defects. To investigate the biological plausibility of a causal relationship, this study investigated in mice the consequences for fetal development and pregnancy outcome of peri-conception clomiphene citrate administration at doses approximating human exposures. A dose-dependent adverse effect of clomiphene citrate given twice in the 36 h after mating was seen,...
Source: Endocrinology - April 12, 2024 Category: Endocrinology Authors: Peck Y Chin Tom E C Kieffer Jelmer R Prins Darryl L Russell Michael J Davies Sarah A Robertson Source Type: research
Clomiphene citrate administered in peri-conception phase causes fetal loss and developmental impairment in mice
Endocrinology. 2024 Apr 12:bqae047. doi: 10.1210/endocr/bqae047. Online ahead of print.ABSTRACTClomiphene citrate is a common treatment for ovulation induction in subfertile women, but its use is associated with elevated risk of adverse perinatal outcomes and birth defects. To investigate the biological plausibility of a causal relationship, this study investigated in mice the consequences for fetal development and pregnancy outcome of peri-conception clomiphene citrate administration at doses approximating human exposures. A dose-dependent adverse effect of clomiphene citrate given twice in the 36 h after mating was seen,...
Source: Endocrinology - April 12, 2024 Category: Endocrinology Authors: Peck Y Chin Tom E C Kieffer Jelmer R Prins Darryl L Russell Michael J Davies Sarah A Robertson Source Type: research
Clomiphene citrate administered in peri-conception phase causes fetal loss and developmental impairment in mice
Endocrinology. 2024 Apr 12:bqae047. doi: 10.1210/endocr/bqae047. Online ahead of print.ABSTRACTClomiphene citrate is a common treatment for ovulation induction in subfertile women, but its use is associated with elevated risk of adverse perinatal outcomes and birth defects. To investigate the biological plausibility of a causal relationship, this study investigated in mice the consequences for fetal development and pregnancy outcome of peri-conception clomiphene citrate administration at doses approximating human exposures. A dose-dependent adverse effect of clomiphene citrate given twice in the 36 h after mating was seen,...
Source: Endocrinology - April 12, 2024 Category: Endocrinology Authors: Peck Y Chin Tom E C Kieffer Jelmer R Prins Darryl L Russell Michael J Davies Sarah A Robertson Source Type: research
Puberty blocker, leuprolide, reduces sex differences in rough-and-tumble play and anxiety-like behavior in juvenile rats
We examined the impact of the puberty blocker, leuprolide acetate, on sex differences in juvenile rough-and-tumble play behavior and anxiety-like behavior in adolescent male and female rats. We also evaluated leuprolide treatment on gonadal and pituitary hormone levels and activity-regulated cytoskeleton-protein mRNA levels within the adolescent amygdala, a region important for both rough-and-tumble play and anxiety-like behavior. Our findings suggest that leuprolide treatment lowered anxiety-like behavior during adolescent development, suggesting that the maturation of GnRH systems may be linked to increased anxiety. Thes...
Source: Endocrinology - April 10, 2024 Category: Endocrinology Authors: Gabriela de Faria Oliveira Amber T Nguyen Leykza Carreras-Simons Thomas Niepsuj Salma H Gadelhak Aimee K Johnson Ashwakh Abdalla Eden Lev Sofia G Torres Rom án Samantha N Fuchs Joan S Jorgensen Walid A Farhat Anthony P Auger Source Type: research
Puberty blocker, leuprolide, reduces sex differences in rough-and-tumble play and anxiety-like behavior in juvenile rats
We examined the impact of the puberty blocker, leuprolide acetate, on sex differences in juvenile rough-and-tumble play behavior and anxiety-like behavior in adolescent male and female rats. We also evaluated leuprolide treatment on gonadal and pituitary hormone levels and activity-regulated cytoskeleton-protein mRNA levels within the adolescent amygdala, a region important for both rough-and-tumble play and anxiety-like behavior. Our findings suggest that leuprolide treatment lowered anxiety-like behavior during adolescent development, suggesting that the maturation of GnRH systems may be linked to increased anxiety. Thes...
Source: Endocrinology - April 10, 2024 Category: Endocrinology Authors: Gabriela de Faria Oliveira Amber T Nguyen Leykza Carreras-Simons Thomas Niepsuj Salma H Gadelhak Aimee K Johnson Ashwakh Abdalla Eden Lev Sofia G Torres Rom án Samantha N Fuchs Joan S Jorgensen Walid A Farhat Anthony P Auger Source Type: research
Puberty blocker, leuprolide, reduces sex differences in rough-and-tumble play and anxiety-like behavior in juvenile rats
We examined the impact of the puberty blocker, leuprolide acetate, on sex differences in juvenile rough-and-tumble play behavior and anxiety-like behavior in adolescent male and female rats. We also evaluated leuprolide treatment on gonadal and pituitary hormone levels and activity-regulated cytoskeleton-protein mRNA levels within the adolescent amygdala, a region important for both rough-and-tumble play and anxiety-like behavior. Our findings suggest that leuprolide treatment lowered anxiety-like behavior during adolescent development, suggesting that the maturation of GnRH systems may be linked to increased anxiety. Thes...
Source: Endocrinology - April 10, 2024 Category: Endocrinology Authors: Gabriela de Faria Oliveira Amber T Nguyen Leykza Carreras-Simons Thomas Niepsuj Salma H Gadelhak Aimee K Johnson Ashwakh Abdalla Eden Lev Sofia G Torres Rom án Samantha N Fuchs Joan S Jorgensen Walid A Farhat Anthony P Auger Source Type: research
Grb7 ablation in mice improved glycemic control, enhanced insulin signaling and increased abdominal fat mass in females
CONCLUSIONS: Our study suggests that Grb7 is a negative regulator of glycemic control. Our results reveal a role for Grb7 in female mice in the regulation of the visceral adipose tissue mass, a powerful predictor of metabolic dysfunction in obesity.PMID:38578949 | DOI:10.1210/endocr/bqae045 (Source: Endocrinology)
Source: Endocrinology - April 5, 2024 Category: Endocrinology Authors: Anke Vermehren-Schmaedick Sonali Joshi Wendy Wagoner Mason A Norgard William Packwood Parham Diba Heike Mendez Lev M Fedorov Shauna Rakshe Byung Park Daniel L Marks Aaron Grossberg Shiuh-Wen Luoh Source Type: research
