Synergistic combinations of gut-and-pancreas hormone-based therapies: Advancements in treatments for metabolic diseases
Endocrinology. 2023 Oct 12:bqad153. doi: 10.1210/endocr/bqad153. Online ahead of print.ABSTRACTMetabolic diseases, such as obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease, and liver disease, have become increasingly prevalent around the world. As an alternative to bariatric surgery, glucagon-like peptide 1 (GLP-1) receptor agonists have been at the forefront of weight-loss medication to combat these metabolic complications. Recently, there has been an exciting rapid emergence of new weight-loss medications that combine GLP-1 receptor (GLP-1R) agonists with other gut and pancreatic-derived hormones, like gl...
Source: Endocrinology - October 12, 2023 Category: Endocrinology Authors: Sulayman Aslan Lyons Jacqueline Leah Beaudry Source Type: research
Ghrelin action in the PVH of male mice: accessibility, neuronal targets and CRH neurons activation
Endocrinology. 2023 Oct 12:bqad154. doi: 10.1210/endocr/bqad154. Online ahead of print.ABSTRACTThe hormone ghrelin displays several well-characterized functions, including some with pharmaceutical interest. The receptor for ghrelin, the growth hormone secretagogue receptor (GHSR), is expressed in the hypothalamic paraventricular nucleus (PVH), a critical hub for the integration of metabolic, neuroendocrine, autonomic and behavioral functions. Here, we performed a neuroanatomical and functional characterization of the neuronal types mediating ghrelin actions in the PVH of male mice. We found that fluorescent-ghrelin mainly ...
Source: Endocrinology - October 12, 2023 Category: Endocrinology Authors: Gimena Fernandez Pablo N De Francesco Mar ía P Cornejo Agustina Cabral Julieta P Aguggia Victor J Duque Nilufer Sayar Sonia Cantel Juan I Burgos Jean-Alain Fehrentz Rodrigo Rorato Deniz Atasoy Andr é S Mecawi Mario Perello Source Type: research
Synergistic combinations of gut-and-pancreas hormone-based therapies: Advancements in treatments for metabolic diseases
Endocrinology. 2023 Oct 12:bqad153. doi: 10.1210/endocr/bqad153. Online ahead of print.ABSTRACTMetabolic diseases, such as obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease, and liver disease, have become increasingly prevalent around the world. As an alternative to bariatric surgery, glucagon-like peptide 1 (GLP-1) receptor agonists have been at the forefront of weight-loss medication to combat these metabolic complications. Recently, there has been an exciting rapid emergence of new weight-loss medications that combine GLP-1 receptor (GLP-1R) agonists with other gut and pancreatic-derived hormones, like gl...
Source: Endocrinology - October 12, 2023 Category: Endocrinology Authors: Sulayman Aslan Lyons Jacqueline Leah Beaudry Source Type: research
Ghrelin action in the PVH of male mice: accessibility, neuronal targets and CRH neurons activation
Endocrinology. 2023 Oct 12:bqad154. doi: 10.1210/endocr/bqad154. Online ahead of print.ABSTRACTThe hormone ghrelin displays several well-characterized functions, including some with pharmaceutical interest. The receptor for ghrelin, the growth hormone secretagogue receptor (GHSR), is expressed in the hypothalamic paraventricular nucleus (PVH), a critical hub for the integration of metabolic, neuroendocrine, autonomic and behavioral functions. Here, we performed a neuroanatomical and functional characterization of the neuronal types mediating ghrelin actions in the PVH of male mice. We found that fluorescent-ghrelin mainly ...
Source: Endocrinology - October 12, 2023 Category: Endocrinology Authors: Gimena Fernandez Pablo N De Francesco Mar ía P Cornejo Agustina Cabral Julieta P Aguggia Victor J Duque Nilufer Sayar Sonia Cantel Juan I Burgos Jean-Alain Fehrentz Rodrigo Rorato Deniz Atasoy Andr é S Mecawi Mario Perello Source Type: research
Synergistic combinations of gut-and-pancreas hormone-based therapies: Advancements in treatments for metabolic diseases
Endocrinology. 2023 Oct 12:bqad153. doi: 10.1210/endocr/bqad153. Online ahead of print.ABSTRACTMetabolic diseases, such as obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease, and liver disease, have become increasingly prevalent around the world. As an alternative to bariatric surgery, glucagon-like peptide 1 (GLP-1) receptor agonists have been at the forefront of weight-loss medication to combat these metabolic complications. Recently, there has been an exciting rapid emergence of new weight-loss medications that combine GLP-1 receptor (GLP-1R) agonists with other gut and pancreatic-derived hormones, like gl...
Source: Endocrinology - October 12, 2023 Category: Endocrinology Authors: Sulayman Aslan Lyons Jacqueline Leah Beaudry Source Type: research
BCAS2 participates in insulin synthesis and secretion via mRNA alternative splicing in mice
Endocrinology. 2023 Oct 11:bqad152. doi: 10.1210/endocr/bqad152. Online ahead of print.ABSTRACTInsulin secreted by pancreatic β cells is essential for maintaining the level of blood glucose. Diabetes is caused primarily by loss of β cells or impairment of β cell function. A previous whole-transcriptome analysis of islets from a type 2 diabetes (T2D) group and a control group showed that splicing disorder occurred in approximately 25% of splicing events. Breast carcinoma amplified sequence 2 (BCAS2) is a spliceosome component whose function in islet β cells is unclear. Here, we report that knockdown of Bcas2 decreased g...
Source: Endocrinology - October 11, 2023 Category: Endocrinology Authors: Xuexue Chen Xiaomei Xie Jianhua Li Longjie Sun Zheng Lv Xiaohong Yao Lei Li Hua Jin Sheng Cui Jiali Liu Source Type: research
Mast cell dynamics in the ovary are governed by GnRH and prolactin
Endocrinology. 2023 Oct 5:bqad144. doi: 10.1210/endocr/bqad144. Online ahead of print.ABSTRACTGonadotrophin releasing hormone (GnRH) facilitates the migration of mast cells (MCs) into the involuting mammary gland. As GnRH is also expressed in the ovary, we examined changes in ovarian MCs. MCs in the ovary were mainly in interstitial tissue and their number increased during the estrous cycle to produce two peaks, one at diestrus 2 (20:00 h) and another at proestrus (17:00 h). Laser microdissection demonstrated that GnRH mRNA is expressed throughout ovarian tissues (corpora lutea, follicles and interstitial tissues). GnRH im...
Source: Endocrinology - October 5, 2023 Category: Endocrinology Authors: Titaree Laoharatchatathanin Duangjai Rieanrakwong Yoshinori Hatsugai Ryota Terashima Tomohiro Yonezawa Shiro Kurusu Mitsumori Kawaminami Source Type: research
Mast cell dynamics in the ovary are governed by GnRH and prolactin
Endocrinology. 2023 Oct 5:bqad144. doi: 10.1210/endocr/bqad144. Online ahead of print.ABSTRACTGonadotrophin releasing hormone (GnRH) facilitates the migration of mast cells (MCs) into the involuting mammary gland. As GnRH is also expressed in the ovary, we examined changes in ovarian MCs. MCs in the ovary were mainly in interstitial tissue and their number increased during the estrous cycle to produce two peaks, one at diestrus 2 (20:00 h) and another at proestrus (17:00 h). Laser microdissection demonstrated that GnRH mRNA is expressed throughout ovarian tissues (corpora lutea, follicles and interstitial tissues). GnRH im...
Source: Endocrinology - October 5, 2023 Category: Endocrinology Authors: Titaree Laoharatchatathanin Duangjai Rieanrakwong Yoshinori Hatsugai Ryota Terashima Tomohiro Yonezawa Shiro Kurusu Mitsumori Kawaminami Source Type: research
Mast cell dynamics in the ovary are governed by GnRH and prolactin
Endocrinology. 2023 Oct 5:bqad144. doi: 10.1210/endocr/bqad144. Online ahead of print.ABSTRACTGonadotrophin releasing hormone (GnRH) facilitates the migration of mast cells (MCs) into the involuting mammary gland. As GnRH is also expressed in the ovary, we examined changes in ovarian MCs. MCs in the ovary were mainly in interstitial tissue and their number increased during the estrous cycle to produce two peaks, one at diestrus 2 (20:00 h) and another at proestrus (17:00 h). Laser microdissection demonstrated that GnRH mRNA is expressed throughout ovarian tissues (corpora lutea, follicles and interstitial tissues). GnRH im...
Source: Endocrinology - October 5, 2023 Category: Endocrinology Authors: Titaree Laoharatchatathanin Duangjai Rieanrakwong Yoshinori Hatsugai Ryota Terashima Tomohiro Yonezawa Shiro Kurusu Mitsumori Kawaminami Source Type: research
Mast cell dynamics in the ovary are governed by GnRH and prolactin
Endocrinology. 2023 Oct 5:bqad144. doi: 10.1210/endocr/bqad144. Online ahead of print.ABSTRACTGonadotrophin releasing hormone (GnRH) facilitates the migration of mast cells (MCs) into the involuting mammary gland. As GnRH is also expressed in the ovary, we examined changes in ovarian MCs. MCs in the ovary were mainly in interstitial tissue and their number increased during the estrous cycle to produce two peaks, one at diestrus 2 (20:00 h) and another at proestrus (17:00 h). Laser microdissection demonstrated that GnRH mRNA is expressed throughout ovarian tissues (corpora lutea, follicles and interstitial tissues). GnRH im...
Source: Endocrinology - October 5, 2023 Category: Endocrinology Authors: Titaree Laoharatchatathanin Duangjai Rieanrakwong Yoshinori Hatsugai Ryota Terashima Tomohiro Yonezawa Shiro Kurusu Mitsumori Kawaminami Source Type: research
Mast cell dynamics in the ovary are governed by GnRH and prolactin
Endocrinology. 2023 Oct 5:bqad144. doi: 10.1210/endocr/bqad144. Online ahead of print.ABSTRACTGonadotrophin releasing hormone (GnRH) facilitates the migration of mast cells (MCs) into the involuting mammary gland. As GnRH is also expressed in the ovary, we examined changes in ovarian MCs. MCs in the ovary were mainly in interstitial tissue and their number increased during the estrous cycle to produce two peaks, one at diestrus 2 (20:00 h) and another at proestrus (17:00 h). Laser microdissection demonstrated that GnRH mRNA is expressed throughout ovarian tissues (corpora lutea, follicles and interstitial tissues). GnRH im...
Source: Endocrinology - October 5, 2023 Category: Endocrinology Authors: Titaree Laoharatchatathanin Duangjai Rieanrakwong Yoshinori Hatsugai Ryota Terashima Tomohiro Yonezawa Shiro Kurusu Mitsumori Kawaminami Source Type: research
Mast cell dynamics in the ovary are governed by GnRH and prolactin
Endocrinology. 2023 Oct 5:bqad144. doi: 10.1210/endocr/bqad144. Online ahead of print.ABSTRACTGonadotrophin releasing hormone (GnRH) facilitates the migration of mast cells (MCs) into the involuting mammary gland. As GnRH is also expressed in the ovary, we examined changes in ovarian MCs. MCs in the ovary were mainly in interstitial tissue and their number increased during the estrous cycle to produce two peaks, one at diestrus 2 (20:00 h) and another at proestrus (17:00 h). Laser microdissection demonstrated that GnRH mRNA is expressed throughout ovarian tissues (corpora lutea, follicles and interstitial tissues). GnRH im...
Source: Endocrinology - October 5, 2023 Category: Endocrinology Authors: Titaree Laoharatchatathanin Duangjai Rieanrakwong Yoshinori Hatsugai Ryota Terashima Tomohiro Yonezawa Shiro Kurusu Mitsumori Kawaminami Source Type: research
Fasting modulates GABAergic synaptic transmission to arcuate kisspeptin neurons in female mice
Endocrinology. 2023 Oct 4:bqad150. doi: 10.1210/endocr/bqad150. Online ahead of print.ABSTRACTIt is well-established that the hypothalamic-pituitary-gonadal (HPG) axis is suppressed due to negative energy balance. However, less information is available on whether kisspeptin neuronal activity contributes to fasting-induced responses. In the present study, female and male mice were fasted for 24 hours or provided food ad libitum (fed group) to determine whether acute fasting is sufficient to modulate kisspeptin neuronal activity. In female mice, fasting attenuated luteinizing hormone (LH) and prolactin (PRL) serum levels and...
Source: Endocrinology - October 4, 2023 Category: Endocrinology Authors: Naira da Silva Mansano Henrique Rodrigues Vieira Roberta Araujo-Lopes Raphael Escorsim Szawka Jose Donato Renata Frazao Source Type: research
LncRNA Hnscr regulates lipid metabolism by mediating adipocyte lipolysis
This study identifies the initial characterization of Hnscr as a critical modifier that regulates lipid metabolism, suggesting that LncRNA Hnscr is a potential target for treating obesity.PMID:37788569 | DOI:10.1210/endocr/bqad147 (Source: Endocrinology)
Source: Endocrinology - October 3, 2023 Category: Endocrinology Authors: Yi-Fan Guo Jing-Yi Sun Ya Liu Zhe-Yu Liu Yan Huang Tian Su Yuan Xiao Source Type: research
The Neuroendocrine Impact of Acute Stress on Synaptic Plasticity
We describe the synaptic plasticity that occurs in four stress-associated brain structures, the hypothalamus, hippocampus, amygdala, and prefrontal cortex, in response to single or short-term stress exposure. The rapid transformative impact of glucocorticoids makes this stress signal a particularly potent effector of acute neuronal plasticity.PMID:37788632 | DOI:10.1210/endocr/bqad149 (Source: Endocrinology)
Source: Endocrinology - October 3, 2023 Category: Endocrinology Authors: Raoni Concei ção Dos-Santos Brook L W Sweeten Claire E Stelly Jeffrey G Tasker Source Type: research
