Impaired growth plate maturation in XLH is due to both excess FGF23 and decreased 1,25Dihydroxyvitamin D signaling
Endocrinology. 2023 Dec 8:bqad186. doi: 10.1210/endocr/bqad186. Online ahead of print.ABSTRACTX-linked hypophosphatemia (XLH) is the most common form of hereditary hypophosphatemic rickets. The genetic basis for XLH is loss of function mutations in the Phosphate-regulating endopeptidase X-linked (PHEX), which leads to increased circulating FGF23. This increase in FGF23 impairs activation of vitamin D and attenuates renal phosphate reabsorption, leading to rickets. Previous studies have demonstrated that ablating FGF23 in the Hyp mouse model of XLH leads to hyperphosphatemia, high levels of 1,25-dihydroxyvitamin D and is no...
Source: Endocrinology - December 9, 2023 Category: Endocrinology Authors: Prem Swaroop Yadav Margaret M Kobelski Janaina S Martins Tao Tao Eva S Liu Marie B Demay Source Type: research

Role for Non-Genomic Estrogen Signaling in Male Fertility
Endocrinology. 2023 Dec 8:bqad180. doi: 10.1210/endocr/bqad180. Online ahead of print.ABSTRACTEstrogen actions are mediated by both nuclear (n) and membrane (m) localized estrogen receptor 1 (ESR1). Male Esr1 knockout (Esr1KO) mice lacking functional Esr1 are infertile, with reproductive tract abnormalities. Male mice expressing nESR1 but lacking mESR1 (nuclear-only estrogen receptor 1 [NOER] mice) are progressively infertile due to testicular, rete testis and efferent ductule abnormalities similar to Esr1KO males, indicating a role for mESR1 in male reproduction. The H2NES mouse expresses only mESR1 but lacks nESR1. The g...
Source: Endocrinology - December 9, 2023 Category: Endocrinology Authors: Jones B Graceli Helena D Zomer Theresa I Medrano Rex A Hess Kenneth S Korach Paul S Cooke Source Type: research

Impaired growth plate maturation in XLH is due to both excess FGF23 and decreased 1,25Dihydroxyvitamin D signaling
Endocrinology. 2023 Dec 8:bqad186. doi: 10.1210/endocr/bqad186. Online ahead of print.ABSTRACTX-linked hypophosphatemia (XLH) is the most common form of hereditary hypophosphatemic rickets. The genetic basis for XLH is loss of function mutations in the Phosphate-regulating endopeptidase X-linked (PHEX), which leads to increased circulating FGF23. This increase in FGF23 impairs activation of vitamin D and attenuates renal phosphate reabsorption, leading to rickets. Previous studies have demonstrated that ablating FGF23 in the Hyp mouse model of XLH leads to hyperphosphatemia, high levels of 1,25-dihydroxyvitamin D and is no...
Source: Endocrinology - December 9, 2023 Category: Endocrinology Authors: Prem Swaroop Yadav Margaret M Kobelski Janaina S Martins Tao Tao Eva S Liu Marie B Demay Source Type: research

Role for Non-Genomic Estrogen Signaling in Male Fertility
Endocrinology. 2023 Dec 8:bqad180. doi: 10.1210/endocr/bqad180. Online ahead of print.ABSTRACTEstrogen actions are mediated by both nuclear (n) and membrane (m) localized estrogen receptor 1 (ESR1). Male Esr1 knockout (Esr1KO) mice lacking functional Esr1 are infertile, with reproductive tract abnormalities. Male mice expressing nESR1 but lacking mESR1 (nuclear-only estrogen receptor 1 [NOER] mice) are progressively infertile due to testicular, rete testis and efferent ductule abnormalities similar to Esr1KO males, indicating a role for mESR1 in male reproduction. The H2NES mouse expresses only mESR1 but lacks nESR1. The g...
Source: Endocrinology - December 9, 2023 Category: Endocrinology Authors: Jones B Graceli Helena D Zomer Theresa I Medrano Rex A Hess Kenneth S Korach Paul S Cooke Source Type: research

Sex-specific perturbation of systemic lipidomic profile in newborn lambs impacted by prenatal testosterone excess
Endocrinology. 2023 Dec 7:bqad187. doi: 10.1210/endocr/bqad187. Online ahead of print.ABSTRACTGestational hyperandrogenism adversely impacts offspring health. Using an ovine model, we found prenatal testosterone (T) excess adversely affects growth and cardiometabolic outcomes in female offspring and sex-specific effects on fetal myocardium. Since lipids are essential to cardiometabolic function, we hypothesized that prenatal T excess will lead to sex-specific disruptions in lipid metabolism at birth. Shotgun lipidomics was performed on the plasma samples collected 48 hours after birth from female (F) and male (M) lambs of ...
Source: Endocrinology - December 7, 2023 Category: Endocrinology Authors: Nadia Saadat Joseph Ciarelli Brooke Pallas Vasantha Padmanabhan Arpita Kalla Vyas Source Type: research

ATOH8 Expression is Regulated by BMP2 and Plays a Key Role in Human Endometrial Stromal Cell Decidualization
This study was carried out to determine if atonal basic helix-loop-helix transcription factor 8 (ATOH8) plays a role in human endometrial stromal fibroblast (ESF) decidualization. ATOH8 mRNA and protein expression levels significantly increased in human ESF cells undergoing in vitro decidualization, with the protein primarily localized to the nucleus. When ATOH8 expression was silenced, the ability of the cells to undergo decidualization was significantly diminished. Overexpression of ATOH8 enhanced the expression of many decidualization markers. Silencing the expression of ATOH8 reduced the expression of FZD4, FOXO1, and ...
Source: Endocrinology - December 7, 2023 Category: Endocrinology Authors: Rupak Thapa Logan Druessel Liang Ma Donald S Torry Brent M Bany Source Type: research

Sex-specific perturbation of systemic lipidomic profile in newborn lambs impacted by prenatal testosterone excess
Endocrinology. 2023 Dec 7:bqad187. doi: 10.1210/endocr/bqad187. Online ahead of print.ABSTRACTGestational hyperandrogenism adversely impacts offspring health. Using an ovine model, we found prenatal testosterone (T) excess adversely affects growth and cardiometabolic outcomes in female offspring and sex-specific effects on fetal myocardium. Since lipids are essential to cardiometabolic function, we hypothesized that prenatal T excess will lead to sex-specific disruptions in lipid metabolism at birth. Shotgun lipidomics was performed on the plasma samples collected 48 hours after birth from female (F) and male (M) lambs of ...
Source: Endocrinology - December 7, 2023 Category: Endocrinology Authors: Nadia Saadat Joseph Ciarelli Brooke Pallas Vasantha Padmanabhan Arpita Kalla Vyas Source Type: research

ATOH8 Expression is Regulated by BMP2 and Plays a Key Role in Human Endometrial Stromal Cell Decidualization
This study was carried out to determine if atonal basic helix-loop-helix transcription factor 8 (ATOH8) plays a role in human endometrial stromal fibroblast (ESF) decidualization. ATOH8 mRNA and protein expression levels significantly increased in human ESF cells undergoing in vitro decidualization, with the protein primarily localized to the nucleus. When ATOH8 expression was silenced, the ability of the cells to undergo decidualization was significantly diminished. Overexpression of ATOH8 enhanced the expression of many decidualization markers. Silencing the expression of ATOH8 reduced the expression of FZD4, FOXO1, and ...
Source: Endocrinology - December 7, 2023 Category: Endocrinology Authors: Rupak Thapa Logan Druessel Liang Ma Donald S Torry Brent M Bany Source Type: research

Vasoinhibin apoptotic, inflammatory, and fibrinolytic actions are in a motif different from its antiangiogenic HGR motif
In conclusion, the functional properties of vasoinhibin are segregated into two different structural determinants. Because apoptotic, inflammatory, and fibrinolytic actions may be undesirable for antiangiogenic therapy, HGR-containing vasoinhibin analogs stand as selective and safe agents for targeting pathological angiogenesis.PMID:38057149 | DOI:10.1210/endocr/bqad185 (Source: Endocrinology)
Source: Endocrinology - December 6, 2023 Category: Endocrinology Authors: Juan Pablo Robles Magdalena Zamora Jose F Garcia-Rodrigo Alma Lorena Perez Thomas Bertsch Gonzalo Martinez de la Escalera Jakob Triebel Carmen Clapp Source Type: research

Vasoinhibin apoptotic, inflammatory, and fibrinolytic actions are in a motif different from its antiangiogenic HGR motif
In conclusion, the functional properties of vasoinhibin are segregated into two different structural determinants. Because apoptotic, inflammatory, and fibrinolytic actions may be undesirable for antiangiogenic therapy, HGR-containing vasoinhibin analogs stand as selective and safe agents for targeting pathological angiogenesis.PMID:38057149 | DOI:10.1210/endocr/bqad185 (Source: Endocrinology)
Source: Endocrinology - December 6, 2023 Category: Endocrinology Authors: Juan Pablo Robles Magdalena Zamora Jose F Garcia-Rodrigo Alma Lorena Perez Thomas Bertsch Gonzalo Martinez de la Escalera Jakob Triebel Carmen Clapp Source Type: research

Interactive association between gut microbiota and thyroid cancer
DISCUSSIONS: These findings implicated the potential role of host-microbiota crosstalk in thyroid cancer, while the discrepancy among observational studies calls for further investigations.PMID:38051644 | DOI:10.1210/endocr/bqad184 (Source: Endocrinology)
Source: Endocrinology - December 5, 2023 Category: Endocrinology Authors: Tianzhichao Hou Qi Wang Huajie Dai Yanan Hou Jie Zheng Tiange Wang Hong Lin Shuangyuan Wang Mian Li Zhiyun Zhao Yuhong Chen Yu Xu Jieli Lu Ruixin Liu Guang Ning Weiqing Wang Min Xu Yufang Bi Source Type: research

Interactive association between gut microbiota and thyroid cancer
DISCUSSIONS: These findings implicated the potential role of host-microbiota crosstalk in thyroid cancer, while the discrepancy among observational studies calls for further investigations.PMID:38051644 | DOI:10.1210/endocr/bqad184 (Source: Endocrinology)
Source: Endocrinology - December 5, 2023 Category: Endocrinology Authors: Tianzhichao Hou Qi Wang Huajie Dai Yanan Hou Jie Zheng Tiange Wang Hong Lin Shuangyuan Wang Mian Li Zhiyun Zhao Yuhong Chen Yu Xu Jieli Lu Ruixin Liu Guang Ning Weiqing Wang Min Xu Yufang Bi Source Type: research

The influence of maternal high fat diet during lactation on offspring hematopoietic priming
Endocrinology. 2023 Dec 4:bqad182. doi: 10.1210/endocr/bqad182. Online ahead of print.ABSTRACTObesity and metabolic diseases are rising in women of reproductive age, increasing offspring metabolic risk. Maternal nutritional interventions during lactation present an opportunity to modify offspring outcomes. We previously demonstrated in mice that adult male offspring have metabolic impairments and increased adipose tissue macrophages (ATM) when dams are fed high fat diet (HFD) during the postnatal lactation window (HFD PN). We sought to understand the effect of HFD during lactation on early life inflammation. HFD PN offspri...
Source: Endocrinology - December 4, 2023 Category: Endocrinology Authors: Katherine Kim Mita Varghese Haijing Sun Simin Abrishami Emily Bowers Dave Bridges Jennifer L Meijer Kanakadurga Singer Brigid Gregg Source Type: research

Dectin-2 Deficiency Promotes Pro-inflammatory Cytokine Release from Macrophages and Impairs Insulin Secretion
This study provides novel insights into the mechanisms underlying the role of Dectin-2 in the development of islet inflammation.PMID:38038367 | DOI:10.1210/endocr/bqad181 (Source: Endocrinology)
Source: Endocrinology - December 1, 2023 Category: Endocrinology Authors: Masamichi Fujita Takashi Miyazawa Keiichiro Uchida Naohiro Uchida Shojiro Haji Seiichi Yano Norifusa Iwahashi Tomomi Hatayama Shunsuke Katsuhara Shintaro Nakamura Yukina Takeichi Maki Yokomoto-Umakoshi Yasutaka Miyachi Ryuichi Sakamoto Yoichiro Iwakura Yo Source Type: research

Dectin-2 Deficiency Promotes Pro-inflammatory Cytokine Release from Macrophages and Impairs Insulin Secretion
This study provides novel insights into the mechanisms underlying the role of Dectin-2 in the development of islet inflammation.PMID:38038367 | DOI:10.1210/endocr/bqad181 (Source: Endocrinology)
Source: Endocrinology - December 1, 2023 Category: Endocrinology Authors: Masamichi Fujita Takashi Miyazawa Keiichiro Uchida Naohiro Uchida Shojiro Haji Seiichi Yano Norifusa Iwahashi Tomomi Hatayama Shunsuke Katsuhara Shintaro Nakamura Yukina Takeichi Maki Yokomoto-Umakoshi Yasutaka Miyachi Ryuichi Sakamoto Yoichiro Iwakura Yo Source Type: research