Top-Down Proteomics of Mouse Islets With Beta Cell CPE Deletion Reveals Molecular Details in Prohormone Processing
Endocrinology. 2023 Nov 2;164(12):bqad160. doi: 10.1210/endocr/bqad160.ABSTRACTAltered prohormone processing, such as with proinsulin and pro-islet amyloid polypeptide (proIAPP), has been reported as an important feature of prediabetes and diabetes. Proinsulin processing includes removal of several C-terminal basic amino acids and is performed principally by the exopeptidase carboxypeptidase E (CPE), and mutations in CPE or other prohormone convertase enzymes (PC1/3 and PC2) result in hyperproinsulinemia. A comprehensive characterization of the forms and quantities of improperly processed insulin and other hormone products...
Source: Endocrinology - November 15, 2023 Category: Endocrinology Authors: James M Fulcher Adam C Swensen Yi-Chun Chen C Bruce Verchere Vladislav A Petyuk Wei-Jun Qian Source Type: research
A Novel Tissue-Specific Insight Into Sex Steroid Fluctuations Throughout the Murine Estrous Cycle
CONCLUSION: This investigation provides a comprehensive analysis of steroid content throughout the estrous cycle in a multitude of tissues and serum. We believe this information will help serve as the basis for the development of physiologically-relevant, tissue-specific hormonal therapies.PMID:37967240 | DOI:10.1210/endocr/bqad175 (Source: Endocrinology)
Source: Endocrinology - November 15, 2023 Category: Endocrinology Authors: Christian A Unger Marion C Hope Ahmed K Aladhami William E Cotham Cassidy E Socia Barton C Rice Deborah J Clegg Kandy T Vel ázquez Holly A LaVoie Fiona Hollis Reilly T Enos Source Type: research
Insights into RNA N6-methyladenosine in glucose and lipid metabolic diseases and their therapeutic strategies
Endocrinology. 2023 Nov 9:bqad170. doi: 10.1210/endocr/bqad170. Online ahead of print.ABSTRACTThe incidence of glucose and lipid metabolism diseases, including type 2 diabetes, obesity, metabolic syndrome, and nonalcoholic fatty liver disease is rising, which places an enormous burden on people around the world. However, the mechanism behind these disorders remains incompletely understood. N6-methyladenosine (m6A) is one type of posttranscriptional RNA modification and research has shown that it plays a crucial role in several metabolic diseases. m6A methylation is reversibly and dynamically regulated by methyltransferases...
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Yifan Wu Yuan Zeng Yaolin Ren Jie Yu Qian Zhang Xinhua Xiao Source Type: research
Progesterone activates histone lactylation-Hif1 α-glycolysis feedback loop to promote decidualization
Endocrinology. 2023 Nov 10:bqad169. doi: 10.1210/endocr/bqad169. Online ahead of print.ABSTRACTDecidualization is a progesterone-dependent cellular differentiation process that is essential for establishing pregnancy. Robust activation of glycolysis and lactate synthesis during decidualization is remarkable, but their developmental functions remain largely unknown. Herein, we identify that endometrial lactate production plays a critical role in establishing local histone lactylation, a newly identified histone modification, and is important for ensuring normal decidualization. Enhanced endometrial glycolysis is the hallmar...
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Wei Zhao Yue Wang Juan Liu Qianying Yang Shuai Zhang Xiao Hu Zhicheng Shi Zhenni Zhang Jianhui Tian Dapeng Chu Lei An Source Type: research
Gestational diabetes induced by low vitamin-B6
Endocrinology. 2023 Nov 10:bqad171. doi: 10.1210/endocr/bqad171. Online ahead of print.NO ABSTRACTPMID:37951839 | DOI:10.1210/endocr/bqad171 (Source: Endocrinology)
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Ricardo Augusto Leoni De Sousa Ricardo Cardoso Cassilhas Source Type: research
Paradigm Shift in the Management of Metabolic Diseases-Next-Generation Incretin Therapy
Endocrinology. 2023 Nov 2;164(12):bqad166. doi: 10.1210/endocr/bqad166.ABSTRACTRecently impressive weight loss has been reported for novel incretin therapies based on dual-and triple-hormone receptor coagonists. These agents have potential as being positioned as early therapeutics for metabolic diseases for which weight loss is preferred, such as type 2 diabetes, obesity, cardiovascular diseases, and nonalcoholic liver disease. This development will change the landscape of future therapy and also place weight reduction at the centerpiece for therapy of metabolic diseases.PMID:37951841 | DOI:10.1210/endocr/bqad166 (Source: Endocrinology)
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Bo Ahr én Source Type: research
Insights into RNA N6-methyladenosine in glucose and lipid metabolic diseases and their therapeutic strategies
Endocrinology. 2023 Nov 9:bqad170. doi: 10.1210/endocr/bqad170. Online ahead of print.ABSTRACTThe incidence of glucose and lipid metabolism diseases, including type 2 diabetes, obesity, metabolic syndrome, and nonalcoholic fatty liver disease is rising, which places an enormous burden on people around the world. However, the mechanism behind these disorders remains incompletely understood. N6-methyladenosine (m6A) is one type of posttranscriptional RNA modification and research has shown that it plays a crucial role in several metabolic diseases. m6A methylation is reversibly and dynamically regulated by methyltransferases...
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Yifan Wu Yuan Zeng Yaolin Ren Jie Yu Qian Zhang Xinhua Xiao Source Type: research
Progesterone activates histone lactylation-Hif1 α-glycolysis feedback loop to promote decidualization
Endocrinology. 2023 Nov 10:bqad169. doi: 10.1210/endocr/bqad169. Online ahead of print.ABSTRACTDecidualization is a progesterone-dependent cellular differentiation process that is essential for establishing pregnancy. Robust activation of glycolysis and lactate synthesis during decidualization is remarkable, but their developmental functions remain largely unknown. Herein, we identify that endometrial lactate production plays a critical role in establishing local histone lactylation, a newly identified histone modification, and is important for ensuring normal decidualization. Enhanced endometrial glycolysis is the hallmar...
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Wei Zhao Yue Wang Juan Liu Qianying Yang Shuai Zhang Xiao Hu Zhicheng Shi Zhenni Zhang Jianhui Tian Dapeng Chu Lei An Source Type: research
Gestational diabetes induced by low vitamin-B6
Endocrinology. 2023 Nov 10:bqad171. doi: 10.1210/endocr/bqad171. Online ahead of print.NO ABSTRACTPMID:37951839 | DOI:10.1210/endocr/bqad171 (Source: Endocrinology)
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Ricardo Augusto Leoni De Sousa Ricardo Cardoso Cassilhas Source Type: research
Paradigm Shift in the Management of Metabolic Diseases-Next-Generation Incretin Therapy
Endocrinology. 2023 Nov 2;164(12):bqad166. doi: 10.1210/endocr/bqad166.ABSTRACTRecently impressive weight loss has been reported for novel incretin therapies based on dual-and triple-hormone receptor coagonists. These agents have potential as being positioned as early therapeutics for metabolic diseases for which weight loss is preferred, such as type 2 diabetes, obesity, cardiovascular diseases, and nonalcoholic liver disease. This development will change the landscape of future therapy and also place weight reduction at the centerpiece for therapy of metabolic diseases.PMID:37951841 | DOI:10.1210/endocr/bqad166 (Source: Endocrinology)
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Bo Ahr én Source Type: research
Insights into RNA N6-methyladenosine in glucose and lipid metabolic diseases and their therapeutic strategies
Endocrinology. 2023 Nov 9:bqad170. doi: 10.1210/endocr/bqad170. Online ahead of print.ABSTRACTThe incidence of glucose and lipid metabolism diseases, including type 2 diabetes, obesity, metabolic syndrome, and nonalcoholic fatty liver disease is rising, which places an enormous burden on people around the world. However, the mechanism behind these disorders remains incompletely understood. N6-methyladenosine (m6A) is one type of posttranscriptional RNA modification and research has shown that it plays a crucial role in several metabolic diseases. m6A methylation is reversibly and dynamically regulated by methyltransferases...
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Yifan Wu Yuan Zeng Yaolin Ren Jie Yu Qian Zhang Xinhua Xiao Source Type: research
Progesterone activates histone lactylation-Hif1 α-glycolysis feedback loop to promote decidualization
Endocrinology. 2023 Nov 10:bqad169. doi: 10.1210/endocr/bqad169. Online ahead of print.ABSTRACTDecidualization is a progesterone-dependent cellular differentiation process that is essential for establishing pregnancy. Robust activation of glycolysis and lactate synthesis during decidualization is remarkable, but their developmental functions remain largely unknown. Herein, we identify that endometrial lactate production plays a critical role in establishing local histone lactylation, a newly identified histone modification, and is important for ensuring normal decidualization. Enhanced endometrial glycolysis is the hallmar...
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Wei Zhao Yue Wang Juan Liu Qianying Yang Shuai Zhang Xiao Hu Zhicheng Shi Zhenni Zhang Jianhui Tian Dapeng Chu Lei An Source Type: research
Gestational diabetes induced by low vitamin-B6
Endocrinology. 2023 Nov 10:bqad171. doi: 10.1210/endocr/bqad171. Online ahead of print.NO ABSTRACTPMID:37951839 | DOI:10.1210/endocr/bqad171 (Source: Endocrinology)
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Ricardo Augusto Leoni De Sousa Ricardo Cardoso Cassilhas Source Type: research
Paradigm shift in the management of metabolic diseases - next generation incretin therapy
Endocrinology. 2023 Nov 10:bqad166. doi: 10.1210/endocr/bqad166. Online ahead of print.ABSTRACTRecently impressive weight loss has been reported for novel incretin therapies based on dual and triple hormone receptor coagonists. These agents have potential as being positioned as early therapeutics for metabolic diseases where weight loss is preferred, such as type 2 diabetes, obesity, cardiovascular diseases and non-alcoholic liver disease. This development will change the landscape of future therapy and also place weight reduction at the centerpiece for therapy of metabolic diseases.PMID:37951841 | DOI:10.1210/endocr/bqad1...
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Bo Ahr én Source Type: research
Insights into RNA N6-methyladenosine in glucose and lipid metabolic diseases and their therapeutic strategies
Endocrinology. 2023 Nov 9:bqad170. doi: 10.1210/endocr/bqad170. Online ahead of print.ABSTRACTThe incidence of glucose and lipid metabolism diseases, including type 2 diabetes, obesity, metabolic syndrome, and nonalcoholic fatty liver disease is rising, which places an enormous burden on people around the world. However, the mechanism behind these disorders remains incompletely understood. N6-methyladenosine (m6A) is one type of posttranscriptional RNA modification and research has shown that it plays a crucial role in several metabolic diseases. m6A methylation is reversibly and dynamically regulated by methyltransferases...
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Yifan Wu Yuan Zeng Yaolin Ren Jie Yu Qian Zhang Xinhua Xiao Source Type: research
