The power of the Heterogenous Stock rat founder strains in modeling metabolic disease
This study determined underappreciated metabolic health traits and the associated endocrine glands within available substrains of the HS rat founders. We hypothesize that the genetic diversity of the HS rat founder strains causes a range of endocrine health conditions contributing to the diversity of cardiometabolic disease risks. ACI/EurMcwi, BN/NHsdMcwi, BUF/MnaMcwi, F344/StmMcwi, M520/NRrrcMcwi, and WKY/NCrl rats of both sexes were studied from birth until 13 weeks-of-age. Birth weight was recorded, body weight was measured weekly, metabolic characteristics were assessed, and blood and tissues were collected. Our data s...
Source: Endocrinology - October 26, 2023 Category: Endocrinology Authors: Valerie A Wagner Katie L Holl Karen C Clark John J Reho Hans-Joachim Lehmler Kai Wang Justin L Grobe Melinda R Dwinell Hershel Raff Anne E Kwitek Source Type: research
Sustained pituitary T3 production explains the T4-mediated TSH feedback mechanism
Endocrinology. 2023 Oct 21:bqad155. doi: 10.1210/endocr/bqad155. Online ahead of print.ABSTRACTThe regulation of thyroid activity and thyroid hormone (TH) secretion is based on feedback mechanisms that involve the anterior pituitary thyrotropin (TSH) and medial basal hypothalamus (MBH) TSH-releasing hormone (TRH). Plasma T3 levels can be "sensed" directly by the anterior pituitary and MBH, plasma T4 levels require local conversion of T4 to T3, which is mediated by the type 2 deiodinase (D2). To study D2-mediated T4 to T3 conversion and T3 production in the anterior pituitary gland, we used mouse pituitary explants incubate...
Source: Endocrinology - October 21, 2023 Category: Endocrinology Authors: Alice Batistuzzo Federico Salas-Lucia Bal ázs Gereben Miriam O Ribeiro Antonio C Bianco Source Type: research
Prolactin inhibits or stimulates the inflammatory response of joint tissues in a cytokine-dependent manner
Endocrinology. 2023 Oct 21:bqad156. doi: 10.1210/endocr/bqad156. Online ahead of print.ABSTRACTThe close association between rheumatoid arthritis (RA), sex, reproductive state, and stress has long linked prolactin (PRL) to disease progression. PRL has both proinflammatory and anti-inflammatory outcomes in RA, but responsible mechanisms are not understood. Here, we show that PRL modifies in an opposite manner the proinflammatory actions of IL-1β and TNF-α in mouse synovial fibroblasts (SF) in culture. Both IL-1β and TNF-α upregulated the metabolic activity and the expression of proinflammatory factors (Il1b, Inos, and I...
Source: Endocrinology - October 21, 2023 Category: Endocrinology Authors: Jose Fernando Garc ía-Rodrigo Georgina Ortiz Oscar Fernando Mart ínez-Díaz Janette Furuzawa-Carballeda Xarubet Ru íz-Herrera Fernando Macias Mar ía G Ledesma-Colunga Gonzalo Mart ínez de la Escalera Carmen Clapp Source Type: research
Sustained pituitary T3 production explains the T4-mediated TSH feedback mechanism
Endocrinology. 2023 Oct 21:bqad155. doi: 10.1210/endocr/bqad155. Online ahead of print.ABSTRACTThe regulation of thyroid activity and thyroid hormone (TH) secretion is based on feedback mechanisms that involve the anterior pituitary thyrotropin (TSH) and medial basal hypothalamus (MBH) TSH-releasing hormone (TRH). Plasma T3 levels can be "sensed" directly by the anterior pituitary and MBH, plasma T4 levels require local conversion of T4 to T3, which is mediated by the type 2 deiodinase (D2). To study D2-mediated T4 to T3 conversion and T3 production in the anterior pituitary gland, we used mouse pituitary explants incubate...
Source: Endocrinology - October 21, 2023 Category: Endocrinology Authors: Alice Batistuzzo Federico Salas-Lucia Bal ázs Gereben Miriam O Ribeiro Antonio C Bianco Source Type: research
Prolactin inhibits or stimulates the inflammatory response of joint tissues in a cytokine-dependent manner
Endocrinology. 2023 Oct 21:bqad156. doi: 10.1210/endocr/bqad156. Online ahead of print.ABSTRACTThe close association between rheumatoid arthritis (RA), sex, reproductive state, and stress has long linked prolactin (PRL) to disease progression. PRL has both proinflammatory and anti-inflammatory outcomes in RA, but responsible mechanisms are not understood. Here, we show that PRL modifies in an opposite manner the proinflammatory actions of IL-1β and TNF-α in mouse synovial fibroblasts (SF) in culture. Both IL-1β and TNF-α upregulated the metabolic activity and the expression of proinflammatory factors (Il1b, Inos, and I...
Source: Endocrinology - October 21, 2023 Category: Endocrinology Authors: Jose Fernando Garc ía-Rodrigo Georgina Ortiz Oscar Fernando Mart ínez-Díaz Janette Furuzawa-Carballeda Xarubet Ru íz-Herrera Fernando Macias Mar ía G Ledesma-Colunga Gonzalo Mart ínez de la Escalera Carmen Clapp Source Type: research
Sustained pituitary T3 production explains the T4-mediated TSH feedback mechanism
Endocrinology. 2023 Oct 21:bqad155. doi: 10.1210/endocr/bqad155. Online ahead of print.ABSTRACTThe regulation of thyroid activity and thyroid hormone (TH) secretion is based on feedback mechanisms that involve the anterior pituitary thyrotropin (TSH) and medial basal hypothalamus (MBH) TSH-releasing hormone (TRH). Plasma T3 levels can be "sensed" directly by the anterior pituitary and MBH, plasma T4 levels require local conversion of T4 to T3, which is mediated by the type 2 deiodinase (D2). To study D2-mediated T4 to T3 conversion and T3 production in the anterior pituitary gland, we used mouse pituitary explants incubate...
Source: Endocrinology - October 21, 2023 Category: Endocrinology Authors: Alice Batistuzzo Federico Salas-Lucia Bal ázs Gereben Miriam O Ribeiro Antonio C Bianco Source Type: research
Prolactin inhibits or stimulates the inflammatory response of joint tissues in a cytokine-dependent manner
Endocrinology. 2023 Oct 21:bqad156. doi: 10.1210/endocr/bqad156. Online ahead of print.ABSTRACTThe close association between rheumatoid arthritis (RA), sex, reproductive state, and stress has long linked prolactin (PRL) to disease progression. PRL has both proinflammatory and anti-inflammatory outcomes in RA, but responsible mechanisms are not understood. Here, we show that PRL modifies in an opposite manner the proinflammatory actions of IL-1β and TNF-α in mouse synovial fibroblasts (SF) in culture. Both IL-1β and TNF-α upregulated the metabolic activity and the expression of proinflammatory factors (Il1b, Inos, and I...
Source: Endocrinology - October 21, 2023 Category: Endocrinology Authors: Jose Fernando Garc ía-Rodrigo Georgina Ortiz Oscar Fernando Mart ínez-Díaz Janette Furuzawa-Carballeda Xarubet Ru íz-Herrera Fernando Macias Mar ía G Ledesma-Colunga Gonzalo Mart ínez de la Escalera Carmen Clapp Source Type: research
Sustained pituitary T3 production explains the T4-mediated TSH feedback mechanism
Endocrinology. 2023 Oct 21:bqad155. doi: 10.1210/endocr/bqad155. Online ahead of print.ABSTRACTThe regulation of thyroid activity and thyroid hormone (TH) secretion is based on feedback mechanisms that involve the anterior pituitary thyrotropin (TSH) and medial basal hypothalamus (MBH) TSH-releasing hormone (TRH). Plasma T3 levels can be "sensed" directly by the anterior pituitary and MBH, plasma T4 levels require local conversion of T4 to T3, which is mediated by the type 2 deiodinase (D2). To study D2-mediated T4 to T3 conversion and T3 production in the anterior pituitary gland, we used mouse pituitary explants incubate...
Source: Endocrinology - October 21, 2023 Category: Endocrinology Authors: Alice Batistuzzo Federico Salas-Lucia Bal ázs Gereben Miriam O Ribeiro Antonio C Bianco Source Type: research
Prolactin inhibits or stimulates the inflammatory response of joint tissues in a cytokine-dependent manner
Endocrinology. 2023 Oct 21:bqad156. doi: 10.1210/endocr/bqad156. Online ahead of print.ABSTRACTThe close association between rheumatoid arthritis (RA), sex, reproductive state, and stress has long linked prolactin (PRL) to disease progression. PRL has both proinflammatory and anti-inflammatory outcomes in RA, but responsible mechanisms are not understood. Here, we show that PRL modifies in an opposite manner the proinflammatory actions of IL-1β and TNF-α in mouse synovial fibroblasts (SF) in culture. Both IL-1β and TNF-α upregulated the metabolic activity and the expression of proinflammatory factors (Il1b, Inos, and I...
Source: Endocrinology - October 21, 2023 Category: Endocrinology Authors: Jose Fernando Garc ía-Rodrigo Georgina Ortiz Oscar Fernando Mart ínez-Díaz Janette Furuzawa-Carballeda Xarubet Ru íz-Herrera Fernando Macias Mar ía G Ledesma-Colunga Gonzalo Mart ínez de la Escalera Carmen Clapp Source Type: research
Ghrelin action in the PVH of male mice: accessibility, neuronal targets and CRH neurons activation
Endocrinology. 2023 Oct 12:bqad154. doi: 10.1210/endocr/bqad154. Online ahead of print.ABSTRACTThe hormone ghrelin displays several well-characterized functions, including some with pharmaceutical interest. The receptor for ghrelin, the growth hormone secretagogue receptor (GHSR), is expressed in the hypothalamic paraventricular nucleus (PVH), a critical hub for the integration of metabolic, neuroendocrine, autonomic and behavioral functions. Here, we performed a neuroanatomical and functional characterization of the neuronal types mediating ghrelin actions in the PVH of male mice. We found that fluorescent-ghrelin mainly ...
Source: Endocrinology - October 12, 2023 Category: Endocrinology Authors: Gimena Fernandez Pablo N De Francesco Mar ía P Cornejo Agustina Cabral Julieta P Aguggia Victor J Duque Nilufer Sayar Sonia Cantel Juan I Burgos Jean-Alain Fehrentz Rodrigo Rorato Deniz Atasoy Andr é S Mecawi Mario Perello Source Type: research
Synergistic combinations of gut-and-pancreas hormone-based therapies: Advancements in treatments for metabolic diseases
Endocrinology. 2023 Oct 12:bqad153. doi: 10.1210/endocr/bqad153. Online ahead of print.ABSTRACTMetabolic diseases, such as obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease, and liver disease, have become increasingly prevalent around the world. As an alternative to bariatric surgery, glucagon-like peptide 1 (GLP-1) receptor agonists have been at the forefront of weight-loss medication to combat these metabolic complications. Recently, there has been an exciting rapid emergence of new weight-loss medications that combine GLP-1 receptor (GLP-1R) agonists with other gut and pancreatic-derived hormones, like gl...
Source: Endocrinology - October 12, 2023 Category: Endocrinology Authors: Sulayman Aslan Lyons Jacqueline Leah Beaudry Source Type: research
Ghrelin action in the PVH of male mice: accessibility, neuronal targets and CRH neurons activation
Endocrinology. 2023 Oct 12:bqad154. doi: 10.1210/endocr/bqad154. Online ahead of print.ABSTRACTThe hormone ghrelin displays several well-characterized functions, including some with pharmaceutical interest. The receptor for ghrelin, the growth hormone secretagogue receptor (GHSR), is expressed in the hypothalamic paraventricular nucleus (PVH), a critical hub for the integration of metabolic, neuroendocrine, autonomic and behavioral functions. Here, we performed a neuroanatomical and functional characterization of the neuronal types mediating ghrelin actions in the PVH of male mice. We found that fluorescent-ghrelin mainly ...
Source: Endocrinology - October 12, 2023 Category: Endocrinology Authors: Gimena Fernandez Pablo N De Francesco Mar ía P Cornejo Agustina Cabral Julieta P Aguggia Victor J Duque Nilufer Sayar Sonia Cantel Juan I Burgos Jean-Alain Fehrentz Rodrigo Rorato Deniz Atasoy Andr é S Mecawi Mario Perello Source Type: research
Synergistic combinations of gut-and-pancreas hormone-based therapies: Advancements in treatments for metabolic diseases
Endocrinology. 2023 Oct 12:bqad153. doi: 10.1210/endocr/bqad153. Online ahead of print.ABSTRACTMetabolic diseases, such as obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease, and liver disease, have become increasingly prevalent around the world. As an alternative to bariatric surgery, glucagon-like peptide 1 (GLP-1) receptor agonists have been at the forefront of weight-loss medication to combat these metabolic complications. Recently, there has been an exciting rapid emergence of new weight-loss medications that combine GLP-1 receptor (GLP-1R) agonists with other gut and pancreatic-derived hormones, like gl...
Source: Endocrinology - October 12, 2023 Category: Endocrinology Authors: Sulayman Aslan Lyons Jacqueline Leah Beaudry Source Type: research
Ghrelin action in the PVH of male mice: accessibility, neuronal targets and CRH neurons activation
Endocrinology. 2023 Oct 12:bqad154. doi: 10.1210/endocr/bqad154. Online ahead of print.ABSTRACTThe hormone ghrelin displays several well-characterized functions, including some with pharmaceutical interest. The receptor for ghrelin, the growth hormone secretagogue receptor (GHSR), is expressed in the hypothalamic paraventricular nucleus (PVH), a critical hub for the integration of metabolic, neuroendocrine, autonomic and behavioral functions. Here, we performed a neuroanatomical and functional characterization of the neuronal types mediating ghrelin actions in the PVH of male mice. We found that fluorescent-ghrelin mainly ...
Source: Endocrinology - October 12, 2023 Category: Endocrinology Authors: Gimena Fernandez Pablo N De Francesco Mar ía P Cornejo Agustina Cabral Julieta P Aguggia Victor J Duque Nilufer Sayar Sonia Cantel Juan I Burgos Jean-Alain Fehrentz Rodrigo Rorato Deniz Atasoy Andr é S Mecawi Mario Perello Source Type: research
Synergistic combinations of gut-and-pancreas hormone-based therapies: Advancements in treatments for metabolic diseases
Endocrinology. 2023 Oct 12:bqad153. doi: 10.1210/endocr/bqad153. Online ahead of print.ABSTRACTMetabolic diseases, such as obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease, and liver disease, have become increasingly prevalent around the world. As an alternative to bariatric surgery, glucagon-like peptide 1 (GLP-1) receptor agonists have been at the forefront of weight-loss medication to combat these metabolic complications. Recently, there has been an exciting rapid emergence of new weight-loss medications that combine GLP-1 receptor (GLP-1R) agonists with other gut and pancreatic-derived hormones, like gl...
Source: Endocrinology - October 12, 2023 Category: Endocrinology Authors: Sulayman Aslan Lyons Jacqueline Leah Beaudry Source Type: research
