Interactive association between gut microbiota and thyroid cancer
DISCUSSIONS: These findings implicated the potential role of host-microbiota crosstalk in thyroid cancer, while the discrepancy among observational studies calls for further investigations.PMID:38051644 | DOI:10.1210/endocr/bqad184 (Source: Endocrinology)
Source: Endocrinology - December 5, 2023 Category: Endocrinology Authors: Tianzhichao Hou Qi Wang Huajie Dai Yanan Hou Jie Zheng Tiange Wang Hong Lin Shuangyuan Wang Mian Li Zhiyun Zhao Yuhong Chen Yu Xu Jieli Lu Ruixin Liu Guang Ning Weiqing Wang Min Xu Yufang Bi Source Type: research
The influence of maternal high fat diet during lactation on offspring hematopoietic priming
Endocrinology. 2023 Dec 4:bqad182. doi: 10.1210/endocr/bqad182. Online ahead of print.ABSTRACTObesity and metabolic diseases are rising in women of reproductive age, increasing offspring metabolic risk. Maternal nutritional interventions during lactation present an opportunity to modify offspring outcomes. We previously demonstrated in mice that adult male offspring have metabolic impairments and increased adipose tissue macrophages (ATM) when dams are fed high fat diet (HFD) during the postnatal lactation window (HFD PN). We sought to understand the effect of HFD during lactation on early life inflammation. HFD PN offspri...
Source: Endocrinology - December 4, 2023 Category: Endocrinology Authors: Katherine Kim Mita Varghese Haijing Sun Simin Abrishami Emily Bowers Dave Bridges Jennifer L Meijer Kanakadurga Singer Brigid Gregg Source Type: research
Dectin-2 Deficiency Promotes Pro-inflammatory Cytokine Release from Macrophages and Impairs Insulin Secretion
This study provides novel insights into the mechanisms underlying the role of Dectin-2 in the development of islet inflammation.PMID:38038367 | DOI:10.1210/endocr/bqad181 (Source: Endocrinology)
Source: Endocrinology - December 1, 2023 Category: Endocrinology Authors: Masamichi Fujita Takashi Miyazawa Keiichiro Uchida Naohiro Uchida Shojiro Haji Seiichi Yano Norifusa Iwahashi Tomomi Hatayama Shunsuke Katsuhara Shintaro Nakamura Yukina Takeichi Maki Yokomoto-Umakoshi Yasutaka Miyachi Ryuichi Sakamoto Yoichiro Iwakura Yo Source Type: research
Dectin-2 Deficiency Promotes Pro-inflammatory Cytokine Release from Macrophages and Impairs Insulin Secretion
This study provides novel insights into the mechanisms underlying the role of Dectin-2 in the development of islet inflammation.PMID:38038367 | DOI:10.1210/endocr/bqad181 (Source: Endocrinology)
Source: Endocrinology - December 1, 2023 Category: Endocrinology Authors: Masamichi Fujita Takashi Miyazawa Keiichiro Uchida Naohiro Uchida Shojiro Haji Seiichi Yano Norifusa Iwahashi Tomomi Hatayama Shunsuke Katsuhara Shintaro Nakamura Yukina Takeichi Maki Yokomoto-Umakoshi Yasutaka Miyachi Ryuichi Sakamoto Yoichiro Iwakura Yo Source Type: research
Dectin-2 Deficiency Promotes Pro-inflammatory Cytokine Release from Macrophages and Impairs Insulin Secretion
This study provides novel insights into the mechanisms underlying the role of Dectin-2 in the development of islet inflammation.PMID:38038367 | DOI:10.1210/endocr/bqad181 (Source: Endocrinology)
Source: Endocrinology - December 1, 2023 Category: Endocrinology Authors: Masamichi Fujita Takashi Miyazawa Keiichiro Uchida Naohiro Uchida Shojiro Haji Seiichi Yano Norifusa Iwahashi Tomomi Hatayama Shunsuke Katsuhara Shintaro Nakamura Yukina Takeichi Maki Yokomoto-Umakoshi Yasutaka Miyachi Ryuichi Sakamoto Yoichiro Iwakura Yo Source Type: research
Dectin-2 Deficiency Promotes Pro-inflammatory Cytokine Release from Macrophages and Impairs Insulin Secretion
This study provides novel insights into the mechanisms underlying the role of Dectin-2 in the development of islet inflammation.PMID:38038367 | DOI:10.1210/endocr/bqad181 (Source: Endocrinology)
Source: Endocrinology - December 1, 2023 Category: Endocrinology Authors: Masamichi Fujita Takashi Miyazawa Keiichiro Uchida Naohiro Uchida Shojiro Haji Seiichi Yano Norifusa Iwahashi Tomomi Hatayama Shunsuke Katsuhara Shintaro Nakamura Yukina Takeichi Maki Yokomoto-Umakoshi Yasutaka Miyachi Ryuichi Sakamoto Yoichiro Iwakura Yo Source Type: research
Elevated Norepinephrine Stimulates Adipocyte Hyperplasia in Ovine Fetuses with Placental Insufficiency and IUGR
Endocrinology. 2023 Nov 30:bqad177. doi: 10.1210/endocr/bqad177. Online ahead of print.ABSTRACTPrevailing hypoxemia and hypoglycemia in near-term fetuses with placental insufficiency-induced intrauterine growth restriction (IUGR) chronically increases norepinephrine concentrations, which lowers adrenergic sensitivity and lipid mobilization postnatally, indicating a predisposition for adiposity. To determine adrenergic-induced responses, we examined the perirenal adipose tissue transcriptome from IUGR fetuses with or without hypercatecholaminemia. IUGR was induced in sheep with maternal hyperthermia, and hypercatecholaminem...
Source: Endocrinology - November 30, 2023 Category: Endocrinology Authors: Rosa I Luna-Ramirez Amy C Kelly Miranda J Anderson Christopher A Bidwell Ravi Goyal Sean W Limesand Source Type: research
Hindbrain adrenergic/noradrenergic control of integrated endocrine and autonomic stress responses
Endocrinology. 2023 Nov 28:bqad178. doi: 10.1210/endocr/bqad178. Online ahead of print.ABSTRACTHindbrain adrenergic/noradrenergic nuclei facilitate endocrine and autonomic responses to physical and psychological challenges. Neurons that synthesize adrenaline and noradrenaline target hypothalamic structures to modulate endocrine responses while descending spinal projections regulate sympathetic function. Furthermore, these neurons respond to diverse stress-related metabolic, autonomic, and psychosocial challenges. Accordingly, adrenergic and noradrenergic nuclei are integrative hubs that promote physiological adaptation to ...
Source: Endocrinology - November 28, 2023 Category: Endocrinology Authors: Sebastian A Pace Brent Myers Source Type: research
Corticosteroid-binding globulin (SERPINA6) consolidates sexual dimorphism of adult rat liver
Endocrinology. 2023 Nov 28:bqad179. doi: 10.1210/endocr/bqad179. Online ahead of print.ABSTRACTProduced by the liver, corticosteroid-binding globulin (CBG) regulates the plasma distribution and actions of glucocorticoids. A sex difference in pituitary growth hormone secretion patterns established during puberty in rats results in increased hepatic CBG production and two-fold higher plasma corticosterone levels in females. Glucocorticoids control hepatic development and metabolic activities, and we have therefore examined how disrupting the SerpinA6 gene encoding CBG influences plasma corticosterone dynamics, as well as liv...
Source: Endocrinology - November 28, 2023 Category: Endocrinology Authors: Julia N C Toews Tristan J Philippe Matthew Dordevic Lesley A Hill Geoffrey L Hammond Victor Viau Source Type: research
Hindbrain adrenergic/noradrenergic control of integrated endocrine and autonomic stress responses
Endocrinology. 2023 Nov 28:bqad178. doi: 10.1210/endocr/bqad178. Online ahead of print.ABSTRACTHindbrain adrenergic/noradrenergic nuclei facilitate endocrine and autonomic responses to physical and psychological challenges. Neurons that synthesize adrenaline and noradrenaline target hypothalamic structures to modulate endocrine responses while descending spinal projections regulate sympathetic function. Furthermore, these neurons respond to diverse stress-related metabolic, autonomic, and psychosocial challenges. Accordingly, adrenergic and noradrenergic nuclei are integrative hubs that promote physiological adaptation to ...
Source: Endocrinology - November 28, 2023 Category: Endocrinology Authors: Sebastian A Pace Brent Myers Source Type: research
Corticosteroid-binding globulin (SERPINA6) consolidates sexual dimorphism of adult rat liver
Endocrinology. 2023 Nov 28:bqad179. doi: 10.1210/endocr/bqad179. Online ahead of print.ABSTRACTProduced by the liver, corticosteroid-binding globulin (CBG) regulates the plasma distribution and actions of glucocorticoids. A sex difference in pituitary growth hormone secretion patterns established during puberty in rats results in increased hepatic CBG production and two-fold higher plasma corticosterone levels in females. Glucocorticoids control hepatic development and metabolic activities, and we have therefore examined how disrupting the SerpinA6 gene encoding CBG influences plasma corticosterone dynamics, as well as liv...
Source: Endocrinology - November 28, 2023 Category: Endocrinology Authors: Julia N C Toews Tristan J Philippe Matthew Dordevic Lesley A Hill Geoffrey L Hammond Victor Viau Source Type: research
Hindbrain adrenergic/noradrenergic control of integrated endocrine and autonomic stress responses
Endocrinology. 2023 Nov 28:bqad178. doi: 10.1210/endocr/bqad178. Online ahead of print.ABSTRACTHindbrain adrenergic/noradrenergic nuclei facilitate endocrine and autonomic responses to physical and psychological challenges. Neurons that synthesize adrenaline and noradrenaline target hypothalamic structures to modulate endocrine responses while descending spinal projections regulate sympathetic function. Furthermore, these neurons respond to diverse stress-related metabolic, autonomic, and psychosocial challenges. Accordingly, adrenergic and noradrenergic nuclei are integrative hubs that promote physiological adaptation to ...
Source: Endocrinology - November 28, 2023 Category: Endocrinology Authors: Sebastian A Pace Brent Myers Source Type: research
Corticosteroid-binding globulin (SERPINA6) consolidates sexual dimorphism of adult rat liver
Endocrinology. 2023 Nov 28:bqad179. doi: 10.1210/endocr/bqad179. Online ahead of print.ABSTRACTProduced by the liver, corticosteroid-binding globulin (CBG) regulates the plasma distribution and actions of glucocorticoids. A sex difference in pituitary growth hormone secretion patterns established during puberty in rats results in increased hepatic CBG production and two-fold higher plasma corticosterone levels in females. Glucocorticoids control hepatic development and metabolic activities, and we have therefore examined how disrupting the SerpinA6 gene encoding CBG influences plasma corticosterone dynamics, as well as liv...
Source: Endocrinology - November 28, 2023 Category: Endocrinology Authors: Julia N C Toews Tristan J Philippe Matthew Dordevic Lesley A Hill Geoffrey L Hammond Victor Viau Source Type: research
Mechanisms of Ovarian Cancer-Associated Cachexia
Endocrinology. 2023 Nov 19:bqad176. doi: 10.1210/endocr/bqad176. Online ahead of print.ABSTRACTCancer-associated cachexia occurs in 50-80% of cancer patients and is responsible for 20-30% of cancer-related deaths. Cachexia limits survival and treatment outcomes, and is a major contributor to morbidity and mortality during cancer. Ovarian cancer is one of the leading causes of cancer-related deaths in women and recent studies have begun to highlight the prevalence and clinical impact of cachexia in this population. Here, we review the existing understanding of cachexia pathophysiology and summarize relevant studies assessin...
Source: Endocrinology - November 19, 2023 Category: Endocrinology Authors: Chandler S Callaway Lila M Mouchantat Benjamin G Bitler Andrea Bonetto Source Type: research
Mechanisms of Ovarian Cancer-Associated Cachexia
Endocrinology. 2023 Nov 19:bqad176. doi: 10.1210/endocr/bqad176. Online ahead of print.ABSTRACTCancer-associated cachexia occurs in 50-80% of cancer patients and is responsible for 20-30% of cancer-related deaths. Cachexia limits survival and treatment outcomes, and is a major contributor to morbidity and mortality during cancer. Ovarian cancer is one of the leading causes of cancer-related deaths in women and recent studies have begun to highlight the prevalence and clinical impact of cachexia in this population. Here, we review the existing understanding of cachexia pathophysiology and summarize relevant studies assessin...
Source: Endocrinology - November 19, 2023 Category: Endocrinology Authors: Chandler S Callaway Lila M Mouchantat Benjamin G Bitler Andrea Bonetto Source Type: research
