Is there a special role for ovarian hormones in the pathogenesis of lobular carcinoma?
Endocrinology. 2024 Mar 29:bqae031. doi: 10.1210/endocr/bqae031. Online ahead of print.ABSTRACTLobular carcinoma represent the most common special histological subtype of breast cancer, with the majority classed as hormone receptor-positive. Rates of invasive lobular carcinoma (ILC) in postmenopausal women have been seen to increase globally, whilst other hormone receptor-positive breast cancers proportionally have not followed the same trend. This has been linked to exposure to exogenous ovarian hormones such as hormone replacement therapy (HRT). Reproductive factors resulting in increased lifetime exposure to endogenous ...
Source: Endocrinology - March 29, 2024 Category: Endocrinology Authors: Ren ée L Flaherty George Sflomos Cathrin Brisken Source Type: research
Is there a special role for ovarian hormones in the pathogenesis of lobular carcinoma?
Endocrinology. 2024 Mar 29:bqae031. doi: 10.1210/endocr/bqae031. Online ahead of print.ABSTRACTLobular carcinoma represent the most common special histological subtype of breast cancer, with the majority classed as hormone receptor-positive. Rates of invasive lobular carcinoma (ILC) in postmenopausal women have been seen to increase globally, whilst other hormone receptor-positive breast cancers proportionally have not followed the same trend. This has been linked to exposure to exogenous ovarian hormones such as hormone replacement therapy (HRT). Reproductive factors resulting in increased lifetime exposure to endogenous ...
Source: Endocrinology - March 29, 2024 Category: Endocrinology Authors: Ren ée L Flaherty George Sflomos Cathrin Brisken Source Type: research
Do We Need a New Unifying Theory for Obesity?
Endocrinology. 2024 Feb 20;165(4):bqae029. doi: 10.1210/endocr/bqae029.NO ABSTRACTPMID:38546853 | DOI:10.1210/endocr/bqae029 (Source: Endocrinology)
Source: Endocrinology - March 28, 2024 Category: Endocrinology Authors: Bruce Blumberg Source Type: research
Correction to: "Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism"
Endocrinology. 2024 Feb 20;165(4):bqae034. doi: 10.1210/endocr/bqae034.NO ABSTRACTPMID:38530285 | PMC:PMC10964842 | DOI:10.1210/endocr/bqae034 (Source: Endocrinology)
Source: Endocrinology - March 26, 2024 Category: Endocrinology Source Type: research
Correction to: "Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism"
Endocrinology. 2024 Feb 20;165(4):bqae034. doi: 10.1210/endocr/bqae034.NO ABSTRACTPMID:38530285 | PMC:PMC10964842 | DOI:10.1210/endocr/bqae034 (Source: Endocrinology)
Source: Endocrinology - March 26, 2024 Category: Endocrinology Source Type: research
Disruption of thyroid hormone receptor thrab leads to female infertility in zebrafish
Endocrinology. 2024 Mar 25:bqae037. doi: 10.1210/endocr/bqae037. Online ahead of print.ABSTRACTThyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3), are vital for development, growth, and metabolism. Thyroid dysfunction can also cause problems in fertility, suggesting involvement of THs in reproduction. In zebrafish, there exist two forms of TH receptor alpha gene (THRα: thraa and thrab). Disruption of these genes by CRISPR/Cas9 showed no reproductive irregularities in thraa mutant; however, inactivation of thrab gene resulted in female infertility. Although young female mutants (thrabm/m) showed normal ovaria...
Source: Endocrinology - March 25, 2024 Category: Endocrinology Authors: Nana Ai Cho Rong Han Hui Zhao Sheue-Yann Cheng Wei Ge Source Type: research
Disruption of thyroid hormone receptor thrab leads to female infertility in zebrafish
Endocrinology. 2024 Mar 25:bqae037. doi: 10.1210/endocr/bqae037. Online ahead of print.ABSTRACTThyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3), are vital for development, growth, and metabolism. Thyroid dysfunction can also cause problems in fertility, suggesting involvement of THs in reproduction. In zebrafish, there exist two forms of TH receptor alpha gene (THRα: thraa and thrab). Disruption of these genes by CRISPR/Cas9 showed no reproductive irregularities in thraa mutant; however, inactivation of thrab gene resulted in female infertility. Although young female mutants (thrabm/m) showed normal ovaria...
Source: Endocrinology - March 25, 2024 Category: Endocrinology Authors: Nana Ai Cho Rong Han Hui Zhao Sheue-Yann Cheng Wei Ge Source Type: research
Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor
Endocrinology. 2024 Mar 22:bqae035. doi: 10.1210/endocr/bqae035. Online ahead of print.ABSTRACTSeminal extracellular vesicles (EVs) contain different subgroups which have diverse effects on sperm function. However, the effect of seminal EVs-especially its subgroups, on the endometrial receptivity was largely unknown. Here, we found that the seminal EVs could be divided into high-density EV (EV-H)、medium density EV (EV-M) and low-density EV (EV-L), after purification using iodixanol. Then we demonstrated that EV-H could promote the expression and secretion of leukemia inhibitor factor (LIF) in human endometrial cells. In ...
Source: Endocrinology - March 22, 2024 Category: Endocrinology Authors: Hanshu Wang Yu Lin Rongrong Chen Yu Zhu Hongqiang Wang Shengxian Li Lei Yu Kaishu Zhang Yujie Liu Tao Jing Fei Sun Source Type: research
Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor
Endocrinology. 2024 Mar 22:bqae035. doi: 10.1210/endocr/bqae035. Online ahead of print.ABSTRACTSeminal extracellular vesicles (EVs) contain different subgroups which have diverse effects on sperm function. However, the effect of seminal EVs-especially its subgroups, on the endometrial receptivity was largely unknown. Here, we found that the seminal EVs could be divided into high-density EV (EV-H)、medium density EV (EV-M) and low-density EV (EV-L), after purification using iodixanol. Then we demonstrated that EV-H could promote the expression and secretion of leukemia inhibitor factor (LIF) in human endometrial cells. In ...
Source: Endocrinology - March 22, 2024 Category: Endocrinology Authors: Hanshu Wang Yu Lin Rongrong Chen Yu Zhu Hongqiang Wang Shengxian Li Lei Yu Kaishu Zhang Yujie Liu Tao Jing Fei Sun Source Type: research
Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor
Endocrinology. 2024 Mar 22:bqae035. doi: 10.1210/endocr/bqae035. Online ahead of print.ABSTRACTSeminal extracellular vesicles (EVs) contain different subgroups which have diverse effects on sperm function. However, the effect of seminal EVs-especially its subgroups, on the endometrial receptivity was largely unknown. Here, we found that the seminal EVs could be divided into high-density EV (EV-H)、medium density EV (EV-M) and low-density EV (EV-L), after purification using iodixanol. Then we demonstrated that EV-H could promote the expression and secretion of leukemia inhibitor factor (LIF) in human endometrial cells. In ...
Source: Endocrinology - March 22, 2024 Category: Endocrinology Authors: Hanshu Wang Yu Lin Rongrong Chen Yu Zhu Hongqiang Wang Shengxian Li Lei Yu Kaishu Zhang Yujie Liu Tao Jing Fei Sun Source Type: research
Cholesterol Availability and Adrenal Steroidogenesis
Endocrinology. 2024 Mar 19:bqae032. doi: 10.1210/endocr/bqae032. Online ahead of print.NO ABSTRACTPMID:38500355 | DOI:10.1210/endocr/bqae032 (Source: Endocrinology)
Source: Endocrinology - March 19, 2024 Category: Endocrinology Authors: Celso E Gomez-Sanchez Elise P Gomez-Sanchez Source Type: research
A Potent Neutralizing Monoclonal Antibody to Human Growth Hormone Suppresses Insulin-Like Growth Factor-1 in female Rats
Endocrinology. 2024 Mar 19:bqae033. doi: 10.1210/endocr/bqae033. Online ahead of print.ABSTRACTAcromegaly and gigantism are disorders caused by hypersecretion of growth hormone (GH), usually from pituitary adenomas. Although somatostatin analogues (SSA), dopamine agonists and GH receptor antagonist are important therapeutic agents, all of these have issues with their effectiveness, safety, and/or convenience of use. To overcome these, we developed a GH-specific potent neutralizing mouse monoclonal antibody (mAb) named 13H02. 13H02 selectively bound to both human and monkey GH with high affinity, and strongly inhibited the ...
Source: Endocrinology - March 19, 2024 Category: Endocrinology Authors: Tomoyuki Hata Yoshikatsu Uematsu Ayumi Sugita Hisashi Adachi Sayaka Kato Maki Hirate Kei-Ichiro Ishikura Ayaka Kaku Hiroki Ohara Naoki Kojima Teisuke Takahashi Tomofumi Kurokawa Source Type: research
Cholesterol Availability and Adrenal Steroidogenesis
Endocrinology. 2024 Mar 19:bqae032. doi: 10.1210/endocr/bqae032. Online ahead of print.NO ABSTRACTPMID:38500355 | DOI:10.1210/endocr/bqae032 (Source: Endocrinology)
Source: Endocrinology - March 19, 2024 Category: Endocrinology Authors: Celso E Gomez-Sanchez Elise P Gomez-Sanchez Source Type: research
A Potent Neutralizing Monoclonal Antibody to Human Growth Hormone Suppresses Insulin-Like Growth Factor-1 in female Rats
Endocrinology. 2024 Mar 19:bqae033. doi: 10.1210/endocr/bqae033. Online ahead of print.ABSTRACTAcromegaly and gigantism are disorders caused by hypersecretion of growth hormone (GH), usually from pituitary adenomas. Although somatostatin analogues (SSA), dopamine agonists and GH receptor antagonist are important therapeutic agents, all of these have issues with their effectiveness, safety, and/or convenience of use. To overcome these, we developed a GH-specific potent neutralizing mouse monoclonal antibody (mAb) named 13H02. 13H02 selectively bound to both human and monkey GH with high affinity, and strongly inhibited the ...
Source: Endocrinology - March 19, 2024 Category: Endocrinology Authors: Tomoyuki Hata Yoshikatsu Uematsu Ayumi Sugita Hisashi Adachi Sayaka Kato Maki Hirate Kei-Ichiro Ishikura Ayaka Kaku Hiroki Ohara Naoki Kojima Teisuke Takahashi Tomofumi Kurokawa Source Type: research
Cholesterol Availability and Adrenal Steroidogenesis
Endocrinology. 2024 Mar 19:bqae032. doi: 10.1210/endocr/bqae032. Online ahead of print.NO ABSTRACTPMID:38500355 | DOI:10.1210/endocr/bqae032 (Source: Endocrinology)
Source: Endocrinology - March 19, 2024 Category: Endocrinology Authors: Celso E Gomez-Sanchez Elise P Gomez-Sanchez Source Type: research
