Grb7 ablation in mice improved glycemic control, enhanced insulin signaling and increased abdominal fat mass in females
CONCLUSIONS: Our study suggests that Grb7 is a negative regulator of glycemic control. Our results reveal a role for Grb7 in female mice in the regulation of the visceral adipose tissue mass, a powerful predictor of metabolic dysfunction in obesity.PMID:38578949 | DOI:10.1210/endocr/bqae045 (Source: Endocrinology)
Source: Endocrinology - April 5, 2024 Category: Endocrinology Authors: Anke Vermehren-Schmaedick Sonali Joshi Wendy Wagoner Mason A Norgard William Packwood Parham Diba Heike Mendez Lev M Fedorov Shauna Rakshe Byung Park Daniel L Marks Aaron Grossberg Shiuh-Wen Luoh Source Type: research
β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
Endocrinology. 2024 Apr 5:bqae044. doi: 10.1210/endocr/bqae044. Online ahead of print.ABSTRACTIn the classical insulin target tissues liver, muscle and adipose tissue, chronically elevated levels of free fatty acids (FFA) impair insulin signaling. Insulin signaling molecules are also present in β-cells where they play a role in β-cell function. Therefore, inhibition of the insulin/IGF-1 pathway may be involved in fat-induced β-cell dysfunction. To address the role of β-cell insulin resistance in FFA-induced β-cell dysfunction we co-infused bisperoxovanadate (BPV) with oleate or olive oil for 48 h in rats. BPV, a tyros...
Source: Endocrinology - April 5, 2024 Category: Endocrinology Authors: Aleksandar Ivovic Justin Hou Ming Yung Andrei I Oprescu Filip Vlavcheski Yusaku Mori S M Niazur Rahman Wenyue Ye Judith A Eversley Michael B Wheeler Minna Woo Evangelia Tsiani Adria Giacca Source Type: research
Grb7 ablation in mice improved glycemic control, enhanced insulin signaling and increased abdominal fat mass in females
CONCLUSIONS: Our study suggests that Grb7 is a negative regulator of glycemic control. Our results reveal a role for Grb7 in female mice in the regulation of the visceral adipose tissue mass, a powerful predictor of metabolic dysfunction in obesity.PMID:38578949 | DOI:10.1210/endocr/bqae045 (Source: Endocrinology)
Source: Endocrinology - April 5, 2024 Category: Endocrinology Authors: Anke Vermehren-Schmaedick Sonali Joshi Wendy Wagoner Mason A Norgard William Packwood Parham Diba Heike Mendez Lev M Fedorov Shauna Rakshe Byung Park Daniel L Marks Aaron Grossberg Shiuh-Wen Luoh Source Type: research
β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
Endocrinology. 2024 Apr 5:bqae044. doi: 10.1210/endocr/bqae044. Online ahead of print.ABSTRACTIn the classical insulin target tissues liver, muscle and adipose tissue, chronically elevated levels of free fatty acids (FFA) impair insulin signaling. Insulin signaling molecules are also present in β-cells where they play a role in β-cell function. Therefore, inhibition of the insulin/IGF-1 pathway may be involved in fat-induced β-cell dysfunction. To address the role of β-cell insulin resistance in FFA-induced β-cell dysfunction we co-infused bisperoxovanadate (BPV) with oleate or olive oil for 48 h in rats. BPV, a tyros...
Source: Endocrinology - April 5, 2024 Category: Endocrinology Authors: Aleksandar Ivovic Justin Hou Ming Yung Andrei I Oprescu Filip Vlavcheski Yusaku Mori S M Niazur Rahman Wenyue Ye Judith A Eversley Michael B Wheeler Minna Woo Evangelia Tsiani Adria Giacca Source Type: research
Grb7 ablation in mice improved glycemic control, enhanced insulin signaling and increased abdominal fat mass in females
CONCLUSIONS: Our study suggests that Grb7 is a negative regulator of glycemic control. Our results reveal a role for Grb7 in female mice in the regulation of the visceral adipose tissue mass, a powerful predictor of metabolic dysfunction in obesity.PMID:38578949 | DOI:10.1210/endocr/bqae045 (Source: Endocrinology)
Source: Endocrinology - April 5, 2024 Category: Endocrinology Authors: Anke Vermehren-Schmaedick Sonali Joshi Wendy Wagoner Mason A Norgard William Packwood Parham Diba Heike Mendez Lev M Fedorov Shauna Rakshe Byung Park Daniel L Marks Aaron Grossberg Shiuh-Wen Luoh Source Type: research
β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
Endocrinology. 2024 Apr 5:bqae044. doi: 10.1210/endocr/bqae044. Online ahead of print.ABSTRACTIn the classical insulin target tissues liver, muscle and adipose tissue, chronically elevated levels of free fatty acids (FFA) impair insulin signaling. Insulin signaling molecules are also present in β-cells where they play a role in β-cell function. Therefore, inhibition of the insulin/IGF-1 pathway may be involved in fat-induced β-cell dysfunction. To address the role of β-cell insulin resistance in FFA-induced β-cell dysfunction we co-infused bisperoxovanadate (BPV) with oleate or olive oil for 48 h in rats. BPV, a tyros...
Source: Endocrinology - April 5, 2024 Category: Endocrinology Authors: Aleksandar Ivovic Justin Hou Ming Yung Andrei I Oprescu Filip Vlavcheski Yusaku Mori S M Niazur Rahman Wenyue Ye Judith A Eversley Michael B Wheeler Minna Woo Evangelia Tsiani Adria Giacca Source Type: research
Zona glomerulosa derived Klotho modulates aldosterone synthase expression in young female mice
Endocrinology. 2024 Apr 4:bqae040. doi: 10.1210/endocr/bqae040. Online ahead of print.ABSTRACTKlotho plays a critical role in the regulation of ion and fluid homeostasis. A previous study reported that haplo-insufficiency of Klotho in mice results in increased aldosterone synthase (CYP11B2) expression, elevated plasma aldosterone and high blood pressure. This phenotype was presumed to be the result of diminished Klotho expression in zona glomerulosa (zG) cells of the adrenal cortex, however systemic effects on adrenal aldosterone production could not be ruled out. To examine whether Klotho expressed in the zG is indeed a c...
Source: Endocrinology - April 4, 2024 Category: Endocrinology Authors: Arezoo Daryadel Cong Tang Ye Xie Mirko Peitzsch Viktoria Fisi Constanze Hantel Dominique Loffing-Cueni David T Breault David Penton Johannes Loffing Felix Beuschlein Source Type: research
Zona glomerulosa derived Klotho modulates aldosterone synthase expression in young female mice
Endocrinology. 2024 Apr 4:bqae040. doi: 10.1210/endocr/bqae040. Online ahead of print.ABSTRACTKlotho plays a critical role in the regulation of ion and fluid homeostasis. A previous study reported that haplo-insufficiency of Klotho in mice results in increased aldosterone synthase (CYP11B2) expression, elevated plasma aldosterone and high blood pressure. This phenotype was presumed to be the result of diminished Klotho expression in zona glomerulosa (zG) cells of the adrenal cortex, however systemic effects on adrenal aldosterone production could not be ruled out. To examine whether Klotho expressed in the zG is indeed a c...
Source: Endocrinology - April 4, 2024 Category: Endocrinology Authors: Arezoo Daryadel Cong Tang Ye Xie Mirko Peitzsch Viktoria Fisi Constanze Hantel Dominique Loffing-Cueni David T Breault David Penton Johannes Loffing Felix Beuschlein Source Type: research
Hormonal basis of biological sex differences in human athletic performance
Endocrinology. 2024 Apr 2:bqae036. doi: 10.1210/endocr/bqae036. Online ahead of print.ABSTRACTBiological sex is a primary determinant of athletic human performance involving strength, power, speed, and aerobic endurance and is more predictive of athletic performance than gender. This perspective article highlights three key medical and physiological insights related to recent evolving research into the sex differences in human physical performance: (1) sex and gender are not the same; (2) males and females exhibit profound differences in physical performance with males outperforming females in events and sports involving s...
Source: Endocrinology - April 2, 2024 Category: Endocrinology Authors: Jonathon W Senefeld Sandra K Hunter Source Type: research
Targeting NAD+ metabolism: Pre-clinical insights into potential cancer therapy strategies
Endocrinology. 2024 Apr 3:bqae043. doi: 10.1210/endocr/bqae043. Online ahead of print.ABSTRACTNAD+ is one of the most important metabolites for cellular activities, and its biosynthesis mainly occurs through the salvage pathway using the NAMPT enzyme. The main NAD consumers, PARP and SIRT enzymes, are heavily involved in DNA repair and chromatin remodeling. Since cancer cells shift their energy production pathway, NAD levels are significantly affected. NAD's roles in cell survival led to the use of NAD depletion in cancer therapies. NAMPT inhibition (alone or in combination with other cancer therapies, including endocrine ...
Source: Endocrinology - April 2, 2024 Category: Endocrinology Authors: Ay ça N Mogol Alanna Z Kaminsky David J Dutton Zeynep Madak Erdogan Source Type: research
Hormonal basis of biological sex differences in human athletic performance
Endocrinology. 2024 Apr 2:bqae036. doi: 10.1210/endocr/bqae036. Online ahead of print.ABSTRACTBiological sex is a primary determinant of athletic human performance involving strength, power, speed, and aerobic endurance and is more predictive of athletic performance than gender. This perspective article highlights three key medical and physiological insights related to recent evolving research into the sex differences in human physical performance: (1) sex and gender are not the same; (2) males and females exhibit profound differences in physical performance with males outperforming females in events and sports involving s...
Source: Endocrinology - April 2, 2024 Category: Endocrinology Authors: Jonathon W Senefeld Sandra K Hunter Source Type: research
Targeting NAD+ metabolism: Pre-clinical insights into potential cancer therapy strategies
Endocrinology. 2024 Apr 3:bqae043. doi: 10.1210/endocr/bqae043. Online ahead of print.ABSTRACTNAD+ is one of the most important metabolites for cellular activities, and its biosynthesis mainly occurs through the salvage pathway using the NAMPT enzyme. The main NAD consumers, PARP and SIRT enzymes, are heavily involved in DNA repair and chromatin remodeling. Since cancer cells shift their energy production pathway, NAD levels are significantly affected. NAD's roles in cell survival led to the use of NAD depletion in cancer therapies. NAMPT inhibition (alone or in combination with other cancer therapies, including endocrine ...
Source: Endocrinology - April 2, 2024 Category: Endocrinology Authors: Ay ça N Mogol Alanna Z Kaminsky David J Dutton Zeynep Madak Erdogan Source Type: research
Hormonal basis of biological sex differences in human athletic performance
Endocrinology. 2024 Apr 2:bqae036. doi: 10.1210/endocr/bqae036. Online ahead of print.ABSTRACTBiological sex is a primary determinant of athletic human performance involving strength, power, speed, and aerobic endurance and is more predictive of athletic performance than gender. This perspective article highlights three key medical and physiological insights related to recent evolving research into the sex differences in human physical performance: (1) sex and gender are not the same; (2) males and females exhibit profound differences in physical performance with males outperforming females in events and sports involving s...
Source: Endocrinology - April 2, 2024 Category: Endocrinology Authors: Jonathon W Senefeld Sandra K Hunter Source Type: research
The planar cell polarity (PCP) protein Fat 1 in Sertoli cell function
Endocrinology. 2024 Mar 30:bqae041. doi: 10.1210/endocr/bqae041. Online ahead of print.ABSTRACTFat (FAT atypical cadherin) and Dchs (Dachsous cadherin-related protein) in adjacent Sertoli:Sertoli, Sertoli:spermatid, and spermatid:spermatid create an important intercellular bridge, whose adhesive function is in turn supported by Fjx1, a non-receptor Ser/Thr protein kinase. This concept is derived from earlier studies of Drosophila, which has been confirmed in this and earlier reports as well. Herein, we use the approach of knockdown of Fat1 by RNAi using primary cultures of Sertoli cells that mimicked the blood-testis barri...
Source: Endocrinology - March 30, 2024 Category: Endocrinology Authors: Tiao Bu Lingling Wang Xiaolong Wu Sheng Gao Xinyao Li Damin Yun Xiwen Yang Linxi Li C Yan Cheng Fei Sun Source Type: research
The planar cell polarity (PCP) protein Fat 1 in Sertoli cell function
Endocrinology. 2024 Mar 30:bqae041. doi: 10.1210/endocr/bqae041. Online ahead of print.ABSTRACTFat (FAT atypical cadherin) and Dchs (Dachsous cadherin-related protein) in adjacent Sertoli:Sertoli, Sertoli:spermatid, and spermatid:spermatid create an important intercellular bridge, whose adhesive function is in turn supported by Fjx1, a non-receptor Ser/Thr protein kinase. This concept is derived from earlier studies of Drosophila, which has been confirmed in this and earlier reports as well. Herein, we use the approach of knockdown of Fat1 by RNAi using primary cultures of Sertoli cells that mimicked the blood-testis barri...
Source: Endocrinology - March 30, 2024 Category: Endocrinology Authors: Tiao Bu Lingling Wang Xiaolong Wu Sheng Gao Xinyao Li Damin Yun Xiwen Yang Linxi Li C Yan Cheng Fei Sun Source Type: research
