Grb7 ablation in mice improved glycemic control, enhanced insulin signaling and increased abdominal fat mass in females

CONCLUSIONS: Our study suggests that Grb7 is a negative regulator of glycemic control. Our results reveal a role for Grb7 in female mice in the regulation of the visceral adipose tissue mass, a powerful predictor of metabolic dysfunction in obesity.PMID:38578949 | DOI:10.1210/endocr/bqae045

Source: Endocrinology - April 5, 2024 Category: Endocrinology Authors: Anke Vermehren-Schmaedick Sonali Joshi Wendy Wagoner Mason A Norgard William Packwood Parham Diba Heike Mendez Lev M Fedorov Shauna Rakshe Byung Park Daniel L Marks Aaron Grossberg Shiuh-Wen Luoh Source Type: research