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Melatonin Does Not Affect the Stress-Induced Phase Shifts of Peripheral Clocks in Male Mice
In this study we test whether Mel can reduce the social-defeat stress-induced phase shifts in peripheral rhythms, either by modulating circadian phase or by modulating the stress axis. Two experiments were performed with male Mel-deficient C57BL/6J mice carrying the circadian reporter gene construct (PER2::LUC). In the first experiment, mice received night-restricted (ZT11-21) Mel in their drinking water, resulting in physiological levels of plasma Mel peaking in the early dark phase. This treatment facilitated re-entrainment of the activity rhythm to a shifted light-dark cycle, but did not prevent the stress-induced (ZT21...
Source: Endocrinology - December 21, 2023 Category: Endocrinology Authors: Xiangpan Kong Peter Meerlo Roelof A Hut Source Type: research

Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz(Wwtr1) Activation in Male LDLR-/- Mice
Endocrinology. 2023 Dec 20:bqad192. doi: 10.1210/endocr/bqad192. Online ahead of print.ABSTRACTWnt16 is expressed in bone and arteries, and maintains bone mass in mice and humans, but its role in cardiovascular physiology is unknown. We show that Wnt16 protein accumulates in murine and human vascular smooth muscle (VSM). WNT16 genotypes that convey risk for bone frailty also convey risk for cardiovascular events in Dallas Heart Study. Murine Wnt16 deficiency, which causes postnatal bone loss, also reduced systolic blood pressure. Electron microscopy demonstrated abnormal VSM mitochondrial morphology in Wnt16-null mice, wit...
Source: Endocrinology - December 20, 2023 Category: Endocrinology Authors: Abraham Behrmann Dalian Zhong Li Li Shangkui Xie Megan Mead Parastoo Sabaeifard Mohammad Goodarzi Andrew Lemoff Julia Kozlitina Dwight A Towler Source Type: research

Role of vitamin D and calcium nutrition in sporadic parathyroid tumorigenesis: Clinical Implications and future research
Endocrinology. 2023 Dec 16:bqad189. doi: 10.1210/endocr/bqad189. Online ahead of print.NO ABSTRACTPMID:38104244 | DOI:10.1210/endocr/bqad189 (Source: Endocrinology)
Source: Endocrinology - December 17, 2023 Category: Endocrinology Authors: Sudhaker D Rao Bhanu Malhotra Sanjay Kumar Bhadada Source Type: research

Anterior Pituitary Transcriptomics Following a High Fat Diet: Impact of oxidative stress on cell metabolism
Endocrinology. 2023 Dec 16:bqad191. doi: 10.1210/endocr/bqad191. Online ahead of print.ABSTRACTAnterior pituitary cell function requires a high level of protein synthesis and secretion which depend heavily on mitochondrial ATP production and functional endoplasmic reticula. Obesity adds stress to tissues, requiring them to adapt to inflammation and oxidative stress, and adding to their allostatic load. We hypothesized that pituitary function is vulnerable to the stress of obesity. Here, we utilized a 10-15 week high fat diet (HFD, 60%) in a thermoneutral environment to promote obesity, testing both male and female FVB.129P...
Source: Endocrinology - December 16, 2023 Category: Endocrinology Authors: Tiffany K Miles Angela K Odle Stephanie D Byrum Alex Lagasse Anessa Haney Victoria G Ortega Cole R Bolen Jewel Banik Milla M Reddick Ashley Herdman Melanie C MacNicol Angus M MacNicol Gwen V Childs Source Type: research

NGAL Mediates Anaplastic Thyroid Carcinoma Cells survival Through FAS/CD95 Inhibition
Endocrinology. 2023 Dec 13:bqad190. doi: 10.1210/endocr/bqad190. Online ahead of print.ABSTRACTNeutrophil Gelatinase-Associated Lipocalin (NGAL), a siderophore-mediated iron binding protein, is highly expressed in human anaplastic thyroid carcinomas (ATC) where it plays pleiotropic pro-tumorigenic roles including that of pro-survival protein. Here we show that NGAL inhibits FAS/CD95 death receptor to control ATC cells survival. FAS/CD95 expression in human specimens from ATC patients and in ATC-derived cell lines negatively correlate with NGAL expression. Silencing of NGAL in ATC cells leads to FAS/CD95 up-regulation, wher...
Source: Endocrinology - December 13, 2023 Category: Endocrinology Authors: Elvira Crescenzi Stefano Mellone Gianluca Gragnano Antonino Iaccarino Antonio Leonardi Francesco Pacifico Source Type: research

Impaired growth plate maturation in XLH is due to both excess FGF23 and decreased 1,25Dihydroxyvitamin D signaling
Endocrinology. 2023 Dec 8:bqad186. doi: 10.1210/endocr/bqad186. Online ahead of print.ABSTRACTX-linked hypophosphatemia (XLH) is the most common form of hereditary hypophosphatemic rickets. The genetic basis for XLH is loss of function mutations in the Phosphate-regulating endopeptidase X-linked (PHEX), which leads to increased circulating FGF23. This increase in FGF23 impairs activation of vitamin D and attenuates renal phosphate reabsorption, leading to rickets. Previous studies have demonstrated that ablating FGF23 in the Hyp mouse model of XLH leads to hyperphosphatemia, high levels of 1,25-dihydroxyvitamin D and is no...
Source: Endocrinology - December 9, 2023 Category: Endocrinology Authors: Prem Swaroop Yadav Margaret M Kobelski Janaina S Martins Tao Tao Eva S Liu Marie B Demay Source Type: research

Role for Non-Genomic Estrogen Signaling in Male Fertility
Endocrinology. 2023 Dec 8:bqad180. doi: 10.1210/endocr/bqad180. Online ahead of print.ABSTRACTEstrogen actions are mediated by both nuclear (n) and membrane (m) localized estrogen receptor 1 (ESR1). Male Esr1 knockout (Esr1KO) mice lacking functional Esr1 are infertile, with reproductive tract abnormalities. Male mice expressing nESR1 but lacking mESR1 (nuclear-only estrogen receptor 1 [NOER] mice) are progressively infertile due to testicular, rete testis and efferent ductule abnormalities similar to Esr1KO males, indicating a role for mESR1 in male reproduction. The H2NES mouse expresses only mESR1 but lacks nESR1. The g...
Source: Endocrinology - December 9, 2023 Category: Endocrinology Authors: Jones B Graceli Helena D Zomer Theresa I Medrano Rex A Hess Kenneth S Korach Paul S Cooke Source Type: research