NGF induces pulmonary arterial hyperreactivity through connexin 43 increased expression

In conclusion, NGF pathway is upregulated in IPAH cells. NGF increases Cx43 PA expression through TrkA receptor. Cx43 increased expression at plasma membrane upregulates GAP junction activity, thus promoting PA hyperreactivity.

Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Cardouat, g., Douard, M., Roubenne, L., Kmecova, Z., Robillard, P., Guignabert, C., Tu, L., Delcambre, F., Marthan, R., Muller, B., Guibert, C., Freund-Michel, V. Tags: Pulmonary hypertension Source Type: research