Regulation of Type I cytokine receptors as a target for pulmonary arterial hypertension treatment?

Conclusions: TypeIR intracellular trafficking regulation is altered in PAH patients compared to controls, due to a shift in USP8/RNF41 ratio. Restoring USP8/RNF41 ratio in PA-SMCs may represent a potential target in PAH.

Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Jutant, E.-M., Tu, L., Le Vely, B., Thuillet, R., Humbert, M., Guignabert, C., Huertas, A. Tags: Pulmonary hypertension Source Type: research