Kidney Response to Heart Failure: Proteomic Analysis of Cardiorenal Syndrome
Conclusion: Chronic HF leads to latent kidney injury, associated with deep changes in kidney protein composition. These alterations may act in concert with intrarenal renin-angiotensin system activation and may serve as markers and/or targets to tackle cardiorenal syndrome.Kidney Blood Press Res 2018;43:1437 –1450 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 20, 2018 Category: Urology & Nephrology Source Type: research

Association of Serum Uric Acid with Arterial Stiffness in Peritoneal Dialysis Patients
Conclusion: SUA was positively associated with baPWV in young PD patients, and this association was significant in males but not in females, which is possibly explained by the higher SUA level in males than in females.Kidney Blood Press Res 2018;43:1451 –1458 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 20, 2018 Category: Urology & Nephrology Source Type: research

Incidence of Hypersensitivity Reactions During Hemodialysis
Conclusion: The incidence of hypersensitivity reactions was in the range found in reports from 20 years ago and is observed associated with synthetic membranes, not just polysulfones. Cellulose triacetate appears to be a good alternative for these patients.Kidney Blood Press Res 2018;43:1472 –1478 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 20, 2018 Category: Urology & Nephrology Source Type: research

A Role of Intestinal Alkaline Phosphatase 3 (Akp3) in Inorganic Phosphate Homeostasis
Conclusion: The present findings indicate that intestinal Akp3 deletion affects Na+-dependent Pi transport in the small intestine. In the adenine-induced renal failure model, Akp3 is predicted to be a factor contributing to suppression of the plasma Pi concentration.Kidney Blood Press Res 2018;43:1409 –1424 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 17, 2018 Category: Urology & Nephrology Source Type: research

Melatonin Attenuates Endothelial-to-Mesenchymal Transition of Glomerular Endothelial Cells via Regulating miR-497/ROCK in Diabetic Nephropathy
Conclusion: Melatonin attenuated EndMT of GEnCs via regulating miR-497/ROCK signaling in diabetic nephropathy. This study improves understanding of EndMT and the role of melatonin in diabetic nephropathy.Kidney Blood Press Res 2018;43:1425 –1436 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 17, 2018 Category: Urology & Nephrology Source Type: research

Sonographic Image of Solitary Kidney in Wilms Tumour Survivors
Conclusion: Ultrasonographic abnormalities in solitary kidney of TWs are frequent. The most frequently detected abnormalities are hyperechoic rings around renal pyramids. Sonographic examination of TWs ought to be performed not only to detect tumour recurrence but also to assess the signs of kidney damage and their progression.Kidney Blood Press Res 2018;43:1363 –1363 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 2, 2018 Category: Urology & Nephrology Source Type: research

Central Aortic Systolic Blood Pressure Exhibits Advantages Over Brachial Blood Pressure Measurements in Chronic Kidney Disease Risk Prediction in Women
Conclusion: CSBP and brachial blood pressure measurements are all predictors of CKD, however the non-invasively obtained CSBP may offer advantages over brachial blood pressure measurements in CKD risk prediction in women.Kidney Blood Press Res 2018;43:1363 –1363 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 2, 2018 Category: Urology & Nephrology Source Type: research

Prognostic Cardiovascular Markers in Chronic Kidney Disease
Chronic kidney disease (CKD), including end-stage renal disease (ESRD), is a public health issue worldwide, and is associated with high rates of morbidity and mortality. In addition, cardiovascular disease is a major cause of mortality in these patients. Both traditional and nontraditional risk factors associated with CKD can lead to remodeling of the myocardium and blood vessels, thereby resulting in cardiomyopathy, atherosclerosis and arterial stiffness. This can subsequently lead to ischemic heart disease, heart failure, cardiovascular death, rapid renal progression and progression to ESRD. Identifying these risk factor...
Source: Kidney and Blood Pressure Research - September 2, 2018 Category: Urology & Nephrology Source Type: research

Erratum
Kidney Blood Press Res 2018;43:1363 –1363 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - September 2, 2018 Category: Urology & Nephrology Source Type: research

Rotenone Protects Against Acetaminophen-Induced Kidney Injury by Attenuating Oxidative Stress and Inflammation
Conclusion: Mitochondrial complex I inhibitor rotenone protected kidneys against APAP-induced injury possibly via the inhibition of mitochondrial oxidative stress and inflammation.Kidney Blood Press Res 2018;43:1297 –1309 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 10, 2018 Category: Urology & Nephrology Source Type: research

The Association of Urinary Sodium and Potassium with Renal Uric Acid Excretion in Patients with Chronic Kidney Disease
Conclusion: We found that in patients with CKD, urinary sodium and potassium excretion is closely correlated to renal handling of uric acid, which was pronounced in hypertensive patients with low eGFR. This phenomenon may be one of the mechanisms of the relationship between hypertension and hyperuricemia. Further research is needed to confirm it. It is expected to manage hyperuricemia in terms of controlling the diet of sodium and potassium.Kidney Blood Press Res 2018;43:1310 –1321 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 10, 2018 Category: Urology & Nephrology Source Type: research

Independent Association of Overhydration with All-Cause and Cardiovascular Mortality Adjusted for Global Left Ventricular Longitudinal Systolic Strain and E/E ’ Ratio in Maintenance Hemodialysis Patients
Conclusion: A higher ∆HS was independently associated with increased all-cause and CV mortality after adjusting for systolic and diastolic function of the LV. This suggests that ∆HS may be a relevant target for improving outcomes in maintenance HD patients.Kidney Blood Press Res 2018;43:1322 –1332 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 10, 2018 Category: Urology & Nephrology Source Type: research

Combined Immunosuppressive Treatment May Improve Short-Term Renal Outcomes in Chinese Patients with Advanced IgA Nephropathy
Conclusion: Immunosuppressive treatment (CS and IT therapy) may improve short-term renal outcome compared with supportive treatment in advanced IgAN patients.Kidney Blood Press Res 2018;43:1333 –1343 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 10, 2018 Category: Urology & Nephrology Source Type: research

Systematic DNA Study for Fabry Disease in the End Stage Renal Disease Patients from a Southern Italy Area
Conclusion: A comprehensive survey of ESRD patients in a geographical area of 2 million residents identified one undiagnosed case of Fabry disease and led to the identification of 8 additional cases among his relatives. Screening protocols starting from the dialysis population and upstream extended to families of affected individuals may be an effective strategy to maximize the early identification of subjects with Fabry disease.Kidney Blood Press Res 2018;43:1344 –1351 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 10, 2018 Category: Urology & Nephrology Source Type: research

Association of Peridialysis Blood Pressure and Its Variability with Cardiovascular Events in Hemodialysis Patients
Conclusion: Peridialytic BPV may be a potential target for improved blood pressure (BP) management in HD patients. Each short-term BPV metric has different advantages and disadvantages and should be applied according to the clinical context and purpose.Kidney Blood Press Res 2018;43:1352 –1362 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 10, 2018 Category: Urology & Nephrology Source Type: research

Beraprost Sodium, a Stable Analogue of PGI2, Inhibits the Renin-Angiotensin System in the Renal Tissues of Rats with Chronic Renal Failure
Conclusion: The results of this study demonstrate that BPS, a PGI2 analogue, inhibits the expression of key factors involved in the local RAS, resulting in a delay in the occurrence and development of CRF. The key findings of the present study ultimately highlight the potential of this PGI2 analogue as a promising therapeutic strategy for treating CRF.Kidney Blood Press Res 2018;43:1231 –1244 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 3, 2018 Category: Urology & Nephrology Source Type: research

Dietary Salt Intake is a Significant Determinant of Impaired Kidney Function in the General Population
Conclusion: Salt intake is associated with the development of impaired kidney function in the general population, independent of its effects on blood pressure. Salt restriction may help prevent the development of impaired kidney function.Kidney Blood Press Res 2018;43:1245 –1254 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 3, 2018 Category: Urology & Nephrology Source Type: research

Prognostic Value of Urinary Calprotectin, NGAL and KIM-1 in Chronic Kidney Disease
Conclusion: In contrast to the traditional biomarker “albuminuria”, neither the inflammatory biomarker calprotectin, nor the tubular biomarkers NGAL and KIM-1, provide robust prognostic information on the loss or renal function in a heterogeneous CKD population. All of them, however, are candidate prognostic biomarkers in primarily inflammatory re nal diseases.Kidney Blood Press Res 2018;43:1255 –1262 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 3, 2018 Category: Urology & Nephrology Source Type: research

Serum Free Light Chains Removal by HFR Hemodiafiltration in Patients with Multiple Myeloma and Acute Kidney Injury: a Case Series
Conclusion: Our study suggests that HFR-SUPRA provides a rapid and effective reduction in serum FLC in patients with MM and AKI, while minimizing the loss of albumin. When started early in combination with chemotherapy, blood purification by HFR-SUPRA was followed by the recovery of renal function in half of the patients treated.Kidney Blood Press Res 2018;43:1263 –1272 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 3, 2018 Category: Urology & Nephrology Source Type: research

Pharmacological Signatures of the Exenatide Nanoparticles Complex Against Myocardial Ischemia Reperfusion Injury
Conclusion: The block copolymer PLL-PEG-PLL may function as a potent exenatide nanocarrier for augmenting pharmacotherapy against MI/RI with unprecedented clinical benefits. Further study is needed to better clarify the underlying mechanisms.Kidney Blood Press Res 2018;43:1273 –1284 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 3, 2018 Category: Urology & Nephrology Source Type: research

Activation of TRPV1 Prevents Salt-Induced Kidney Damage and Hypertension After Renal Ischemia-Reperfusion Injury in Rats
Conclusion: Activation of TRPV1 plays an anti-inflammatory and anti-oxidative stress role in preventing renal tissue damage and salt-induced hypertension after I/R injury, indicating that TRPV1 conveys preconditioning protection that may have therapeutic implication.Kidney Blood Press Res 2018;43:1285 –1296 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 3, 2018 Category: Urology & Nephrology Source Type: research

Metabonomic Profiling Reveals Difference in Altered Metabolic Pathways Between Chronic Kidney Disease and High-Fat-Induced Insulin Resistance in Rats
Conclusion: Alterations in metabolites and relevant pathways were significantly different between the CKD- and HFD-induced IR rats. These findings may offer important information regarding the pathogenesis specific to IR caused by the decline in the renal function.Kidney Blood Press Res 2018;43:1199 –1211 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 2, 2018 Category: Urology & Nephrology Source Type: research

Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification
Conclusion: Silencing of SHMT1 promotes osteo-/chondrogenic signaling in VSMCs, at least in part, by inducing cellular oxidative stress. It thus aggravates phosphate-induced calcification of VSMCs. The present findings support a regulatory role of SHMT1 in vascular calcification during conditions of hyperphosphatemia such as chronic kidney disease.Kidney Blood Press Res 2018;43:1212 –1221 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 2, 2018 Category: Urology & Nephrology Source Type: research

Bone Biopsy Results in Chronic Kidney Disease: a Single-Center Experience
Conclusion: In CKD 5D patients, high-turnover ROD was associated with elevated iPTH at a low cutoff but not with BAP. The same diagnosis in CKD NOD was associated both with iPTH and BAP.Kidney Blood Press Res 2018;43:1222 –1230 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - August 2, 2018 Category: Urology & Nephrology Source Type: research

The Association of Fibroblast Growth Factor 23 with Arterial Stiffness and Atherosclerosis in Patients with Autosomal Dominant Polycystic Kidney Disease
Conclusion: In patients with ADPKD, as the disease stage advanced, serum FGF-23 levels increased while s-KL decreased. In ADPKD patients, AS and atherosclerosis development increased as compared to healthy subjects, and as CKD advanced. In ADPKD patients, the effect of serum FGF-23 on the development of AS and atherosclerosis in peripheral vessels is independent of s-KL.Kidney Blood Press Res 2018;43:1160 –1173 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 31, 2018 Category: Urology & Nephrology Source Type: research

Circulating α-Klotho Levels in Hemodialysis Patients and Their Relationship to Atherosclerosis
Conclusion: Serum sKlotho was related to systolic pressure, pulse pressure, ultrafiltration volume, hemoglobin, serum phosphorus, corrected serum calcium ×phosphorus, Hs-CRP, increased cIMT, carotid atherosclerotic plaque quantity and atherosclerosis. Age, dry weight, Hs-CRP, and serum sKlotho were risk factors for atherosclerosis in MHD patients. Serum sKlotho may be a novel risk factor for atherosclerosis in MHD patients.Kidney Blood Press Res 2018;43:1174 –1182 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 31, 2018 Category: Urology & Nephrology Source Type: research

Efficacies of Various Surgical Regimens in the Treatment of Renal Calculi Patients: a Network Meta-Analysis in 25 Enrolled Controlled Clinical Trials
Conclusion: This meta-analysis demonstrated that the URS + RIRS surgical procedure has the best stone-free rate and the lowest number of auxiliary procedures. The RIRS and Microperc both have the shortest hospital stay and operative time.Kidney Blood Press Res 2018;43:1183 –1198 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 31, 2018 Category: Urology & Nephrology Source Type: research

RANK Deficiency Ameliorates Podocyte Injury by Suppressing Calcium/Calcineurin/ NFATc1 Signaling
Conclusion: Our findings demonstrated that RANK deficiency ameliorates podocyte injury by suppressing calcium/calcineurin/NFATc1 signaling, which may present a promising target for therapeutic intervention.Kidney Blood Press Res 2018;43:1149 –1159 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 23, 2018 Category: Urology & Nephrology Source Type: research

Derivation and Validation of Risk Scores to Predict Cerebrovascular Mortality Among Incident Peritoneal Dialysis Patients
Conclusion: The new risk score, developed and validated using clinical measurements that are accessible on entry into PD, could be used clinically to screen for patients at high risk of CeVD mortality. Such patients might benefit from therapies reducing the incidence of CeVD related events.Kidney Blood Press Res 2018;43:1141 –1148 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 23, 2018 Category: Urology & Nephrology Source Type: research

The Unexpected Effects of L-Carnitine Supplementation on Lipid Metabolism in Hemodialysis Patients
Conclusion: Our results show significant effects of L-carnitine supplementation on lipid metabolism. Further clinical trials, as well as experimental research are needed to define the role of lipid metabolism in CKD population. Significant benefits of L-carnitine supplementation in patients with better initial serum albumin levels suggest that this therapy should not be restricted to patients with the worst nutritional and overall status.Kidney Blood Press Res 2018;43:1113 –1120 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 17, 2018 Category: Urology & Nephrology Source Type: research

Association Between Thyroid-Stimulating Hormone and Renal Function: a Mendelian Randomization Study
Conclusion: By a genetic approach that limits residual confounding and reverse causation in observational conventional epidemiological studies, TSH and eGFR are not causally associated, which suggests genetically elevated TSH concentrations may not affect the renal function.Kidney Blood Press Res 2018;43:1121 –1130 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 17, 2018 Category: Urology & Nephrology Source Type: research

Clinicopathological Characteristics, Role of Immunosuppressive Therapy and Progression in IgA Nephropathy with Hyperuricemia
Conclusion: Hyperuricemic IgAN patients presented more severe clinical features. Tubulointerstitial injury could be a pathological feature closely related to hyperuricemia in IgAN. Immunosuppressive therapy and RAS blockade could reduce proteinuria and improve renal outcome in IgAN patients with hyperuricemia.Kidney Blood Press Res 2018;43:1131 –1140 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 17, 2018 Category: Urology & Nephrology Source Type: research

Lentivirus-Mediated Silencing of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 Inhibits Release of Inflammatory Cytokines and Apoptosis in Renal Tubular Epithelial Cells Via Inhibition of the TLR4/NF-kB Pathway in Renal Ischemia-Reperfusion Injury
Conclusion: The results indicated that lentivirus-mediated silencing of SHP-2 inhibited the release of inflammatory cytokines and the apoptosis of renal tubular epithelial cells, and promoted the proliferation of these cells by inhibiting the TLR4/NF- κB signaling pathway in rats with renal I/R injury.Kidney Blood Press Res 2018;43:1084 –1103 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 10, 2018 Category: Urology & Nephrology Source Type: research

Clinical Outcome of Twice-Weekly Hemodialysis Patients with Long-Term Dialysis Vintage
Conclusion: The similar survival between twice-weekly HD and thrice-weekly HD in patients with long-term dialysis vintage is likely relating to patient selection, individualized treatment for dialysis patients based on clinical features and socioeconomic factors remains a tough task for the clinicians.Kidney Blood Press Res 2018;43:1104 –1112 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 10, 2018 Category: Urology & Nephrology Source Type: research

Association of Thyroid Function With the Estimated Glomerular Filtration Rate in a Large Chinese Euthyroid Population
Conclusion: Our findings suggest that TSH is associated with eGFR in euthyroid individuals and that higher FT4 is associated with an increased risk of CKD. More cohort studies are warranted to confirm whether the association is causal.Kidney Blood Press Res 2018;43:1075 –1083 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 5, 2018 Category: Urology & Nephrology Source Type: research

Adenine-Induced Chronic Renal Failure in Rats: A Model of Chronic Renocardiac Syndrome with Left Ventricular Diastolic Dysfunction but Preserved Ejection Fraction
Conclusion: Rats with ACRF develop LV hypertrophy and diastolic dysfunction while systolic performance was preserved. There was an increased hypertrophy and apoptosis of cardiomyocytes in the LV of ACRF rats. The cardiac abnormalities in ACRF rats resemble those in patients with CKD in which heart failure with preserved ejection fraction is common. Hence, this experimental model is well suited for studying pathophysiological mechanisms in chronic renocardiac syndromes.Kidney Blood Press Res 2018;43:1053 –1064 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 3, 2018 Category: Urology & Nephrology Source Type: research

Applying Regional Citrate Anticoagulation in Continuous Renal Replacement Therapy for Acute Kidney Injury Patients with Acute Liver Dysfunction: a Retrospective Observational Study
Conclusion: The present study demonstrated that, with proper monitoring and adjustment of citrates and calcium infusion, applying RCA in CRRT is reasonably safe for AKI patients with acute liver dysfunction, as long as circuit time stays below roughly 50 hours.Kidney Blood Press Res 2018;43:1065 –1074 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - July 3, 2018 Category: Urology & Nephrology Source Type: research

Effect of Home Blood Pressure Monitoring on Patient ’s Awareness and Goal Attainment Under Antihypertensive Therapy: The Factors Influencing Results in Anti-HypertenSive Treatment (FIRST) Study
Conclusion: In a large Swiss cohort of patients with arterial hypertension, information and training on BP self-measurement and direct involvement of patients by using HBPM led to improvement in BP control. Treatment with irbesartan alone or in combination with hydrochlorothiazide was well tolerated and markedly reduced BP.Kidney Blood Press Res 2018;43:979 –986 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 25, 2018 Category: Urology & Nephrology Source Type: research

Multiple Primary Malignancies in Renal Transplant Recipients: a Single Centre Retrospective Cohort Study
Conclusion: MPM are more frequent in renal transplant recipients than in the general population. It is associated with a high mortality rate, especially in the metachronous group. An increased awareness and frequent screening tests are necessary when managing this condition.Kidney Blood Press Res 2018;43:1034 –1041 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 25, 2018 Category: Urology & Nephrology Source Type: research

A Prospective Cohort Study Showing No Association Between Serum Sclerostin Level and Mortality in Maintenance Hemodialysis Patients
Conclusion: Serum sclerostin level was not an independent predictor of mortality in MHD patients after adjustment for several confounders. However, whether clinical interventions to modulate serum sclerostin levels in MHD patients would improve their survival remains to be determined.Kidney Blood Press Res 2018;43:1023 –1033 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 25, 2018 Category: Urology & Nephrology Source Type: research

Assessment of Peritoneal Membrane Arteriolar Structure in Conjunction with Traditional Cardiovascular System Evaluation in Chronic Kidney Disease (CKD) Stage 5 Patients
Conclusion: Peritoneal membrane arteriolar damage seems to be an integrated part of cardiovascular system damage in CKD stage 5 patients.Kidney Blood Press Res 2018;43:1042 –1052 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 25, 2018 Category: Urology & Nephrology Source Type: research

Exosomes: The New Mediator of Peritoneal Membrane Function
Fibrosis and angiogenesis are the most common processes that result in progressive peritoneal tissue remodeling and, eventually, peritoneal membrane dysfunction. The role of exosomes, which contributes to intercellular communication, in these processes has been neglected. Various biomolecules, including DNA, mRNA, proteins, lipids, and particular certain miRNAs, can be transferred by exosomes to local, neighboring and distal cells. Upon stimulation by cytokines or other microenvironment stimuli, donor cells release a mass of exosomes to peritoneal mesothelial cells, further affecting fibrosis and angiogenesis. This importa...
Source: Kidney and Blood Pressure Research - June 25, 2018 Category: Urology & Nephrology Source Type: research

Uremic Pruritus is Associated with Two-Year Cardiovascular Mortality in Long Term Hemodialysis Patients
Conclusion: Uremic pruritus is one of the predictor of 24-month cardiovascular mortality in MHD patients.Kidney Blood Press Res 2018;43:1000 –1009 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 18, 2018 Category: Urology & Nephrology Source Type: research

Anti-Inflammatory Action of Sitagliptin and Linagliptin in Doxorubicin Nephropathy
Conclusion: NLRP3 inflammasome activation was shown in our rat model of doxorubicin nephropathy. DPP4 inhibitors can suppress the activity of NLRP3, with or without relieving NADPH oxidase 2-related oxidative stress.Kidney Blood Press Res 2018;43:987 –999 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 18, 2018 Category: Urology & Nephrology Source Type: research

Progression of Chronic Kidney Disease Affects HDL Impact on Lipoprotein Lipase (LPL)-Mediated VLDL Lipolysis Efficiency
Conclusion: The progression of CKD affects lipoprotein composition and properties, and modulates the positive impact of HDL on VLDL lipolysis efficiency. In CKD patients, HDL deficiency and dysfunction can directly affect hypertriglyceridaemia development.Kidney Blood Press Res 2018;43:970 –978 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 18, 2018 Category: Urology & Nephrology Source Type: research

Diagnosis and Treatment of Metabolic Acidosis in Patients with Chronic Kidney Disease – Position Statement of the Working Group of the Polish Society of Nephrology
Metabolic acidosis is commonly found in patients with chronic kidney disease (CKD), and its causes are: impaired ammonia excretion, reduced tubular bicarbonate reabsorption and insufficient renal bicarbonate production in relation to the amount of acids synthesised by the body and ingested with food. As the consequence, numerous metabolic abnormalities develop, which may lead to dysfunction of several organs. In observational studies, it has been found that CKD patients with metabolic acidosis are characterised by faster progression of kidney disease towards end stage kidney failure, and by increased mortality. Results of ...
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Trace Urine Albumin and Mortality: Kangbuk Samsung Health Study
Conclusion: Trace albumin with low SG in urine dipstick test was associated with higher all-cause mortality in Korean adults. We should not neglect the significance of trace albumin and SG when interpreting urinalysis results.Kidney Blood Press Res 2018;43:951 –958 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Continuous Blood Purification Ameliorates Multiple Organ Failure Through Inhibiting the Activation of the P38 MAPK Signaling Pathway in a Rat Model
Conclusion: Our study proved that CBP could downregulate the p38 MAPK signaling pathway, suppress iNOS expression, reduced the serum levels of nitric oxide and TNF- α, thus ameliorate symptom of MOF.Kidney Blood Press Res 2018;43:938 –950 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Different Doses of < b > < i > Tripterygium < /i > < /b > Glycosides in the Treatment of Diabetic Nephropathy: Effects on Blood Lipids
Conclusion: The double dose of TG has improved clinical efficacy, compared with the low dose, and the same safety profile.Kidney Blood Press Res 2018;43:931 –937 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Investigation of the Oxidative Stress and DIO1 Expression in CRF Patients Accompanied With and Without Euthyroid Sick Syndrome
Conclusions: CRF patients showed elevated oxidative stress. The CRF patients without ESS showed higher expression of DIO1 than patients with ESS and the control group. The concentration of serum 8-Isoprostane was not correlated with FT3 and DIO1 levels.Kidney Blood Press Res 2018;43:924 –930 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research