Uremic Pruritus is Associated with Two-Year Cardiovascular Mortality in Long Term Hemodialysis Patients
Conclusion: Uremic pruritus is one of the predictor of 24-month cardiovascular mortality in MHD patients.Kidney Blood Press Res 2018;43:1000 –1009 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 18, 2018 Category: Urology & Nephrology Source Type: research

Anti-Inflammatory Action of Sitagliptin and Linagliptin in Doxorubicin Nephropathy
Conclusion: NLRP3 inflammasome activation was shown in our rat model of doxorubicin nephropathy. DPP4 inhibitors can suppress the activity of NLRP3, with or without relieving NADPH oxidase 2-related oxidative stress.Kidney Blood Press Res 2018;43:987 –999 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 18, 2018 Category: Urology & Nephrology Source Type: research

Progression of Chronic Kidney Disease Affects HDL Impact on Lipoprotein Lipase (LPL)-Mediated VLDL Lipolysis Efficiency
Conclusion: The progression of CKD affects lipoprotein composition and properties, and modulates the positive impact of HDL on VLDL lipolysis efficiency. In CKD patients, HDL deficiency and dysfunction can directly affect hypertriglyceridaemia development.Kidney Blood Press Res 2018;43:970 –978 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 18, 2018 Category: Urology & Nephrology Source Type: research

Diagnosis and Treatment of Metabolic Acidosis in Patients with Chronic Kidney Disease – Position Statement of the Working Group of the Polish Society of Nephrology
Metabolic acidosis is commonly found in patients with chronic kidney disease (CKD), and its causes are: impaired ammonia excretion, reduced tubular bicarbonate reabsorption and insufficient renal bicarbonate production in relation to the amount of acids synthesised by the body and ingested with food. As the consequence, numerous metabolic abnormalities develop, which may lead to dysfunction of several organs. In observational studies, it has been found that CKD patients with metabolic acidosis are characterised by faster progression of kidney disease towards end stage kidney failure, and by increased mortality. Results of ...
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Trace Urine Albumin and Mortality: Kangbuk Samsung Health Study
Conclusion: Trace albumin with low SG in urine dipstick test was associated with higher all-cause mortality in Korean adults. We should not neglect the significance of trace albumin and SG when interpreting urinalysis results.Kidney Blood Press Res 2018;43:951 –958 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Continuous Blood Purification Ameliorates Multiple Organ Failure Through Inhibiting the Activation of the P38 MAPK Signaling Pathway in a Rat Model
Conclusion: Our study proved that CBP could downregulate the p38 MAPK signaling pathway, suppress iNOS expression, reduced the serum levels of nitric oxide and TNF- α, thus ameliorate symptom of MOF.Kidney Blood Press Res 2018;43:938 –950 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Different Doses of < b > < i > Tripterygium < /i > < /b > Glycosides in the Treatment of Diabetic Nephropathy: Effects on Blood Lipids
Conclusion: The double dose of TG has improved clinical efficacy, compared with the low dose, and the same safety profile.Kidney Blood Press Res 2018;43:931 –937 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Investigation of the Oxidative Stress and DIO1 Expression in CRF Patients Accompanied With and Without Euthyroid Sick Syndrome
Conclusions: CRF patients showed elevated oxidative stress. The CRF patients without ESS showed higher expression of DIO1 than patients with ESS and the control group. The concentration of serum 8-Isoprostane was not correlated with FT3 and DIO1 levels.Kidney Blood Press Res 2018;43:924 –930 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Depression and Physical Frailty Have Additive Effect on the Nutritional Status and Clinical Outcome of Chinese Peritoneal Dialysis
Conclusion: Physical frailty and depressive symptoms are both common in Chinese PD patients, and they have additive adverse effect on the nutritional status and clinical outcome.Kidney Blood Press Res 2018;43:914 –923 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 12, 2018 Category: Urology & Nephrology Source Type: research

Tempol Protects Against Acute Renal Injury by Regulating PI3K/Akt/mTOR and GSK3 β Signaling Cascades and Afferent Arteriolar Activity
Conclusion: Tempol attenuates renal I/R injury. The protective mechanisms seem to relate with activation of PI3K/Akt/mTOR and GSK3 β pathways, inhibition of cellular damage markers and inflammation factors, as well as improvement of afferent arteriolar activity.Kidney Blood Press Res 2018;43:904 –913 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 5, 2018 Category: Urology & Nephrology Source Type: research

New Factors Predicting Delayed Graft Function: a Multi-Center Cohort Study of Kidney Donation After Brain Death Followed by Circulatory Death
Conclusion: The novel factors, confirmed for the first time in our study, will help to improve risk prediction of DGF and to determine optimal interventions to prevent DGF in clinical practice.Kidney Blood Press Res 2018;43:893 –903 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 5, 2018 Category: Urology & Nephrology Source Type: research

Association of Intradialytic Hypertension with Left Ventricular Mass in Hypertensive Hemodialysis Patients Enrolled in the Blood Pressure in Dialysis (BID) Study
Conclusion: IDH is independently associated with higher LVMI in hypertensive HD patients and may contribute to increased cardiovascular events.Kidney Blood Press Res 2018;43:882 –892 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 5, 2018 Category: Urology & Nephrology Source Type: research

A Prospective Observational Study on the Predictive Value of Serum Cystatin C for Successful Weaning from Continuous Renal Replacement Therapy
Conclusion: Serum CysC, at the time of CRRT cessation, is an independent predictor of the successful weaning from CRRT in critically ill patients with acute kidney injury.Kidney Blood Press Res 2018;43:872 –881 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 5, 2018 Category: Urology & Nephrology Source Type: research

Enhanced Renal Afferent Arteriolar Reactive Oxygen Species and Contractility to Endothelin-1 Are Associated with Canonical Wnt Signaling in Diabetic Mice
Conclusion: Increased ROS, notably H2O2 contributes to enhanced afferent arteriolar responses to ET-1 in diabetes, which is closely associated with Wnt signaling. Antioxidant pharmacological strategies targeting Wnt signaling may improve vascular function in diabetic nephropathy.Kidney Blood Press Res 2018;43:860 –871 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 5, 2018 Category: Urology & Nephrology Source Type: research

Assessment of Renal Pathological Changes in Lupus Nephritis Using Diffusion Weighted Imaging: A Multiple Correspondence Analysis
Conclusion: DWI is a noninvasive technique that may be used to detect renal pathophysiological changes. Renal cell proliferation and intestinal fibrosis may impact the movement of water in certain microenvironments. Enhanced perfusion may be a compensatory mechanism that is associated with renal pathological injuries.Kidney Blood Press Res 2018;43:847 –859 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 5, 2018 Category: Urology & Nephrology Source Type: research

Impaired Microcirculation in Children After Kidney Transplantation: Everolimus Versus Mycophenolate Based Immunosuppression Regimen
Conclusion: Endothelial dysfunction seems more frequent in KTx patients on EVR-based immunosuppressive regimen compared to standard immunosuppression.Kidney Blood Press Res 2018;43:793 –806 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Add-On Effect of Angiotensin Receptor Blockade (Candesartan) on Clinical Remission in Active IgA Nephropathy Patients Treated with Steroid Pulse Therapy and Tonsillectomy: a Randomized, Parallel-Group Comparison Trial
Conclusion: Early candesartan treatment combined with TSP may not benefit clinical remission regardless of the blood pressure. ARB titration later during the treatment might provide benefit for patients with active IgA nephropathy.Kidney Blood Press Res 2018;43:780 –792 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on All-Cause Mortality and Renal Outcomes in Patients with Diabetes and Albuminuria: a Systematic Review and Meta-Analysis
Conclusion: In patients with diabetes and albuminuria, ARBs reduced risks of ESRD and doubling of the serum creatinine level. ACE inhibitors and ARBs failed to reduce all-cause mortality and CV. Based on the renoprotective effects, ARBs may be preferred for diabetic patients with albuminuria.Kidney Blood Press Res 2018;43:768 –779 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Metabolite Profiling of Feces and Serum in Hemodialysis Patients and the Effect of Medicinal Charcoal Tablets
Conclusion: Parallel fecal and serum metabolomics uncovered the systematic metabolic variations of HD patients, especially disturbances in amino acid metabolism in the colon. Medicinal charcoal tablets had an impact on the serum and fecal metabolomes of HD patients, but their exact effects still need to be studied further.Kidney Blood Press Res 2018;43:755 –767 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Serum Fas Ligand, Serum Myostatin and Urine TGF- β1 Are Elevated in Autosomal Dominant Polycystic Kidney Disease Patients with Impaired and Preserved Renal Function
Conclusions: ADPKD patients with moderately preserved renal function have higher levels of FasL, myostatin and urine TGF- β1 than controls. These results indicate that an interplay between endothelial dysfunction and renal ischemia with mechanisms linked to apoptosis and fibrosis may be present even in early stages of ADPKD.Kidney Blood Press Res 2018;43:744 –754 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Circulating α-Klotho is Related to Plasma Aldosterone and Its Follow-Up Change Predicts CKD Progression
Conclusion: The change in concentration of soluble α-klotho during the 1.5-years follow-up was an indicator of CKD progression. Renal damage associated with a reduction of α-klotho may involve the upregulation of plasma aldosterone. Future studies are needed to validate our findings, and to investigate the underlying mechanism by which α-klotho a nd aldosterone may cause renal damage.Kidney Blood Press Res 2018;43:836 –846 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Mucin 4 Gene Silencing Reduces Oxidative Stress and Calcium Oxalate Crystal Formation in Renal Tubular Epithelial Cells Through the Extracellular Signal-Regulated Kinase Signaling Pathway in Nephrolithiasis Rat Model
Conclusion: Taken together, silencing of MUC4 can inactivate the ERK signaling pathway and further restrain oxidative stress and CaOx crystal formation in RTEC. Thus, MUC4 represents a potential investigative focus target in nephrolithiasis.Kidney Blood Press Res 2018;43:820 –835 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Erythropoietin Protects the Kidney by Regulating the Effect of TNF- α in L-NAME-Induced Hypertensive Rats
Conclusion: Erythropoietin protects kidney tissue against hypertension by preventing the apoptotic effects of TNF- α by blocking macrophage accumulation, decreasing TNF-α levels, and switching the TNF-α receptors from the apoptotic receptor TNFR1 to the proliferative receptor TNFR2.Kidney Blood Press Res 2018;43:807 –819 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 29, 2018 Category: Urology & Nephrology Source Type: research

Different Relevance of Peripheral, Central or Nighttime Blood Pressure Measurements in the Prediction of Chronic Kidney Disease Progression in Patients with Mild or No-Proteinuria
Conclusion: 1. In patients with CKD stages 3 or 4 and mild or no- proteinuria, peripheral and central blood pressure did not change significantly during a one-year observation period despite the significant decline of eGFR and seems not to participate in the CKD progression. 2. Reduced magnitude of the diastolic dipping, which reflects the increase of diastolic blood pressure load during the nighttime, may play an important role in the pathogenesis of deterioration of kidney function in these patients.Kidney Blood Press Res 2018;43:735 –743 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 15, 2018 Category: Urology & Nephrology Source Type: research

The Calcium-Sensing Receptor Gene Polymorphism rs1801725 and Calcium-Related Phenotypes in Hemodialysis Patients
Conclusion: The variant allele ofCASR rs1801725 solely and together with the variant allele of rs7652589 increases risk of more advanced sHPT. Homozygosity of the rs1801725 variant allele contributes to infection-related mortality in HD patients.Kidney Blood Press Res 2018;43:719 –734 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 15, 2018 Category: Urology & Nephrology Source Type: research

Endothelial Progenitor Cells and Kidney Diseases
Endothelial progenitor cells (EPC) are bone marrow derived or tissue-resident cells that play major roles in the maintenance of vascular integrity and repair of endothelial damage. Although EPCs may be capable of directly engrafting and regenerating the endothelium, the most important effects of EPCs seem to be depended on paracrine effects. In recent studies, specific microvesicles and mRNAs have been found to mediate the pro-angiogenic and regenerative effects of EPCs on endothelium. EPC counts have important prognostic implications in cardiovascular diseases (CVD). Uremia and inflammation are associated with lower EPC c...
Source: Kidney and Blood Pressure Research - May 15, 2018 Category: Urology & Nephrology Source Type: research

Clinical Correlates of Ambulatory Blood Pressure Phenotypes at a Tertiary Care Hospital in Turkey
Conclusion: Potential usages of ABPM in Turkey may include screening of high risk individuals who have traditional cardiovascular risk factors. It also provides clinicians valuable information on abnormal ABP phenotypes. Future studies are needed to clarify the risk factors of different ABP phenotypes and to evaluate the role of ABPM on detection and control of hypertension.Kidney Blood Press Res 2018;43:690 –700 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 15, 2018 Category: Urology & Nephrology Source Type: research

Prognostic Factors of Renal Involvement in Systemic Sclerosis
Conclusion: In SSc patients, renal function was normal for 4.1 years despite the presence of increased intrarenal arterial stiffness. SRC was observed in 4.9% of SSc patients. In SSc patients, a periodic follow-up based on clinical and laboratory evaluation, colorDoppler ultrasound and, in some cases, renal biopsy is required to evaluate renal involvement.Kidney Blood Press Res 2018;43:682 –689 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 15, 2018 Category: Urology & Nephrology Source Type: research

Dose-Response Between Cardiovascular Risk Factors and Cardiovascular Mortality Among Incident Peritoneal Dialysis Patients
Conclusion: Our findings highlight the potential importance of more intensive glucose management, anti-hypertensive treatment and dietary management among PD patients. We recommend that the clinical relevance of these epidemiological associations be tested using randomized controlled trials of multifaceted interventions.Kidney Blood Press Res 2018;43:628 –638 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 9, 2018 Category: Urology & Nephrology Source Type: research

Cell-Based Therapies in Acute Kidney Injury (AKI)
Acute kidney injury frequently occurs in hospitalized patients all over the world. The prognosis remains poor since specific therapies for promoting kidney regeneration/repair are still missing. In recent years cell-based strategies have improved AKI outcomes under experimental circumstances. Four groups of cells, each of them displaying certain biological and functional characteristics have been evaluated in AKI, induced Pluripotent Stem Cells (iPSCs), Spermatagonial Stem Cells (SSCs), Proangiogenic Cells (PACs) and Endothelial Colony Forming Cells (ECFCs), and Mesenchymal Stem Cells (MSCs). All of these have been documen...
Source: Kidney and Blood Pressure Research - May 7, 2018 Category: Urology & Nephrology Source Type: research

Soluble Urokinase Plasminogen Activator Receptor is Associated with Coronary Artery Calcification and Cardiovascular Disease in Patients Undergoing Hemodialysis
Conclusion: suPAR is associated with the CAC score and is a risk factor for new-onset CVD in patients undergoing hemodialysis.Kidney Blood Press Res 2018;43:664 –672 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 7, 2018 Category: Urology & Nephrology Source Type: research

Protective Effect of Nicotinamide Adenine Dinucleotide Phosphate on Renal Ischemia-Reperfusion Injury
Conclusion: NADPH treatment may protect against renal IRI and should be further developed as a new treatment for acute kidney injury.Kidney Blood Press Res 2018;43:651 –663 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - May 7, 2018 Category: Urology & Nephrology Source Type: research

Intrarenal Arterial Lesions Are Associated with Higher Blood Pressure, Reduced Renal Function and Poorer Renal Outcomes in Patients with IgA Nephropathy
Conclusion: Our study demonstrates the high prevalence of vascular lesions, including the chronic and acute arterial pathological changes, in patients with IgAN. The presence of vascular lesions is associated with higher MAP, reduced eGFR and poorer renal outcomes, which could be influenced by the RAS blockade treatment.Kidney Blood Press Res 2018;43:639 –650 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 26, 2018 Category: Urology & Nephrology Source Type: research

Nestin Improves Preeclampsia-Like Symptoms by Inhibiting Activity of Cyclin-Dependent Kinase 5
Conclusions: Our findings suggest that Nestin could improve preeclampsia-like symptoms by inhibiting the activity of CDK5, and Nestin may become a new prognostic factor and a potential therapy target for PE.Kidney Blood Press Res 2018;43:616 –627 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 24, 2018 Category: Urology & Nephrology Source Type: research

Urate-Lowering Agents in Asymptomatic Hyperuricemia: Role of Urine Sediment Analysis and Musculoskeletal Ultrasound
Current urate-lowering therapy (ULT) includes three direct acting drugs (allopurinol, febuxostat, Rasburicase) and at least four ‘indirect’ drugs with other important targets (canagliflozin, losartan, fenofibrate and sevelamer). Moreover, the alcalinization of urines using bicarbonate can be used to dissolve urate crystals and the clinician may discontinue several drugs are known to increase serum levels of uric acid, suc h as diuretics, aspirin, cyclosporine, theophylline, mycophenolate and ACE inhibitors. While there is a consensus to start ULT in cases of symptomatic hyperuricemia (gout, urate-nephrolithiasi...
Source: Kidney and Blood Pressure Research - April 24, 2018 Category: Urology & Nephrology Source Type: research

Paritaprevir/Ritonavir/Ombitasvir Plus Dasabuvir Regimen in the Treatment of Genotype 1 Chronic Hepatitis C Infection in Patients with Severe Renal Impairment and End-Stage Renal Disease: a Real-Life Cohort
Conclusion: PrOD regimen demonstrated an excellent efficacy and good tolerability. Both prospective adjustment of concomitant medication and further on-treatment adjustment allowed for a safe treatment course.Kidney Blood Press Res 2018;43:594 –605 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 17, 2018 Category: Urology & Nephrology Source Type: research

Previous Exercise Effects in Cisplatin-Induced Renal Lesions in Rats
Conclusions: The protective effect of previous training in CP-treated rats was associated with reduced endothelial cell lesions and increased renal production of NO in trained rats.Kidney Blood Press Res 2018;43:582 –593 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 17, 2018 Category: Urology & Nephrology Source Type: research

Integrative Bioinformatics Analysis Provides Insight into the Molecular Mechanisms of Chronic Kidney Disease
Conclusion: Our study not only further reveals the unifying molecular mechanism of CKD pathogenesis but also provides a valuable resource of potential biomarkers and therapeutic targets.Kidney Blood Press Res 2018;43:568 –581 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 11, 2018 Category: Urology & Nephrology Source Type: research

Metabolic Syndrome Severity and Risk of CKD and Worsened GFR: The Jackson Heart Study
Conclusion: MetS-severity exhibited sex-based interactions regarding risk for future GFR deterioration and CKD, with increasing risk in women but not men. These data may have implications for triggering CKD screening among African-American women with higher degrees of MetS-severity.Kidney Blood Press Res 2018;43:555 –567 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 11, 2018 Category: Urology & Nephrology Source Type: research

Angiopoietin-2, Renal Deterioration, Major Adverse Cardiovascular Events and All-Cause Mortality in Patients with Diabetic Nephropathy
Conclusion: Angpt2 is an independent predictor of adverse clinical outcomes in diabetic patients. Further studies are needed to identify the pathogenic role of Angpt2 in renal deterioration and cardiovascular complications of diabetes mellitus.Kidney Blood Press Res 2018;43:545 –554 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 11, 2018 Category: Urology & Nephrology Source Type: research

Effect of Lanthanum Carbonate on All-Cause Mortality in Patients Receiving Maintenance Hemodialysis: a Meta-Analysis of Randomized Controlled Trials
Conclusion: Compared with standard therapy, LC reduced all-cause mortality in patients on hemodialysis but did not decrease the risk of cardiovascular events. The decrease in serum phosphorus level was similar between LC and the other phosphate binders, but the risk of hypercalcemia was lower in patients who received LC.Kidney Blood Press Res 2018;43:536 –544 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 6, 2018 Category: Urology & Nephrology Source Type: research

Lung Dysfunction and Mortality in Patients with Chronic Kidney Disease
Conclusion: Lung dysfunction and in particular restrictive lung dysfunction associates with degree of renal function impairment and presence of comorbidities, and is an independent predictor of increased mortality in CKD patients.Kidney Blood Press Res 2018;43:522 –535 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 6, 2018 Category: Urology & Nephrology Source Type: research

Genotype –Phenotype Analysis in Pediatric Patients with Distal Renal Tubular Acidosis
Conclusions:SLC4A1 is the most common defective gene in Korean children with dRTA. Patients withSLC4A1 mutations show later onset and milder disease severity. Long-term follow-up of hearing ability, renal function, and growth is necessary for patients with dRTA.Kidney Blood Press Res 2018;43:513 –521 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 6, 2018 Category: Urology & Nephrology Source Type: research

Protective Effect of Znt7 on High Glucose-Induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells
Conclusion: The present study provides evidence that ZnT7 has a protective effect over EMT of RTECs in DN and suggests that the inhibition of HG-induced EMT may be achieved through the MAPK/ERK and TGF- β/Smad pathways. Thereby, ZnT7 could be a potential target for translation medicine and prevention program in DN.Kidney Blood Press Res 2018;43:500 –512 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 6, 2018 Category: Urology & Nephrology Source Type: research

High Neutrophil-to-Lymphocyte Ratio is a Significant Predictor of Cardiovascular and All-Cause Mortality in Patients Undergoing Peritoneal Dialysis
Conclusion: Our results suggest that high NLR is independently associated with arterial stiffness and predicts cardiovascular and all-cause mortality in PD patients.Kidney Blood Press Res 2018;43:490 –499 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 6, 2018 Category: Urology & Nephrology Source Type: research

Combination of Mean Platelet Volume/Platelet Count Ratio and the APACHE II Score Better Predicts the Short-Term Outcome in Patients with Acute Kidney Injury Receiving Continuous Renal Replacement Therapy
Conclusion: Severity of illness was significantly associated with prognosis of patients with AKI. The combination of MPR and APACHE II score may be helpful in predicting the short-term outcome of AKI.Kidney Blood Press Res 2018;43:479 –489 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - April 6, 2018 Category: Urology & Nephrology Source Type: research

Identification of Three Novel Frameshift Mutations in the PKD1 Gene in Iranian Families with Autosomal Dominant Polycystic Kidney Disease Using Efficient Targeted Next-Generation Sequencing
Conclusion: This study demonstrates the effectiveness of NGS in significantly reducing the cost and time for simultaneous sequence analysis of PKD1 and PKD2, simplifying the genetic diagnostics of ADPKD. Although a probable correlation between the mutation types and phenotypic outcome is possible, however for more extensive studies in future, the consideration of renal hypouricemia (RHUC) and PKD1 coexistence may be helpful. The novel frameshift mutations reported by this study are p. Q1997X, P. D73X and p. V336X.Kidney Blood Press Res 2018;43:471 –478 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 28, 2018 Category: Urology & Nephrology Source Type: research

Urinary Iron Excretion is Associated with Urinary Full-Length Megalin and Renal Oxidative Stress in Chronic Kidney Disease
Conclusions: Our findings suggest that renal iron handling may be associated with megalin-mediated endo-lysosomal metabolic load in PTECs of residual nephrons and oxidative stress in renal tubules.Kidney Blood Press Res 2018;43:458 –470 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 28, 2018 Category: Urology & Nephrology Source Type: research

The Relationships of the Fractional Excretion of Uric Acid with Brachial-Ankle Pulse Wave Velocity and Ankle Brachial Index in Chinese Young Adults
Conclusion: Kidney function exerted a profound influence on the relationship between UA and baPWV or ABI, revealing complex interactions among cardiovascular risk factors.Kidney Blood Press Res 2018;43:234 –245 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 23, 2018 Category: Urology & Nephrology Source Type: research

Apabetalone Mediated Epigenetic Modulation is Associated with Favorable Kidney Function and Alkaline Phosphatase Profile in Patients with Chronic Kidney Disease
Conclusion: A post-hoc analysis of CKD subjects from the SUSTAIN and ASSURE randomized controlled trials demonstrated favorable effects of apabetalone on ALP and eGFR, and generated the hypothesis that epigenetic modulation by BET inhibition may potentially offer a novel therapeutic strategy to treat CVD and progressive kidney function loss in CKD patients. This is being examined in the phase III trial BETonMACE.Kidney Blood Press Res 2018;43:449 –457 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 22, 2018 Category: Urology & Nephrology Source Type: research