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The Association Between Oxidative Stress Alleviation via Sulforaphane-Induced Nrf2-HO-1/NQO-1 Signaling Pathway Activation and Chronic Renal Allograft Dysfunction Improvement
Conclusion: Oxidative stress alleviation caused by continuous sulforaphane-induced Nrf2-HO-1/NQO-1 signaling pathway activation is associated with functional and morphological improvements of CRAD.Kidney Blood Press Res 2018;43:191 –205 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 21, 2018 Category: Urology & Nephrology Source Type: research

A Prospective Cohort Study in Patients with Type 2 Diabetes Mellitus for Validation of Biomarkers (PROVALID) – Study Design and Baseline Characteristics
Conclusion: PROVALID will provide information on incidence and progression of renal and cardiovascular disease and therapy in patients with type 2 diabetes mellitus in different European countries. Thus, in contrast to many other cohort studies we will be able to associate national clinical practise pattern with outcome in this highly vulnerable patient population.Kidney Blood Press Res 2018;43:181 –190 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 21, 2018 Category: Urology & Nephrology Source Type: research

Antithrombin Ⅲ is a Novel Predictor for Contrast Induced Nephropathy After Coronary Angiography
Conclusions: Patients with low AT Ⅲ activity had a higher risk of developing CIN after CAG. The initial ATⅢ activity may be a novel independent predictor for CIN.Kidney Blood Press Res 2018;43:170 –180 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 21, 2018 Category: Urology & Nephrology Source Type: research

Dialysate Creatinine Response Patterns During Peritoneal Equilibration Test and the Association Between Cardiovascular Mortality: Findings from a Prospective Cohort Study
Conclusion: Patients with decreased Dt/P ratio between 0-hour and 2-hour and low ratios at 2-hour and 4-hour tend to have low cardiovascular mortality. Latent class analysis seems to be a promising method to reveal unidentified subgroups that do not fit into the risk category defined by Dt/P ratio at 4-hour.Kidney Blood Press Res 2018;43:162 –169 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 21, 2018 Category: Urology & Nephrology Source Type: research

Comprehensive miRNA Analysis of Human Umbilical Cord-Derived Mesenchymal Stromal Cells and Extracellular Vesicles
Conclusion: MSCs and their EVs shared similar miRNA component, and some selectively enriched miRNAs observed in MSCs and EVs may affect different target genes through some specific signaling pathways.Kidney Blood Press Res 2018;43:152 –161 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 14, 2018 Category: Urology & Nephrology Source Type: research

Associations Between Intravenous Iron, Inflammation and FGF23 in Non-Dialysis Patients with Chronic Kidney Disease Stages 3-5
Conclusion: Intravenous iron supplementation may only transiently affect the production and degradation of FGF23 resulting in hypophosphatemia at the commencement of iron therapy. Chronic low-grade inflammation does not seem to play a role in that mechanism.Kidney Blood Press Res 2018;43:143 –151 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 14, 2018 Category: Urology & Nephrology Source Type: research

Cardiac Magnetic Resonance Imaging of the Myocardium in Chronic Kidney Disease
Early stages of chronic kidney disease (CKD) are often underdiagnosed, while their deleterious effects on the cardiovascular (CV) system are already at work. Thus, the assessment of early CV damage is of crucial importance in preventing major CV events. Myocardial fibrosis is one of the major consequences of progressive CKD, as it may lead to reentry arrhythmias and long-term myocardial dysfunction predisposing to sudden death and/or congestive heart failure. Subclinical myocardial fibrosis, with a potential key role in the development of uraemic cardiac disease, can be measured and characterised by appropriate cardiac mag...
Source: Kidney and Blood Pressure Research - February 14, 2018 Category: Urology & Nephrology Source Type: research

Comparison of Three Methods Estimating Baseline Creatinine For Acute Kidney Injury in Hospitalized Patients: a Multicentre Survey in Third-Level Urban Hospitals of China
Conclusions: Because of the scarcity of SCr data, imputation of the baseline SCr is necessary to remedy the missing data. The detection rate of AKI varies depending on the different imputation methods. SCrGFR-75 can identify more AKI cases than the other two methods.Kidney Blood Press Res 2018;43:125 –133 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 14, 2018 Category: Urology & Nephrology Source Type: research

Variability in Predialysis Systolic Blood Pressure and Long-Term Outcomes in Hemodialysis Patients
Conclusion: In this study, we demonstrate that greater variability in predialysis SBP is associated with long-term mortality in hemodialysis patients. Controlling volume variation, avoiding hypoalbuminemia and reducing blood calcium levels might reduce SBP variability and thereby improve prognoses in these patients.Kidney Blood Press Res 2018;43:115 –124 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 8, 2018 Category: Urology & Nephrology Source Type: research

Phosphate Removal During Conventional Hemodialysis: a Decades-Old Misconception
Conclusion: despite the P serum concentration normalizing in the first hour of hemodialysis, the removal in the same period reaches only 25% of the entire session.Kidney Blood Press Res 2018;43:110 –114 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 7, 2018 Category: Urology & Nephrology Source Type: research

Estimating of Residual Kidney Function by Multi-Frequency Bioelectrical Impedance Analysis in Hemodialysis Patients Without Urine Collection
Conclusion: We present a valid and clinically obtainable method to predict RKF in MHD patients. This method, which uses BIA, may prove as accurate, convenient and easily reproducible while it is operator independent.Kidney Blood Press Res 2018;43:98 –109 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 7, 2018 Category: Urology & Nephrology Source Type: research

The Association of Weekly pre-Hemodialysis Systolic Blood Pressure and Following Week Mortality
Conclusion: This study confirms an association of L preSBP with increased short-term mortality which is maintained over the first HD year. Percent of L preSBP in prior weeks, switching between L and H, and “current” week L are all associated with short-term mortality risk, but “current” week L preSBP is most significant.Kidney Blood Press Res 2018;43:88 –97 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 7, 2018 Category: Urology & Nephrology Source Type: research

Rs1520220 and Rs2195239 Polymorphisms of IGF-1 Gene Associated with Histopathological Grades in IgA Nephropathy in Northwestern Chinese Han Population
Conclusion: These results indicate that IGF-1 gene polymorphisms play crucial roles in the histopathological progression of IgAN in the Chinese Han population.Kidney Blood Press Res 2018;43:80 –87 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - February 2, 2018 Category: Urology & Nephrology Source Type: research

Chlormethine Hydrochloride is Not Inferior to Tacrolimus in Treating Steroid-Resistant Nephrotic Syndrome
Conclusion: The non-inferior efficacy of CHL treatment on the SRNS patients with FSGS or MN compared to TAC treatment, which highlighted CHL can be considered to be alternative treatment for SRNS patients in the clinical setting.Kidney Blood Press Res 2018;43:68 –79 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - January 30, 2018 Category: Urology & Nephrology Source Type: research

Tick-Tock Chimes the Kidney Clock – from Biology of Renal Ageing to Clinical Applications
Ageing of the kidney is a multi-dimensional process that occurs simultaneously at the molecular, cellular, histological, anatomical and physiological level. Nephron number and renal cortical volume decline, renal tubules become atrophic and glomeruli become sclerotic with age. These structural changes are accompanied by a decline in glomerular filtration rate, decreased sodium reabsorption and potassium excretion, reduced urinary concentrating capacity and alterations in the endocrine activity of the kidney. However, the pace of progression of these changes is not identical in everyone - individuals of the same age and see...
Source: Kidney and Blood Pressure Research - January 30, 2018 Category: Urology & Nephrology Source Type: research

Treatment of Hypertension in Renal Transplant Recipients in Four Independent Cross-Sectional Analyses
Conclusion: The study showed intensification of hypertension treatment in RTRs in subsequent years with BB assuming a dominant role.Kidney Blood Press Res 2018;43:45 –54 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - January 30, 2018 Category: Urology & Nephrology Source Type: research

Mild Salt-Sensitive Hypertension in Genetically Determined Low Nephron Number is Associated with Chloride but Not Sodium Retention
Conclusion: We hereby firstly report significant total body and skin chloride retention in salt sensitive hypertension of GDNF+/-mice with genetically determined lower nephron number. Thus, in contrast to the prevailing opinion our data argue for the involvement of non-volume related mechanisms.Kidney Blood Press Res 2018;43:1 –11 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - January 23, 2018 Category: Urology & Nephrology Source Type: research

Danhong Injection Protects Against Hypertension-Induced Renal Injury Via Down-Regulation of Myoglobin Expression in Spontaneously Hypertensive Rats
Conclusion: Hypertension-induced renal injury in SHR may be alleviated by DHI in part by local suppression of Kidney injury molecule-1 and down-regulation of Myoglobin. However, if this effect is independent of the known anti-hypertensive action of DHI in blood vessel remains to be determined.Kidney Blood Press Res 2018;43:12 –24 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - January 23, 2018 Category: Urology & Nephrology Source Type: research

Association of Circulating Levels of ADMA with Carotid Intima-Media Thickness in Patients with CKD: a Systematic Review and Meta-Analysis
Conclusion: Circulating levels of ADMA in CKD patients were positively related to CIMT, which could be a predictor of early-onset atherosclerosis and atherosclerotic disease in patients with CKD.Kidney Blood Press Res 2018;43:25 –33 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - January 23, 2018 Category: Urology & Nephrology Source Type: research

Impact of Recurrent Acute Kidney Injury on Patient Outcomes
Conclusion: Episodes of recurrent AKI have a high potential to be associated with relevant complications such as cardiovascular events, mortality and CKD development.Kidney Blood Press Res 2018;43:34 –44 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - January 23, 2018 Category: Urology & Nephrology Source Type: research

The Role of β-Adrenergic Overstimulation in the Early Stages of Renal Injury
Conclusion: These findings support relevant information regarding the contribution of specific β-adrenergic hyperactivity in early stage of renal injury, indicating the reactive oxygen species, ER stress and intrarenal RAS as important factors in this process.Kidney Blood Press Res 2017;42:1277 –1289 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 21, 2017 Category: Urology & Nephrology Source Type: research

Early Markers of Cardiovascular Risk in Autosomal Dominant Polycystic Kidney Disease
Conclusion: In our study, ADPKD patients, in the early stages of disease, showed a greater insulin resistance, endothelial dysfunction, inflammation and mineral metabolism disorders, respect to control group. Moreover, these patients presented reduced tolerance to stress, and decreased anaerobic threshold to CPET. Our results indicate a major and early cardiovascular risk in ADPKD patients. Therefore early and noninvasive markers of cardiovascular risk and CPET should be carried out, in ADPKD patients, in the early stages of disease, despite the cost implication.Kidney Blood Press Res 2017;42:1290 –1302 (Source: Kidn...
Source: Kidney and Blood Pressure Research - December 21, 2017 Category: Urology & Nephrology Source Type: research

Association Between Plasma Homocysteine and Microalbuminuria in Untreated Patients with Essential Hypertension: a Case-Control Study
Conclusion: This matched case-control study indicates that Hcy may increase the susceptibility of essential hypertensive subjects to MAU.Kidney Blood Press Res 2017;42:1303 –1311 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 21, 2017 Category: Urology & Nephrology Source Type: research

The Impact of Osteocalcin, Osteoprotegerin and Osteopontin on Arterial Stiffness in Chronic Renal Failure Patients on Hemodialysis
Conclusion: Except for OC, our results failed to document direct association of vascular lesion with OP and OPG, therefore their high circulating levels may be an epiphenomenon or they may have counter-regulatory role to attenuate the uremic calcification process.Kidney Blood Press Res 2017;42:1312 –1321 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 19, 2017 Category: Urology & Nephrology Source Type: research

MiRNA and mRNA Profiling in Systemic Lupus Reveals a Novel Set of Cytokine - Related miRNAs and their Target Genes in Cases With and Without Renal Involvement
Conclusions: We reported some human miRNAs which were differentially expressed in SLE patients according to disease activity and renal involvement. Larger studies are necessary to confirm our findings and detect further biomarkers.Kidney Blood Press Res 2017;42:1322 –1337 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 19, 2017 Category: Urology & Nephrology Source Type: research

Irisin and Volume Overload are Associated with Protein Energy Wasting in Peritoneal Dialysis Patients
Conclusion: Our results are the first to provide clinical evidence of the association between serum irisin, volume overload, and PEW in PD patients. PEW may inhibit the release or synthesis of irisin from skeletal muscles, and volume overload may aggravate PEW in PD patients.Kidney Blood Press Res 2017;42:1216 –1224 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 15, 2017 Category: Urology & Nephrology Source Type: research

Association Between Comprehensive Nutritional Scoring System (CNSS) and Outcomes of Continuous Ambulatory Peritoneal Dialysis Patients
Conclusion: CNSS provides an integrated scoring system with significant associations with hospitalization and mortality in PD patients. The CNSS grade differentiates patients with malnutritional risk and independently predicts high risk of morbidity and mortality.Kidney Blood Press Res 2017;42:1225 –1237 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 15, 2017 Category: Urology & Nephrology Source Type: research

Relationship Between Short-Term Blood Pressure Variability and Incidence of Acute Kidney Injury in Critically Ill Patients
Conclusion: BP variability is correlated with the incidence of AKI in critically ill patients.Kidney Blood Press Res 2017;42:1238 –1246 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 15, 2017 Category: Urology & Nephrology Source Type: research

Whole-Genome Analysis of an Extensive Drug-Resistant < b > < i > Acinetobacter Baumannii < /i > < /b > ST195 Isolate from a Recipient After DCD Renal Transplantation in China
Conclusion: Understanding the genetic characteristics associated with drug resistance mechanism and antimicrobial profiles of pathogen is important in controlling infection outbreak and preventing serious complications and gives a new insight into the development of antimicrobial agents.Kidney Blood Press Res 2017;42:1247 –1257 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 15, 2017 Category: Urology & Nephrology Source Type: research

Screening for Fabry Disease in Kidney Disease: a Cross-Sectional Study in Males and Females
Conclusion: The prevalence was higher in women, and the most prevalent symptom was heart diseases.Kidney Blood Press Res 2017;42:1258 –1265 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 15, 2017 Category: Urology & Nephrology Source Type: research

Risk Factors and Outcomes of Early-Onset Peritonitis in Chinese Peritoneal Dialysis Patients
Conclusion: Male gender and a low serum albumin level before PD were strongly associated with EOP. Additionally, EOP patients had a higher risk of poor clinical outcomes. More importantly, an early peritonitis onset was associated with a high peritonitis rate.Kidney Blood Press Res 2017;42:1266 –1276 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 15, 2017 Category: Urology & Nephrology Source Type: research

Association of –1082A & #x3e;G Polymorphism in the Interleukin-10 Gene with Estimated Glomerular Filtration Rate in Type 2 Diabetes
Conclusion: Our findings support the hypothesis that the -1082A#x3e;G polymorphism in theIL10 gene might be associated with DKD in white Brazilians with type 2 diabetes.Kidney Blood Press Res 2017;42:1164 –1174 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2017 Category: Urology & Nephrology Source Type: research

Higher Serum Hepatocyte Growth Factor Concentration is Associated with Better Preservation of GFR in Hemodialysis Patients
Conclusions: We found that a higher HGF serum level during hemodialysis treatment is associated with a slower loss of residual renal function.Kidney Blood Press Res 2017;42:1175 –1182 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2017 Category: Urology & Nephrology Source Type: research

Serum Hepcidin and Iron Indices Affect Anemia Status Differently According to the Kidney Function of Non-Dialysis Chronic Kidney Disease Patients: Korean Cohort Study For Outcome in Patients with Chronic Kidney Disease (KNOW-CKD)
Conclusions: TSAT was associated with less severe anemia in early CKD patients. Serum hepcidin was associated with more severe anemia in advanced CKD patients.Kidney Blood Press Res 2017;42:1183 –1192 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2017 Category: Urology & Nephrology Source Type: research

Red Blood Cell Distribution Width is an Independent Predictor of AKI and Mortality in Patients in the Coronary Care Unit
Conclusion: RDW is an independent predictor of AKI and mortality in patients in the CCU.Kidney Blood Press Res 2017;42:1193 –1204 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2017 Category: Urology & Nephrology Source Type: research

High Phosphate-Induced Calcification of Vascular Smooth Muscle Cells is Associated with the TLR4/NF- κb Signaling Pathway
Conclusion: These data suggest that high-phospha te conditions directly induce vascular calcification via the activation of TLR4/NF-κB signaling in VSMCs. Moreover, inhibition of the TLR4/NF-κB signaling pathway might be a key intervention to prevent vascular calcification in patients with CKD.Kidney Blood Press Res 2017;42:1205 –1215 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 11, 2017 Category: Urology & Nephrology Source Type: research

Response of Renal Podocytes to Excessive Hydrostatic Pressure: a Pathophysiologic Cascade in a Malignant Hypertension Model
Conclusions: Hypertension induces podocyte detachment by autocrine and paracrine effects. In a direct response to pressure, podocytes increase Angiotensin-II levels. This leads, via AT1 receptors, to structural changes in adhesion proteins, culminating in viable podocyte detachment. Paracrine effects of hypertension, mediated by mesangial cells, lead to higher levels of both Angiotensin-II and TGF- β1, culminating in apoptosis and detachment of non-viable podocytes.Kidney Blood Press Res 2017;42:1104 –1118 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 8, 2017 Category: Urology & Nephrology Source Type: research

Comparison of Muscle Mass Indices Using Computed Tomography or Dual X-Ray Absorptiometry for Predicting Physical Performance in Hemodialysis Patients
Conclusion: TMA indices using CT may be more valuable in predicting physical performance or strength in HD patients.Kidney Blood Press Res 2017;42:1119 –1127 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 8, 2017 Category: Urology & Nephrology Source Type: research

Renal Resistive Index as a Novel Indicator for Renal Complications in High-Fat Diet-Fed Mice
Conclusion: This study seems to confirm the utility of a noninvasive and repeatable ultrasound parameter to rapidly evaluate renal fibrosis in a HFD-induced type 2 diabetic mouse modelin vivo. This highly sensitive and comparable renal RI measurement could monitor the whole procedure of disease development in real-time. RI measurement of the renal artery is capable of differentiating responses to standard therapy with lovastatin in HFD-fed mice from the CHD group.Kidney Blood Press Res 2017;42:1128 –1140 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 8, 2017 Category: Urology & Nephrology Source Type: research

Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population
Conclusion: In this relatively healthy adult Chinese population, the CKD-EPI equation determined that the TG/HDL-c and non-HDL-c/HDL-c ratios as well as TG and HDL-c correlate with the prevalence of CKD.Kidney Blood Press Res 2017;42:1141 –1154 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 8, 2017 Category: Urology & Nephrology Source Type: research

Association Between GLCCI1 Promoter Polymorphism (Rs37972) and Post-Transplant Hypertension in Renal Transplant Recipients
Conclusion: GLCCI1 promoter polymorphism rs37972 may be associated with post-transplant hypertension.Kidney Blood Press Res 2017;42:1155 –1163 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 8, 2017 Category: Urology & Nephrology Source Type: research

Plasma ET-1 Concentrations Are Elevated in Pregnant Women with Hypertension -Meta-Analysis of Clinical Studies
Conclusion: Plasma ET-1 concentrations are elevated in hypertensive disorders during human pregnancy. In particular women with preeclampsia (hypertensive pregnant women with proteinuria) have substantially elevated plasma ET-1 concentration as compared to pregnant women with normal blood pressure.Kidney Blood Press Res 2017;42:654 –663 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 6, 2017 Category: Urology & Nephrology Source Type: research

In Patients with Chronic Kidney Disease Short Term Blood Pressure Variability is Associated with the Presence and Severity of Sleep Disorders
Conclusions: In CKD patients impaired sleep quality increases BPV, might contribute to their disease progression and worsen prognosis. Searching for sleep problems in CKD patients could help planning their treatment of sleep problems contributing to CV risk reduction. Our data provide the rationale working hypothesis for the need of studies with larger number of patients aimed to demonstrate improved outcome of CKD progression and CV risk with the treatment also of sleep disorders.Kidney Blood Press Res 2017;42:804 –815 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 6, 2017 Category: Urology & Nephrology Source Type: research

Clinical Evaluation of Continuous Renal Replacement Therapy in Combination with Ultrasound-Guided Percutaneous Transhepatic Gallbladder Drainage for Acute Severe Biliary Pancreatitis: a Retrospective Study
Conclusion: CRRT in combination with PTGD is more effective in the treatment of ASBP than CRRT alone.Kidney Blood Press Res 2017;42:1030 –1039 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 6, 2017 Category: Urology & Nephrology Source Type: research

Resveratrol Does Not Protect from Ischemia-Induced Acute Kidney Injury in an in Vivo Rat Model
Conclusion: RSV did not exert protective effects on I/R-induced AKI in the present short-termin vivo rat model. The lack of protection is potentially connected to aggravation of blood pressure instability.Kidney Blood Press Res 2017;42:1090 –1103 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 5, 2017 Category: Urology & Nephrology Source Type: research

Cuff-Based Oscillometric Central and Brachial Blood Pressures Obtained Through ABPM are Similarly Associated with Renal Organ Damage in Arterial Hypertension
Conclusion: Compared with peripheral ABPM, cuff-based oscillometric central ABPM does not show a closer association with presence of renal organ damage in hypertensive patients. More studies, however, need to be done to better identify the role of central BP in clinical practice.Kidney Blood Press Res 2017;42:1068 –1077 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 1, 2017 Category: Urology & Nephrology Source Type: research

Detection of Acute Tubular Necrosis Using Blood Oxygenation Level-Dependent (BOLD) MRI
Conclusion: BOLD-MRI is able to detect even mild tubular injury but necessitates a tubule-specific pharmacological maneuver, e.g. blocking the Na+-K+-2Cl- transporter by furosemide.Kidney Blood Press Res 2017;42:1078 –1089 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 1, 2017 Category: Urology & Nephrology Source Type: research

Carvedilol and Cardiac Biomarkers in Dialysis Patients: Secondary Analysis of a Randomized Controlled Trial
Conclusions: NT-proBNP and hs-TnT were associated with GLS. However, changes in levels of the biomarkers from baseline to 12 months were not different between groups randomized to carvedilol and placebo.Kidney Blood Press Res 2017;42:1033 –1044 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 1, 2017 Category: Urology & Nephrology Source Type: research

Biopsy-Free Prediction of Pathologic Type of Primary Nephrotic Syndrome Using a Machine Learning Algorithm
Conclusion: To our knowledge, this is the first such application of machine learning to predict the pathologic type of primary nephrotic syndrome, which may be clinically useful by itself as well as helpful for guiding future efforts at machine learning-based prediction in other disease contexts.Kidney Blood Press Res 2017;42:1045 –1052 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - December 1, 2017 Category: Urology & Nephrology Source Type: research

N-Terminal Prohormone of Brain Natriuretic Peptide but not C-Terminal Pre-Pro Vasopressin (Copeptin) Level is Associated with the Response to Antihypertensive Therapy in Haemodialysis Patients
Conclusions: 1. Increased levels of NT-proBNP seems to be a better biomarker of multidrug antihypertensive therapy requirement than CT-proAVP. 2. Whether estimation of NT-proBNP in these patients will be also better biomarker than copeptin in the prediction of cardiovascular complications related to hypertension needs further investigations.Kidney Blood Press Res 2017;42:1013 –1022 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - November 30, 2017 Category: Urology & Nephrology Source Type: research