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No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Cancer, hypertension and risk for cardiovascular disease
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Association of central arterial stiffness with hippocampal blood flow and N-acetyl aspartate concentration in hypertensive adult Dahl salt sensitive rats
Conclusion: These findings implicate increased CAS in cerebral hypoperfusion and loss of neuronal density and function in the Dahl-S model of age-associated cardiovascular dysfunction. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Basic science Source Type: research

Myocardial strain in hypertension: a meta-analysis of two-dimensional speckle tracking echocardiographic studies
Aim: Available evidence on systolic dysfunction in systemic hypertension, as assessed by left ventricular (LV) mechanics, is still based on single studies. Thus, we performed a systematic meta-analysis of two-dimensional speckle-tracking studies in order to provide an updated comprehensive information on this issue. Methods: The PubMed, OVID-MEDLINE, and Cochrane library databases were analyzed to search English language articles published from the inception up to 31 December 2020. Studies were identified by using MeSH terms and crossing the following search items: ‘myocardial strain’, ‘left ve...
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Cardiac function Source Type: research

Impact of stroke work on the ability of left ventricular mass to account for pressure effects on function in a community with prevalent systemic flow-dependent hypertension
Aims: To determine whether the confounding influence of stroke work on left ventricular mass (LVM) limits the ability of LVM to detect hypertensive LV dysfunction in systemic flow-dependent hypertension. Methods: In a community with prevalent systemic flow-dependent hypertension (n = 709), arterial haemodynamics, LVM and LV function were determined using central arterial pressure, aortic velocity and diameter measurements in the outflow tract, and echocardiography with tissue Doppler imaging. Results: In multivariate models, stroke work showed markedly stronger relations with LVM index (LVMI) than blo...
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Cardiac function Source Type: research

The cardio-ankle vascular index as a predictor of adverse pregnancy outcomes
Objective: To assess the association between maternal hemodynamic parameters; cardio-ankle vascular index (CAVI), representing arterial stiffness; mean arterial pressure (MAP), uterine artery pulsatility index (Ut-PI), and adverse pregnancy outcomes including preeclampsia (PE), fetal growth restriction (FGR), and gestational diabetes mellitus (GDM). Methods: A prospective cohort study was conducted on low-risk pregnancies. All were serially measured for the mean CAVI, MAP, and Ut-PI for four times at gestational age (GA) 11–14, 18–22, 28–32, and after 36 weeks. Also, the women were followed u...
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: BP variability and monitoring Source Type: research

Feasibility of 24-h blood pressure telemonitoring in community pharmacies: the TEMPLAR project
Conclusion: Ambulatory BP telemonitoring is feasible in community pharmacies as long as potential predictors of unsuccessful outcomes are taken into account and adequately managed. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: BP variability and monitoring Source Type: research

The association of blood pressure variability with adverse outcomes in a primary care chronic kidney disease cohort
Conclusion: Blood pressure variability may be an accessible, routinely collected, noninvasive measure for stratifying the risk of adverse events in individuals with chronic kidney disease in a primary care setting. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: BP variability and monitoring Source Type: research

Synergistic harmful interaction between sustained physical inactivity and hypertension/diabetes mellitus on the risk of all-cause mortality: a retrospective observational cohort study
This study used Korea National Health Insurance Service (KNHIS) database and included about 6.5 million participants who underwent health screening in 2009 and 2011. Physical activity was evaluated as 2-year change based on self-reported survey using 7-day recall method, and grouped as remained active, inactive-to-active, active-to-inactive, or remained inactive. Participants were categorized into groups according to the presence of hypertension/diabetes mellitus. Outcome included all-cause mortality. Results: In total, 6 554 082 participants (48.4 ± 13.3 years; 56.7% men) were included. During a me...
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Prehypertension Source Type: research

Effects of hormone replacement therapy on endothelial function, arterial stiffness and myocardial deformation in women with Turner syndrome
Objectives: Turner syndrome (TS) is associated with increased cardiovascular risk. We investigated whether hormone replacement therapy (HRT) affects endothelial function, arterial stiffness and myocardial deformation in women with TS. Methods: Twenty-five women with TS were studied in the estrogen phase of the HRT and two months after discontinuation of HRT. The following measurements were made: flow-mediated dilation (FMD) of the brachial artery, pulse wave velocity (PWV-Complior) and central systolic blood pressure (cSBP), carotid intima-media thickness (cIMT), aortic (Ao) elastic indexes – namely Ao str...
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Prehypertension Source Type: research

Abnormalities in emotional and motor reactions among young prehypertensive individuals: employing continuous blood pressure analysis
Conclusion: Considering the high frequency and health risks related to prehypertension, understanding the autonomic reactions to emotional and motor stimuli in this population is of clinical and theoretical importance and could serve as a behavioural marker to identify at-risk groups. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Prehypertension Source Type: research

Association of self-measured home, ambulatory, and strictly measured office blood pressure and their variability with intracranial arterial stenosis
Conclusion: The magnitude of association of strictly measured office BP for asymptomatic ICAS was comparable with that of BP measured at home or in ambulatory BP monitoring. Circadian BP variation based on ambulatory BP monitoring was positively associated with asymptomatic ICAS burden. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: BP and other risk factor epidemiology Source Type: research

Novel insights into stroke risk beyond resting and maximal bicycle exercise systolic blood pressure
Conclusion: Stroke risk increased with increasing difference between resting and maximal exercise SBP, independent of BP at rest, suggesting that an exaggerated BP response to physical exercise may be an independent predictor of stroke. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: BP and other risk factor epidemiology Source Type: research

Trends in cause-related comorbidities in hospitalized patients with secondary hypertension in China from 2013 to 2016: a retrospective analysis of hospital quality monitoring system data
Background: Secondary hypertension has emerged as a major public health problem in China. Early diagnosis and treatment can significantly improve the clinical outcomes. However, data on the current cause composition in China are seldom reported. Objective: To describe the trends in cause-related comorbidities in hospitalized patients with secondary hypertension in China from 2013 to 2016. Methods: This was a retrospective analysis based on the national Hospital Quality Monitoring System (HQMS) database, which collects information from the front pages of in-hospital medical records. Hospitalized patients w...
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: BP and other risk factor epidemiology Source Type: research

Relationships between cardiovascular risk factors and white-coat hypertension diagnosed by home blood pressure recordings in a middle-aged population
Objective: To study risk in white-coat hypertension (WCH) by measurement of coronary artery calcium score (CACS), carotid--femoral pulse-wave velocity (PWV) and carotid plaques. Methods: Cross-sectional population-based cohort with randomized selection of participants from Linköping, Sweden. An Omron m10-IT oscillometric device was used for clinic and home blood pressures (HBP) in the morning and evening for 1 week. Results: We recruited 5029 middle-aged and mainly defined WCH as SBP at least 140 mmHg and/or DBP at least 90 mmHg with HBP less than 135/85 mmHg. There were 2680 normotensive parti...
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: BP and other risk factor epidemiology Source Type: research

Isolated diastolic vs. systolic hypertension phenotypes and outcomes: prospective cohort of newly diagnosed individuals with hypertension
Conclusion: In hypertensive patients at low/moderate CV risk, IDH and SDH phenotypes defined by clinic BP measurements, equally determined CV events but to a lower extent compared with ISH. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: BP and other risk factor epidemiology Source Type: research

Characteristics of people with severe hypertension in France and determinants of medication persistence after 6 years
Conclusion: These results based on a large primary prevention population should encourage the implementation of new pharmacological and nonpharmacological management strategies for people with severe hypertension in France. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: BP and other risk factor epidemiology Source Type: research

Relation between elevated first SBP from baseline (delta SBP) and postoperative outcome
Conclusion: Delta SBP contributed to the elevated risk over and beyond the SBP at rest in patients who underwent elective noncardiac surgery. A rise of SBP of more than 49 mmHg from baseline in the operating room was significantly associated with an increased risk of postoperative MACE. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: BP and other risk factor epidemiology Source Type: research

An exploratory analysis of comparative plasma metabolomic and lipidomic profiling in salt-sensitive and salt-resistant individuals from The Dietary Approaches to Stop Hypertension Sodium Trial
Conclusion: In DASH-Sodium Trial participants on a regular diet, plasma metabolomic or lipidomic signatures were not different between salt-sensitive and salt-resistant participants. High-sodium intake was associated with changes in specific circulating metabolites in salt-sensitive participants. Further studies are needed to validate the identified metabolites as potential biomarkers that are associated with the salt sensitivity of blood pressure. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Diagnostics Source Type: research

Time trends in the relation between blood pressure and dementia in 85-year-olds
Conclusion: Our findings show that time-trends of lower blood pressure in western populations also applies to the very old, and that individuals with dementia continue to have lower blood pressure compared to the rest of the population. The latter finding suggests that the pathophysiological processes in dementia affect blood pressure regulating regions in the brain independent of time trends. Still, hypertension is common in dementia and needs to be detected and treated. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Diagnostics Source Type: research

Maternal myocardial dysfunction after hemolysis, elevated liver enzymes, and low platelets syndrome: a speckle-tracking study
Conclusions: In the first years after a pregnancy complicated by HELLP syndrome, irrespective of whether there was concomitant PE, a higher rate of abnormal STE myocardial function is observed. Therefore, these women may benefit from CV risk management. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Diagnostics Source Type: research

Blood pressure in adults with cerebral palsy: a systematic review and meta-analysis of individual participant data
Conclusion: Our findings underscore the importance of clinical screening for blood pressure in individuals with cerebral palsy beginning in young adulthood. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: REVIEWS AND META-ANALYSES Source Type: research

Adaptation of left ventricular diastolic function to pregnancy: a systematic review and meta-analysis
Conclusion: LVDF in normotensive pregnancy was improved in the first trimester after which LVDF progressively worsened. Large-scale studies in normotensive and hypertensive complicated pregnancies are needed for a more precise insight into LVDF changes during pregnancy. (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: REVIEWS AND META-ANALYSES Source Type: research

The Journal Executive Team
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: EDITOR'S CORNER Source Type: research

First international consensus on the diagnosis and management of fibromuscular dysplasia: Erratum
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ERRATUM Source Type: research

Reply
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Aortic dilatation influences on cardiovascular events; why?
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Reply
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Magnitude and significance of interarm blood pressure differences in children and adolescents
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Reply
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Uterine fibroids in hypertension and pregnancy
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Computed tomography image fusion, Coaxial guidewire technique, Fast intraprocedural cortisol testing technique improves success rate and decreases radiation exposure, procedure time, and contrast use for adrenal vein sampling
Background: Adrenal vein sampling (AVS) is recommended for discriminating patients with unilateral primary aldosteronism from bilateral disease. However, it is a technically demanding procedure that is markedly underused. We developed a computed tomography image fusion, coaxial guidewire technique, fast intraprocedural cortisol testing (CCF) technique to improve AVS success rate, which combines CT image fusion, coaxial guidewire technique, and fast intraprocedural cortisol testing. Objective: To evaluate the effectiveness and safety of the AVS--CCF technique. Methods: We retrospectively evaluated 105 pati...
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Aldosteronism Source Type: research

Aldosterone contributes to hypertension in male mice inducibly overexpressing human endothelin-1 in endothelium
Conclusion: These results demonstrate that aldosterone contributes to BP elevation and vascular norepinephrine sensitivity and remodeling caused by hET-1 overexpression in endothelium in mice. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Aldosteronism Source Type: research

Waist circumference change and risk of high carotid intima-media thickness in a cohort of Chinese children
Conclusion: In this cohort of children, WC gain and persistently high WC were associated with increased cIMT whereas WC loss was not. These findings emphasize the importance of maintaining a normal WC in childhood to promote vascular health. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Children Source Type: research

Determining pediatric hypertension criteria: concordance between observed physician methods and guideline-recommended methods
Conclusion: Physicians applied a shorthand method to evaluate pediatric BPs. Computer-simulated comparison of the shorthand and guideline methods using clinical data suggest the shorthand method could yield an inaccurate impression of a child's BP history in 17% of pediatric ambulatory visits. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Children Source Type: research

Childhood vascular phenotypes have differing associations with prenatal and postnatal growth
Conclusion: Higher postnatal linear growth and adiposity gain are related to higher SBP and carotid--femoral pulse wave velocity in childhood. In contrast, faster growth in early gestation is associated with greater childhood carotid intima--media thickness, perhaps resulting from subtle changes in vascular structure that reflect physiological adaptations rather than subclinical atherosclerosis. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Children Source Type: research

Birth weight, childhood obesity and risk of hypertension: a Mendelian randomization study
Purposes: Observational studies indicate that birth weight and childhood obesity are associated with essential hypertension, but their causal effect on essential hypertension remains unclear. The aim of our study is to elucidate the causal relationship between birth weight, childhood obesity, and essential hypertension by Mendelian randomization (MR) with genetic variants as instrumental variables (IVs). Methods: We identified IVs based on single nucleotide polymorphisms (SNPs) associated with birth weight (n = 160 295) and childhood obesity (n = 6889, 1509 cases and 5380 controls) from the meta-analysis...
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Children Source Type: research

Within-visit SBP variability from childhood to adulthood and markers of cardiovascular end-organ damage in mid-life
Conclusion: Within-visit SBP variability from childhood to adulthood does not provide additional predictive utility over SBP over the same period of the life course. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Blood pressure variability Source Type: research

Blood pressure, blood pressure variability and the risk of poststroke dementia
Conclusion: Among patients with a recent noncardioembolic ischemic stroke, there appears to be a U-shaped association between achieved SBP and dementia. High blood pressure variability is associated with an increased risk of poststroke dementia. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Blood pressure variability Source Type: research

Impact of visit-to-visit blood pressure variability on hypertensive-mediated target organ damage and future cardiovascular events: the Campania salute network
Conclusion: VVV is associated with prevalent HMOD and development of cardiovascular events, independently of mean BP value during follow-up and HMOD. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Blood pressure variability Source Type: research

Predictive value of within-visit and visit-to-visit blood pressure variability for all-cause mortality: the Minhang Study
Conclusion: Visit-to-visit and sustained high within-visit blood pressure variability were significant positive prognostic factors for all-cause mortality. Our findings underlined the clinical significance of achieving stable blood pressure in an effective plan of hypertension management. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Blood pressure variability Source Type: research

Impact of dietary intake of sodium and potassium on short-term blood pressure variability
Conclusion: Dietary sodium and potassium can jointly modulate short-term BPV in addition to BP. Combined DASH diet and low sodium intake may reduce systolic and diastolic ARV via different mechanisms. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Blood pressure variability Source Type: research

Capillary vascular density in the retina of hypertensive patients is associated with a non-dipping pattern independent of mean ambulatory blood pressure
Conclusion: Foveal vascular density was associated with the nocturnal BP dipping pattern in hypertensive patients. These associations were robust to adjustment of relevant factors such as daytime BP. Our findings highlight the importance of nocturnal BP features reflected in ambulatory BP monitoring in the assessment of HMOD. Whether routine assessment of retinal damage markers may improve risk management of hypertensive patients remains to be determined. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Risk factors Source Type: research

Associations of plasma PAPP-A2 and genetic variations with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults
Conclusions: This study shows that dietary salt intake affects plasma PAPP-A2 levels and that PAPP-A2 may play a role in salt sensitivity, BP progression and development of hypertension in the Chinese populations. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Risk factors Source Type: research

Gut microbiome diversity and composition is associated with hypertension in women
Objectives: Animal studies support a role for the gut microbiota in hypertension development, but large human studies are lacking. Here, we investigated the relationship between hypertension prevalence and gut microbial composition in two cohorts. Methods: We included 871 unrelated TwinsUK women with faecal microbiome data (16s rRNA gene sequencing). Multivariable linear models adjusted for age, age2 and BMI as well as MiRKAT models, were used to estimate the association of hypertension with alpha- and beta-diversity metrics. To identify taxa associated with hypertension, a generalized additive model for locatio...
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Gut bacteria and hypertension Source Type: research

Integrated metagenome and metabolome analyses of blood pressure studies in early postmenopausal Chinese women
Conclusion: Multi-omics datasets integration has the potential to capture complementary effect and their interactions for BP variation, revealed the potential pathogenesis of BP variation and may be useful for studying other complex diseases/traits. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Gut bacteria and hypertension Source Type: research

Genetically determined hypertensive phenotype affects gut microbiota composition, but not vice versa
Conclusion: Genetically induced hypertension in SHR is associated with alterations in the composition of gut bacteria and histological morphology of the colon. An inter-strain fecal transplant does not affect BP and does not produce long-term changes in gut bacteria composition. We propose that the impact of the host genotype and/or phenotype on the gut bacteria may be greater than the impact of the gut bacteria on the host BP. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Animal studies Source Type: research

Pyridostigmine ameliorates preeclamptic features in pregnant rats by inhibiting tumour necrosis factor-α synthetsis and antagonizing tumour necrosis factor-α-related effects
Conclusion: Collectively, PYR ameliorated hypertension and other preeclampsia-like symptoms in rat models of preeclampsia not only by inhibiting the synthesis of TNF-α but also by acting against TNF-α-induced detrimental effects directly, which is worthy of further investigation and may be used as a potential agent for preeclampsia management. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: Animal studies Source Type: research

Blood pressure variability: a new therapeutic target on the horizon
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: EDITORIAL COMMENTARIES Source Type: research

Gut dysbiosis and hypertension: is it cause or effect?
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 13, 2021 Category: Cardiology Tags: EDITORIAL COMMENTARIES Source Type: research