Recommendations and Practical Guidance for performing and reporting validation studies according to the Universal Standard for the validation of blood pressure measuring devices by the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization (AAMI/ESH/ISO): Erratum
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ERRATUM Source Type: research

Reply
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Prehypertension: unresolved problem
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Reply
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Hypertensive emergencies and urgencies: a single-centre experience in Northern Italy 2008–2015
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Severe impaired blood pressure control caused by baroreflex failure as a late sequela of neck irradiation
A 64-year-old man, whose medical history was significant only for locally advanced squamocellular carcinoma of the right palatine tonsil treated with extended neck radiotherapy 9 years before, was evaluated for traumatic cerebral haemorrhage secondary to syncope after a postural change. The selective angiographic study of cerebral vessels was negative. No heart arrhythmias were recorded at ECG monitoring. The 24-h ABPM revealed sudden pressor and depressor episodes during day-time and a reverse dipper pattern during night-time. Noninvasive autonomic nervous system function testing showed supine hypertension and orthostatic...
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: Case Report Source Type: research

Statin therapy is associated with better ambulatory blood pressure control: a propensity score analysis
Objective: Statin therapy was associated with lower blood pressure (BP) in some but not all studies. We evaluated the association between statin therapy and ambulatory BP in a large hypertensive population using ‘propensity score matching’. Methods: Retrospective observational study on 1827 consecutive essential hypertensive patients evaluated with 24-h ambulatory BP monitoring. Antihypertensive treatment intensity (ATI) was calculated to compare different drug associations. We used a propensity score matching to compare two equally-sized cohorts of patients with similar characteristics according to statin...
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Effects of third-generation β-blockers, atenolol or amlodipine on blood pressure variability and target organ damage in spontaneously hypertensive rats
Conclusion: Chronic treatment with carvedilol or nebivolol attenuates carotid BP and short-term BPV, and reduces target organ damage in SHR to a greater extent than atenolol. Our findings suggest that the lower cardiovascular protection of nonvasodilating β-blockers, as atenolol, in hypertension must not be translated to third-generation β-blockers. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Real-world efficacy and safety of nebivolol in Korean patients with hypertension from the BENEFIT KOREA study
Objective: The efficacy and safety of nebivolol in patients with hypertension is well established, but its effect in Asian patients with essential hypertension in the real world has not been studied. Methods: Adult South Korean patients with essential hypertension, with or without comorbidities, were enrolled to participate in this prospective, single-arm, open, observational study; 3011 patients received nebivolol either as monotherapy or add-on therapy. Changes in SBP, DBP and heart rate (HR) at 12 and 24 weeks were evaluated. Subgroup analysis for BP changes in newly diagnosed (de novo) patients and those receiving...
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Lack of a significant legacy effect of baseline blood pressure ‘treatment naivety’ on all-cause and cardiovascular mortality in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
Conclusion: Physicians are concerned about ‘legacy effects’ of not treating individuals with a BP of 140 mmHg or over and low absolute risk. When treatment intensification was taken into consideration in the primary prevention population in this study, no adverse legacy effect as a result of baseline BP ‘treatment naivety’ was evident in 14 years of follow-up. The nonsignificant associations were consistent across the CVD risk subgroups. However, the results may be biased due to unobserved residual confounding and therefore should be interpreted with caution. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Easy-to-use tool for evaluating the elevated acute kidney injury risk against reduced cardiovascular disease risk during intensive blood pressure control
Conclusion: By predicting the risks of CVD and AKI at baseline, the developed tool can be used to weigh the benefits of intensive versus standard blood pressure control and to identify those who are likely to benefit most from intensive treatment. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

No difference in medication regimes and dosing in study participants with and without blood pressure control: longitudinal data of the population-based Heinz Nixdorf Recall Study
Conclusion: Although the prevalence of antihypertensive medication use increased in the study period, the BP control rate did not. In contrast to clinical reasoning, participants with uncontrolled BP did neither receive more agents nor higher dosing despite outcome-relevant hypertension. Our approach to analyze medication dosing suggests a potential to improve cardiovascular outcomes by increasing dosages of antihypertensive agents. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Dissociation between hypertrophy and fibrosis in the left ventricle early after experimental kidney transplantation
Conclusion: LVMI reversed and MAP and renal function were normalized early after transplantation of a healthy kidney. However, LV fibrosis persisted, dissociating LV hypertrophy from LV fibrosis within 6 weeks. Elucidating cardiac ECM dynamics in CKD patients, although challenging, appears promising. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Organ damage Source Type: research

Does early life programming influence arterial stiffness and central hemodynamics in adulthood?
This study included 1598 participants, that is, 340 elderly individuals from the Malmö Birth Data Cohort (MBDC) and 1258 young-middle aged individuals from the Malmö Offspring Study (MOS) with full data on birth weight and gestational age. Participants underwent cfPWV and AIx measurements with Sphygmocor (AtCor, Australia). Analysis of data was performed with multiple linear regression models including adjustments for age, sex, gestational age and risk factors. Furthermore, comparisons were made between participants born prematurely or at term or born small-for-gestational age (SGA) or appropriate-for-gestational...
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Organ damage Source Type: research

Family patterns of arterial stiffness across three generations in the Malmö Offspring Study
Background: Central haemodynamics have in recent years emerged as a promising predictor of cardiovascular health and risk of cardiovascular disease (CVD). Central haemodynamics are affected early in the development of vascular aging and contributes to target organ damage. Carotid–femoral pulse wave velocity (c-f PWV), augmentation index (Aix) and central SBP (cSBP) are variables that reflect arterial stiffness and central haemodynamics. Aim: To study the association between patterns of central haemodynamics across three related generations focusing on c-f PWV. Methods: In all, 1131 participants from the Malm&...
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Organ damage Source Type: research

Association of increased arterial stiffness with diastolic dysfunction in ischemic stroke patients: the Norwegian Stroke in the Young Study
Background: Young and middle-aged ischemic stroke survivors have a high prevalence of hypertension, increased arterial stiffness and abnormal left ventricular (LV) geometry, which all are associated with the presence of LV diastolic dysfunction. However, the prevalence and covariates of diastolic dysfunction in these patients have not been reported. Objectives: To explore diastolic dysfunction in ischemic stroke patients aged 15–60 years included in the Norwegian Stroke in the Young Study. Methods: Data from 260 patients with acute ischemic stroke was analyzed. Diastolic dysfunction was assessed by combining ...
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Organ damage Source Type: research

Chromogranin A pathway: from pathogenic molecule to renal disease
Conclusion: These findings improve understanding of the role of elevated CHGA in the progression of CKD and reveal novel pathways that could be exploited for therapeutic strategies in hypertensive kidney disease. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Organ damage Source Type: research

Blood pressure dipping and sleep quality in the Wisconsin Sleep Cohort
Conclusion: Clinical features of insomnia and poor sleep quality are associated with nondipping BP. Our findings suggested nondipping might be one possible mechanism by which poor sleep quality was associated with worse cardiovascular outcomes. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Diagnostic aspects Source Type: research

Increased detection of suspected atrial fibrillation in elderly and female hypertensive patients through home blood pressure monitoring: the HOME-AF study
This study aimed to investigate the incidence of new suspected atrial fibrillation cases detected through home blood pressure (BP) screening among hypertensive patients. Association of new suspected atrial fibrillation cases with arterial hypertension (AH) phenotypes and the CHA2DS2-VASc score was also investigated. Methods: The prospective study recruited hypertensive patients at least 50 years old from private and hospital hypertensive clinics. An ECG was performed during the first visit. Microlife BP A6 PC was used to measure office and home BP for at least 3 and preferably 7 consecutive days. Results: A total of ...
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Diagnostic aspects Source Type: research

Prevalence of isolated nocturnal hypertension according to 2018 European Society of Cardiology and European Society of Hypertension office blood pressure categories
Objectives: To estimate the prevalence of isolated nocturnal hypertension (INH) and its relationships with office blood pressure (BP) categories defined by 2018 ESC/ESH guidelines. Methods: We conducted a prospective cohort study in consecutive patients referred to perform an ambulatory blood pressure monitoring (ABPM) for diagnosis or therapeutic purposes. Office BP measurements and ABPM were performed in the same visit. The cohort was divided according to office BP in optimal, normal, high-normal and hypertension. The prevalence and adjusted risk for combined daytime and nocturnal hypertension and INH were estimated...
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

Cancer patients with potential eligibility for vascular endothelial growth factor antagonists use have an increased risk for cardiovascular diseases comorbidities
Conclusion: Cancer patients carry a high burden of CVD-related comorbidities before the application of VEGF antagonists. HTN is the most prevalent comorbid condition, and cancer patients with HTN constitute substantial cardiovascular risks and a higher co-prevalence of other CVDs. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

Visit-to-visit blood pressure variation and outcomes in heart failure with reduced ejection fraction: findings from the Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms trial
Background: Visit-to-visit office blood pressure (BP) variability (BPV) has been associated with morbidity and mortality outcomes in several cardiovascular conditions. The aim of this study was to evaluate the association between BPV and outcomes in patients with heart failure and reduced ejection fraction and the effect of eplerenone on BPV. Methods and results: We evaluated the associations between BPV, calculated as SBP coefficient of variation (SBP-CoV = SD/mean × 100%), and the primary composite endpoint of cardiovascular mortality or heart failure hospitalization (HFH), and its components, in 2549 ...
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

Serum uric acid and fatal myocardial infarction: detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study
Objective: The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad-hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting fatal myocardial infaction (MI) in women and men. Methods: The URic acid Right for heArt Health study is a nationwide, multicentre, observational cohort study involving data on individuals aged 18–95 years recruited on a regional community basis from all the territory of Italy under the patronage of the Italian Society of Hypertension with a mean follow-up period of 122.3 ±...
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

Do really statins reduce blood pressure?
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: EDITORIAL COMMENTARIES Source Type: research

Reduction of blood pressure variability: an additional protective cardiovascular effect of vasodilating beta-blockers?
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: EDITORIAL COMMENTARIES Source Type: research

Time to rethink the management of underlying sleep disturbances in nondippers?
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: EDITORIAL COMMENTARIES Source Type: research

How common is isolated nocturnal hypertension?
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: EDITORIAL COMMENTARIES Source Type: research

STRIDE BP: an international initiative for accurate blood pressure measurement
The diagnosis and management of hypertension is dependent upon accurate blood pressure (BP) measurement. Despite intense efforts over several decades by the international medical community worldwide, the use of inaccurate devices has resulted in the misdiagnosis and poor management of hypertension, which remains a largely unresolved public health problem. STRIDE BP (www.stridebp.org) is an international nonprofit organization the mission of which is to improve the accuracy of BP measurement and the diagnosis of hypertension. STRIDE BP comprises a group of 24 recognized experts in BP monitoring from across the world and ope...
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: CONSENSUS AND META-ANALYSES Source Type: research

Weight gain and blood pressure
Conclusion: In sum, weight gain between early adulthood and mid-life was associated with higher mid-life blood pressure. The magnitude of the association indicates a potentially great public health impact of strategies to prevent weight gain throughout adulthood. (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: CONSENSUS AND META-ANALYSES Source Type: research

Cardiovascular, renal and liver protection with novel antidiabetic agents beyond blood glucose lowering in type 2 diabetes: consensus article from the European Society of Hypertension Working Group on Obesity, Diabetes and the High-risk Patient
The prevalence of type 2 diabetes (T2D) has increased over the past few decades. T2D has a strong genetic propensity that becomes overt when a patient is exposed to a typical Western lifestyle, gain weight and becomes obese, whereas weight loss protects from the development of T2D. Except of lifestyle modifications, the choice of the appropriate treatment is essential in the management of patients with T2D and appears critical for the obese population with T2D. The new pharmacological approach for the treatment of T2D, sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists, seems to be effe...
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: CONSENSUS AND META-ANALYSES Source Type: research

Highlights of the March issue
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: EDITOR'S CORNER Source Type: research

Candidate genes identified by whole-exome sequencing in preeclampsia families: insights into functional annotation and in-silico prediction of deleterious variants
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Reply
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Could fasting blood glucose predict hypertension: findings from a low-resource community
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Reply
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Supine heart rate measurement in elderly Chinese
No abstract available (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: CORRESPONDENCE Source Type: research

Use of simulated patients to assess hypertension case management at public healthcare facilities in South Africa
Conclusion: Simulated patients can assess the quality of hypertension case management, yielding granular and comprehensive information that can help mobilize resources to improve care. The management of hypertension patients in South African public healthcare facilities is critically insufficient. Given that hypertension is responsible for a rising share of deaths in South Africa and many of these deaths are preventable, urgent intervention is needed. (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Neonatal effects of intrauterine metoprolol/bisoprolol exposure during the second and third trimester: a cohort study with two comparison groups
Conclusion: Long-term intrauterine exposure to metoprolol or bisoprolol may increase the risk of being born small-for-gestational-age. It is still a matter of debate to which extent maternal hypertension contributes to the lower birth weight. Serious neonatal symptoms are rare. Altogether, metoprolol and bisoprolol are well tolerated treatment options, but a case-by-case decision on close neonatal monitoring is recommended. (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Left-versus-right-adrenal-volume ratio as a screening index before adrenal venous sampling to identify unilateral primary aldosteronism patients
Conclusion: Although not perfect, the L/Rv is an applicable index to screen unilateral primary aldosteronism patients for surgery. Primary aldosteronism patients, even those aged more than 35 years, with an L/Rv more than 1.908 or less than 0.765 can be spared AVS before surgery. (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Secondary hypertension Source Type: research

Concurrent heterozygous Von-Hippel–Lindau and transmembrane-protein-127 gene mutation causing an erythropoietin-secreting pheochromocytoma in a normotensive patient with severe erythrocytosis
Conclusion: Congenital polycythemia was clinically diagnosed, mimicking Chuvash polycythemia. Chuvash polycythemia is an autosomal recessive disorder that usually harbors a homozygous mutation of VHL598C>T but not predispose to pheochromocytoma development; in contrast our patient showed for the first time that the concurrent heterozygous VHL and TMEM mutations, resulted in a clinical phenotype of a normotensive patient with polycythemia due to erythropoietin-secreting pheochromocytoma that improved after adrenalectomy. (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Secondary hypertension Source Type: research

Atrial fibrillation as presenting sign of primary aldosteronism: results of the Prospective Appraisal on the Prevalence of Primary Aldosteronism in Hypertensive (PAPPHY) Study
Conclusion: These results provided compelling evidence that primary aldosteronism is highly prevalent in hypertensive patients with unexplained atrial fibrillation. Accordingly, they suggest that patients with no identifiable cause of the arrhythmia should be screened for primary aldosteronism to identify those who can be cured or markedly improved with target treatment. Clinical Trial Registration: : https://clinicaltrials.gov, Identifier: NCT01267747. (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Secondary hypertension Source Type: research

Biological convergence of three human and animal model quantitative trait loci for blood pressure
Conclusions: Two pathogenic pathways of hypertension biologically unify mechanisms of BP regulations for humans and their functional surrogates. The mechanism-based biology for the M3R-mediated pathway in raising BP has established M3R as a novel pathogenesis-driven target for antihypertension therapies. (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Experimental hypertension Source Type: research

Augmented blood pressure variability following continuous infusion of noradrenaline in rats
Conclusion: Continuous infusion of noradrenalin augmented 24-h BP variability partly through an α1-adrenergic receptor-mediated mechanism in rats, suggesting that the noradrenalin-infused rat is an animal model of augmented BP variability induced by persistent adrenergic activation. (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Experimental hypertension Source Type: research

Differences in regional grey matter volume of the brain are related to mean blood pressure and muscle sympathetic nerve activity in normotensive humans
Conclusion: We conclude that small differences in MBP and MSNA are associated with significant differences in grey matter volume in cortical and subcortical regions known to be involved in blood pressure regulation, suggesting that these structural differences contribute to resting MBP and MSNA and can predict the establishment of hypertension. (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Brain Source Type: research

Interrelation between midwall mechanics and longitudinal strain in newly diagnosed and never-treated hypertensive patients without clinically defined hypertrophy
Background: In hypertensive patients, an impairment of midwall myocardial mechanics was described in presence of left ventricular (LV) concentric geometry. Under these circumstances, also LV longitudinal dysfunction was found. Purpose: Our aim was to evaluate longitudinal and circumferential systolic function and correlations between these two functional components in newly diagnosed hypertensive patients without clinically defined LV hypertrophy (LVH). One hundred and thirty-eight newly diagnosed, never-treated hypertensive patients without LVH and a control group of 105 healthy normotensive individuals underwent two...
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Cardiac damage Source Type: research

Cardiac organ damage in patients with Parkinson's disease and reverse dipping
Conclusion: Reverse dipping and nocturnal hypertension are related to higher LV mass and increased prevalence of LV hypertrophy in Parkinson's disease patients. (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Cardiac damage Source Type: research

The association between 24-h blood pressure patterns and left ventricular mechanics
Conclusion: Nondipping and reverse dipping BP patterns had stronger impact on LV mechanics compared with patients with dipping and extreme dipping BP patterns in hypertensive population. LV functional and mechanical remodeling deteriorated from extreme dippers and dippers, to nondippers and reverse dippers. (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Cardiac damage Source Type: research

Right ventricular–pulmonary arterial uncoupling in mild-to-moderate systemic hypertension
Background: Mild-to-moderate hypertension with preserved left ventricular (LV) function may be associated with right ventricular (RV) dysfunction and increased pulmonary vascular resistance (PVR). Methods: The present study explored the adequacy of RV–pulmonary arterial (PA) coupling in 211 never-treated hypertensive patients (mean blood pressure, BP 112 ± 12 mmHg) and 246 controls (BP 93 ± 12 mmHg). They underwent a comprehensive transthoracic Doppler echocardiography, and RV–PA coupling was estimated by the tricuspid annular plane systolic excursion (TAPSE) to systolic pulmonary...
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Cardiac damage Source Type: research

Central arterial stiffness and retinal vessel calibers: the Atherosclerosis Risk in Communities Study–Neurocognitive Study
Conclusions: In older adults, cfPWV was associated with wider retinal venular caliber, particularly in individuals without hypertension. Central arterial stiffening may be associated with cerebral microvascular changes, as exhibited in its retinal vasculature component. (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Vascular damage Source Type: research

Acute vascular effects of vascular endothelial growth factor inhibition in the forearm arterial circulation
Objective: Although vascular endothelial growth factor inhibition (VEGFi) represents a major therapeutic advance in oncology, it is associated with hypertension and adverse vascular thrombotic events. Our objective was to determine whether VEGFi caused direct vascular dysfunction through increased endothelin-1 (ET-1) activity or impaired endothelial vasomotor or fibrinolytic function. Methods: Using forearm venous occlusion plethysmography, we measured forearm blood flow during intra-arterial infusions of bevacizumab (36–144 μg/dl forearm volume per minute) administered for 15–60 min in healthy volu...
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Vascular damage Source Type: research