Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis.

Conclusions: MCT-RVfib manifest a DNMT1-HIF-1α-PDK-mediated, chamber-specific, metabolic memory that promotes collagen production and RV fibrosis. This epigenetic mitochondrial-metabolic pathway is a potential antifibrotic therapeutic target. PMID: 32216531 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32216531?dopt=Abstract

Source: Circulation Research - March 26, 2020 Category: Cardiology Authors: Tian L, Wu D, Dasgupta A, Chen KH, Mewburn J, Potus F, Lima PA, Hong Z, Zhao YY, Hindmarch C, Kutty S, Provencher S, Bonnet S, Sutendra G, Archer SL Tags: Circ Res Source Type: research

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