Role of Connexin 43 increased expression in pulmonary arterial hyperreactivityinduced by the nerve growth factor NGF

In conclusion, NGF pathway is upregulated in IPAH cells. NGF increases Cx43 PA expression through activation of its TrkA receptor. NGF-induced Cx43 increased expression upregulates GAP junction activity, thus promoting PA hyperreactivity.

Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Cardouat, g., Douard, M., Roubenne, L., Bouchet, C., Kmecova, Z., Robillard, P., Guignabert, C., Tu, L., Delcambre, F., Marthan, R., Muller, B., Guibert, C., Freund-Michel, V. Tags: Pulmonary hypertension Source Type: research