Iron metabolism disorder regulated by BMP signaling in hypoxic pulmonary hypertension

CONCLUSIONS: Iron deficiency promoted oxidative stress and apoptosis in HPAECs in hypoxia-induced PH, and enhanced expression of hepcidin regulated by BMP6/BMPR2 signaling may contribute to iron metabolic disorder.PMID:36343841 | DOI:10.1016/j.bbadis.2022.166589

Source: Biochimica et Biophysica Acta - November 7, 2022 Category: Biochemistry Authors: Yujie Jiang Yingfan Guo Xuexiang Feng Pingting Yang Yi Liu Xuejing Dai Feilong Zhao Dongyu Lei Xiaohui Li Yuan Liu Ying Li Source Type: research