miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding

In conclusion, miR-145 alleviates phenotype transition from contractile to synthetic type via ADAM17-mediated ACE2 shedding in VSMCs and retains the activation of ACE2-Ang-(1-7)-Mas axis, which may benefit the vascular structural remodeling in the metabolic hypertension.PMID:37521117 | PMC:PMC10374374 | DOI:10.1155/2023/9497716

https://pubmed.ncbi.nlm.nih.gov/37521117/?utm_source=no_user_agent&utm_medium=rs...

Source: International Journal of Hypertension - July 31, 2023 Category: Cardiology Authors: Juan Wen Baiyi Tang Lan Guo Wei Chen Xiaohong Tang Source Type: research