[Renal hemosiderosis following mechanical hemolysis: An original case report].
We report here the case of a 73-year-old patient with acute kidney caused by a massive hemosiderosis following the proximal disinsertion of a prosthesis of the ascendant aorta with chronic aortic dissection. The kidney biopsy revealed the diagnosis, showing massive iron deposits inside the proximal tubules, especially with Perls staining and also diffuse hematic casts in the lumen of the tubules. Pathophysiology of hemosiderosis is well described, as well as protective mechanisms. This case report is one of the numerous different causes of renal hemosiderosis that can be related to genetic, infectious or mechanical hemolys...
Source: Nephrologie and Therapeutique - February 23, 2019 Category: Urology & Nephrology Authors: Zettl J, Mirgaine P, Aymard B, Valla M, Rahmati M, Tubail Z, Flechon-Meibody F, Savenkoff B Tags: Nephrol Ther Source Type: research

[Assessment of iron deficiency anemia management in the general hospital of Grenoble: A 12-month follow-up of an intravenous ferric carboxymaltose treatment program in a cohort of patients with non-dialysis-dependent chronic kidney disease].
Abstract INTRODUCTION: The FIND-CKD study has validated the use of ferric carboxymaltose (FCM) injection with a target of ferritin level between 400 and 600ng/mL to treat iron deficiency anemia in non-dialysis-dependent chronic kidney disease (ND-CKD) patients. In order to assess this strategy in clinical practice, we constituted a cohort of patients within our nephrology department. PATIENTS AND METHODS: Patients had CKD stages 3 to 5, hemoglobin level (Hb)
Source: Nephrologie and Therapeutique - February 22, 2019 Category: Urology & Nephrology Authors: Romanet T, Bedouch P, Zaoui P Tags: Nephrol Ther Source Type: research

Reprint of: Burden, access, and disparities in kidney disease.
PMID: 30799281 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - February 21, 2019 Category: Urology & Nephrology Authors: Crews DC, Bello AK, Saadi G, World Kidney Day Steering Committee Tags: Nephrol Ther Source Type: research

[What future for renal transplantation facing the challenges of the 2021 transplant program?]
PMID: 30765150 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - February 11, 2019 Category: Urology & Nephrology Authors: Moulin B, Hourmant M Tags: Nephrol Ther Source Type: research

[Lupus nephritis].
cute; Abstract Systemic lupus erythematosus is the most characteristic of auto-immune disorders that can lead to tissue damage in many organs, including kidney. Lupus nephritis occurs in 10 to 40% of lupus patients. Its clinical hallmark is the appearance of a proteinuria as soon as a 0.5 g/g or 0.5 g/d threshold, which calls for a renal histological evaluation in order to determine the lupus nephritis severity and the need for specific therapy. More than half of renal biopsies lead to the diagnosis of active lupus nephritis-class III or class IV A according to the ISN/RPS classification-t...
Source: Nephrologie and Therapeutique - February 7, 2019 Category: Urology & Nephrology Authors: Raimbourg Q, Daugas É Tags: Nephrol Ther Source Type: research

Beta-blockers use from the general to the hemodialysis population.
Abstract Beta-blockers have numerous indications in the general population and are strongly recommended in heart failure, post-myocardial infarction and arrhythmias. In hemodialysis patients, their use is based on weak evidence because of the lack of a sufficient number of randomized clinical trials. The strongest evidence is based on two trials. The first showed better survival with carvedilol in hemodialysis patients with four sessions per week and systolic heart failure. The second found reduced cardiovascular morbidity with atenolol compared to lisinopril in mostly black hypertensive hemodialysis patients. No ...
Source: Nephrologie and Therapeutique - February 1, 2019 Category: Urology & Nephrology Authors: Aoun M, Tabbah R Tags: Nephrol Ther Source Type: research

Intravenous infusion of glucose 5% despite sodium mixed, is main contributor of acquired hyponatremia in adult polyvalent medicine service: Case control study.
Abstract BACKGROUND: Acquired hyponatremia is a life threatening event. Intravenous infusion of a mixture of 5% glucose and sodium solute is mainly used, but its contribution in the occurrence of acquired hyponatremia in adult, is under-investigated outside intensive care unit. OBJECTIVE: To evaluate the place of intravenous infusion of a mixture of 5% glucose and sodium in predicting acquired hyponatremia in adult polyvalent medicine service. PATIENTS AND METHODS: A case-control study have been conducted. The main exposure was intravenous infusion of a mixture of 5% glucose and sodium solute (4 gra...
Source: Nephrologie and Therapeutique - February 1, 2019 Category: Urology & Nephrology Authors: Mackanga JR, Dibambou N, Mouloungui EM, Iba-Ba J, Kombila UD, Bignoumba PI, Moussavou IM, Missounga L, Kombila JM, Boguikouma JB Tags: Nephrol Ther Source Type: research

[Lyme nephritis in humans: Physio-pathological bases and spectrum of kidney lesions].
ing L Abstract Known in less than half a century, borreliosis, or Lyme disease, is a zoonosis caused by the tick bite. It is the most common vector disease in Europe and the United States. Borrelia burgdorferi sensu lato, the bacterium in question, is fitted with a "cunning device" that allows it to trick the immune system and implant the infection chronically. It causes multi-system tissue damage mediated by the inflammatory response of the host. Renal involvement is rarely reported and is better known in dogs as Lyme nephritis. The first case of kidney impairment in the human being was d...
Source: Nephrologie and Therapeutique - January 31, 2019 Category: Urology & Nephrology Authors: Gueye S, Seck SM, Kane Y, Tosi PO, Dahri S, Kounde C, Algouzmari I, Gouin A, Ged É, Allal A, Rostaing L Tags: Nephrol Ther Source Type: research

Interest of therapeutic drug monitoring of aminoglycosides administered by a monodose regimen.
The objective of this study is to evaluate the impact of TDM in achievement or maintaining target serum concentrations in patients receiving once-daily administration of AG. METHODS: We performed a retrospective analysis of data from patients having received a once daily amikacin or gentamicin and underwent routine TDM. A longitudinal follow up was performed. Data were analyzed according to the adhesion or not to recommendations. A logistic regression was performed in order to evaluate the effect of covariates (age, gender, weight, creatinine clearance [CLcr], TDM-based dose adjustment, weighted dose of AG) on the ach...
Source: Nephrologie and Therapeutique - January 16, 2019 Category: Urology & Nephrology Authors: Ben Romdhane H, Ben Fredj N, Chaabane A, Ben Aicha S, Chadly Z, Ben Fadhel N, Boughattas N, Aouam K Tags: Nephrol Ther Source Type: research

[Clinical management of patients with hemophilia A in nephrology: Diagnostic and therapeutic challenges illustrated by the cases of 2 patients].
che N Abstract Hemophilia A is an X-linked genetic hemorrhagic disorder characterized by a factor VIII deficiency. The availability of secured substitution products has led to a dramatic improvement of life expectancy in hemophiliac patients. Nowadays, adult hemophiliac patients may develop Chronic Kidney Disease (CKD) resulting from age-related comorbidities (hypertension, obesity, diabetes). In addition, the high prevalence of viral infections in this population exposes patients to an increased risk of CKD. The risk of hemorrhage in hemophiliac patients is a challenge for their clinical management, both for...
Source: Nephrologie and Therapeutique - January 16, 2019 Category: Urology & Nephrology Authors: Fedi M, Falaise C, Lanot A, Von Kotze C, Robert T, Piétri L, Henri P, Delmotte N, Botta D, Verhelst D, Chambost H, Brunet P, Jourde-Chiche N Tags: Nephrol Ther Source Type: research

[Renal toxicity of lithium].
Discussion about stopping or not lithium in case of renal failure needs multidisciplinary expertise and depends on psychiatric status and renal function. PMID: 30658901 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - January 15, 2019 Category: Urology & Nephrology Authors: Servais A Tags: Nephrol Ther Source Type: research

[Risk control of dialysis fluids production in a teledialysis unit].
CONCLUSION: The exhaustive analysis of the risks and their prioritisation have permitted to establish a relevant action plan in this improving quality of dialysis fluids approach. The risk control of dialysis fluids is necessary for the security of dialysis sessions for patients, even more when these sessions are realized by telemedicine in Saint-Pierre-et-Miquelon. PMID: 30655239 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - January 14, 2019 Category: Urology & Nephrology Authors: Letournel C, Babinet F, Allard B, Montecot V Tags: Nephrol Ther Source Type: research

[Epidemiology of acute renal failure].
tte A Abstract The acute renal failure is common in the hospitalized patients with the incidence is increasing. This results from the aging of the population and the widespread use of nephrotoxic therapies or diagnostic techniques. The acute renal failure is associated with an increased length of stay in hospital and the short and long-term mortality. The most common histological injury is the acute tubular necrosis. Although the most of acute renal failure is recovering, recent works have shown that there is a strong association between an acute renal failure and the increased risk of developing a chronic kidney ...
Source: Nephrologie and Therapeutique - January 10, 2019 Category: Urology & Nephrology Authors: Aniort J, Heng AÉ, Deteix P, Souweine B, Lautrette A Tags: Nephrol Ther Source Type: research

[Short-term effects with sucroferric oxyhydroxide in hemodialysis patients: Experience in NephroCare France].
Abstract INTRODUCTION: Despite a better management of hyperphosphatemia in haemodialysis patients observed during the past years, most of them remain insufficiently treated and exposed to bone and cardiovascular complications that are associated with this biological abnormality. The availability of calcium-free phosphate binders among therapeutical options is confirmed to significantly reduce serum phosphate levels without the risk of excess exposure to calcium. Currently sucroferric oxyhydroxyde (SO) is the only iron-based phosphate binder available in France. METHODS: A cohort of patients prescribed OHS has...
Source: Nephrologie and Therapeutique - January 10, 2019 Category: Urology & Nephrology Authors: Chazot C, Fadel B, Kareche M, Puyoo O, Jean G Tags: Nephrol Ther Source Type: research

[Effects of acoustic treatment of a dialysis room on the quality of life of patients].
Abstract The impairment of quality of life experienced by patients treated with chronic hemodialysis results from many factors, including the care environment. Current regulations have significantly improved reception and treatment conditions for patients, but perhaps insufficient attention has been paid to the noise nuisance associated with dialysis equipment. We therefore found it useful to conduct a study on acoustic parameters in the dialysis room, and to evaluate the effects on perceived quality of life of an acoustic treatment intended to reduce the level of ambient noise. After measurements carried out unde...
Source: Nephrologie and Therapeutique - December 11, 2018 Category: Urology & Nephrology Authors: Fumey F, Benarrous E, Souquet L, Rousset B, Soares J, Oltra-Gay C, Laville M Tags: Nephrol Ther Source Type: research

[Tubulointerstitiel nephritis and Crohn's disease, nephrotoxicity or extraintestinal manifestation of Crohn's disease? About a case].
Abstract Extraintestinal manifestations in inflammatory bowel disease involve most frequently the joints, the skin, the eyes, the liver and the biliary tract. Renal involvement is rare, and manifested as nephrolithiasis, tubulointerstitial nephritis, glomerulonephritis and amyloidosis. In patients with inflammatory bowel disease, renal disease is most frequently due to treatment nephrotoxicity and rarely as a guenine extraintestinal manifestation of inflammatory bowel disease. We are reporting a case of tubulointerstitial nephritis as an extraintestinal manifestation of Crohn's disease and we are explaining the di...
Source: Nephrologie and Therapeutique - November 29, 2018 Category: Urology & Nephrology Authors: Treffel M, Champigneulle J, Meibody F, Laurain E, Frimat L, Busby-Venner H Tags: Nephrol Ther Source Type: research

[Nephrotoxicity of plasma volume expanders].
Abstract Expansion of extracellular volume is a treatment traditionally proposed to correct abnormalities of renal perfusion and prevent ischemic injury. However, vascular filling is not at risk for tissue oxygenation and renal function. The use of synthetic colloids exposes the patient to the risk of developing lesions such as osmotic nephrosis. Hyperoncotic colloids reduce glomerular filtration pressure. The nephrotoxicity of hydroxyethyl starches is now clearly established regardless of their characteristics. Colloids have never demonstrated their superiority as plasma volume expanders, they should be abandoned...
Source: Nephrologie and Therapeutique - November 12, 2018 Category: Urology & Nephrology Authors: Commereuc M, Schortgen F Tags: Nephrol Ther Source Type: research

[Calcific uremic arteriolopathy in hemodialysis patient, review of literature through five cases reports].
Abstract Calcific uremic arteriolopathy, also called calciphylaxis, is a rare and severe disorder that presents with skin ischemia and necrosis, sometimes it presents with systemic necrosis, the process is secondary to the obliteration of the arterioles first by sub-intimal calcium deposits and then by thrombosis. These lesions can often lead to death due to infectious complications and comorbidities such as diabetes, obesity, arteritis, diffuse vascular calcifications, heart disease and undernutrition. The diagnosis is suggested by the characteristic ischemic skin lesions and their distribution, often bilateral a...
Source: Nephrologie and Therapeutique - November 1, 2018 Category: Urology & Nephrology Authors: Chettati M, Adnouni A, Fadili W, Laouad I Tags: Nephrol Ther Source Type: research

[Life-threatening hypercalcemia and acute kidney injury induced by etanercept].
We report a case of sarcoid-like granulomatosis manifesting as life-threatening hypercalcemia and acute kidney injury in a woman treated with etanercept for a rheumatoid arthritis. Seven days after admission, she developed hypoxemic interstitial pneumonia with negative mycobacterial and fungal analysis. This picture suggested sarcoid-like disease induced by tumor necrosis factor blockers and prompted etanercept cessation. Kidney biopsy performed 30 days after admission revealed significant acute interstitial nephritis and intratubular calcium crystals. Staining for acid-fast bacilli and fungi was negative. Clinical pi...
Source: Nephrologie and Therapeutique - November 1, 2018 Category: Urology & Nephrology Authors: Tsevi YM, Aydin S, Durez P, Labriola L Tags: Nephrol Ther Source Type: research

[Hyperthyroidism-induced calciphylaxis: A case report].
CONCLUSION: This is the first description of AUC secondary to hyperthyroidism in a dialysis patient. Multidisciplinary care is essential to achieve clinical improvement in those critical situations. PMID: 30385137 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - October 29, 2018 Category: Urology & Nephrology Authors: Delma S, Isnard-Bagnis C, Deray G, Barthelemy RN, Mercadal L, Desbuissons G Tags: Nephrol Ther Source Type: research

[Management of Gitelman syndrome during pregnancy reporting 12 cases].
CONCLUSION: Gitelman syndrome is a rare pathology where there is a lack of homogeneity in management of pregnancy. Monitoring of monthly ionogram is necessary. The goal is to obtain stable, non-symptomatic kaliemias, which will never be standardized even in increasing treatment. The most important is to inform and detect situations at risk of decompensation, including vomiting or the use of certain anesthetics. In agreement with literature data, monitoring of fetal growth and the amount of amniotic fluid in the third trimester is still warranted. These pregnancies require the development of a common care in multidisciplina...
Source: Nephrologie and Therapeutique - October 8, 2018 Category: Urology & Nephrology Authors: Elbouajaji K, Blanchier D, Pourrat O, Sarreau M Tags: Nephrol Ther Source Type: research

Plasmacytoma-like post-kidney-transplant lymphoproliferative disorder confined to renal allograft and urinary tract: A case report.
We report a case of a patient who developed an extramedullary plasmacytoma-like PTLD around his transplanted kidney treated with standard multiple myeloma chemotherapy. Three years after benefiting of a deceased donor kidney transplant for an end stage kidney disease secondary to nephroangiosclerosis, our patient developed an extra-medullary plasmacytoma confined to the transplant compartment. The transplant function was unaltered, and due to the absence of reduction of the lesion after immunosuppression reduction, a chemotherapy by bortezomib-cyclophosphamide-dexamethasone (VCD) known to be efficient in multiple myeloma w...
Source: Nephrologie and Therapeutique - October 6, 2018 Category: Urology & Nephrology Authors: Thibaud V, Rivalan J, Llamas F, Cherel M, Decaux O, Vigneau C Tags: Nephrol Ther Source Type: research

[Non-iodinated contrast media nephrotoxicity].
This article focuses on the description of the risks of gadolinium-based contrast agents, reviews existing recommendations and best practices to guide the choice of clinicians. PMID: 30301611 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - October 6, 2018 Category: Urology & Nephrology Authors: Janus N, Launay-Vacher V, Deray G Tags: Nephrol Ther Source Type: research

[Human resources allocated to kidney transplantation in 2016  in France: A national survey].
In conclusion, this survey shows that an increase in the number of medical, surgical and paramedical staff will be necessary to achieve departmental objectives. PMID: 30154055 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - August 25, 2018 Category: Urology & Nephrology Authors: Gatault P, Hazzan M, Anglicheau D, Moulin B, Commission transplantation de la SFNDT Tags: Nephrol Ther Source Type: research

[Up to date of pathophysiology mechanism of idiopathic nephrotic syndromes: Minimal change disease and focal and segmental glomerulosclerosis].
Abstract Idiopathic nephrotic syndrome represents up to 30% of adult glomerulopathies. However, its prognosis according to remission, relapse and renal failure remains unchanged since the 80s and prediction remains difficult. Physiopathology of adult idiopathic nephrotic syndrome is complex and multifactorial, including immunologic and environmental factors and a putative permeability-circulating factor, still unknown. In this point of view, we propose to summarize actual knowledge about idiopathic minimal change disease and focal and segmental glomerulosclerosis physiopathology. PMID: 30150079 [PubMed - as s...
Source: Nephrologie and Therapeutique - August 24, 2018 Category: Urology & Nephrology Authors: Dumas De La Roque C, Combe C, Rigothier C Tags: Nephrol Ther Source Type: research

Intracellular organelles in health and kidney disease.
Abstract Subcellular organelles consist of smaller substructures called supramolecular assemblies and these in turn consist of macromolecules. Various subcellular organelles have critical functions that consist of genetic disorders of organelle biogenesis and several metabolic disturbances that occur during non-genetic diseases e.g. infection, intoxication and drug treatments. Mitochondrial damage can cause renal dysfunction as ischemic acute renal injury, chronic kidney disease progression. Moreover, mitochondrial dysfunction is an early event in aldosterone-induced podocyte injury and cardiovascular disease due ...
Source: Nephrologie and Therapeutique - June 7, 2018 Category: Urology & Nephrology Authors: Shamekhi Amiri F Tags: Nephrol Ther Source Type: research

[Immunizations for patients with kidney disease].
cute; Abstract Chronic kidney disease (CKD) is associated with significant infectious complications leading to adverse health outcomes. This increased susceptibility to infection can be related to the nephropathy itself as observed in nephrotic syndrome, to the treatment especially in situations requiring immunosuppressive drugs or related to dialysis. Despite a less effective response to vaccination, some data emphasize similar benefits from immunization among people with CKD to the general population. However, some situations encountered in nephrology require adaptation of immunization practices. The aim of this...
Source: Nephrologie and Therapeutique - June 7, 2018 Category: Urology & Nephrology Authors: Trivin-Avillach C, Thervet É Tags: Nephrol Ther Source Type: research

[Description of immunosuppressive maintenance treatments post kidney transplant through the National System of Health Insurance].
This study confirms the difficulty of apprehending drug consumption based only on dispensing in pharmacies or punctual recording even if it allows a fairly comprehensive view of French practices. PMID: 29887268 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - June 7, 2018 Category: Urology & Nephrology Authors: Sitruk L, Couchoud C, Hourmant M, Tuppin P, Macher MA, Legeai C Tags: Nephrol Ther Source Type: research

[The different modalities of isonatric hemodialysis].
Abstract Setting dialysate sodium allows to adequately adjust sodium balance and plasma sodium at the end of dialysis session. In accordance with the set-point theory based on the concept of restoring cellular hydration, an adequate target for plasma sodium at the end of the session could be the value of predialysis plasma sodium concentration (isonatric hemodialysis). Some recently available dialysis monitors provide an on-line value of plasma-water conductivity usually converted in on-line natremia. There are different modalities of isonatric hemodialysis depending on whether the online value of natremia is used...
Source: Nephrologie and Therapeutique - June 7, 2018 Category: Urology & Nephrology Authors: Petitclerc T, Gaillard F Tags: Nephrol Ther Source Type: research

Cytomegalovirus infection in the first year after pediatric kidney transplantation.
This study confirms the influence of donor and recipient CMV status on infection propensity and highlights the importance of adequate follow-up for intermediate risk patients. PMID: 29887270 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - June 7, 2018 Category: Urology & Nephrology Authors: Tanné C, Roy P, Frobert É, Duncan A, Laurent A, Cochat P Tags: Nephrol Ther Source Type: research

[Post-streptococcal glomerulonephritis in the south of Tunisia: A 12-year retrospective review].
CONCLUSION: PSGN remains a common nephropathy in our region. The detection and effective treatment of any infection that may be involved can reduce the incidence of this disease. PMID: 29735420 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - May 4, 2018 Category: Urology & Nephrology Authors: Maalej B, Ben Amor M, Jallouli M, Weli M, Charfi M, Abdelkefi Y, Chakroun O, Kamoun K, Hachicha J, Rekik N, Gargah T, Gargouri L, Mahfoudh A Tags: Nephrol Ther Source Type: research

[Impact of the adjunction of boiled-egg during the chronic hemodialysis session on the nutrition state].
Abstract Denutrition for chronic hemodialysed patients is common and severe, often the first step of many complication and comorbidities. This work was aimed to study the impact of the adjunction of hard-boiled egg during six months, at the time of the hemodialysis session, if the classic nutritional support with oral nutritional supplements and intradialytic parenteral nutrition has failed. Required criteria were: Albuminemia, prealbuminemia and Moreau and Gaudry's score. Thirty-six patients have been included. During the six months, the following nutritional parameters have improved: Moreau and Gaudry's score de...
Source: Nephrologie and Therapeutique - April 27, 2018 Category: Urology & Nephrology Authors: Muller C, Knoerr F, Kolb I, Garstka A, Fumaroli JV, Richter S Tags: Nephrol Ther Source Type: research

[Severe hypercalcemia of unusual cause, looking for the culprit: Case report and review of the literature].
CONCLUSION: We report an original case of intoxication by dihydrotachysterol. The risk of hypercalcemia encountered with this molecule must be known. The close medical follow-up recommended in case of hypoparathyroidism seems to be particularly necessary in case of supplementation by this molecule. PMID: 29709532 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - April 27, 2018 Category: Urology & Nephrology Authors: Jalbert M, Mignot A, Gauchez AS, Dobrokhotov AC, Fourcade J Tags: Nephrol Ther Source Type: research

[Current insights about recurrence of glomerular diseases after renal transplantation].
Abstract Recurrence of glomerular disease after renal transplantation is a frequent cause of graft loss. Incidence, risk factors and outcome of recurrence are widely due to the underlying glomerular disease. Graft biopsy analysis is required to confirm the definitive diagnosis of recurrence and to start an appropriate therapy that, in some cases, remains challenging to prevent graft failure. Increased use of protocol biopsy and recent advances in our understanding of the pathogenesis of some glomerular diseases with the identification of some relevant biomarkers provide a unique opportunity to initiate kidney-prot...
Source: Nephrologie and Therapeutique - April 26, 2018 Category: Urology & Nephrology Authors: Kofman T, Oniszczuk J, Lang P, Grimbert P, Audard V Tags: Nephrol Ther Source Type: research

[PKHD1  mutations in autosomal recessive polycystic kidney disease (ARPKD): Genotype-phenotype correlations from a series of 308 cases to improve prenatal counselling].
This study was performed in 308 ARPKD patients with a genetic diagnosis from our genetic center. Related physicians provided minimal clinical and biological data. RESULTS: Patients were divided into three genotypic groups: the first group (G1; n=65) consisted of patients with two truncating mutations, the second group (G2; n=117) of patients with one truncating and one non-truncating mutation, and the third group (G3; n=126) of patients with two non-truncating mutations. In the entire cohort, the outcomes consisted of 31% of pregnancy termination, 18% of neonatal deaths and 51% of patient survival after the neona...
Source: Nephrologie and Therapeutique - April 24, 2018 Category: Urology & Nephrology Authors: Hamo S, Bacchetta J, Bertholet-Thomas A, Ranchin B, Cochat P, Michel-Calemard L Tags: Nephrol Ther Source Type: research

[The reality on peritoneal dialysis in France: 40years after].
Abstract The share of peritoneal dialysis (PD) in the spectrum of chronic dialysis has decreased in France over the last ten years. Despite various facilities offered by the health authorities, PD remains confidential in many private units and some public hospitals. The enthusiasm present at the beginning of this technology, forty years ago, is declining, despite a real improvement in new developments, a real increase in patient survival, today at least similar to that on hemodialysis. Then, the aim of this review is first to give a summary of the principles and practice of patient and staff education and to descr...
Source: Nephrologie and Therapeutique - April 11, 2018 Category: Urology & Nephrology Authors: Rottembourg J, Rostoker G Tags: Nephrol Ther Source Type: research

Women and kidney disease: reflections on World Kidney Day 2018.
PMID: 29631701 [PubMed - in process] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - April 1, 2018 Category: Urology & Nephrology Authors: Piccoli GB, Alrukhaimi M, Liu ZH, Zakharova E, Levin A, World Kidney Day Steering Committee Tags: Nephrol Ther Source Type: research

[Cyclophosphamide in idiopathic nephrotic syndrome: Outcome and outlook].
The objectives of this study are to determine long-term outcomes of cyclophosphamide and identify the factors associated with sustained remission. METHODS: We retrospectively studied the data from 50 patients with idiopathic nephrotic syndrome, treated by oral cyclophosphamide and followed at service of pediatric for more than 8 years for idiopathic nephrotic syndrome and related factors for survival without relapse were evaluated by univariate analysis. RESULTS: The median age at the time of diagnosis was 4.3 years, and median follow-up time was 1.7 years with the median of 8 years at the first use of CYC. Patie...
Source: Nephrologie and Therapeutique - April 1, 2018 Category: Urology & Nephrology Authors: Berkane M, Adarmouch L, Amine M, Bourrahouat A, Ait Sab I, Sbihi M Tags: Nephrol Ther Source Type: research

Recent advances in the physiopathology of IgA nephropathy.
Abstract Immunoglobulin A nephropathy or Berger's disease is the most common type of primary glomerulonephritis, which is characterized by IgA1-containing immune-deposits in the glomerular mesangium. Microscopic haematuria and proteinuria are the most common presentations. Mesangial cell proliferation with IgA deposition is found on renal biopsy. Mechanims of the disease implicate at least four key molecules have been implicated in immune complex formation: galactose-deficient IgA1, autoantibodies anti-galactose-deficient-IgA1, soluble CD89 (Fc receptor for IgA) and the CD71 mesangial IgA receptor (transferrin rec...
Source: Nephrologie and Therapeutique - April 1, 2018 Category: Urology & Nephrology Authors: Monteiro RC Tags: Nephrol Ther Source Type: research

[Renal toxicity of high-dose methotrexate].
CONCLUSION: Sixty-one percent of patients received a glucarpidase perfusion during acute kidney injury. Despite a dramatic decrease of methotrexate serum levels, glucarpidase as compared with conservative treatment did not modify acute kidney injury stage, recovery delay, need for renal replacement therapy or the incidence of extrarenal toxicities. Net clinical benefit was not observed even after stratification according to eligibility criteria for glucarpidase use. Glucarpidase has probably no or little effects on methotrexate localized into tubular lumen or proximal tubular cells and that may account for the absence of n...
Source: Nephrologie and Therapeutique - April 1, 2018 Category: Urology & Nephrology Authors: Garcia H, Leblond V, Goldwasser F, Bouscary D, Raffoux E, Boissel N, Broutin S, Joly D Tags: Nephrol Ther Source Type: research

[Ifosphamide nephrotoxicity].
In conclusion, ifosfamide nephrotoxicity is often severe and irreversible, leading to proximal tubulopathy and sometimes-severe chronic kidney failure, that can be immediate or delayed, sometimes diagnosed months after chemotherapy completion. PMID: 29606257 [PubMed - in process] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - April 1, 2018 Category: Urology & Nephrology Authors: Ensergueix G, Karras A Tags: Nephrol Ther Source Type: research

Treatment of IgA nephropathy: Recent advances and prospects.
Abstract IgA nephropathy, identified 50 years ago in France, is the most frequent glomerular disease worldwide. The course is variable, but in most of the cases there is a relentless decline in renal function, reaching end-stage renal failure in 10-60% of the cases after 10 years and in 40% after 20 years. These data justify the interest for finding a suitable therapeutic approach particularly in progressive cases. A supportive care, including renin-angiotensin system inhibitors is the priority in cases with slowly declining renal function, particularly when developing proteinuria. The recent supportive versus imm...
Source: Nephrologie and Therapeutique - April 1, 2018 Category: Urology & Nephrology Authors: Coppo R Tags: Nephrol Ther Source Type: research

[Vancomycin nephrotoxicity: Frequency and mechanistic aspects].
Abstract Vancomycin, discovered in 1953 and widely used today, has a nephrotoxic potential that has long been debated. The frequency of renal involvement is variable and can range from 5% to 30% depending concomitant risk factors: overdose, chronic kidney disease, obesity, hypovolemia, and use of other nephrotoxic drugs as aminoglycosides. Its association with piperacillin-tazobactam also appears to increase the risk of nephrotoxicity. This hypothesis should be confirmed experimentally. Vancomycin-induced oxidative stress in tubular cells and intraluminal cast formation are the two physiopathological mechanisms ex...
Source: Nephrologie and Therapeutique - April 1, 2018 Category: Urology & Nephrology Authors: Luque Y, Mesnard L Tags: Nephrol Ther Source Type: research

[Transplantation strategy in type 1 diabetic patients].
Abstract Beta cell replacement by pancreas or Langerhans islets transplantation is the only way to restore glucose homeostasis in type 1 diabetic patients. The counterpart is the need for long-term immunosuppression. These transplantations are therefore mainly indicated for patients candidates for kidney transplantation and for patients with poor quality of life due to unstable diabetes with life-threatening hypoglycemic events. Both beta cell replacement techniques have different benefits and risks and should be adapted to each type 1 diabetic patient. The transplant strategy must be personalized according to par...
Source: Nephrologie and Therapeutique - April 1, 2018 Category: Urology & Nephrology Authors: Buron F, Badet L, Morelon E Tags: Nephrol Ther Source Type: research

Prognosis and treatment of diabetic nephropathy: Recent advances and perspectives.
ler M Abstract Approximately 20 to 40% of patients with type 1 or type 2 diabetes develop diabetic kidney disease. It is a clinical syndrome characterized by persistent albuminuria (>300mg/24h, or 300mg/g creatinine), a relentless decline in glomerular filtration rate, raised arterial blood pressure and enhanced cardiovascular morbidity and mortality. The natural course of classical diabetic nephropathy is initially microalbuminuria or moderately increased urine albumin excretion (30-300mg/g creatinine). Untreated microalbuminuria may then rise gradually, reaching severely increased albuminuric (macroalbuminuri...
Source: Nephrologie and Therapeutique - April 1, 2018 Category: Urology & Nephrology Authors: Rossing P, Persson F, Frimodt-Møller M Tags: Nephrol Ther Source Type: research

[Identifying the specific causes of kidney allograft loss: A population-based study].
CONCLUSION: The main causes of allograft loss were antibody-mediated rejection and thrombosis. These results encourage efforts to prevent and detect these complications earlier in order to improve allograft survival. PMID: 29606262 [PubMed - in process] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - April 1, 2018 Category: Urology & Nephrology Authors: Lohéac C, Aubert O, Loupy A, Legendre C Tags: Nephrol Ther Source Type: research

[Multidimensional approaches for risk stratification in transplantation].
te; M Abstract Despite considerable progress in the short-term outcomes of renal transplantation, there has been little improvement over the last 15years on long-term survival. The main limitation is the lack of precise knowledge of the determinants of renal allograft loss and robust prognostic systems providing an individual prediction. Kidney transplantation must address a pressing clinical need to accurately define the determinants of kidney renal allograft survival in order to improve risk stratification. To achieve this goal, four steps need to be considered in the development of prognostic tools: the charact...
Source: Nephrologie and Therapeutique - April 1, 2018 Category: Urology & Nephrology Authors: Aubert O, Racapé M Tags: Nephrol Ther Source Type: research

[Glomerular filtration rate estimation and measurement: The quest for precision].
Abstract Glomerular filtration rate measurement is still the best way to assess the global renal function. In daily practice, glomerular filtration rate is estimated by creatinine-based equations. Serum creatinine as a renal biomarker has however several limitations. We discuss the current recommended creatinine-based equations. The potential added value of a new biomarker, cystatin C, and alternative equations will be discussed. Finally, the potential interest of measured glomerular filtration rate by a reference method in specific patients and/or situations will be discussed and justified. PMID: 29606264 [P...
Source: Nephrologie and Therapeutique - April 1, 2018 Category: Urology & Nephrology Authors: Delanaye P Tags: Nephrol Ther Source Type: research

[Evaluation of living kidney donors renal function].
Abstract End-stage renal disease risk of living kidney donors is lower than the one in general population. In 2014, two independent studies confirmed this result but evidenced an increased risk of end-stage renal disease after donation. In this context, long-term consequences of living donation need to be better defined. Evaluation of renal function is a cornerstone of living donor screening. Precise knowledge of kidney donation physiology is required to propose a relevant predonation screening. In this review, we present the risks of donation, the physiology of living donation and discuss international guidelines...
Source: Nephrologie and Therapeutique - April 1, 2018 Category: Urology & Nephrology Authors: Gaillard F, Courbebaisse M Tags: Nephrol Ther Source Type: research

[Pulmonary ultrasound and dialysis].
L, Massy ZA Abstract Profound deficit of the body fluid composition regulation system is present at the end stage kidney disease, leading to the increase the risk of acute or chronic volume overload, which impacts the morbidity and mortality in these patients. Pulmonary ultrasound by its ability to estimate extrapulmonary water at an infraclinical stage has helped to make progress in this area. Line B is the element of fundamental semiology that reflects the presence of water in the pulmonary alveoli. The alteration of left ventricular function and the increase of pulmonary capillary permeability are the determini...
Source: Nephrologie and Therapeutique - April 1, 2018 Category: Urology & Nephrology Authors: Seidowsky A, Vilaine È, Mansencal N, Ébel A, Villain C, Cheddani L, Massy ZA Tags: Nephrol Ther Source Type: research