[How to manage abdominal hernia on peritoneal dialysis?]
bet M Abstract Abdominal hernias are a frequent complication in peritoneal dialysis, representing up to 60.4% of anatomical complications. Their prevalence varies between 7 and 27.5%. Established risk factors are male gender, an older age, multiparity, a low body mass index and a paramedian approach for the catheter insertion. Polykystic renal disease and the intra-peritoneal volume are controversial risk factors. The diagnosis is mainly clinical, though peritoneography imaging can be useful in difficult cases. Hernia's complications, of strangulation, incarceration, bowel occlusion and peritonitis; can be very se...
Source: Nephrologie and Therapeutique - January 27, 2020 Category: Urology & Nephrology Authors: Boyer A, Bonnamy C, Lanot A, Guillouet S, Béchade C, Recorbet M Tags: Nephrol Ther Source Type: research

[Clarification of the method used for drug dosage adjustment in patients with renal failure: The CLEAR study].
CONCLUSION: The majority of summaries of product characteristics do not mention the Cockcroft-Gault formula and in the majority of cases it is not possible to identify the formula or technique used in the studies on which is based the reference to dosage adjustment in the summarie of product characteristics. In addition, there are discrepancies between the wording of the summaries of product characteristics and the data from development studies. The use of Cockcroft-Gault for dosage adjustment is to be questioned, especially since the Isotope-dilution mass spectrometry, or IDMS, standardization of creatinine dosage makes o...
Source: Nephrologie and Therapeutique - January 24, 2020 Category: Urology & Nephrology Authors: Berdougo J, Delorière É, Deray G, Launay-Vacher V Tags: Nephrol Ther Source Type: research

[End stage kidney disease in Maghreb and Africa: Overview of transplant programs in Maghreb and Africa].
sig M Abstract Kidney transplantation is the best treatment for the patient with end stage kidney disease in term of increasing the survival rate, reducing complications, improving quality of live and its lower cost compared to peritoneal dialysis or hemodialysis. However, the number of patients waiting for kidney transplantation is growing day by day and the gap between demand and supply is still huge. This situation is even more complicated in developing countries where the lack of legislation, infrastructure and government involvement is common. Some national transplantation programs have been implemented, with...
Source: Nephrologie and Therapeutique - January 24, 2020 Category: Urology & Nephrology Authors: Nlandu Y, Hamaz S, Robert A, Cheddani L, Vilaine È, Seidowsky A, Ebel A, Massy Z, Essig M Tags: Nephrol Ther Source Type: research

[Low Body Mass Index and impact of antiretroviral therapy on nephrotoxicity, chronic renal disease among HIV-infected patients in Brazzaville, Congo].
Abstract OBJECTIVE: To describe the incidence and risks factors of ART induced nephrotoxicity and chronic kidney disease in HIV-1-infected adults with low body mass index (
Source: Nephrologie and Therapeutique - January 24, 2020 Category: Urology & Nephrology Authors: Herbas Ekat M, Tidiane Ndour C, Bienvenue Ossibi Ibara R, Diafouka M, Boumandoki P, Adoua Doukaga T, Axel Aloumba G, Mahambou-Nsonde D, Roger Nzounza P, Obengui P, Seydi M Tags: Nephrol Ther Source Type: research

[Amending of the 3rd cycle of medical studies in France: What the nephrologists stand for].
io JP Abstract 2017 was the year during which France has seen the amendment of the 3rd cycle of medical education. Three new steps have been uploaded: "basement", "in depth", and "liability". The latter has been particularly discussed as it is really close to the former post-graduate state. Nephrology has always been a very attractive discipline. While most others have been increased in terms of length in initial medical education, nephrology has been assigned to 4 years. Altogether, nephrologists whatever their generation have led a series of questionnaires we report here. From 3 of ...
Source: Nephrologie and Therapeutique - January 17, 2020 Category: Urology & Nephrology Authors: Lohéac C, Maisons V, Bureau C, Bertocchio JP Tags: Nephrol Ther Source Type: research

[Ericksonian hypnosis and mindfulness meditation: Towards a behavioral medicine in nephrology].
The objective of this report is to describe how Ericksonian hypnosis, mindfulness meditation and compassion meditation could support chronic kidney disease patients, their caregivers and the health-care professional. PMID: 31928954 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - January 9, 2020 Category: Urology & Nephrology Authors: Thuillier Lecouf A, Videloup L, Letrecher S, Béchade C, Recorbet M, Chatelet V Tags: Nephrol Ther Source Type: research

[Nephropathy associated with hypocomplementemic urticarial vasculitis: A case report and literature review].
Abstract Hypocomplementemic urticarial vasculitis is a rare systemic vasculitis, affecting small vessels, characterised by chronicle urticaria, hypocomplementemia, and systemic manifestations. Renal involvement, whose prevalence varies between 9% and 60%, is mainly glomerular. We here report the case of a 59 years old woman presenting kidney failure, associated with chronicle urticaria and arthralgias. Laboratory investigation showed haematuria, proteinuria, hypocomplementemia and anti-SSa antibody positivity. A percutaneous kidney biopsy revealed focal and segmental glomerulonephritis associated with an acute int...
Source: Nephrologie and Therapeutique - January 9, 2020 Category: Urology & Nephrology Authors: Boyer A, Gautier N, Comoz F, Hurault de Ligny B, Aouba A, Lanot A Tags: Nephrol Ther Source Type: research

[Premature immune senescence and chronic kidney disease: Update and perspectives].
In conclusion, to reduce the increasing incidence of morbidity and mortality of chronic kidney disease patients, a better knowledge of uremia-induced immune senescence would help to pave the way to build clinical studies and promote innovative therapeutic approaches. We believe that therapeutic reversion and immune senescence prevention approaches will be part of the management of chronic kidney disease patients in the future. PMID: 31848067 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - December 14, 2019 Category: Urology & Nephrology Authors: Crépin T, Legendre M, Courivaud C, Vauchy C, Laheurte C, Rebibou JM, Saas P, Ducloux D, Bamoulid J Tags: Nephrol Ther Source Type: research

[Immune check point inhibitor-associated renal toxicity].
Abstract Immune checkpoint inhibition had a major clinical success in clinical oncology and impacted the treatment paradigm in many cancers. Immune related adverse events are well-described toxicities that are closely associated with CPI therapies and can involve any organ in the body. Renal toxicity is multifocal. In addition to the predominant tubulointerstitial involvement, immunotherapy can lead to a variety of glomerular damage and electrolyte disorders. Suggested mechanisms include direct renal interstitium lymphocyte infiltration, renal immune complex deposition, microangiopathic endothelial disease, or cyt...
Source: Nephrologie and Therapeutique - December 13, 2019 Category: Urology & Nephrology Authors: Izzedine H, Gueutin V Tags: Nephrol Ther Source Type: research

[Potential application of fibroblast growth factor 23-klotho axis in chronic kidney disease].
Abstract Membrane Alpha Klotho (α-klotho) is expressed in the kidney and functions as a co-receptor of FGF receptors (FGFRs) to activate specific fibroblast growth factor 23 (FGF23) signal pathway. FGF23 is produced in bones and participates in mineral homeostasis. The extracellular domain of transmembrane αklotho can be cleaved by proteases and released into the circulation as soluble α-klotho. Klotho deficiency is a pathogenic factor for chronic kidney disease progression and cardiovascular diseases. The FGF23 excess may also contribute to cardiovascular diseases where its pathogenic effect act...
Source: Nephrologie and Therapeutique - December 13, 2019 Category: Urology & Nephrology Authors: Lacroix JS, Urena-Torres P Tags: Nephrol Ther Source Type: research

[Renal toxicities of targeted therapies in oncology].
This article reviews the renal toxicity associated with targeted anticancer therapies directed against Epidermal growth factor receptor, Human epidermal growth factor-2, B-rapidly accelerated fibrosarcoma, Mitogen-activated protein kinase, Anaplastic lymphoma kinase, Programmed cell death-1/programmed cell death ligand-1, Cytotoxic T lymphocyte antigen-4 and Vascular endothelial growth factor/receptor. The early diagnosis and management of these renal adverse events is essential for the clinician who cares for such patients. PMID: 31818703 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - December 6, 2019 Category: Urology & Nephrology Authors: Izzedine H Tags: Nephrol Ther Source Type: research

[Erratum to "A better characterization of kidney allograft rejection infiltrates using in situ multiplex immunofluorescence" [Nephrol. Ther. 15S (2019) S43-S52]].
[Erratum to "A better characterization of kidney allograft rejection infiltrates using in situ multiplex immunofluorescence" [Nephrol. Ther. 15S (2019) S43-S52]]. Nephrol Ther. 2019 Dec;15(7):553 Authors: Calvani J, Terada M, Lesaffre C, Duong Van Huyen JP, Bruneval P, Rabant M PMID: 31787168 [PubMed - in process] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - December 1, 2019 Category: Urology & Nephrology Authors: Calvani J, Terada M, Lesaffre C, Duong Van Huyen JP, Bruneval P, Rabant M Tags: Nephrol Ther Source Type: research

Evolution of secondary hyperparathyroidism in patients following return to hemodialysis after kidney transplant failure.
Abstract INTRODUCTION: Severe uncontrolled secondary hyperparathyroidism and kidney transplantation history are both risk factors for fractures in hemodialyzed patients. Moreover, patients who return to dialysis after transplant failure have more severe infections/anemia and higher mortality risk than transplant-naive patients starting dialysis with native kidneys. In this context, our aim was to test the hypothesis that transplant failure patients have more secondary hyperparathyroidism than transplant-naive patients. METHODS: We retrospectively compared 29 transplant failure patients to 58 transpl...
Source: Nephrologie and Therapeutique - November 29, 2019 Category: Urology & Nephrology Authors: Jannot M, Normand M, Chabroux-Seffert A, Azzouz L, Afiani A, Jurine J, Ziane A, Mariat C, Lafage-Proust MH Tags: Nephrol Ther Source Type: research

[Sodium metabolism: An update in 2019].
Abstract The classical theory of sodium metabolism considers mostly its role on the extracellular volume according to a daily response to the variations of salt intake, correlated to the variations of water volume. Recent works consider sodium tissular storage. This non-osmotic pool could play a role in blood pressure regulation and in immunity mechanisms. The regulation modalities could be more complex, organised over the long term, with a modification of the sodium-water relationship. The aim of this article is to give a new insight on sodium metabolism, based on recent works, especially on the role and regulati...
Source: Nephrologie and Therapeutique - November 29, 2019 Category: Urology & Nephrology Authors: Robert A, Cheddani L, Ebel A, Vilaine E, Seidowsky A, Massy Z, Essig M Tags: Nephrol Ther Source Type: research

[The contribution of an ethical concertation group in nephrology validated by a research protocol].
ing L Abstract For more than 10 years, nephrologists in the Grenoble-region have sought advice from the Ethical Concertation Unit in Nephrology with regards to whether to stop or continue dialysis for patients under palliative care. This process deserves a multidisciplinary debate between health professionals and qualified non-health professionals. Thus, we organized a qualitative research protocol in three parts (medical, philosophical, judicial) to explore this issue. Our study aimed to assess the impact of Ethical Concertation Unit in Nephrology's discussions regarding perception, knowledge, and judicial and et...
Source: Nephrologie and Therapeutique - November 11, 2019 Category: Urology & Nephrology Authors: Maurizi-Balzan J, Fourneret É, Cimar L, Noble J, Naciri-Bennani H, Tetaz R, Rostaing L Tags: Nephrol Ther Source Type: research

[Criteria to indicate kidney biopsy in type 2 diabetic patients with proteinuria: Survey among French nephrologists].
sik F Abstract Diabetic nephropathy is usually a presumptive diagnosis based on clinical and biological evidence. Renal biopsies are performed in diabetic patients with atypical findings evoking non-diabetic renal disease who could benefit from specific therapies. French speaking nephrologists were asked which criteria they retain to indicate renal biopsy in patients with type 2 diabetes and albuminuria>0.5g/day or equivalent through an online anonymous questionnaire. Among the suggested criteria were absence of diabetic retinopathy, hematuria, rapid decrease in GFR, short diabetes duration or rapid raise ...
Source: Nephrologie and Therapeutique - November 9, 2019 Category: Urology & Nephrology Authors: Chemouny JM, Sannier A, Hanouna G, Raimbourg Q, Daugas É, Vigneau C, Vrtovnsik F Tags: Nephrol Ther Source Type: research

[Descriptive study of practices with patients in conservative care practices in a French district, the Normandy].
CONCLUSION: The results of this study show that the course of the patients in conservative treatment is heterogeneous and is not formalized. Improvements are needed to integrate conservative treatment for patients with chronic kidney disease. PMID: 31718994 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - November 9, 2019 Category: Urology & Nephrology Authors: Uteza S, Thuillier Lecouf A, Videloup L, Béchade C, Henri P, Guillouët S Tags: Nephrol Ther Source Type: research

[Kidney disease care for the elderly].
This article aims to focus on the kidney diseases commonly observed in elderly patients and analyze their specific nephrogeriatric care modalities. It should be noticed that all known kidney diseases can be also observed in the elderly, most often with a quite similar clinical presentation. This review is thus focused on the diseases most frequently and most specifically observed in elderly patients (except for monoclonal gammopathy associated nephropathies, out of the scope of this work), as well as the peculiarities of old age nephrological care. PMID: 31711751 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - November 8, 2019 Category: Urology & Nephrology Authors: Hamroun A, Frimat M, Beuscart JB, Buob D, Lionet A, Lebas C, Daroux M, Provôt F, Hazzan M, Boulanger É, Glowacki F Tags: Nephrol Ther Source Type: research

[Anxiety and depression during chronic renal failure before end stage at the University hospital center Yalgado Ouedraogo of Ouagadougou (Burkina Faso)].
ogo A Abstract AIM: We wanted to know the prevalence of depression and anxiety, as well as the associated factors in patients with chronic renal failure in Burkina Faso. PATIENTS AND METHODS: This was an analytical cross-sectional study conducted from February to May 2016. We included all adult patients with moderate or severe chronic renal failure. The diagnosis of anxiety and depression was made using the Hamilton scales. Identification of factors associated with both conditions required bi- and multivariate analyzes. RESULTS: The study involved 191 patients, with a mean age of 53.2±14.2&nb...
Source: Nephrologie and Therapeutique - November 3, 2019 Category: Urology & Nephrology Authors: Coulibaly G, Goumbri PP, Lengani HYA, Millogo T, Zoma VP, Dabilgou A, Napon C, Karfo K, Ouango GJ, Lengani A, Ouédraogo A Tags: Nephrol Ther Source Type: research

[Hygieno-dietetic recommendations in the prevention of accumulation of advanced glycation products].
Abstract Advanced glycation products are proteins whose structural and functional properties have been modified by a process of oxidative glycation. The accumulation of advanced glycation products in most tissues and the oxidative stress and inflammatory reactions that accompany it, account for the multi-systemic impairment observed particularly in the elderly, diabetics and in chronic renal failure. The advanced glycation products endogenous production is continuous, related to oxidative stress, but the most important source of advanced glycation products is exogenous, mainly of food origin. Exogenous advanced gl...
Source: Nephrologie and Therapeutique - October 31, 2019 Category: Urology & Nephrology Authors: Chauveau P, Lasseur C, Azar R, Niu W, Combe C, Aparicio M Tags: Nephrol Ther Source Type: research

[Epidemiology of acute renal failure during dengue fever in the city of Ouagadougou].
CONCLUSION: The acute renal failure in our dengue fever patients population was very common, severe, and highly lethal. The prognosis should improve with early management. It would be even better to promote primary prevention through effective vector control. PMID: 31669117 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - October 25, 2019 Category: Urology & Nephrology Authors: Coulibaly G, Lengani HYA, Sondo KA, Konvolbo HP, Diendéré ÉA, Nitiéma IJ, Karambiri AR, Sanou G, Lengani A Tags: Nephrol Ther Source Type: research

Reasons for dialysis patients choosing or refusing kidney transplantation as renal replacement therapy: A qualitative study.
Abstract This paper aims to identify the reasons for choosing or refusing kidney transplantation as renal replacement therapy among patients with Chronic Kidney Disease (CKD). Data were collected through interviews with CKD patients treated by dialysis. Health professionals were also interviewed. A thematic analysis was used to analyze the data. Results show that various reasons account for CKD patients' refusal to have a kidney transplant: the perception of kidney transplantation as a renal replacement therapy without positive outcome, refusal to have an allograft. There are also situations such as the lack of or...
Source: Nephrologie and Therapeutique - October 23, 2019 Category: Urology & Nephrology Authors: Senghor AS Tags: Nephrol Ther Source Type: research

[Renal transplantation: Procedure and early follow-up].
ute; D, Méjean A, Legendre C Abstract More than fifty years after the success of the two first renal transplantations in Boston and in Necker hospital in Paris, renal transplantation became the treatment of choice of end stage renal failure, because it improves not only the quality of life of the patients but also their long-term survival. In France, more than 3,700 kidney transplantations are performed every year and more than 40,000 patients are living with a functioning kidney allograft. This treatment of end stage renal disease requires a fine-tuned pre-transplant evaluation and a multidi...
Source: Nephrologie and Therapeutique - October 19, 2019 Category: Urology & Nephrology Authors: Anglicheau D, Tinel C, Canaud G, Loupy A, Zuber J, Delville M, Rabaté C, Scemla A, Snanoudj R, Sberro-Soussan R, Mamzer-Bruneel MF, Bererhi L, Martinez F, Timsit MO, Rabant M, Correas JM, Bienaimé F, Duong JP, Hélénon O, Prié D, Méjean A, Legendre C Tags: Nephrol Ther Source Type: research

[e-Health in nephrology: 1st French survey on telenephrology].
In conclusion, French nephrologists are yet connected but they really need more help again to face new challenges raised by e-health. PMID: 31640944 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - October 19, 2019 Category: Urology & Nephrology Authors: Citarda S, Camarroque AL, Seret G, De Laforcade L, Bureau C, Caillette-Beaudoin A, Bertocchio JP, Comité scientifique du club des jeunes néphrologues Tags: Nephrol Ther Source Type: research

[Risk analysis and validation of the process for producing the substitution fluid for online hemodiafiltration].
CONCLUSION: This work has enabled us to validate our production process in extreme cases to promote safer use of the technique. PMID: 31636047 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - October 18, 2019 Category: Urology & Nephrology Authors: Yousfi MA, Ben Saada R, Ourir A, Bafoun A, Jalel Hmida M Tags: Nephrol Ther Source Type: research

[A patient with rheumatoid arthritis presenting a nephrotic syndrome: A case report].
Abstract A fifty-one years-old patient with a history of rheumatoid arthritis of recent diagnosis is hospitalized for exploration of a rapidly progressive anasarca state. First analysis discovered an impure nephrotic syndrome (acute renal failure, hematuria) and massive glomerular proteinuria. Auto-medication by nonsteroidal anti-inflammatory drug was revealed. Renal biopsy showed minimal glomerular disease and acute tubular necrosis. Corticosteroid use permitted a normalization of proteinuria and renal recovery was obtained. Literature review showed renal impairment occurring in rheumatoid polyarthritis. Minimal ...
Source: Nephrologie and Therapeutique - October 18, 2019 Category: Urology & Nephrology Authors: Daniel A, Gibier JB, Azar R Tags: Nephrol Ther Source Type: research

[Prevention of iatrogenic risk and screening of chronic kidney disease].
Abstract Ten percent of the world's population is affected by chronic kidney disease that can lead to kidney failure. In France, nearly three million people are concerned, half of whom are undiagnosed, 85,000 people are on dialysis or waiting for a kidney transplant. Each year, 11,000 new diagnoses of severe renal failure are made, one third of which had not been treated before. Kidney failure is constantly increasing due to the aging of the population and the resurgence of chronic diseases, including obesity and cardiovascular diseases such as high blood pressure and diabetes, two conditions that impair...
Source: Nephrologie and Therapeutique - October 18, 2019 Category: Urology & Nephrology Authors: Vasmant D Tags: Nephrol Ther Source Type: research

Complement inhibition in ANCA vasculitis.
Abstract A role for the alternative complement pathway has emerged in the understanding of ANCA vasculitis pathogenesis. Current therapies of ANCA vasculitis are limited by partial efficacy and toxicity and many patients pursue a relapsing course. Improved therapies are needed. Inhibition of the alternative complement pathway component C5a is attractive due to its role in neutrophil activation and migration, and engagement of other inflammatory and thrombotic mechanisms. Two inhibitors of C5a are in clinical development for ANCA vasculitis: avacopan, an oral C5a receptor inhibitor has demonstrated efficacy, safety...
Source: Nephrologie and Therapeutique - October 17, 2019 Category: Urology & Nephrology Authors: Jayne D Tags: Nephrol Ther Source Type: research

[How to implement a complete apheresis program within a hemodialysis unit].
Abstract Many apheresis techniques can be performed in a blood-bank facility or a hemodialysis (HD) facility. However, it makes sense to perform apheresis in a hemodialysis facility as apheresis involves extra-corporeal circuits and because HD can be performed at the same time as apheresis (tandem procedure). Apheresis techniques comprise therapeutic plasma exchange, double-filtration plasmapheresis, and its derivative (rheopheresis and LDL-apheresis), and immunoadsorption (specific and semi-specific). We have setup an apheresis platform in our hospital that fulfills health recommendations. This process has involv...
Source: Nephrologie and Therapeutique - October 1, 2019 Category: Urology & Nephrology Authors: Maurizi-Balzan J, Jouve T, Naciri-Bennani H, Noble J, Tanoukhi K, Motte L, Malvezzi P, Rostaing L Tags: Nephrol Ther Source Type: research

Prevalence of herbal medicine use among patients with kidney disease: A cross-sectional study from Morocco.
CONCLUSIONS: The prevalence of herbal medicine use is high among patients with kidney disease in nephrology department. PMID: 31383617 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - August 2, 2019 Category: Urology & Nephrology Authors: Touiti N, Houssaini TS, Iken I, Benslimane A, Achour S Tags: Nephrol Ther Source Type: research

[Etiological and evolving profile of renal disability of children in hospital in Togo].
CONCLUSION: The renal failure of child is relatively common in our daily practice. The low socio-economic level and the lack of adapted equipment make the care difficult. PMID: 31377136 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - July 31, 2019 Category: Urology & Nephrology Authors: Akolly DAE, Tsevi YM, Djadou EK, Guedenon KM, Amekoudi EYM, Tsolenyanu E, Agbeko F, Takassi EO, Gbadoe AD, Atakouma Y Tags: Nephrol Ther Source Type: research

Renouveler son adh ésion en ligne ou devenir membre de la SFNDT et bénéficiez de tous les privilèges.
Renouveler son adhésion en ligne ou devenir membre de la SFNDT et bénéficiez de tous les privilèges. Nephrol Ther. 2019 Jul;15(4):259 Authors: Revel N PMID: 31202436 [PubMed - in process] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - June 17, 2019 Category: Urology & Nephrology Authors: Revel N Tags: Nephrol Ther Source Type: research

[Complications and treatment of mineral and bone disorders in chronic kidney disease].
Abstract Mineral and bone disorders are frequently observed in chronic kidney disease. Prevening these metabolic, bone and cardiovascular consequences requires a treatment strategy based on physiopathology and international recommendations. The precise diagnosis of these mineral and bone disorders is based on serum parathyroid hormone and alkaline phosphatases values allowing to identify secondary hyperparathyroidism and adynamic bone disease, that are both associated with cardiovascular complication together with calcium and phosphate imbalance. Chronic kidney disease-mineral and bone disorders are associated wit...
Source: Nephrologie and Therapeutique - May 25, 2019 Category: Urology & Nephrology Authors: Jean G, Chazot C Tags: Nephrol Ther Source Type: research

[Kidney disease in cobalamin C deficiency].
rot D Abstract Cobalamin C deficiency (cblC) is the most common inborn error of vitamin B12 metabolism. This autosomal recessive disease is due to mutations in MMACHC gene, encoding a cyanocobalamin decyanase. It leads to hyperhomocysteinemia associated with hypomethioninemia and methylmalonic aciduria. Two distinct phenotypes have been described : early-onset forms occur before the age of one year and are characterized by a severe multisystem disease associating failure to thrive to neurological and ophthalmological manifestations. They are opposed to late-onset forms, less severe and heterogeneous. Cbl...
Source: Nephrologie and Therapeutique - May 23, 2019 Category: Urology & Nephrology Authors: Lemoine M, Grangé S, Guerrot D Tags: Nephrol Ther Source Type: research

Variables linked to hepatitis B vaccination success in non-dialyzed chronic kidney disease patients: Use of a bayesian model.
CONCLUSION: The Bayesian network confirmed that both kidney function and nutritional status of patients are important factors to explain the success of vaccination against hepatitis B in CKD patients before dialysis. For research purposes, before an external validation, the network can be used online at www.hed.cc/?s=Bhepatitis&n=ReseauhepatiteBsup10.neta. PMID: 31129001 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - May 22, 2019 Category: Urology & Nephrology Authors: Dimitrov Y, Ducher M, Kribs M, Laurent G, Richter S, Fauvel JP Tags: Nephrol Ther Source Type: research

[Therapeutic education program should be adapted to the specificity of chronic kidney disease].
CONCLUSION: Therapeutic patient education (TPE) has become a need in the care of CKD patients, even at early stages of the disease. TPE allows to prepare the patients, favoring autonomy and shared decision making about his disease, in collaboration with healthcare workers and patient's relatives. PMID: 31126878 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - May 21, 2019 Category: Urology & Nephrology Authors: Dufey Teso A, Lasserre Moutet A, Lefuel P, de Seigneux S, Golay A, Martin PY Tags: Nephrol Ther Source Type: research

[Disseminated tuberculosis revealed by obstructive and prerenal acute kidney failure].
Abstract A 56-year-old Philippine seaman without any medical history presented an obstructive and prerenal acute kidney failure near the coasts of Normandy. He was hospitalized in intensive care units because of the seriousness of kidney failure and because of impaired consciousness. Abdominal computed tomography showed a destroyed left kidney, a right hydronephrosis and ureteral strictures, which is typical of urinary tuberculosis. Koch bacillus was positive in urine sample, confirming the diagnosis. Thoracic computed tomography, brain magnetic resonance imaging revealed a tuberculosis miliary with concomitant tu...
Source: Nephrologie and Therapeutique - May 13, 2019 Category: Urology & Nephrology Authors: Beaumier M, Roger H, Sauneuf B, Dugardin F, Camparo P, Queffeulou G Tags: Nephrol Ther Source Type: research

The baseline glomerular filtration rate, predictive of six-year survival in sub-Saharan African patients on antiretroviral therapy for HIV: Cohort study.
guikouma JB Abstract BACKGROUND: Recently, serious morbidity events associated with initial glomerular filtration rate (GFR) have been described during HIV infection, but this is insufficiently investigated in sub-Saharan Africa very affected by HIV. OBJECTIVE: To assess the impact of baseline GFR prevailing during the first semester of the HIV infection management on six-year survival in peoples taking antiretroviral therapy. PATIENTS AND METHODS: Closed retrospective cohort study. The death was the expected outcome, the baseline GFR (mL/min/1.73m2) in the first semester of the follow-up was the main ex...
Source: Nephrologie and Therapeutique - May 11, 2019 Category: Urology & Nephrology Authors: Mackanga JR, Alène C, Doumingou N, Mouloungui ÉM, Nsie A, Edou P, Lacmou B, Nzouto P, Bere GO, Odzaga FE, Kombila UD, Bignoumba PI, Missounga L, Ibaba J, Kombila JM, Boguikouma JB Tags: Nephrol Ther Source Type: research

Is red meat consumption the confounding factor explaining the association between chronic kidney disease and proton pump inhibitors?
PMID: 31056405 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - May 2, 2019 Category: Urology & Nephrology Authors: Desbuissons G, Mercadal L Tags: Nephrol Ther Source Type: research

[Dietary control of metabolic acidosis in chronic kidney disease].
Abstract Metabolic acidosis is a frequent complication of chronic kidney disease. Although it is known to appear at advanced stages, many studies suggest a state of "global protonic retention" starting at early stages of the disease, responsible of tissue damage, particularly musculoskeletal, alteration of protidic metabolism and endocrine disorders, promoting malnutrition and chronic inflammation, and finally increasing mortality. The majority of international recommandations suggest of supplementation by alkali, most of the time by sodium bicarbonate, to struggle against this complication. An interesti...
Source: Nephrologie and Therapeutique - May 2, 2019 Category: Urology & Nephrology Authors: Laboux T, Azar R Tags: Nephrol Ther Source Type: research

[Fabry disease's screening: Results from the first French survey on nephrologists habits].
This study aimed to know the formation of nephrologists, their knowledge, and their habits both in terms of screening and management in this field. Answers form 152 nephrologists have been analyzed: few doctors directly managed Fabry disease patient (22 %) and 18 % have already made the diagnosis by their own. Formation seems to be insufficient and most of them did not fully know symptoms, as resources already available (associations, collecting database, etc.). Some indications for the treatment are also poorly known (mainly regarding end stage renal disease). Information is mainly provided by of firms' sta...
Source: Nephrologie and Therapeutique - April 30, 2019 Category: Urology & Nephrology Authors: Muller C, Delion A, Hogan J, Bertocchio JP, Comité scientifique du Club des jeunes néphrologues Tags: Nephrol Ther Source Type: research

[Daily practices of protein energy wasting management in hemodialysis patients: A French national survey].
Abstract Protein energy wasting (PEW) is frequent among hemodialysis patients. Published international recommendations in this field are sometimes difficult to implement in daily practices. We evaluated daily practices of PEW screening and treatment in French hemodialysis centers using an online computerized questionnaire sent by email (1 answer required per center). Eighty-six centers returned the questionnaire filled by a nephrologist (43%), nurse (14%) or dietician (43%). The mean number of patients per center was 112±64 patients. PEW screening was performed at least once/month in 56% of center...
Source: Nephrologie and Therapeutique - April 30, 2019 Category: Urology & Nephrology Authors: Bataille S, Bon J, Kolko A, Chauveau P, Cluze J, Orthwein-Finck M, Mouelhi Y, Mira M Tags: Nephrol Ther Source Type: research

[Towards an extension of the REIN registry to patients with chronic kidney disease at stage 5 not treated with dialysis or transplantation? A pilot study].
stre REIN Abstract To date, it is important to know more about the population of CKD stage 5 patients in order to better understand the practices of access to renal replacement therapy (RRT) or conservative treatment and to anticipate future needs. In April 2015, at the instigation of the Scientific Committee of REIN, a working group was formed to reflect on the opportunity and feasibility of a data collection on these patients. Between September 2017 and March 2018, 21 participating centers included 390 patients over a period of at least one month. The data collected included the patient's living conditions, leve...
Source: Nephrologie and Therapeutique - April 30, 2019 Category: Urology & Nephrology Authors: Vigneau C, Ayav C, Noël N, Gomis S, Glaudet F, Siébert M, Kessler M, Nogier MB, Villar E, Allot V, Edet S, Glowacki F, Baudoin V, Allain-Launay E, Dunand O, Moranne O, Hogan J, Couchoud C, registre REIN Tags: Nephrol Ther Source Type: research

[18F-FDG positron emission tomography in non-oncological renal pathology: Current indications and perspectives].
Abstract Positron emission tomography combined with computed tomography (PET/CT) is a nuclear imaging technique which provides anatomical and functional information. PET/CT is increasingly used in non-oncological nephrology since conventional radiological approaches after injection of contrast agents are relatively contra-indicated in patients with chronic kidney disease (CKD). PET/CT after i.v. injection of 18F-fluoro-deoxy-glucose (FDG) is not toxic and is characterized by a high sensitivity. The level of irradiation (∼5mSv) is acceptable. CKD does not significantly influence tissue uptake of 18F-FDG. The pu...
Source: Nephrologie and Therapeutique - April 11, 2019 Category: Urology & Nephrology Authors: Hanssen O, Lovinfosse P, Weekers L, Hustinx R, Jouret F Tags: Nephrol Ther Source Type: research

"Doctor, can I have less frequent injection with highly efficient treatment?" A patient centered study using an electronic choice-based conjoint analysis (ePRO) to assess real world preferences regarding erythropoiesis stimulating agent to treat anaemia in chronic kidney disease (PERCEPOLIS study).
CONCLUSIONS: Using CBC design for the first time in a non-interventional ESA study with an electronic Patient Reported Outcome (ePRO) in an elderly population, these data showed that monthly injections and treatment efficacy were key patients' expectations relative to ESAs. CERA efficacy to maintain stable haemoglobin within the recommended range was confirmed in real-life conditions. PMID: 30962139 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - April 5, 2019 Category: Urology & Nephrology Authors: Vigneau C, Choukroun G, Isnard-Bagnis C, Pau D, Sinnasse-Raymond G, Pibre S, Moranne O Tags: Nephrol Ther Source Type: research

[Middle-molecule uremic toxins: A renewed interest].
sy ZA Abstract Cardiovascular mortality in patients with chronic kidney disease remains a major problem. The uremic toxins among which the molecules of middle molecular weight are counted contribute significantly to this high mortality, alongside the traditional risk factors. They generate and maintain a chronic inflammatory state called low-level chronic inflammatory state. A growing interest in these molecules has been noted for some years and the uremic toxins associated with this cardiovascular mortality are currently identified: FGF23, cytokines, pentraxin-3 and recently light chains. The existence of an inte...
Source: Nephrologie and Therapeutique - April 1, 2019 Category: Urology & Nephrology Authors: Nlandu Y, Padden M, Seidowsky A, Hamaz S, Vilaine É, Cheddani L, Essig M, Massy ZA Tags: Nephrol Ther Source Type: research

[Potential value of placental angiogenic factors as biomarkers in preeclampsia for clinical physicians].
uis E Abstract The role of angiogenic factors in the onset of clinical manifestations of preeclampsia was demonstrated in 2003 by the implication of sFlt-1, PlGF and VEGF, and in 2006 by the implication of soluble endoglin. Placental ischemia and inflammation observed in preeclampsia alter both the production and progression of angiogenic factors during pregnancy. During the first trimester, the combination of PlGF with clinical, biophysical and biological factors results in a better test than the conventional one. However, the clinical value of this method remains to be confirmed. During the second and third trim...
Source: Nephrologie and Therapeutique - March 29, 2019 Category: Urology & Nephrology Authors: Boulanger H, Lefèvre G, Ahriz Saksi S, Achiche J, Bailleul S, Ekoukou D, Drouin D, Sault C, Stawiarski N, Dupuis E Tags: Nephrol Ther Source Type: research

[Impact of comorbidities on hemoglobin stability in patients with chronic kidney insufficiency on hemodialysis, treated with CERA in current practice: The MIRIADE study].
te;tude MIRIADE Abstract This national, prospective and multicenter study aimed to describe the real-life impact of comorbidities on hemoglobin stability in patients with chronic kidney disease on hemodialysis, treated with CERA in relay of an erythropoietin stimulating agent. Comorbidities were defined by the Charlson Index (adjusted on age) and hemoglobin stability as a variation of ±1g/dL after the 6-month treatment period. The 585 analyzed patients were distributed as follows according to the adjusted Charlson index: score≤3 (12% of patients), 4≤score≤5 (17%), 6≤score≤7 (31%) and score&ge...
Source: Nephrologie and Therapeutique - March 21, 2019 Category: Urology & Nephrology Authors: Frimat L, Amirou M, Jaulin JP, Sinnasse-Raymond G, Pau D, Zaoui P, Rostoker G, au nom des investigateurs participant à l’étude MIRIADE Tags: Nephrol Ther Source Type: research

[Cardiovascular drugs and renal function: Pitfall of renal adaptation].
CONCLUSION: The privileged use of Cockcroft and Gault formula for dose adjustment, as recommended by the Haute Autoritéde santé, does not seem to be justified. An overhaul of recommendations for pharmacokinetic studies and renal function assessment methods for dose adjustments appears necessary. PMID: 30827822 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - February 28, 2019 Category: Urology & Nephrology Authors: Keller N, Ruppert M, Fourtage M, Hannedouche T Tags: Nephrol Ther Source Type: research

[Renal hemosiderosis following mechanical hemolysis: An original case report].
We report here the case of a 73-year-old patient with acute kidney caused by a massive hemosiderosis following the proximal disinsertion of a prosthesis of the ascendant aorta with chronic aortic dissection. The kidney biopsy revealed the diagnosis, showing massive iron deposits inside the proximal tubules, especially with Perls staining and also diffuse hematic casts in the lumen of the tubules. Pathophysiology of hemosiderosis is well described, as well as protective mechanisms. This case report is one of the numerous different causes of renal hemosiderosis that can be related to genetic, infectious or mechanical hemolys...
Source: Nephrologie and Therapeutique - February 23, 2019 Category: Urology & Nephrology Authors: Zettl J, Mirgaine P, Aymard B, Valla M, Rahmati M, Tubail Z, Flechon-Meibody F, Savenkoff B Tags: Nephrol Ther Source Type: research