Clinical and Laboratory Characteristics of MODY (Maturity Onset Diabetes of Young) Cases, Genetic Mutation Spectrum and Phenotype-genotype Relationship
CONCLUSION: This was the largest genetically diagnosed series from Turkey. The most common gene variants were GCK and HNF1A with much lower proportions for other MODY types. Hyperglycemia was the most common presenting symptom while 11% of patients had diabetes-associated autoantibodies and 7% were obese. The majority of patients received dietary management only.PMID:38665000 | DOI:10.4274/jcrpe.galenos.2024.2023-10-16 (Source: Cell Research)
Source: Cell Research - April 26, 2024 Category: Cytology Authors: Elif Özsu Semra Çetinkaya Semih Bolu Nihal Hatipo ğlu Şenay Savaş Erdeve Olcay Evliyao ğlu Firdevs Ba ş Atilla Çayır İsmail Dündar Emine Demet Akba ş Seyid Ahmet U çaktürk Merih Berbero ğlu Zeynep Şıklar Şervan Özalkak Nursel Murato ğl Source Type: research
Possible etiological role of impaired endogenous double strand RNA editing in β‐cells in type 1 diabetes
Proposed mechanisms by which disruption of endogenous dsRNA editing in β-cells leads to type 1 diabetes-like phenotypes in βAdarKO mice. Disruption of endogenous dsRNA editing in β-cells initiates IFN responses, thereby inducing pancreatic islet inflammation and β-cell dysfunction. Hyperglycemia induced by β-cell dysfunction further promotes islet inflammation, li kely via increased dsRNA resulting from increased β-cell workload, thereby producing a vicious cycle. The mechanism by which impairment of dsRNA editing is integrated with autoimmune-mediated pathogenesis of type 1 diabetes remains to be clarified. (Source:...
Source: Journal of Diabetes Investigation - April 26, 2024 Category: Endocrinology Authors: Junta Imai Tags: Commentary Source Type: research
Historical trends of breast cancer burden attributable to metabolic factors among Chinese women, 1990 –2019: A population‐based epidemiological study
ConclusionsAge was the main reason for the increase of attributable burden, and postmenopausal women were the high-risk groups. Therefore, targeted prevention measures should be developed to improve postmenopausal women's awareness and effectively reduce the prevalence of obesity and diabetes, thereby reducing the breast cancer burden caused by metabolic factors in China. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Liang ‐Zi Zhang,
Qi‐Cheng Sun,
Hang‐Hang Luan,
Qian‐Qian Yuan,
Tong Deng,
Li‐Sha Luo,
Xiao‐Lin Tan Tags: ORIGINAL ARTICLE Source Type: research
Exploring Australian Dietitians' knowledge, experience and perspectives of time ‐restricted eating in private practice: A qualitative study
SummaryTime-restricted eating is a novel nutrition intervention with evidence of beneficial effects on weight loss, blood glucose management, and other metabolic health outcomes. Adherence to time-restricted eating is higher than some traditional nutrition interventions to support individuals living with overweight/obesity and type 2 diabetes mellitus. However, there may be an evidence-practice gap of time-restricted eating in Australian dietetic practice. The present study aimed to explore dietitians' knowledge, experiences, and perspectives of time-restricted eating and timing of eating advice in practice. Semi-structure...
Source: Clinical Obesity - April 26, 2024 Category: Eating Disorders & Weight Management Authors: Caitlin Pye,
Evelyn B. Parr,
Steve A. Flint,
Brooke L. Devlin Tags: ORIGINAL RESEARCH Source Type: research
Ezrin Contributes to the Damage of Airway Epithelial Barrier Related to Diabetes Mellitus
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - April 26, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
Viruses, Vol. 16, Pages 688: Long-Term Impairment of Working Ability in Subjects under 60 Years of Age Hospitalised for COVID-19 at 2 Years of Follow-Up: A Cross-Sectional Study
Conclusions: Our findings suggest that PASC promotes conditions that could result in decreased working ability and unemployment. These results highlight the significant impact of this syndrome on public health and the global economy, and the need to develop clinical pathways and guidelines for long-term care with specific focus on working impairment. (Source: Viruses)
Source: Viruses - April 26, 2024 Category: Virology Authors: Luisa Frallonardo Annunziata Ilenia Ritacco Angela Amendolara Domenica Cassano Giorgia Manco Cesari Alessia Lugli Mariangela Cormio Michele De Filippis Greta Romita Giacomo Guido Luigi Piccolomo Vincenzo Giliberti Francesco Cavallin Francesco Vladimiro Se Tags: Article Source Type: research
Polygenic scores for longitudinal prediction of incident type 2 diabetes in an ancestrally and medically diverse primary care physician network: a patient cohort study
ConclusionsGenetic information can help identify high-risk patients even among those perceived to be low risk in a clinical evaluation. (Source: Genome Medicine)
Source: Genome Medicine - April 26, 2024 Category: Genetics & Stem Cells Source Type: research
Molecules, Vol. 29, Pages 2007: Pharmacological Potential of Kaempferol, a Flavonoid in the Management of Pathogenesis via Modulation of Inflammation and Other Biological Activities
udi
Rahmani
Natural products and their bioactive compounds have been used for centuries to prevent and treat numerous diseases. Kaempferol, a flavonoid found in vegetables, fruits, and spices, is recognized for its various beneficial properties, including its antioxidant and anti-inflammatory potential. This molecule has been identified as a potential means of managing different pathogenesis due to its capability to manage various biological activities. Moreover, this compound has a wide range of health-promoting benefits, such as cardioprotective, neuroprotective, hepatoprotective, and anti-diabetic, and has a role...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Alrumaihi Almatroodi Alharbi Alwanian Alharbi Almatroudi Rahmani Tags: Review Source Type: research
The Effect of Sodium-Glucose Transporter 2 Inhibitors on Stroke in Patients With Type 2 Diabetes: A Meta-analysis
To provide an update on the effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors on stroke in patients with type 2 diabetes (T2D). (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 26, 2024 Category: Neurology Authors: Eric Pasqualotto, Farley Reis Rodrigues, Giovana Barros e Silva Ribeiro, Gustavo de Oliveira Almeida, J úlia Camargo Kabariti, Rafael Oliva Morgado Ferreira, Matheus Pedrotti Chavez, Mariana R.C. Clemente, Nicole B. Sur, Daniel G. Di Luca Source Type: research
Comparison of central diabetes insipidus (antidiuretic hormone deficiency) and stalk effect in patients with adamantinomatous and papillary craniopharyngioma
AbstractCraniopharyngioma (CP), a rare benign intracranial tumor, is still a major clinical challenge. There are two major histologic phenotypes: papillary CP (PCP) and adamantinomatous CP (ACP). This research aimed to assess the occurrence of central diabetes insipidus (antidiuretic hormone deficiency), the level of prolactin, and the stalk effect between PCP and ACP subtypes prior to and after surgery. Clinical data of CP patients before and after surgical resection of the tumor were analyzed retrospectively. These patients were divided into PCP and ACP groups, in accordance with the pathologic classification. The data o...
Source: Acta Neurologica Belgica - April 26, 2024 Category: Neurology Source Type: research
Population incidence and associated mortality of urinary tract infection in people living with dementia
Urinary tract infections (UTIs) frequently cause hospitalisation and death in people living with dementia (PLWD). We examine UTI incidence and associated mortality among PLWD relative to matched controls and people with diabetes and investigate whether delayed or withheld treatment further impacts mortality. (Source: Journal of Infection)
Source: Journal of Infection - April 26, 2024 Category: Infectious Diseases Authors: Helen Lai, Magdalena Kolanko, Lucia M Li, Megan E Parkinson, Niall J Bourke, Neil SN Graham, Michael CB David, Emma-Jane Mallas, Bowen Su, Sarah Daniels, Danielle Wilson, Mara Golemme, Claire Norman, Kirsten Jensen, Raphaella Jackson, Martin Tran, Paul S Source Type: research
The glucose tolerance peak parameter revisited. Definition for a novel use in Gestational Diabetes Mellitus confirmation
ConclusionsGTp, an index derived exclusively from the OGTT peak glycaemia, proves valuable in confirming the presence of GDM. The GTp could be used to confirm the presence of GDM under necessity of a second OGTT as test confirmation in pregnant woman. A cut-off of < 0. 36 has a specificity of 100% and a sensitivity of 75% for the diagnosis of GDM. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 26, 2024 Category: Endocrinology Source Type: research
Long-Term Efficacy and Safety of Once-Weekly Semaglutide for Weight Loss in Patients Without Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Semaglutide, a glucagon-like peptide-1 receptor agonist, has demonstrated clinically important weight loss effects in patients with type 2 diabetes. However, its effects on sustained weight loss among individuals without diabetes remains unclear. Our objective was to examine the long-term efficacy and safety of semaglutide use for weight loss among individuals with overweight/obesity and without diabetes. MEDLINE, Embase, and the Cochrane Libraries were systematically searched to identify randomized controlled trials (RCTs) that randomized participants with overweight/obesity but without diabetes to once-weekly 2.4 mg subc...
Source: The American Journal of Cardiology - April 26, 2024 Category: Cardiology Authors: Areesha Moiz, Jeremy Y. Levett, Kristian B. Filion, Katya Peri, Pauline Reynier, Mark J. Eisenberg Source Type: research
Can science find ways to ease loneliness?
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Kelly Servick
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Ariana Remmel
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Angela Saini
Podcast
25 Apr 2024
One Wednesday in May 2023, a small group gathered at an outdoor café in Barcelona, Spain, sipping coffee in t...
Source: Science of Aging Knowledge Environment - April 25, 2024 Category: Geriatrics Source Type: research
Pediatric Endocrine Society Statement on Considerations for Use of Teplizumab (Tzield ™) in Clinical Practice
We present considerations on all aspects of teplizumab administration, utilizing evidence where possible and providing a spectrum of expert opinions on unknown aspects. We discuss patient selection and prescreening, highlighting the safety and considerations for monitoring and treatment of side effects. We propose a schedule of events, a protocol for administration and discuss practice management aspects. We advocate for the need for further long-term systematic surveillance studies to continue evaluating the efficacy and safety of teplizumab.PMID:38663372 | DOI:10.1159/000538775 (Source: Cell Research)
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Shilpa Mehta Anna Ryabets-Lienhard Neha Patel Emily Breidbart Ingrid Libman Michael J Haller Kimber M Simmons Emily K Sims Linda A DiMeglio Stephen E Gitelman Kurt J Griffin Ksenia N Tonyushkina Source Type: research
