Glycemic control and associated factors among Iranian population with type 2 diabetes mellitus: a cross-sectional study
This study aimed to investigate glycemic control status and its relevant factors among patients with Type 2 DM.MethodsIn this cross-sectional study, the glycemic control status of patients with type 2 DM was investigated. In addition, relevant risk factors including demographic, clinical characteristics, self-care management behavior, medication adherence and laboratory data and their relationship with glycemic control status were assessed. Glycemic control status was defined as very good (HbA1c  
Source: Journal of Diabetes and Metabolic Disorders - July 8, 2020 Category: Endocrinology Source Type: research

Serum vitamin E level and gestational diabetes mellitus: a systematic review and meta-analysis
ConclusionThis study showed that the level of vitamin E is significantly lower in GDM women compared to healthy pregnant women. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - July 4, 2020 Category: Endocrinology Source Type: research

The most important challenges ahead of microbiome pattern in the post era of the COVID-19 pandemic
AbstractAs the ongoing COVID-19 pandemic posed a huge challenge to global public health, emphasis on personal hygiene caused extraordinary daily use of detergents and household cleaning products. Since antibacterial cleaning products have the capacity to change the environmental microbiome, increased exposure to household disinfectants could be associated with alterations in human microbiota composition and function. Moreover, the emerging links between household cleaning products and occurrence of non-communicable diseases and antibiotic resistance may involve the gut microbiome. The mediating effects of disturbed gut mic...
Source: Journal of Diabetes and Metabolic Disorders - July 3, 2020 Category: Endocrinology Source Type: research

Diagnostic validity of the pre-diabetes scale among at-risk rural Iranian adults for screening for pre-diabetes
ConclusionsThe Persian version of the ADA questionnaire had good sensitivity and fair specificity for pre-diabetes diagnosis among rural adults at high risk for developing type 2 diabetes. The study provided evidence for the ADA questionnaire as a valid and reliable tool for identifying pre-diabetes in a rural area. Identifying rural residents in the early stage of developing diabetes with a simple and accurate instrument without the need for a FBG test contributes to controlling the disease in areas with limited access to health services.Trial registrationThe study is not a trial; the registration number is not applicable...
Source: Journal of Diabetes and Metabolic Disorders - July 2, 2020 Category: Endocrinology Source Type: research

Design and psychometric evaluation of self-care behavior assessment tool in diabetic patients
AbstractObjective (s)Diabetes is the most common metabolic disease with an increasing prevalence throughout the world due to the changes in lifestyle. Appropriate self-care promotes the life condition of people with chronic illnesses and reduces the side effects of such diseases, so this study was designed to develop a scale for evaluating self-care in middle-aged patients diabetes.MethodsIn this methodological study, the following 4 steps were conducted for design and psychometric measurement of the questionnaire: 1) Data collection was carried out during a supplementary cross-sectional survey of the qualitative study; 2)...
Source: Journal of Diabetes and Metabolic Disorders - July 2, 2020 Category: Endocrinology Source Type: research

Lifestyle and silymarin: a fight against liver damage in NAFLD associated - prediabetic disease
This study investigates the effects of hepatic steatosis on fibrosis and evaluates the major predictors of liver injury in prediabetes and whether this damage is reversible with Mediterranean diet and administration of the nutraceutical silymarin.MethodsFirst, a case-control study was conducted in which 212 patients with prediabetes, not known to have NAFLD, and 126 healthy controls underwent clinical evaluation, transient elastography with measurement of liver stiffness (LS) and controlled attenuation parameter (CAP). Subsequently, the 212 prediabetic patients were enrolled into a prospective randomized interventional stu...
Source: Journal of Diabetes and Metabolic Disorders - June 30, 2020 Category: Endocrinology Source Type: research

Diabetic retinopathy screening barriers among Palestinian primary health care patients: a qualitative study
ConclusionsBarriers to completing retinopathy screening are multidimensional with financial, personal, educational, health system, and cultural factors. These should be taken into consideration by policy makers in order to increase the uptake and quality of service. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 29, 2020 Category: Endocrinology Source Type: research

Correction to: Association of eNOS and ACE gene polymorphisms as a genetic risk factor in gestational diabetes in Iranian women
The authors would like to clarify that Shahnaz Babayanzad Ahari was incorrectly removed from the original article and should be included in the authorship. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 25, 2020 Category: Endocrinology Source Type: research

Association of microbiota-derived propionic acid and Alzheimer ’s disease; bioinformatics analysis
ConclusionsPPA interacted genes implicated in AD act through pathways initiate neuronal cell death. In sum up, AD-PPA shared genes exhibited evidence that supports the idea PPA secreted from bacteria could alter brain physiology toward the emerging AD signs. This idea needs to confirm by more future investigation in animal models. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 23, 2020 Category: Endocrinology Source Type: research

Mechanistic dissection of diabetic retinopathy using the protein-metabolite interactome
ConclusionsOur interactome mapping suggests that mitochondrial dysfunction could be tightly linked to various phases of DR pathogenesis including altered visual cycle, cytoskeletal remodeling, altered lipid concentration, inflammation, PHB depletion, tubulin phosphorylation, and altered energy metabolism. The protein-metabolite interactions in the current network demonstrate the etiology of retinal degeneration and suggest the potential therapeutic approach to treat DR. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 18, 2020 Category: Endocrinology Source Type: research

Insulin injection practices among youngsters with diabetes in Tikur Anbesa Specialized Hospital, Ethiopia
AbstractPurposeThe main aim of this study was to explore how participants were practicing insulin injections and assess its association with the insulin related-outcomes.MethodsA hospital-based cross-sectional study was conducted among 176 youngsters with diabetes in Tikur Anbesa Specialized Hospital, Ethiopia. The inclusion criterion was the use of insulin treatment for a minimum of one year. Data about insulin injection practices was derived from participants ’ report. Descriptive statistics was presented using frequency distributions and percentages for categorical variables while measure of central tendencies and...
Source: Journal of Diabetes and Metabolic Disorders - June 16, 2020 Category: Endocrinology Source Type: research

Vitamin D pathway-related gene polymorphisms and their association with metabolic diseases: A literature review
ConclusionsOverall, this literature review suggests that ethnic-specific genetic associations are involved. Further research utilizing large studies is necessary to better understand these ethnic-specific genetic associations between vitamin D deficiency and metabolic diseases. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 16, 2020 Category: Endocrinology Source Type: research

Application of protection motivation theory to diabetic foot care Behaviours in Egypt
ConclusionThere was a low level of foot self-care amongst the sample. Health education programs reinforcing the intention to adhere to foot care behaviours can improve foot care practices among people with diabetes through increasing self-efficacy and perceived seriousness and reducing perceived barriers. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 16, 2020 Category: Endocrinology Source Type: research

Betaine alleviated hepatic and renal injury in diabetic pregnant rats: biochemical and histopathological evidences
ConclusionFindings of the current paper, for the first time, provided evidence regarding protective effects of betaine on liver and kidney function against maternal diabetes in an animal model of STZ-induced diabetic pregnancy. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 13, 2020 Category: Endocrinology Source Type: research

Assessing impaired fasting blood glucose criteria for high-risk dysglycaemic populations: an experience from a European population state
ConclusionHigh-risk dysglycaemic and body mass populations may establish a more accurate dysglycaemia diagnosis and outcome when following an FBG cut-off point of>5.60  mmol/L for IFG. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 13, 2020 Category: Endocrinology Source Type: research

Effects of therapeutic education on self-efficacy, self-care activities and glycemic control of type 2 diabetic patients in a primary healthcare center in Lebanon
The objectives of this study are to assess the effects of TPE in type 2 Diabetic patients in Lebanon on their glycemic control, Diabetes Management Self-Efficacy Scale (DMSES) and their self-care activities (Summary of Diabetes Self-Care Activities SDSCA).Materials and methodsA total of 100 diabetic patients (50 experimental, 50 control) were recruited from a primary care center according to inclusion and exclusion criteria. The experimental group followed the TPE by a multidisciplinary team. Glycemic control, DMSES and SDSCA were measured at baseline and after three months. The experimental group (EG) was followed up by p...
Source: Journal of Diabetes and Metabolic Disorders - June 12, 2020 Category: Endocrinology Source Type: research

Prevalence of cardiometabolic syndrome in HIV-infected persons: a systematic review
ConclusionsCMetS was a common problem among HIV infected persons. Several RFs can contribute to the development of CMetS with smoking and hypertension highly interrelated.PROSPERO-numberCRD42018107187. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 9, 2020 Category: Endocrinology Source Type: research

Telehealth for fighting the novel coronavirus: review of activities on Diabetes and Osteoporosis management in outbreak
(Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 9, 2020 Category: Endocrinology Source Type: research

Gene ontology enrichment analysis of α-amylase inhibitors from Duranta repens in diabetes mellitus
ConclusionsThe α-amylase inhibitors fromD. repens may not be limited within the gastrointestinal tract to inhibit α-amylase but may get absorbed into the systemic circulation and modulate multiple pathways involved in the pathogenesis of diabetes mellitus to produce synergistic/additive effect. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 7, 2020 Category: Endocrinology Source Type: research

The effects of omega-3 fatty acids supplementation on metabolic status in pregnant women: a systematic review and meta-analysis of randomized controlled trials
ConclusionBased on the results of this meta-analysis omega-3 PUFA supplementation during pregnancy has a significant beneficial effect on HDL-cholesterol, and C-reactive protein. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 6, 2020 Category: Endocrinology Source Type: research

Vildagliptin ameliorates renal injury in type 2 diabetic rats by suppressing oxidative stress
ConclusionsThe treatment with vildagliptin can be useful in controlling the renal complications of type 2 diabetes mellitus through inhibiting lipid peroxidation and increasing the antioxidant enzymes. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 4, 2020 Category: Endocrinology Source Type: research

The effects of iron overload, insulin resistance and oxidative stress on metabolic disorders in patients with β- thalassemia major
AbstractBackgroundSerum lipids and glycemic dysregulation are the known characteristics of β- thalassemia major (β-TM). Here, we evaluated the association of these disorders with insulin resistance (IR), oxidative stress and serum ferritin values in patients with β-TM.MethodsThis case-control study was performed in thalassemia unite of Darab Hospital (Darab, Fars province, Iran) from December 2016 to December 2017. Forty-eight patients with β-TM and 33 healthy individuals were enrolled. Serum fasting blood sugar (FBS), insulin, total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), l...
Source: Journal of Diabetes and Metabolic Disorders - June 3, 2020 Category: Endocrinology Source Type: research

Impact of pharmacist counseling on health-related quality of life of patients with type 2 diabetes mellitus: a cluster randomized controlled study
ConclusionPharmacist counseling may help improve the HRQoL of Prolanis T2DM patients. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 3, 2020 Category: Endocrinology Source Type: research

Substituting white rice with brown and black rice as an alternative to prevent diabetes mellitus type 2: a case-study among young adults in Yogyakarta, Indonesia
ConclusionSubstituting white to brown and black rice is still a challenge for young adults in Indonesia. Several barriers such as culture, accessibility, and affordability need to be considered. Further efforts are important to manage a program to increase brown and black rice consumption. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 2, 2020 Category: Endocrinology Source Type: research

Prevention of myocardial infarction and stroke with PCSK9 inhibitors treatment: a metanalysis of recent randomized clinical trials
ConclusionsPCSK9 inhibitors reduce the incidence of myocardial infarction by 19% and stroke by 25%. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 1, 2020 Category: Endocrinology Source Type: research

Drug repurposing using computational methods to identify therapeutic options for COVID-19
ConclusionThe above-mentioned drugs can be regarded as candidates to treat COVID-19 infections, but further study on the efficiency of these drugs is also necessary. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 30, 2020 Category: Endocrinology Source Type: research

CREATE (Community deRivEd AutomaTEd insulin delivery) trial. Randomised parallel arm open label clinical trial comparing automated insulin delivery using a mobile controller (AnyDANA-loop) with an open-source algorithm with sensor augmented pump therapy in type 1 diabetes
AbstractBackgroundCommercialised automated insulin delivery (AID) systems have demonstrated improved outcomes in type 1 diabetes (T1D), however, they have limited capacity for algorithm individualisation, and can be prohibitively expensive if an individual is without access to health insurance or health funding subsidy. Freely available open-source algorithms, which have the ability to individualise algorithm parameters paired with commercial insulin pumps, and continuous glucose monitoring make up the so-called"do it yourself" (DIY) approach to AID. Limited data on the open-source approach have shown promising r...
Source: Journal of Diabetes and Metabolic Disorders - May 30, 2020 Category: Endocrinology Source Type: research

Hostile personality as a risk factor for hyperglycemia and obesity in adult populations: a systematic review
ConclusionsThere is a need for research to enhance the understanding of biological, psychological and social factors related to hostility with a view to prevention and effective intervention. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 30, 2020 Category: Endocrinology Source Type: research

Comparison of EWGSOP-1and EWGSOP-2 diagnostic criteria on prevalence of and risk factors for sarcopenia among Iranian older people: the Bushehr Elderly Health (BEH) program
ConclusionsResults showed that a prevalence of sarcopenia varied largely by using different criteria, in both sexes. EWGSOP2- defined sarcopenia prevalence was lower than that defined using EWGSOP-1 criteria due to different diagnostic factors to detect sarcopenia. Some adverse outcomes should be considered for evaluating sarcopenia to compare the accuracy of EWGSOP-1 and EWGSOP-2. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 29, 2020 Category: Endocrinology Source Type: research

Gene set enrichment analysis of α-amylase and α-glucosidase inhibitors of Cassia glauca
AbstractBackgroundThe present study aimed to evaluatein vitroα-amylase and α-glucosidase inhibitory activity of various extracts ofCassia glauca, predict the binding affinity of multiple phytoconstituents with both enzymes via in silico molecular docking and identify the probably modulated pathways by the lead hit.MethodsDifferent extracts ofCassia glauca i.e. acetone, ethanol, and aqueous extracts were evaluated for α-amylase and α-glucosidase inhibitory activity usingin vitro method in which starch and 4-Nitrophenyl β-D-glucopyranoside were used as substrate respectively. Similarly, the docki...
Source: Journal of Diabetes and Metabolic Disorders - May 28, 2020 Category: Endocrinology Source Type: research

Identifying spatial variation in the burden of diabetes among women across 640 districts in India: a cross-sectional study
ConclusionProgram with an aim to lower the intensity of community-based prevalence of diabetes, especially among women in their late reproductive ages, should adopt differential approaches across different states/districts in the context of their lifestyle, dietary pattern, working pattern, and other socio-cultural practices. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 27, 2020 Category: Endocrinology Source Type: research

The comparison of efficacy and safety between different doses of empagliflozin in insulin-treated type 1 diabetes mellitus patients: a systematic review and meta-analysis protocol
ConclusionsBased on the contemporary literature, the proposed review will synthesize the evidence on how the efficacy and safety profile of high dose empagliflozin varies with its lower doses and placebo, respectively, in insulin-treated T1DM patients. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 21, 2020 Category: Endocrinology Source Type: research

The association of tobacco smoking and bone health in the elderly population of Iran: results from Bushehr elderly health (BEH) program
ConclusionCurrent cigarette smoking is associated with both the quantity and quality of bone mass in elderly men. Although we could not detect a significant association between hookah and osteoporosis in men, considering the prevalence of hookah smoking in the middle eastern countries, further studies are needed to determine the effect of hookah smoking on bone health. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 16, 2020 Category: Endocrinology Source Type: research

Excess serum uric acid is associated with metabolic syndrome in obese adolescent patients
AbstractPurposeObesity is a significant cause of morbidity in adolescents. Excess serum uric acid (SUA) has been associated with metabolic syndrome (MS) among adults. We evaluated the relationship among SUA and markers of insulin resistance (IR) and low-grade inflammation in obese adolescents with and without MS.MethodsThe study was a retrospective chart review of obese patients seen in the LeBonheur Endocrine clinic seen in clinic between September 2016 and December 2017. MS was defined as according to the International Diabetes Federation. Body mass index standard deviation score (BMI SDS), systolic blood pressure (SBP),...
Source: Journal of Diabetes and Metabolic Disorders - May 16, 2020 Category: Endocrinology Source Type: research

Metformin/Donepezil combination modulates brain antioxidant status and hippocampal endoplasmic reticulum stress in type 2 diabetic rats
ConclusionMetformin/donepezil combination appeared more efficacious than metformin only and could be considered for managing diabetes-associated dementia. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 16, 2020 Category: Endocrinology Source Type: research

The effect of green coffee extract supplementation on cardio metabolic risk factors: a systematic review and meta-analysis of randomized controlled trials
ConclusionThis meta-analysis indicated that green coffee supplementation significantly decreased FBS, insulin, and triglyceride, but improved HDL. No statistically significant improvement was found in HOMA-IR, LDL, and CRP indices following the green coffee supplementation. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 15, 2020 Category: Endocrinology Source Type: research

Correction to: Anti-diabetic effects of Ficus Asperifolia in Streptozotocin-induced diabetic rats
The author names are incorrectly displayed in the original article and should be Faith Pwaniyibo Samson (F.P. Samson), Ambrose Teru Patrick (A.T. Patrick), Margret Samuel Nadro (M.S. Nadro), and Jin Jahng Wan (J.J. Wan). (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 13, 2020 Category: Endocrinology Source Type: research

Comparison home care service versus hospital-based care in patients with diabetic foot ulcer : an economic evaluation study
ConclusionsRegarding current evidence, home care strategy for patients suffering diabetic foot ulcer enjoys more cost effectiveness compared to hospital care. It is suggested that healthcare policy makers determine the tariff for health care services for disease groups according to the activity based costing approach. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 12, 2020 Category: Endocrinology Source Type: research

Methylglyoxal and soluble RAGE in type 2 diabetes mellitus: Association with oxidative stress
ConclusionsThe findings of the present study showed that increased plasma MGO level is significantly associated with the HbA1c levels in T2DM patients. Moreover, the study shows that plasma sRAGE level is significantly augmented at increased level of glycation (HbA1c  >  10%) in T2DM patients. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 12, 2020 Category: Endocrinology Source Type: research

Gongronema latifolium leaf extract modulates hyperglycaemia, inhibits redox imbalance and inflammation in alloxan-induced diabetic nephropathy
AbstractBackgroundGongronema latifolium leaf is used traditionally to treat diabetes and other diseases. The present study aimed to provide the modulatory effect ofG. latifolium on hyperglycemia, inhibitory effect of redox imbalance and inflammation in alloxan-induced nephropathy in Wistar rats.MethodsAlloxan monohydrate was used to induce diabetes by an intraperitoneal injection of (150  mg/kg). Three diabetic groups were administered aqueous leaf extract ofG. latifolium at 6.36, 12.72 and 25.44  mg/kg bodyweight (BW) respectively; a group was administered with metformin (5 mg/kg BW), while the other two we...
Source: Journal of Diabetes and Metabolic Disorders - May 12, 2020 Category: Endocrinology Source Type: research

Edmonton frail score is associated with diabetic control in elderly type 2 diabetic subjects
ConclusionsWe think that frailty is associated with poor glucose control in subjects with T2DM and better control of the disease may prevent or slow down the development of frailty, as well as microvascular complications in subjects with type 2 diabetes mellitus. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 12, 2020 Category: Endocrinology Source Type: research

Hyssopus officinalis exerts hypoglycemic effects on streptozotocin-induced diabetic rats via modulating GSK-3 β , C-fos, NF-κB , ABCA1 and ABGA1 gene expression
ConclusionFrom the data recorded, it could be concluded thatH. officinalis exerts a great hypoglycemic potential via modulatingC-fos,GSK-3 β, NF-κB,TNF- α, ABCA1 andABCG1 gene expression and signaling pathways and could be considered as an effective candidate for DMT2 treatment. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 11, 2020 Category: Endocrinology Source Type: research

Therapeutic effects of in vivo- differentiated stem cell and Matricaria chamomilla L. Oil in diabetic rabbit
ConclusionsTogether these data demonstrated chamomile oil along with in vivo-differentiated stem cell is a promising new treatment for diabetes. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 11, 2020 Category: Endocrinology Source Type: research

The reference value of trabecular bone score (TBS) in the Iranian population
ConclusionsThis was the first study to propose evaluation of the normal range for TBS values in both genders in the Middle- East and Iran. According to our results: TBS  ≤ 1.231 in men and TBS ≤ 1.287 in women is considered to be degraded microarchitecture among the Iranian population. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 11, 2020 Category: Endocrinology Source Type: research

The Effects of Exercise Training on the Brain-Derived Neurotrophic Factor (BDNF) in the Patients with Type 2 Diabetes: A Systematic Review of the Randomized Controlled Trials
ConclusionDecreased energy intake and increased energy expenditure through exercise training may modulate BDNF levels in patients with type 2 diabetes. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 6, 2020 Category: Endocrinology Source Type: research

Association Between Metabolic Syndrome and Diabetes Mellitus According to International Diabetic Federation and National Cholesterol Education Program Adult Treatment Panel III Criteria: a Cross-sectional Study
AbstractPurposeLifestyle changes in diabetes mellitus leads to metabolic syndrome, thus resulting in a hike in micro and macrovascular complications in diabetes mellitus patients. The main objective of the study  was to identify the occurrence of metabolic syndrome and to evaluate the gender-associated difference in each component of metabolic syndrome by using International Diabetic Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III)criteria.MethodsThis is a cross-sectional study conducted in 350 type II diabetes mellitus patients. All the study participants withi...
Source: Journal of Diabetes and Metabolic Disorders - May 5, 2020 Category: Endocrinology Source Type: research

Intestinal effect of the probiotic Escherichia coli strain Nissle 1917 and its OMV
AbstractSeveral investigations have been conducted during the past years to examine the correlation between dysbiosis and both intestinal and extra-intestinal diseases such as inflammatory bowel disease (IBD) and ulcerative colitis (UC).E. coli Nissle 1917 (EcN) is a nonpathogenic gram-negative strain utilized in numerous gastrointestinal issues, consisting of diarrhea, uncomplicated diverticular malady, IBD and specifically UC. Many investigations have been done to examine the capability of assertive bacteria, inclusive of commensal and probiotic strains to enhance IBD in clinical testing. Bacterial secreted factors have ...
Source: Journal of Diabetes and Metabolic Disorders - May 1, 2020 Category: Endocrinology Source Type: research

Ramadan fasting during Covid-19 pandemic
(Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 30, 2020 Category: Endocrinology Source Type: research

Antidiabetic activity of watermelon ( Citrullus lanatus ) juice in alloxan-induced diabetic rats
This study was carried out to explore the antidiabetic potential of watermelon (Citrullus lanatus) juice in alloxan-induced diabetic rats.MethodsWatermelon juice was used for the determination of in vitro parameters such as 1,1-diphenyl-2-picryl-hydrazil (DPPH), nitric oxide and ferric reducing antioxidant potential (FRAP) as well as phytochemicals such as total phenol, total flavonoids. In vitro,α-glucosidase and α-amylase inhibitory activities were also accessed using standard procedures. Diabetes was induced in the rats by a single intraperitoneal (I.P) injection of freshly prepared alloxan (150 mg/kg b...
Source: Journal of Diabetes and Metabolic Disorders - April 28, 2020 Category: Endocrinology Source Type: research

The regulation of Niemann-Pick C1-Like 1 (NPC1L1) gene expression in opposite direction by Bacteroides spp. and related outer membrane vesicles in Caco-2 cell line
ConclusionThe opposite effect ofB. fragilis,B. thetaiotaomicron and related OMVs on theNPC1L1 gene expression was observed in Caco-2 cells. Interestingly, these effects partially were in line with the alternation ofLXRs expression. However, based on pathway enrichment analysis, further molecular investigations are required to elaborate in details the specific association betweenBacteroides spp. and OMVs with regulation of cholesterol signaling pathways including cholesterol transport, lipid storage, lipid homeostasis and cholesterol homeostasis. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 22, 2020 Category: Endocrinology Source Type: research