The effect of probiotics on lipid profile & amp; anthropometric indices in diabetic nephropathy; a systematic review and meta-analysis of clinical trials
ConclusionThere is limited evidence to support the efficacy of probiotics for the modulation of lipid profile and anthropometric indices in DN patients.Graphical abstractProbiotics did not beneficial effect on lipid profile& anthropometric markers in Diabetic Nephropathy; anyway, more trials should be conducted. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 23, 2021 Category: Endocrinology Source Type: research

Investigation of attitude, awareness, belief, and practice of complementary and alternative medicine among type 2 diabetic patients: a cross sectional study
ConclusionsThe results showed that patients have a positive attitude, and most of them have experience of using CAM. However, most patients report that they have rather little awareness in this field. Thus, healthcare providers must provide patients with the necessary information so that these modalities are used correctly. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 22, 2021 Category: Endocrinology Source Type: research

The effects of foot exercise with audiovisual and group support foot exercises to diabetes mellitus patients
ConclusionsAudiovisual and group support foot exercises significantly influenced the Ankle Brachial Pressure Index value and foot sensation in diabetic mellitus patients. This intervention is encouraged for diabetic mellitus patients who would like to see the benefits of exercise  and group support. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 22, 2021 Category: Endocrinology Source Type: research

The effect of physical activity on total homocysteine concentrations and cardiovascular risk in older Brazilian adults with type 2 diabetes
AbstractA low level of physical activity has a potential association with high levels of homocysteine, which implies an increased chance of older adults with type 2 diabetes mellitus developing cardiovascular disease (CVD). However, the effects of physical activity on homocysteine levels have been poorly explored in the literature. Therefore, this study compared homocysteine levels and cardiovascular risk among physically active and inactive older women with type 2 diabetes mellitus. Fifty-nine women with type 2 diabetes mellitus, between 60 and 91  years old, were evaluated. The level of physical activity was assesse...
Source: Journal of Diabetes and Metabolic Disorders - February 22, 2021 Category: Endocrinology Source Type: research

Prevalence and determinants of vitamin D deficiency in Iranian children and adolescents: the CASPIAN-V study
AbstractPurposeTo examine the prevalence and determinants of vitamin D deficiency in Iranian children and adolescents.MethodsWe used data from a national school-based surveillance program conducted among 7-18-year-old children and adolescents living in rural and urban areas in 30 provinces of Iran. Data on student ’s lifestyle, health behaviors, and health status was obtained through a validated questionnaire. Serum 25-hydroxy vitamin D (25-OH-D) level was measured by chemiluminescent immunoassay. Vitamin D deficiency was defined as serum 25-OH-D concentrations 
Source: Journal of Diabetes and Metabolic Disorders - February 20, 2021 Category: Endocrinology Source Type: research

Benfotiamine reduced collagen IV contents of sciatic nerve in hyperglycemic rats
This study was designed to evaluate the effects of benfotiamine (BT) on the structural, biological and mechanical characteristics of rat sciatic nerve in hyperglycemic condition.Materials and methodsForty eight adult male Wistar rats were assigned to 6 groups (n  = 8): control (healthy rats with no treatment; C), positive control (healthy rats received BT treatment; B), negative control groups 1&2 (hyperglycemic rats kept for 4 and/or 8 weeks; 4WD and 8WD, respectively) and experimental groups 1&2 (hyperglycemic rats treated by daily oral gavage of 100  mg kg− 1 body weight BT for 4 ...
Source: Journal of Diabetes and Metabolic Disorders - February 20, 2021 Category: Endocrinology Source Type: research

Decomposition of socioeconomic inequality in growth disorders to its determinants in pediatric population: the CASPIAN IV study
ConclusionOur findings show a considerable inequality in prevalence of growth disorders in Iranian children and adolescents. These findings provide practical information for health policies and programs. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 20, 2021 Category: Endocrinology Source Type: research

Gene set enrichment analysis of PPAR- γ regulators from Murraya odorata Blanco
ConclusionsThe anti-diabetic property of the  Murraya odorata Blanco of  fruit pulp may be due to the presence of n-hexadecanoic acid and stigmasterol; may also involve in the regulation of the PI3K-Akt pathway which needs further investigated byin-vitro andin-vivo protocols. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 17, 2021 Category: Endocrinology Source Type: research

The investigation of the efficacy ratio of cress seeds supplementation to moderate hyperglycemia and hepatotoxicity in streptozotocin ‐induced diabetic rats
ConclusionsCress seeds supplementation confirmed their potential anti-diabetic and antioxidant activities with higher efficacy of 5  % dose than the lower dose of 2 %. Therefore, 5 % of cress seeds administration seems to be the excellent rate recommended in controlling diabetes and its complications. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 16, 2021 Category: Endocrinology Source Type: research

Role of interdigital sensory nerve conduction study as a noninvasive approach for early diagnosis of diabetic peripheral neuropathy
This study designed to compare more distal techniques of electrodiagnostic testing, including interdigital sensory nerve conduction studies (NCSs), with conventional approaches and to investigate its role in confirming the early stages of polyneuropathy.MethodsThis cross-sectional study was performed in the Physical Medicine and Rehabilitation Department of Hazrat Fatemeh Reconstruction Surgery Hospital. Thirty one symptomatic diabetic outpatients and 23 asymptomatic nondiabetic subjects included in our study. We performed nerve conduction studies on five sensory nerves consist of the dorsal sural nerve, medial plantar ner...
Source: Journal of Diabetes and Metabolic Disorders - February 15, 2021 Category: Endocrinology Source Type: research

Cardiovascular diseases risk prediction in patients with diabetes: Posthoc analysis from a matched case-control study in Bangladesh
ConclusionBangladeshi patients with diabetes showed a significant burden of CVD risk at a relatively younger age. Strategies for reducing tobacco use and improving BP control in people with diabetes is needed for lowering future CVD risks. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 15, 2021 Category: Endocrinology Source Type: research

Genetic research in Immunogenetics Group of Endocrinology and Metabolism Research Institute
AbstractDue to the high prevalence of metabolic diseases and the role of genetic factors in their susceptibility, the use of basic research in this field can be useful for screening, prevention, and treatment of metabolic disorders. Therefore, in the Immunogenetics group of Endocrinology and Metabolism Research Institute (EMRI), various studies have been conducted to investigate the relationship between genetic markers and the risk of monogenic and complex disorders such as diabetes, obesity, thyroid malignancies, and cardiovascular disease. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 15, 2021 Category: Endocrinology Source Type: research

High anti-inflammatory and antidiabetic activities of Hammada elegans (Bge.)Botsch (Chenopodiaceae) extracts: an in vivo assessment
ConclusionsHammada elegans Botsch extracts seem to have therapeutic opportunities for the treatment of the inflammation and diabetes. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 13, 2021 Category: Endocrinology Source Type: research

Serum Uric acid is a better indicator of kidney impairment than serum uric acid to creatine ratio ; a cross sectional study of type 2 diabetes mellitus patients
This study investigated the ability of serum uric and uric acid to creatinine ratio in assessing the kidney function of T2DM patients and determined the relationship between serum uric acid to creatinine ratio and estimated glomerular filtration rate (eGFR).Methods One hundred and fifty-five (155) consented T2DM patients were recruited from the diabetes clinic of the Cape Coast Teaching hospital. Anthropometric variables and blood pressure were measured. Serum uric acid (SUA), serum creatinine and urine protein were estimated using standard protocols. Uric acid to creatinine ratio (UA:CR), eGFR were then calculated.Results...
Source: Journal of Diabetes and Metabolic Disorders - February 10, 2021 Category: Endocrinology Source Type: research

Endocrinology and metabolism research institute educational achievements on diabetes at a glance: conventional review and Scientometrics
ConclusionIt is notable that, the national strategic planning to establish courses and produce materials and programs to empower health care providers and patients with diabetes and families. According to the strategic plan, further research and infrastructures are required for various aspects of diabetes prevention and education. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 9, 2021 Category: Endocrinology Source Type: research

Correction to: trisected pancreas model for testing tissue dissociation enzyme combinations: a novel methodology for improving human islet yield for clinical islet transplantation
A Correction to this paper has been published:https://doi.org/10.1007/s40200-021-00747-w (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 8, 2021 Category: Endocrinology Source Type: research

Association of ADIPOQ rs266729 and rs1501299 gene polymorphisms and circulating adiponectin level with the risk of type 2 diabetes in a population of Iran: a case-control study
ConclusionWe concluded that ADIPOQ rs266729 (SNP-11377 C  >  G) gene polymorphism but no rs1501299 is associated with increased risk of T2D in our population. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 6, 2021 Category: Endocrinology Source Type: research

Momordica charantia silver nanoparticles modulate S OCS /JAK/STAT and P13K/Akt/PTEN signalling pathways in the kidney of streptozotocin-induced diabetic rats
This study was designed to evaluateM. charantia silver nanoparticles ’ therapeutic effect on DN-induced by streptozotocin (STZ) in Wistar rats.MethodsTheM. charantia nanoparticles used was synthesized using the filtrate from the plant methanolic extract added to 1  mM concentration of aqueous silver nitrate. DM was induced in Wistar rats by intraperitoneal injection of STZ (65 mg/kg). The animals’ treatment groups were divided into; Diabetic control (65 mg/kg STZ), Control, and groups treated with silver nitrate (10 mg/kg),M. charantia nanoparticles (50  mg/kg), metformin (100 mg/k...
Source: Journal of Diabetes and Metabolic Disorders - February 5, 2021 Category: Endocrinology Source Type: research

Luffa cylindrica : a promising herbal treatment in progesterone induced obesity in mice
ConclusionAfter assimilating the In vivoand in vitro studiesLuffa cylindrical extract highlighted the antilipidemic, anti-hyperglycaemic, antioxidant potential in hormone-induced obesity. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 5, 2021 Category: Endocrinology Source Type: research

Phloridzin ameliorates type 2 diabetes ‐induced depression in mice by mitigating oxidative stress and modulating brain‐derived neurotrophic factor
ConclusionsPhloridzin may ameliorates T2D-induced depression by mitigating the oxidative stress, and up-regulation of neurotrophins in the brain. Therefore, phloridzin can be used as a therapeutic intervention for the management of depression co-morbid with T2D. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 5, 2021 Category: Endocrinology Source Type: research

Effectiveness of an adapted diabetes nutrition education program on clinical status, dietary behaviors and behavior mediators in adults with type 2 diabetes: a randomized controlled trial
ConclusionsNEP had limited effects on HbA1c, targeted dietary behaviors and behavior mediators but showed positive effects on blood pressure. The NEP health cost savings potential supports the need for improving program participation.Trial registrationClinicalTrials.gov. number NCT03334773; 7 November 2017 retrospectively registered. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 4, 2021 Category: Endocrinology Source Type: research

Effect of apple peel extract on diabetes-induced peripheral neuropathy and wound injury
ConclusionsOn the basis of the findings, we conclude that APE has a potential to be used as a therapeutic intervention for the management of DPN and delayed wound healing in the diabetic condition. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 3, 2021 Category: Endocrinology Source Type: research

Geographical, gender and age inequalities in non-communicable diseases both at national and provincial levels in Iran
In this study, we describe the status of most lethal NCDs in the country at national and provincial level. In addition, study on the inequality of deaths due to NCDs at provincial level in Iran showed that there is a considerable difference between different provinces. Furthermore, there is an age inequality so that mortality of main NCDs increased dramatically after the age of 70. Therefore, health policy makers and decision makers should adopt appropriate policies to reduce gender, geographic and age disparities to reduce gender and inter-provincial inequalities in Iran. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 2, 2021 Category: Endocrinology Source Type: research

Value-based eating habits; exploring religio-cultural nutritional behavior norms
ConclusionThere is strong emphasis on nutritional habits in value-based religio-cultural sources. The use of these norms in later policies and practices is advised. This approach can lead to healthier nutritional choices and a decrease in non-communicable diseases. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 1, 2021 Category: Endocrinology Source Type: research

The dynamics of metabolic syndrome development from its isolated components among Iranian adults: findings from 17  years of the Tehran lipid and glucose study (TLGS)
ConclusionThe results indicated that obesity and hypertension components played a more important role in the further development of MetS compared to other components in the Iranian adult population. This necessitates careful and serious attention in preventive and control planning. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 1, 2021 Category: Endocrinology Source Type: research

Effect of yoga on glycemia and lipid parameters in type-2 diabetes: a meta-analysis
AbstractPurposePrior systematic reviews on yoga and diabetes have given conflicting results. They have been limited by inclusion of uncontrolled unblinded single group observational studies. No reviews are available which have used the Cochrane methodology and GRADE (Grades of Recommendation, Assessment, Development and Evaluation) approach. This meta-analysis evaluated the efficacy of yoga on glycaemia and lipids in T2DM using the Cochrane methodology and GRADE approach.MethodsMajor repositories were searched to pick randomized controlled trials involving T2DM patients receiving yoga. Primary outcome was to evaluate chang...
Source: Journal of Diabetes and Metabolic Disorders - February 1, 2021 Category: Endocrinology Source Type: research

Effect of pre-meal water intake on the serum levels of Copeptin, glycemic control, lipid profile and anthropometric indices in patients with type 2 diabetes mellitus: a randomized, controlled trial
In this study, 40 patients with T2DM were randomly assigned to two intervention groups for 8 weeks; a) drinking 1 liter of water per day before each main meal (PW group)., and b) no water consumption before any meal (NPW group). At the beginning and at the end of the study, blood samples were taken to assess glycemic indices, lipid profile, copeptin and anthropometric indices.ResultsPre-meal water intake was associated with lower energy intake, BMI, waist circumference (WC) and greater weight loss, in compared with the controls (P 
Source: Journal of Diabetes and Metabolic Disorders - February 1, 2021 Category: Endocrinology Source Type: research

The association between job stress and metabolic syndrome among medical university staff
ConclusionsOur findings revealed a close association between job-related stress and the impaired well-being in the presence of metabolic syndrome among the medical university staff. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 1, 2021 Category: Endocrinology Source Type: research

Assessment of immune-alternations and their correlations with therapeutic outcomes of transplantation of autologous Mesenchymal and Allogenic fetal stem cells in patients with type 1 diabetes: a study protocol
AbstractIntroductionStem-cell therapy, which has recently emerged as a potentially therapeutic option for diabetes, is demonstrated to significantly alter both cellular and non-cellular elements of the immune system. In addition, it is demonstrated that allogenic stem-cells, once considered immune-privileged, can be rejected by the host immune system almost similar to any other somatic cell. To date, nonetheless, details of these intricate interactions remain obscure. The current study is designed to illuminate both aforementioned favorable and unfavorable stem cell-mediated immune reactions. Findings of this study may she...
Source: Journal of Diabetes and Metabolic Disorders - January 29, 2021 Category: Endocrinology Source Type: research

National innovation system for diabetes and metabolic disorders can promote biomedical research accountability; a literature review and designing a conceptual framework
ConclusionsThe effective communication of 10 components, which are included in this study, is an essential element that can play a vital role in the effectiveness of diabetes and metabolic disorders innovation system in order to meet the community needs. Moreover, these components were categorized by experts in four groups of policymaking, financing, research and development, and education, as the functions of the National Innovation System for diabetes and metabolic disorders in Iran. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 29, 2021 Category: Endocrinology Source Type: research

Scientometric analyzing the output of researchers and organizations on COVID-19 for better conducting the scientific efforts: with a glance to endocrinology
ConclusionThe literature on COVID-19 is increasing with a high and fast growth. In this regard, there is a need to evaluate these publications once in a while and their results should be published to use this information for more effective management of future research works with emphasizes on the gaps of researches and more citable documents and allocation of budgets on more needed research and don ’t carry out the duplicates research. This would be helpful for prevention, control, and treatment of COVID-19 that is now among the most common topics in the world. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 29, 2021 Category: Endocrinology Source Type: research

Multidimensional perspective of obesity; prevention to treatment
ConclusionFurther population-based studies focusing on national and international collaborations are needed to progress more practical strategies to face with obesity challenge in different age ranges. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 28, 2021 Category: Endocrinology Source Type: research

Significant association of LXR β (NR1H2) polymorphisms (rs28514894, rs2303044) with type 2 diabetes mellitus and laboratory characteristics
AbstractPurposeTo investigate if single-nucleotide polymorphisms (SNPs) in theNR1H2 gene encodingLXR β contribute to the development of type-2 diabetes mellitus (T2DM) and whether genotypes of two  NR1H2 polymorphisms, rs28514894 and rs2303044, are associated with laboratory characteristics of T2DM patients.MethodA total of 900 subjects (450 T2DM cases and 450 healthy subjects) of Iranian ancestry were genotyped forNR1H2 polymorphisms via ARMS-PCR and PCR-RFLP techniques.ResultOur findings showed a significant correlation between both polymorphisms and increased risk of T2DM. The haplotype analysis showed an asso...
Source: Journal of Diabetes and Metabolic Disorders - January 27, 2021 Category: Endocrinology Source Type: research

Vitamin D Receptor gene polymorphisms and susceptibility to type 2 diabetes: evidence from a meta-regression and meta-analysis based on 47 studies
ConclusionsThis meta-analysis suggested a significant association betweenVDR geneFokI, andBsmI (heterozygote model) polymorphisms and T2D susceptibility in overall population and ethnic-specific analysis. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 25, 2021 Category: Endocrinology Source Type: research

Review of osteoporotic fracture research in Endocrinology and Metabolism Research Institute; where we started and where to go
ConclusionsConsidering the importance of osteoporotic fractures in Iran with an ageing trend, Osteoporosis Research Centers can play an essential role in providing evidence for policymakers. Worldwide, there is a large care gap to assess bone health and start treatments after fragility fractures. Accordingly, following international recommendations, practical interventions are required to fill this gap. EMRI began developing the “Registry of osteoporosis” and also pilot the “Fracture Liaison Services”, as an operative model to address the existing care gap and implement applied research in this scie...
Source: Journal of Diabetes and Metabolic Disorders - January 23, 2021 Category: Endocrinology Source Type: research

Assessment of fecal Akkermansia muciniphila in patients with osteoporosis and osteopenia: a pilot study
AbstractObjectivesOsteoporosis is characterized by slow deterioration in bone mass and disruption of its structure, leading to an increased risk of bone fractures. Gut microbiota plays an important role in the transport and absorption of nutrients needed for bone health.Akkermansia muciniphila is one of the gut microbiota members that its beneficial role in prevention of metabolic disorder was suggested. The aim of the current pilot study was the assessment of fecalA. muciniphila in patients with osteoporosis and osteopenia.MethodsA total of 36 subjects including eight with osteoporosis (three men and five women), eight wi...
Source: Journal of Diabetes and Metabolic Disorders - January 23, 2021 Category: Endocrinology Source Type: research

Diabetic foot care course: a quasi-experimental study on E-learning versus interactive workshop
AbstractBackgroundNurses, as multidisciplinary Diabetic Foot Care (DFC) team members, need to be trained in DF prevention and management. Regarding the increasing use of e-learning educational courses as the new learning strategy with potential benefits among health care providers, this study attempted to evaluate the educational effects of an e-learning course on DFC compared to that of an interactive workshop in the related knowledge attainment.MethodsThis was a quasi-experimental study compared two non-randomized groups consisting of nurses who attended an e-learning course (intervention group) and a face-to-face intera...
Source: Journal of Diabetes and Metabolic Disorders - January 23, 2021 Category: Endocrinology Source Type: research

Effect of community and peer support based healthy lifestyle program (CP-HELP) on self care behavior and fasting blood glucose in patient with type 2 Diabetes Mellitus
Conclusion: CP-HELP may be a promising interventional strategy to improve self-care behavior and imp roving of fasting blood glucose in patient with T2DM. The research results can be used as an important reference for improving self care behavior and fasting blood glucose in patient with type 2 Diabetes Mellitus. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 23, 2021 Category: Endocrinology Source Type: research

Analysis of genetic selection at insulin receptor substrate-2 gene loci
ConclusionThese findings indicate that genetic selection has occurred at theIRS2 locus, warranting further research into the adaptive evolution of metabolic disorder-associated genes. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 23, 2021 Category: Endocrinology Source Type: research

Association of a body shape index and hip index with cardiometabolic risk factors in children and adolescents: the CASPIAN-V study
This study designed to discover the link between a body shape index (ABSI) and hip index (HI) with cardiometabolic risk factors (CMRFs) in Iranian children and adolescents.Subjects and methodsIn a nationwide cross-sectional survey, 4200 students who were 7 –18 years old were chosen via a multistage cluster sampling method in 30 provinces of Iran in 2015. Metabolic syndrome (MetS) was defined in line with the Adult Treatment Panel III criteria. ABSI and HI were defined as waist circumference (m)/ [body mass index2/3 * height (m)1/2] and hip circumference (cm) *(height/ 166  cm)0.310 *(weight / 73  kg)&m...
Source: Journal of Diabetes and Metabolic Disorders - January 22, 2021 Category: Endocrinology Source Type: research

Trend of nutrition research in endocrine disorders, gaps, and future plans: a collection of experiences of an endocrinology research institute
ConclusionAn increasing trend in the publications related to nutrition science is observed at EMRI. However, nutrition research and publications can grow further through expanding collaborations with other fields related to endocrine. Given nutritional assessments in national projects and focusing on the identification of preventive nutritional strategies, considering the situations of our society can be helpful to make nutritional findings more practical. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 22, 2021 Category: Endocrinology Source Type: research

Non-communicable diseases ’ risk factors in Iran; a review of the present status and action plans
AbstractNon-communicable Diseases (NCDs) are the leading causes of death globally, imposing a heavy burden on the healthcare systems, especially in low- and middle-income countries. Iran is a country in the Middle-East region with an aging population and changing disease risk factors, and now is facing NCDs as the major health problem of the country. Investigating NCDs ’ risk factors and tackling preventable ones is the main intervention to control their heavy burden. In this review, we discussed the most critical risk factors in Iran and the implemented programs and action plans to control them. A better knowledge o...
Source: Journal of Diabetes and Metabolic Disorders - January 22, 2021 Category: Endocrinology Source Type: research

Effect of Alpinia officinarum extract on reproductive damages in streptozotocin induced diabetic male rats
AbstractPurposeInfertility is one of the systemic problems in diabetic men. The purpose of the present study is investigation of the effects of theAlpinia officinarum (AO) hydro-alcoholic extract on the reproductive system damages in diabetic male rats.MethodsTwenty four male rats were randomly assigned into 4 groups (n = 6); i.e., control, diabetic control, and diabetic rats treated orally withAO extract (200 and 500  mg kg−1). A single dose (60  mg kg-1) of streptozotocin (STZ) was injected intraperitoneally (IP) to induce diabetes. After 8 weeks of treatment, blood samples, t...
Source: Journal of Diabetes and Metabolic Disorders - January 22, 2021 Category: Endocrinology Source Type: research

Modeling and simulation in medical sciences: an overview of specific applications based on research experience in EMRI (Endocrinology and Metabolism Research Institute of Tehran University of Medical Sciences)
AbstractThe concomitant use of various types of models (in silico, in vitro, and in vivo) has been exemplified here within the context of biomedical researches performed in the Endocrinology and Metabolism Research Institute (EMRI) of Tehran University of Medical Sciences. Two main research aeras have been discussed: the search for new small molecules as therapeutics for diabetes and related metabolic conditions, and diseases related to protein aggregation. Due to their multidisciplinary nature, the majority of these studies have needed the collaboration of different specialties. In both cases, a brief overview of the subj...
Source: Journal of Diabetes and Metabolic Disorders - January 22, 2021 Category: Endocrinology Source Type: research

New ‐onset type 1 diabetes complicated by diabetic ketoacidosis and severe sepsis requiring extracorporeal membrane oxygenation and kidney replacement therapy
We report an atypical case of new onset diabetes with severe DKA and underlying severe sepsis, which responded poorly to traditional therapy resulting in maximal intensive care management including mechanical ventilation, inotropes, extracorporeal membrane oxygenation (ECMO) for cardiorespiratory support, and kidney replacement therapy. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 22, 2021 Category: Endocrinology Source Type: research

Diabetes and rhino-orbito-cerebral mucormycosis – A deadly duo
AbstractBackgroundRhino-orbito-cerebral mucormycosis(ROCM) is an uncommon yet potentially fatal fungal infection predominantly seen in immunocompromised individuals. However, there is very limited data available from India regarding outcome of patients with ROCM and diabetes mellitus.ObjectiveTo ascertain clinical parameters and factors in the final outcome of patients with diabetes mellitus and ROCM.Materials and MethodsThis series included retrospective analysis of medical records of 91 patients with diabetes mellitus who were diagnosed with ROCM from january 2007 to june 2019  at a tertiary care hospital in Punjab....
Source: Journal of Diabetes and Metabolic Disorders - January 21, 2021 Category: Endocrinology Source Type: research

A case-control study to determination FBXW7 and Fetuin-A levels in patients with type 2 diabetes in Iraq
ConclusionsLevels of FBXW7 and Fetuin-A proteins in sera of Diabetic patients were elevated. FBXW7 was significantly correlated with newly diagnosed patients. Metformin reduces FBXW7 and Fetuin-A levels. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 21, 2021 Category: Endocrinology Source Type: research

An overview of diabetes research achievements during a quarter of a century in Diabetes Research Center
ConclusionsAs one of the most comprehensive research institute, the EMRI has developed its national and international research activities to improve diabetes management and cure through developing new treatment strategies, improving translational research, and applying new emerging technologies such as regenerative medicine. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 20, 2021 Category: Endocrinology Source Type: research

Polymorphic genetic markers and how they are associated with clinical and metabolic indicators of type 2 diabetes mellitus in the Kazakh population
ConclusionsGenetic polymorphisms that influence pancreatic gland beta-cells insulin release and secretion associate with metabolic and anthropometric measures definitive for type 2 DM in Kazakh population. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 20, 2021 Category: Endocrinology Source Type: research

Effect of spirulina and chlorella alone and combined on the healing process of diabetic wounds: an experimental model of diabetic rats
ConclusionsThe results of this study showed that supplementation with spirulina and chlorella alone and combined could improve wound healing indices in diabetic rats and could therefore be recommended for the management of diabetic ulcer. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 19, 2021 Category: Endocrinology Source Type: research