Concurrent metformin and silibinin therapy in diabetes: assessments in zebrafish ( Danio rerio ) animal model
In this study, zebrafish was used as a biological model to induce type 2 diabetes mellitus through glucose. Then, the effect of metformin and silibinin combination was examined on elevated blood glucose, intestinal tissues, liver enzymes, and TNF- α, IFN-γ, INL1β genes as inflammation marker genes.MethodsThe liver enzymes (AST, ALT, and ALP) derived from fish viscera homogenate supernatants were assayed in an auto-analyzer. The expression of target genes was quantified on RNA extracted from the tails by an in-house RT-PCR method, with fine intestine tissue staining performed by hematoxylin and eosin protoc...
Source: Journal of Diabetes and Metabolic Disorders - October 25, 2020 Category: Endocrinology Source Type: research

Cymene consumption and physical activity effect in Alzheimer ’s disease model: an in vivo and in vitro study
Conclusionp-cymene can improve AD-related disorders including memory impairment. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - October 23, 2020 Category: Endocrinology Source Type: research

Biological response modifier glucan through balancing of blood glucose may have a prophylactic potential in COVID-19 patients
AbstractWith the COVID-19 pandemic causing huge threat to public health and definite treatment modalities and preventive vaccines yet to be arrived at, some of the key indicators of relevance to its prognosis have started emerging. One such independent predictor of outcome has been fasting plasma glucose (FPG) at the time of admission. Earlier, co-morbidities such as diabetes also have been reported to have a risk of relatively increased mortality due to COVID-19. In this background, we herein report on the beneficial effects of Biological response modifier glucan (BRMG) secreted by the black yeastAureobasidium pullulans A...
Source: Journal of Diabetes and Metabolic Disorders - October 21, 2020 Category: Endocrinology Source Type: research

Epidemiologic pattern of cancers in Iran; current knowledge and future perspective
AbstractIran is a developing country facing demographic transition. Cancers are among the major non-communicable disorders with remarkable budern on the health-care governing systems. Extended life expectancy of Iranian population, change in living style, as well as promoted diagnostic and treatment methods have resulted into significant malignancies emergence and detection. Understanding the trend of this epidemiologic transition is required for proper allotment of resources. In this manuscript, overall epidemiologic pattern of cancers and their burden transition is reviewed. In addition, more concerning neoplasia (gastro...
Source: Journal of Diabetes and Metabolic Disorders - October 20, 2020 Category: Endocrinology Source Type: research

Investigation of the synergistic effect of glimepiride and rosuvastatin on alloxan-induced diabetic rat
ConclusionsConcluding the results of this study, it can be said that the treatment of glimepiride in combination with rosuvastatin may be more efficacious than monotherapy for preventing diabetes in rats with dyslipidemia. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - October 20, 2020 Category: Endocrinology Source Type: research

The burden of type 2 diabetes pre-and during the COVID-19 pandemic – a review
ConclusionBy understanding the challenges and burdens faced by this population both evident pre-covid and during, targeted healthcare can be provided during the COVID-19 pandemic. Furthermore, implementation of targeted action plans and recommendations ensures the care provided is done in a safe and effective environment. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - October 19, 2020 Category: Endocrinology Source Type: research

Macrophages in diabetes mellitus (DM) and COVID-19: do they trigger DM?
AbstractDiabetes mellitus (DM) augments the risk of hospitalization and mortality resulting from viral, bacterial, or fungal pathogen infection. This has been also true for the past SARS and MERS, and current SARS-CoV-2 coronavirus epidemics. Clinical data indicate that SARS-CoV-2 infection triggers a severe course of COVID-19 more frequently in diabetic than non-diabetic patients. Here we overview the cellular and molecular mechanisms associated with this phenomenon. We focus on alterations in the immune cells, especially monocytes and macrophages, involved in innate immune response and inflammatory processes, which diffe...
Source: Journal of Diabetes and Metabolic Disorders - October 17, 2020 Category: Endocrinology Source Type: research

Therapeutic potential of mesenchymal stem cells in treating both types of diabetes mellitus and associated diseases
AbstractDiabetes mellitus is a common lifestyle disease which can be classified into type 1 diabetes mellitus and type 2 diabetes mellitus. While both result in hyperglycemia due to lack of insulin action and further associated chronic ailments, there is a marked distinction in the cause for each type due to which both require a different prophylaxis. As observed, type 1 diabetes is caused due to the autoimmune action of the body resulting in the destruction of pancreatic islet cells. On the other hand, type 2 diabetes is caused either due to insulin resistance of target cells or lack of insulin production as per physiolog...
Source: Journal of Diabetes and Metabolic Disorders - October 17, 2020 Category: Endocrinology Source Type: research

Integration of in silico, in vitro and ex vivo pharmacology to decode the anti-diabetic action of Ficus benghalensis L. bark
ConclusionThe analogs of 3,4-dihydroxybenzoic acid, apigenin, and ursolic acid could be the choice of lead hits as the α-amylase, α-glucosidase, and PTP1B inhibitors respectively. Additionally, the majority of secondary metabolites from the hydroalcoholic extract ofF. benghalensis may be involved in enhancing the glucose uptake to support the process of glycogenesis. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - October 17, 2020 Category: Endocrinology Source Type: research

Intervention of Ayurvedic drug Tinospora cordifolia attenuates the metabolic alterations in hypertriglyceridemia: a pilot clinical trial
AbstractPurposeHypertriglyceridemia (HG) is an independent risk factor with more prevalence than hypercholesterolemia and its attributes to cardiovascular disease (CVD) and pancreatitis. Hence, it becomes imperative to search for new triglyceride (TG) lowering agents.Tinospora cordifolia (TC) is a well-known Ayurvedic drug and a rich source of protoberberine alkaloids hence can contribute to TG lowering without side effects. Hence, to explore the therapeutic efficacy of T. cordifolia and its effects on biochemistry and metabolome in the patients of hyper-triglyceridemia, clinical trials were conducted.MethodsPatients (n &t...
Source: Journal of Diabetes and Metabolic Disorders - October 16, 2020 Category: Endocrinology Source Type: research

Prevalence and associated factors of painful diabetic peripheral neuropathy among diabetic patients on follow up at Jimma University Medical Center
AbstractBackgroundDespite having significant impact on the patient ’s quality of life, painful diabetic peripheral neuropathy (PDPN) is usually underdiagnosed. Screening for PDPN in patients with diabetes is needed in order to get timely identification and management. Hence, the purpose of this study was to assess the prevalence and determinants of PDPN among dia betes patients attending outpatient at Jimma University Medical Center from September 1 November 10, 2019.MethodsHospital based cross-sectional study was conducted and douleur neuropathique-4 was used to identify the presence of PDPN. Data were collected usi...
Source: Journal of Diabetes and Metabolic Disorders - October 15, 2020 Category: Endocrinology Source Type: research

Antioxidant activities of Dhanwantaram Kashayam –an Ayurvedic poly herbal formulation alleviates diabetic complications in rats
ConclusionThis study reveals the protective role of DK in diabetic condition through its antioxidant and antihyperglycemic activity. Our results strongly indicate the possibility of DK being developed as a potent antidiabetic drug. DK could be an alternative in the treatment of diseases with ROS imbalance to expensive and toxic synthetic ‘medicines’. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - October 14, 2020 Category: Endocrinology Source Type: research

Relationship between guanosine triphosphate pathway and tetrahydrobiopterin in gestational diabetes mellitus
ConclusionsDecreased NO bioavailability plays an important role in the progression of such macrovascular diseases as diabetes. BH4 levels decrease in diabetes patients, while the increased gene expression of GCHI reverses the diabetes-related BH4 deficiency and allows the endothelial cells to regain their ability to produce NO. Since GCHI is the rate-limiting enzyme in the biosynthesis of BH4, changes in GCHI levels directly affect the BH4 levels and the NO metabolism, leading to an increased risk of macrovascular complications. The significant increase in neopterin levels suggest that this is a potential biomarker for the...
Source: Journal of Diabetes and Metabolic Disorders - October 13, 2020 Category: Endocrinology Source Type: research

Bacteriological profile and antibiotic susceptibility of diabetic Foot infections at Ribat University hospital; a retrospective study from Sudan
ConclusionAmong the studied samples, gram-negative bacteria were found to be more common in DFI patients,Proteus spp. andS. aureus were the most common microorganisms. Moreover, different isolated microorganisms showed to have different degrees of resistance and sensitivity to various antibacterial drugs. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - October 13, 2020 Category: Endocrinology Source Type: research

The efficacy of physiotherapy interventions in mitigating the symptoms and complications of diabetic peripheral neuropathy: A systematic review
ConclusionsThe results showed that most diabetic peripheral neuropathy patients suffer from muscle weakness, pain, loss of balance, and lower limb dysfunction. As a result, their daily activity and Life satisfaction are gradually impaired. Exercise therapy, electrotherapy, and other physiotherapy methods have been used to reduce the mentioned cases. Among these interventions, exercise therapy has been the most effective. Although there was little evidence of aerobic exercise in these patients, further studies should be done on other therapies ’ effects. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - October 12, 2020 Category: Endocrinology Source Type: research

Factors associated with the poor outcomes in diabetic patients with COVID-19
AbstractPurposeDiabetic ’s patients are supposed to experience higher rates of COVID-19 related poor outcomes. We aimed to determine factors predicting poor outcomes in hospitalized diabetic patients with COVID-19.MethodsThis retrospective cohort study included all adult diabetic patients with radiological or laboratory confirmed COVID-19 who hospitalized between 20 February 2020 and 27 April 2020 in Alborz province, Iran. Data on demographic, medical history, and laboratory test at presentation were obtained from electronic medical records. Diagnosis of diabetes mellitus was self-reported. Comorbidities including ca...
Source: Journal of Diabetes and Metabolic Disorders - October 9, 2020 Category: Endocrinology Source Type: research

Predicting type 2 diabetes mellitus among fishermen in Cape Coast: a comparison between the FINDRISC score and the metabolic syndrome
This study assessed two significant diabetes mellitus predictive tools for effectiveness and accuracy among people living in fishing communities in Cape Coast, Ghana.MethodIn April 2019, we recruited one hundred and thirty-five (135) fishermen from three fishing communities in Cape Coast in the Central Region of Ghana. Each participant underwent a standard metabolic procedure including clinical examination as well as taking of anthropometric variables such as weight, height, waist and hip circumference were also measured. The FINDRISC questionnaire was used to gather data from the respective participants. Serum glucose and...
Source: Journal of Diabetes and Metabolic Disorders - October 8, 2020 Category: Endocrinology Source Type: research

Impact of glycemic control over cardiac autonomic neuropathy
ConclusionsCAN is associated strongly with poor glycemic control. Obesity seems to be involved in the impairments of the cardiac autonomic function and this factor must therefore be taken into account in future studies when interpreting the results. Body mass control and glycemic control could provide an important approach to reducing CAN. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - October 8, 2020 Category: Endocrinology Source Type: research

Mormodica charantia L. fruit and Genistein ameliorates type 2 diabetes in rats by preventing lipid accumulation, insulin resistance and enhancing beta cell function
AbstractPurposeThe present study was aimed at evaluating the role ofMomordica charantia L. fruit and Genistein on beta cell, insulin resistance/sensitivity and lipid profile in type 2 diabetic rats.MethodsThirty-five (35) albino rats were divided into seven (7) groups of 5 rats each comprising of five (5) non-diabetic and thirty (30) diabetic rats. Groups 1 and 2 served as the normal control and diabetic control groups respectively and received distill water, groups 3 and 4 receivedMormodica charantia L. at 250  mg/kg and 500 mg/kg respectively. Groups 5 and 6 received Genistein at 10  mg/kg and 20 mg/k...
Source: Journal of Diabetes and Metabolic Disorders - October 2, 2020 Category: Endocrinology Source Type: research

NDSP 05: Prevalence and pattern of dyslipidemia in urban and rural areas of Pakistan; a sub analysis from second National Diabetes Survey of Pakistan (NDSP) 2016 –2017
ConclusionPrevalence of dyslipidemia seems to be very high in Pakistan, necessitating an urgent call for early screening and effective management through lifestyle intervention and appropriate lipid lowering drugs to prevent this important cardiovascular risk factor. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - October 2, 2020 Category: Endocrinology Source Type: research

Endocrinology and Metabolism Research Institute from inception to maturity: an overview of 25-year activity
This article provides an overview of EMRI activities during a quarter of a century. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - October 2, 2020 Category: Endocrinology Source Type: research

Attenuating properties of Rubus fruticosus L. on oxidative damage and inflammatory response following streptozotocin-induced diabetes in the male Wistar rats
ConclusionsRFHE might have anti-diabetic properties; this outcome may be mediated by high antioxidant and anti-inflammatory effects. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - October 2, 2020 Category: Endocrinology Source Type: research

Effects of interval training on cardio metabolic risk factors and nitric oxide in type 2 diabetes patients: a randomized controlled trial
AbstractPurposeThe purpose of this study was to investigate the effects of interval training on cardio metabolic risk factors and nitric oxide in type 2 diabetes patients.MethodThis single blinded randomized controlled trial was conducted at cardiology clinic of Rajaee hospital in Karaj. Thirty female patients with type 2 diabetes randomly assigned to interval training exercise (n = 15) and control (n = 15). In interval training exercise patients received interval training exercise with 18 sessions (three sessions per week). Each training session took 25 min and consists a single set of exe...
Source: Journal of Diabetes and Metabolic Disorders - September 30, 2020 Category: Endocrinology Source Type: research

Visualization of knowledge flow in interpersonal scientific collaboration network endocrinology and metabolism research institute
ConclusionKnowledge flow between EMRI researchers with international collaborations, engagement with leading countries, and interdisciplinary collaborations have an increasing trend. To develop a full picture of co-authorship, using social network analysis indicators are suggested for future studies. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - September 30, 2020 Category: Endocrinology Source Type: research

Bacterial ecology and antibiotic resistance mechanisms of isolated resistant strains from diabetic foot infections in the north west of Algeria
ConclusionAllAcinetobacter Baumannii were Multidrug-Resistant (MDR), as the majority ofStaphylococci, and Enterobacteriaceae. These results should be taken into account by the clinician in the prescription of probabilistic antibiotic therapy in this context. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - September 29, 2020 Category: Endocrinology Source Type: research

Relationship of angiotensin converting enzyme (I/D) polymorphism (rs4646994) and coronary heart disease among a male Iraqi population with type 2 diabetes mellitus
The objective of this study was to investigate the association between theACE gene polymorphism and CHD among male Iraqi patients with and without type2 diabetes mellitus (T2DM).MethodsA case-control study of total 217 male subjects participated in this study, divided into three groups; Group 1 including 86 CHD patients with T2DM, group 2 including 78 CHD patients without T2DM, and group 3 including 53 age and sex-matched healthy individuals (as a control group). Genotyping ofACE (I/D) gene was performed using polymerase chain reaction (PCR) technique.ResultsThe II allele was significantly more frequent in CHD patients wit...
Source: Journal of Diabetes and Metabolic Disorders - September 29, 2020 Category: Endocrinology Source Type: research

Comparative study of emphysematous pyelonephritis and pyelonephritis in type 2 diabetes: a single-centre experience
ConclusionComplications frequently occur in EPN patients as compared to pyelonephritis. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - September 27, 2020 Category: Endocrinology Source Type: research

Organizing framework to investigate associations between diabetes knowledge, health literacy, and self-care behaviors in patients with type 2 diabetes based on the extended parallel process model
AbstractObjectiveThe mechanisms underlying the relations between diabetes self-care behaviors, cognition, and social factors are still equivocal, and it is unclear how diabetes knowledge and health literacy is associated with self-care behaviors. Here, we tested a hypothetical path model linking diabetes self-care behaviors to knowledge, health literacy, and constructs of the extended parallel process model (EPPM) to understand potential predictors that may influence patients ’ self-care behavior with type 2 diabetes.MethodsA cross-sectional study was conducted, and 404 patients with type 2 diabetes were recruited fr...
Source: Journal of Diabetes and Metabolic Disorders - September 27, 2020 Category: Endocrinology Source Type: research

Therapeutic effects of supplementation with Curcuminoids in critically ill patients receiving enteral nutrition: a randomized controlled trial protocol
DiscussionTo the best of our knowledge, this is the first clinical trial investigating the effect of curcuminoids supplementation in critically ill patient with TBI. The findings of the present study will provide evidence on the efficacy and safety of curcuminoids in these patients.Trial registration number(http://www.irct.ir, identifier: IRCT20180619040151N1), Registration date:18.09.2018. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - September 25, 2020 Category: Endocrinology Source Type: research

Medicinal plants in the adjunctive treatment of patients with type-1 diabetes: a systematic review of randomized clinical trials
ConclusionsThe evidence is scarce and no recommendations can be made based on current evidence. Further trials with more rigorous methodology and stronger quality of reporting are needed to make conclusions. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - September 21, 2020 Category: Endocrinology Source Type: research

A systematic analysis on prevalence and sub-regional distribution of undiagnosed diabetes mellitus among adults in African countries
ConclusionOur findings indicate a high prevalence of undiagnosed diabetes in Africa and suggest that it may be more prevalent in Western Africa than the rest of the regions. Given the high levels of undiagnosed diabetes in the Africa region, more attention should be paid to incorporating diabetes screening and treatment services into existing diabetes related programs to reduce the prevalence of undiagnosed cases. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - September 21, 2020 Category: Endocrinology Source Type: research

Type 2 diabetes mellitus: pathogenesis and genetic diagnosis
AbstractType 2 diabetes mellitus (T2DM) is a heterogeneous condition that is related to both defective insulin secretion and peripheral insulin resistance. Beta cells are the major organ for secreting insulin hence, it is important to maintain an adequate beta-cell mass in response to various changes. Insulin resistance is a major cause of T2DM leads to elevated free fatty acid (FFA) levels which increases beta-cell mass and insulin secretion to compensate for insulin insensitivity. Chronic increase of plasma FFA levels results in disturbances in lipid metabolism, which contributes to decreased beta-cell function and lipot...
Source: Journal of Diabetes and Metabolic Disorders - September 21, 2020 Category: Endocrinology Source Type: research

Effects of traditional fermented food (Ash-Kardeh) consumption on blood glucose, blood pressure, and lipid profile in type 2 diabetes: a study protocol for a randomized clinical trial
This study is a randomized, no-blinded, controlled clinical trial in which 44 type 2 diabetic patients will be randomly allocated to intervention and control groups. Individuals in both the intervention and control groups will receive (the usual treatment of diabetic patients) for 6  weeks, while those in the intervention group will receive (250 g of traditional fermented food daily in addition to the usual treatment) at the same time. Assessment of anthropometric measures, blood pressure, and biochemical parameters including serum concentrations of fasting blood sugar, high- density lipoproteins-cholesterol, low...
Source: Journal of Diabetes and Metabolic Disorders - September 18, 2020 Category: Endocrinology Source Type: research

Health service utilization and adherence to medication for hypertension and diabetes among Syrian refugees and affected host communities in Lebanon
ConclusionFurther efforts are needed to facilitate lower and more predictable health service costs for refugees and vulnerable host community members, as is continued communication on available subsidized care.PurposeTo characterize care-seeking, health service utilization and spending, and medication prescribing and adherence for hypertension and diabetes among Syrian refugees and host communities in Lebanon. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - September 17, 2020 Category: Endocrinology Source Type: research

Diabetes-associated dermatological manifestations in primary care and their association with vascular complications
AbstractIntroductionAlthough type 2 diabetes mellitus (DM) is a global public health problem, the diabetes-associated dermatological (non-infectious) manifestations (DADM) remain poorly understood and under-diagnosed. We aimed to evaluate the prevalence of 7 known DADM in a primary care setting, and their association macro/microvascular complications.MethodsCross-sectionnal study included patients consulting in general practice for DM-follow up, from November 2016 to January 2017. Patients aged
Source: Journal of Diabetes and Metabolic Disorders - September 15, 2020 Category: Endocrinology Source Type: research

The effects of L-carnitine supplementation on indicators of inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials
ConclusionsL-carnitine supplementation was associated with lowering of CRP, IL-6, TNF- α, and MDA, and increasing SOD levels, but did not affect other inflammatory and oxidative stress biomarkers. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - September 14, 2020 Category: Endocrinology Source Type: research

Evaluation of skin lesions in diabetic patients: a systematic review and meta-analysis
AbstractBackgroudPrevalence of skin lesions among diabetic patients is a major health concern. Therefore, this systematic review and meta-analysis study was conducted to determine the prevalence of skin lesions in diabetic patients.MethodsTo identify and select relevant articles, the SID, MagIran, IranMedex, IranDoc, Google Scholar, Cochrane, Embase, ScienceDirect, Scopus, PubMed, and Web of Science (WoS) databases were searched without a lower time limit and until April 2020. The random effects model was used to perform the analysis, and the heterogeneity of studies was assessed using the I2 index. Data were analyzed with...
Source: Journal of Diabetes and Metabolic Disorders - September 8, 2020 Category: Endocrinology Source Type: research

Indian Traditional medicinal plants as a source of potent Anti-diabetic agents: A Review
ConclusionBased on this review it can be concluded that herbs can serve as more efficient, safer, and cost-effective adjuvant therapy in the management and treatment of diabetes. Further investigations mainly focusing on the isolation of phytocompounds from these herbs can lead to the discovery of newer antidiabetic agents. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - September 8, 2020 Category: Endocrinology Source Type: research

Letter to the editor - Transcranial direct current stimulation improves quality of life and physical fitness in diabetic polyneuropathy: a pilot double blind randomized controlled trial ”
(Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - September 5, 2020 Category: Endocrinology Source Type: research

Anti-inflammatory and antidiabetic effects of grape-derived stilbene concentrate in the experimental metabolic syndrome
This study aimed to investigate the carbohydrate and lipid dynamics, associated inflammation markers and the effectiveness of a grape-derived stilbene concentrate (GDSC) treatment in experimental metabolic syndrome (MetS).MethodsThe study was carried out on 40 male 12-weeks of age Wistar rats. The MetS was induced using the fructose model (feeding with 60%-solid fructose diet for 24  weeks). Rats with induced MetS were treated with polyphenolic GDSC, which was obtained by water-alcohol extraction ofVitis vinifera grapevine (Ressfood LLC, Russia).ResultsThe experimentally induced MetS development leads to classic MetS ...
Source: Journal of Diabetes and Metabolic Disorders - September 4, 2020 Category: Endocrinology Source Type: research

Effect of ertugliflozin on glycemic levels, blood pressure and body weight of patients with type 2 diabetes mellitus: a systematic review and meta-analysis
AbstractPurposeTo conduct a meta-analysis to evaluate the effect of ertugliflozin on long-term hemoglobin A1c (HbA1c), body weight and blood pressure (BP).MethodsOnline databases available were searched from their inception to February 2020. Randomized controlled trials (RCTs) comparing ertugliflozin to either placebo or an active control drug were included. Data on four efficacy outcomes were extracted, namely: HbA1c, systolic blood pressure (SBP), diastolic blood pressure (DBP) and body weight. Continuous outcomes were pooled using a random-effects model and presented as weighted mean differences (WMDs) and corresponding...
Source: Journal of Diabetes and Metabolic Disorders - September 2, 2020 Category: Endocrinology Source Type: research

Anti-hypercholesterolemic potential of diet supplemented with Anchomanes difformis and Pleurotus tuberregium tubers in high cholesterol fed rats
AbstractBackgroundOne significant ethnomedicinal motivation behind Pleurotus tuberregium (PTT) and Anchomanes difformis (ADT) tubers is cardiovascular-related conditions treatment. This investigation is in this way planned for deciding the impact of PTT and ADT enhanced eating routine on key enzymes linked with hypercholesterolemia in elevated cholesterol fed rodents.MethodsRats were isolated into control group, hypercholesterolemic-prompted untreated group, hypercholesterolemic-treated groups with dietary routine containing PTT (5% and 10%), ADT (5% and 10%), 5% PTT and 5% ADT conbination and traditional medication, atorv...
Source: Journal of Diabetes and Metabolic Disorders - August 31, 2020 Category: Endocrinology Source Type: research

Intestinal Microbiota Composition in Iranian Diabetic, Pre-diabetic and Healthy Individuals
ConclusionThere is a correlation between intestinal microbiota composition and type 2 diabetes. Determination and restoration of this microbiota composition pattern may have a possible role in prevention and control of type 2 diabetes in a certain population. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - August 30, 2020 Category: Endocrinology Source Type: research

Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels
The objective of this study was to evaluate preserved C-peptide secretion in patients with T1DM without overt chronic complications and to explore associations with resistin and uric acid as biomarkers of microvascular complication pathogenesis.Materials and methodsWe assessed residual beta-cell function in 164 T1DM patients (male/female  = 91/73; age/diabetes duration range = 18–70/1–30 years) using an ultrasensitive C-peptide ELISA assay with detection limit of 2.5 pmol/L and total coefficient of variation (CV) 5,8% (Mercodia, Sweden). Serum level of uric acid was measure...
Source: Journal of Diabetes and Metabolic Disorders - August 28, 2020 Category: Endocrinology Source Type: research

The impact of type D personality on self-care of patients with type 2 diabetes: the mediating role of coping strategies
ConclusionIn general, assessing psychological background (such as personality traits and coping strategies) can facilitate the treatment of patients with diabetes by means of self-care enhancement. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - August 28, 2020 Category: Endocrinology Source Type: research

Scientometric study of academic publications on herbal medicines in Endocrinology & amp; Metabolism Research Institute (EMRI) of Tehran University of Medical Sciences
ConclusionsA promising scientific productivity is shown in the studied field. However, the number of publications is insufficient, and more evidence-based publications are required on this topic. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - August 27, 2020 Category: Endocrinology Source Type: research

A narrative review of current trends in liraglutide: insights into the unmet needs in management of type 2 diabetes and obesity
AbstractLiraglutide is a long-acting human glucagon-like peptide-1 (GLP-1) analogue and an effective treatment for patients with metabolic diseases including type 2 diabetes mellitus (T2DM) and obesity. This review focuses on the mechanism of action of liraglutide as a well-known glucagon-like peptide-1 receptor agonist (GLP-1 RA) in patients with T2DM and obesity. The lower and the higher doses of GLP-1 RAs are used for glycaemic control in T2DM and in obesity respectively. GLP-1 RAs such as liraglutide enhance insulin secretion and inhibit glucagon release via the stimulation of glucagon-like peptide-1 receptors (GLP-1Rs...
Source: Journal of Diabetes and Metabolic Disorders - August 27, 2020 Category: Endocrinology Source Type: research

The effects of curcumin and Lactobacillus acidophilus on certain hormones and insulin resistance in rats with metabolic syndrome
In this study, we tried to investigate the effects of curcumin andLactobacillus acidophilus probiotics, given individually and in combination, to insulin, adipokines and nitric oxide changes and insulin resistance as experimental treatment of metabolic syndrome.MethodsFive groups were formed in the study. Fructose (20%) was administered with drinking water for 8 weeks to develop metabolic syndrome. For treatment, curcumin (100 mg/kg/day) andL. acidophilus (2  × 108 cfu/ml/day) were given individually or in combination for the last four weeks. At the end of the experiment; insulin, resistin, leptin, adip...
Source: Journal of Diabetes and Metabolic Disorders - August 26, 2020 Category: Endocrinology Source Type: research

Low advanced Glycation end product diet improves the central obesity, insulin resistance and inflammatory profiles in Iranian patients with metabolic syndrome: a randomized clinical trial
AbstractThe study aimed to investigate the effects of 8-weeks AGEs restricted diet on glycemic control as well as lipid profile, inflammatory and oxidative stress biomarkers and IR in overweight patients with Mets. In this randomized, controlled clinical trial 40 clients were randomly assigned to take either a low AGE (L-AGE) or a regular AGE (Reg-AGE) diet. Also, both groups were advised to follow an energy-restricted diet. At baseline and after 8-weeks of intervention, anthropometric parameters, dietary intake, plasma concentrations of malondialdehyde, carboxymethyllysine, TNF- α, hs-CRP and levels of serum glucose...
Source: Journal of Diabetes and Metabolic Disorders - August 25, 2020 Category: Endocrinology Source Type: research

Effect of Curculigo pilosa supplemented diet on blood sugar, lipid metabolism, hepatic oxidative stress and carbohydrate metabolism enzymes in streptozotocin-induced diabetic rats
In this study, the in vitro antioxidant abilities of CP and the effects of CP-supplemented diets on blood sugar, lipid metabolism, oxidative stress and key carbohydrate metabolizing enzymes in streptozotocin (STZ)-induced diabetic rats were investigated.MethodsPolyphenol contents (total phenolic and total flavonoid) and antioxidant ability of different extracts of CP were determined in vitro. Diabetes mellitus were stimulated in healthy rats by single intraperitoneal administration of 50  mg/kg streptozotocin and it was confirmed by elevated blood glucose level after 3 days. Thirty six rats were distributed into ...
Source: Journal of Diabetes and Metabolic Disorders - August 25, 2020 Category: Endocrinology Source Type: research