Effect of mobile learning (application) on self-care behaviors and blood glucose of type 2 diabetic patients
ConclusionsThe results indicated the positive effect of the mobile application on self-care behavior, FBS, and HbA1C. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - July 12, 2019 Category: Endocrinology Source Type: research

Effect of selenium supplementation on glycemic indices: a meta-analysis of randomized controlled trials
ConclusionThis meta-analysis indicated that selenium supplementation significantly decreased HOMA-B and increased QUICKI score. There was no statistically significant improvement in FPG, insulin, HOMA-IR, HbA1c and adiponectin indices following selenium supplementation. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - July 4, 2019 Category: Endocrinology Source Type: research

Determining minimum set of features for diabetes mobile apps
ConclusionsThe present study is the first step towards the development of our mobile apps for people with type II diabetes, and highest the essential features that are required for an optimal self-care comprehensively. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 27, 2019 Category: Endocrinology Source Type: research

Quantitative analysis of key periodontopathic bacteria in gestational diabetic and non-diabetic women
ConclusionThis study showed that there is significant association between the severity of periodontal disease and increased levels ofPg andPi in gestational diabetic women. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 27, 2019 Category: Endocrinology Source Type: research

Age, period and cohort analysis of high cholesterol levels in Iranian adults over a 20-year period
ConclusionThe present study provides evidence that age, period and birth cohort affect the prevalence of borderline and high cholesterol levels. Thus, these factors should be considered when developing and implementing care plans for people with hypercholesterolemia. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 25, 2019 Category: Endocrinology Source Type: research

Anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency: a randomized, double-blinded, placebo-controlled clinical trial
ConclusionResults demonstrated that vitamin D supplementation in addition to resistance training had positive effects on some inflammatory markers in T2D and vitamin D deficient men. Vitamin D supplementation was especially effective when it was complemented with exercise training. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 24, 2019 Category: Endocrinology Source Type: research

The association between sleep duration and lipid profiles: the NHANES 2013 –2014
ConclusionShort sleep duration was associated with low HDL cholesterol/high triglyceride. Further longitudinal studies are warranted to shed extra light on this relationship. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 22, 2019 Category: Endocrinology Source Type: research

Life style activities and feeling state responses in community sample of diabetic patients in Eastern Providence Saudi Arabia
ConclusionThe use of exercise physiologists or physiotherapists and psychologists, education system is highly needed to explaining about the health benefits of physical activity. Physical activities should be promoted within the real context of the built environment in the eastern province, KSA. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 21, 2019 Category: Endocrinology Source Type: research

Investigating the effects of endurance, resistance and combined training on reproductive hormones and sperm parameters of streptozotocin –nicotinamide diabetic male rats
AbstractPurposeDiabetes mellitus type 2 with damaging effects on reproductive hormones and sperm quality parameters can often cause infertility in men. The aim of this study was to evaluate the effects of endurance, resistance and concurrent training on reproductive hormones, sperm parameter in the diabetic type 2 male rats.MethodsIn this experimental study 60 Wistar rats (200  ± 50 g) were randomly assigned into 5 groups: control; diabetic; diabetic endurance training; diabetic resistance training and diabetic concurrent training. For inducing diabetes, after 12 hours of food starvation nico...
Source: Journal of Diabetes and Metabolic Disorders - June 19, 2019 Category: Endocrinology Source Type: research

Impact of alexithymia on glycemic control among Lebanese adults with type 2 diabetes
ConclusionGiven the impact of alexithymia on D2 regulation, screening of alexithymia in case of D2 and appropriate psychological follow-up are important for a better prognosis, management and treatment of the disease. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - June 7, 2019 Category: Endocrinology Source Type: research

An evaluation of the effectiveness of foot care education in rural clinics
ConclusionsDetailed prospective research is required to determine if implementing education early in the patient ’s plan of care will improve the patient’s overall health care status thus, decreasing facility costs. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 29, 2019 Category: Endocrinology Source Type: research

Minocycline attenuates the development of diabetic neuropathy by modulating DREAM and BDNF protein expression in rat spinal cord
ConclusionThis study revealed that minocycline could attenuate DNP by modulating spinal BDNF and DREAM protein expressions. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 18, 2019 Category: Endocrinology Source Type: research

Factors influencing diabetes self-care practice among type 2 diabetes patients attending diabetic care follow up at an Ethiopian General Hospital, 2018
ConclusionDespite, the importance of diabetes self-care practice for the management of diabetes and preventing its complications, a significant number of type 2 diabetes patients had poor diabetes self-care practice. So, to enhance this poor practice of diabetes self-care, provision of diabetes self-care education and counseling on self-monitoring blood glucose should be promote by health care providers during their follow up. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 17, 2019 Category: Endocrinology Source Type: research

Periodontitis and diabetes interrelationships in rats: biochemical and histopathological variables
AbstractBackgroundA two-way relationship between diabetes and periodontitis is now clinically established. Both conditions share common mechanisms of pathogenesis that are related to altered immune-inflammatory responses at local and/or systemic levels. The aim of this study is to investigate whether periodontitis is associated with the development and progression of diabetes and to evaluate the health impact of coexistence of both diseases.Material and methodsMale Sprague Dawley rats (10  weeks old) were randomized into seven groups (n = 12): Group 1) Control; Groups 2 and 6) Periodontitis induced at tw...
Source: Journal of Diabetes and Metabolic Disorders - May 16, 2019 Category: Endocrinology Source Type: research

Diabetes mellitus and cancer incidence: the Atherosclerosis Risk in Communities (ARIC) cohort study
ConclusionsIn conclusion, DM may be associated with an increased risk of colorectal cancer in non-menopausal women and a decreased risk of prostate cancer and all cancers combined. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 16, 2019 Category: Endocrinology Source Type: research

The effects of high intensity interval training on appetite management in individuals with type 2 diabetes: influenced by participants weight
AbstractBackground and purposeThe connection between exercise and appetite has ramifications for acute energy balance and weight-management. Research would suggest that exercise training can transiently suppress appetite, particularly in overweight and T2D, healthy-weight individuals. However, the effect of such a transient appetite suppression on subsequent food intake may be restricted. The aim of this thesis was to investigate appetite responses to HIIT in obesity with T2D and to assess the effect of other exercise characteristics, as well as exercise intensity, in mediating these responses especially appetite hormones....
Source: Journal of Diabetes and Metabolic Disorders - May 15, 2019 Category: Endocrinology Source Type: research

Plantar pressure distribution in diverse stages of diabetic neuropathy
ConclusionThe progression of diabetic neuropathy would have been increased followed by the peak plantar pressure. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 11, 2019 Category: Endocrinology Source Type: research

A therapeutic approach towards microRNA29 family in vascular diabetic complications: A boon or curse?
AbstractDiabetes Mellitus (DM) is one of the major metabolic disorders and its severity leads to death. Enhancement in hyperglycaemic conditions of DM gives rise to endothelial impairment in small and large blood vessels contributing towards microvascular and macrovascular complications respectively. The pathogenesis of diabetic complications is associated with interruption of various signal transduction pathways due to epigenetic modifications such as aberrant histone modifications, DNA methylation and expression of miRNAs along with the long non-coding RNAs (lncRNAs). Amongst these epigenetic alterations, modulated expre...
Source: Journal of Diabetes and Metabolic Disorders - May 11, 2019 Category: Endocrinology Source Type: research

Novel ambulatory glucose-sensing technology improves hypoglycemia detection and patient monitoring adherence in children and adolescents with type 1 diabetes
AbstractPurposeGlucose monitoring [GM] is a mainstay of diabetes control and management. Improving glycemic control is essential to prevent microvascular complications. However, adherence to GM can be a challenge in children and adolescents. Detecting hypoglycemia is essential for its prevention and treatment. We aim to study the impact of the flash ambulatory glucose monitoring in detecting hypoglycemia and enhancing adherence in children and adolescents with type 1 diabetes.MethodsThe study is prospective involving 3 hospital visits. Children and adolescents with diabetes were enrolled in the study which involved a perio...
Source: Journal of Diabetes and Metabolic Disorders - May 9, 2019 Category: Endocrinology Source Type: research

Prospective of managing impaired brain insulin signalling in late onset Alzheimers disease with excisting diabetic drugs
AbstractLate onset Alzheimer ’s disease (AD) is the most common cause of dementia among elderly. The exact cause of the disease is until now unknown and there is no complete cure for the disease. Growing evidence suggest that AD is a metabolic disorder associated with impairment in brain insulin signalling. These findings enr iched the scope for the repurposing of diabetic drugs in AD management. Even though many of these drugs are moving in a positive direction in the ongoing clinical studies, the extent of the success has seen to influence by several properties of these drugs since they were originally designed to ...
Source: Journal of Diabetes and Metabolic Disorders - May 9, 2019 Category: Endocrinology Source Type: research

Serum miR-17 levels are downregulated in obese, African American women with elevated HbA1c
ConclusionsThe results suggest that serum miR-17 is involved in the regulation of glucose and calcium homeostasis, which may contribute to the development of type 2 diabetes. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 9, 2019 Category: Endocrinology Source Type: research

Socioeconomic inequality in cardio-metabolic risk factors in a nationally representative sample of Iranian adolescents using an Oaxaca-Blinder decomposition method: the CASPIAN-III study
ConclusionsThe study revealed the considerable inequality in the prevalence of cardio-metabolic risk factors between the highest and the lowest SES groups of Iranian adolescents. Living area and BMI are the two main factors which explained inequality in prevalence of cardio metabolic risk factors between SES groups. These estimations could provide health policy markers with practical information for future complementary analyses. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 28, 2019 Category: Endocrinology Source Type: research

Rationale of family medicine physicians in effectively identifying patients with chronic hyperglycemia through point-of-care hemoglobin A1C screenings
AbstractPurposeMany patients are unknowingly living with chronic hyperglycemia, possibly due to low screening rates. We aimed to correlate detection of unidentified chronic hyperglycemia to practitioner reported rationale for conducting diabetes screening.MethodsPhysicians screened patients via a point-of-care A1C tests and recorded corresponding rationales. Elevated outcomes (A1C  ≥ 5.7%) were correlated to recorded rationales, frequency of repeat screenings, documented diagnoses, and therapeutic actions taken as a result of elevated A1C.ResultsNearly one-half (45%) of selected patients were unknowingly l...
Source: Journal of Diabetes and Metabolic Disorders - April 25, 2019 Category: Endocrinology Source Type: research

Gestational diabetes mellitus: the correlation between umbilical coiling index, and intrapartum as well as neonatal outcomes
The objective of this study was to investigate the relationship between the postnatal umbilical coiling index (pUCI), and intrapartum and neonatal outcomes in parturients with gestational diabetes mellitus (GDM) and non-GDM.MethodsAn evaluation of the umbilical cords and pUCI of 117 neonates of GDM and 105 of non-GDM parturients were prospectively studied within 24  h after delivery. Furthermore, obstetric history, intrapartum and neonatal data were recorded.ResultsPremature rupture of membrane (PROM) (p = 0.001), emergency cesarean delivery (p = 0.01), spontaneous preterm delivery (p&thins...
Source: Journal of Diabetes and Metabolic Disorders - April 23, 2019 Category: Endocrinology Source Type: research

Potential value of serum Progranulin as a biomarker for the presence and severity of micro vascular complications among Egyptian patients with type 2 diabetes mellitus
AbstractObjectiveThe increasing prevalence of type 2 diabetes mellitus (T2DM) calls for evolving a concomitant screening strategies for early disease detection and prediction of the complications. Progranulin (PRGN) was recently introduced as a biomarker of inflammation in T2DM. However, little data have been published as regarding progranulin in relation to diabetic micro angiopathy among Egyptian patients with T2DM. The aim of this study was therefore to investigate and evaluate serum progranulin as a biomarker for the presence and severity of micro vascular complications among Egyptian patients with T2DM.MethodsA total ...
Source: Journal of Diabetes and Metabolic Disorders - April 19, 2019 Category: Endocrinology Source Type: research

Healthcare resource utilization and cost of care for Gaucher patients in Iran
ConclusionGD is amongst the high-cost diseases and should be managed effectively. The application of oral medication for eligible GPs could improve allocative efficiency in GD management significantly. A sound, valid and reliable national clinical guideline could improve the efficiency of healthcare resources effectively. Selecting appropriate strategies for reducing the birth of a child with Gaucher, could support allocative efficiency of the limited resources effectively. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 9, 2019 Category: Endocrinology Source Type: research

In vivo studies demonstrate that endothelin-1 traps are a potential therapy for type I diabetes
ConclusionData from this study show that in a mouse model ET-traps have a potent and significant therapeutic effect on diabetes disease pathology. Future studies could further evaluate the use of ET-traps as a therapy for diabetes, including taking them through clinical trials. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 8, 2019 Category: Endocrinology Source Type: research

Oncogenic osteomalacia and metastatic breast cancer: a case report and review of the literature
ConclusionsTo our knowledge, this is the first reported case of oncogenic osteomalacia in a patient with breast cancer. Oncogenic osteomalacia constitutes a diagnostic and therapeutic challenge. Pre-clinical and clinical evidence suggest that a possible underlying mechanism is the presence of molecular alterations in the FGF/FGFR signalling pathway leading to overexpression of FGF23. In metastatic setting, anticancer treatment can potentially lead to the normalisation of the electrolytic disturbances and reduction of the activity of oncogenic osteomalacia. The use of antiresorptive therapy in patients with bone metastases ...
Source: Journal of Diabetes and Metabolic Disorders - March 22, 2019 Category: Endocrinology Source Type: research

Effects of ginger supplementation on anthropometric, glycemic and metabolic parameters in subjects with metabolic syndrome: A randomized, double-blind, placebo-controlled study
This study aimed to evaluate the safety and efficacy of ginger powder on biochemical and anthropometric parameters in patients with MetS.MethodsThis randomized controlled clinical trial was conducted on 37 patients with MetS. We supplemented the individuals with MetS with either 2  g per day ginger powder or placebo for 12 weeks. Biochemical and anthropometric parameters before and after the intervention were compared between the two groups.ResultsAfter 12  weeks of treatment, the levels of triglyceride (TG), FBS, and insulin resistance were significantly improved in the patients receiving ginger in compare ...
Source: Journal of Diabetes and Metabolic Disorders - March 22, 2019 Category: Endocrinology Source Type: research

Ottawa charter framework as a guide for type 2 diabetes prevention and control in Iran
AbstractThe growth of T2DM in Iran is predicted to be even greater than the global trend. So a new public health movement to effectively prevent and manage T2DM is required more than ever. The solution has lain in the heart of the Ottawa Charter, the first international conference on health promotion more than 30  years ago. The charter contains five useful actions to facilitate the process of diseases prevention and control: 1) building healthy public policy, 2) creating supportive environments, 3) strengthening community action, 4) developing personal skills, and 5) reorienting health care services toward promotion ...
Source: Journal of Diabetes and Metabolic Disorders - March 19, 2019 Category: Endocrinology Source Type: research

Rice bran oil ameliorates hepatic insulin resistance by improving insulin signaling in fructose fed-rats
ConclusionHFD impaired the insulin sensitivity of the hepatocytes by down-regulating the insulin receptor genes. Addition of RBO alleviated all the hazardous effects. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - March 9, 2019 Category: Endocrinology Source Type: research

Effect of diabetes on BMD and TBS values as determinants of bone health in the elderly: Bushehr Elderly Health program
AbstractBackgroundConsidering the aging population associated with higher osteoporotic fracture risk, high prevalence of diabetes and its effect on bone health along with lack of information on bone quality using common methods (BMD) the aim of present study was to determine the association between trabecular bone score (TBS) and diabetes in an elderly population participating in Bushehr Elderly Health (BEH) program.Materials and methodsThis cross-sectional study was performed on data collected during the BEH Program, stage II. Anthropometric indices were measured based on NHANES III protocol. Diabetes and pre-diabetes wer...
Source: Journal of Diabetes and Metabolic Disorders - March 9, 2019 Category: Endocrinology Source Type: research

Evaluating the impact of an insulin pump discontinuation action plan on patient or caregiver confidence and anxiety
ConclusionPatient recall of prior insulin pump action plan education is poor, with the vast majority of patients interested in further written anticipatory education regarding potential pump failure. The provision of an insulin pump action plan increases self-reported confidence in managing unexpected pump failure with a small associated increase in anxiety. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - March 5, 2019 Category: Endocrinology Source Type: research

A single whole body vibration session influences quadriceps muscle strength, functional mobility and balance of elderly with osteopenia and/or osteoporosis? Pragmatic clinical trial
ConclusionAn WBV training session was able to alter the muscular strength of the LQ and the balance of the elderly with Osteopenia and/or Osteoporosis. It is suggested, however, that future studies involving larger sample number and/or populations should be developed to analyze the short-term effects of WBV. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 27, 2019 Category: Endocrinology Source Type: research

Gestational diabetes mellitus in association with macrosomia in Iran: a meta-analysis
ConclusionsThis meta-analysis shows that GDM is directly associated with the risk of macrosomia in the Iranian population. This confirms the findings of previous studies in the wider scientific literature. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 21, 2019 Category: Endocrinology Source Type: research

Insulin pump initiation and education for children and adolescents – a qualitative study of current practice in New Zealand
ConclusionsDifferences seen between hospitals reflected team preference, and possibly a lack of consensus/guidance from the medical literature. Lessons may be learnt and further rationalisation and improvement in education remains possible by combining and adopting strengths from different hospitals. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - February 12, 2019 Category: Endocrinology Source Type: research

Effect of Falcaria vulgaris on oxidative damage of liver in diabetic rats
This study was designed in order to evaluate the effect ofF. vulgaris on the damaged liver in diabetic rats.MethodsIn this study, hydroalcoholic extract ofF. vulgaris was prepared. Sixty four male rats were divided into 8 groups (n = 8), including saline (normal control), streptozotocin (STZ) (diabetic control) (60 mg/kg),F. vulgaris (50, 100, 150  mg/kg), and STZ plusF. vulgaris (50, 100, 150  mg/kg) were administered through oral gavage on treated group once a day for 28 consecutive days. Serum nitrite oxide (NO) level, Ferric reducing/antioxidant power (FRAP), Malondialdehyde (MDA), liver we...
Source: Journal of Diabetes and Metabolic Disorders - February 9, 2019 Category: Endocrinology Source Type: research

Neuromodulatory effect of microbiome on gut-brain axis; new target for obesity drugs
AbstractConsidering the increasing prevalence of obesity worldwide, new approaches for its control have been investigated. Recent evidences highlighted the role of the gut microbiome in weight management. Obesity-associated gut microbiota alters host energy uptake, insulin sensitivity, inflammation, and fat storage. Moreover, the gut microbiota-derived metabolites could control appetite directly by affecting the central nervous system or indirectly through modifying the gut hormones secretion. Metabolites of the gut microbiome-brain axis could be novel targets for designing drugs in obesity. They can be prescribed directly...
Source: Journal of Diabetes and Metabolic Disorders - February 1, 2019 Category: Endocrinology Source Type: research

Sugary beverages are associated with cardiovascular risk factors in diabetic patients
AbstractPurposeSugar-sweetened beverages (SSBs) containing high amount of added sugars have increased over the last decades. Due to increased risk of cardiovascular events in type 2 diabetes mellitus (T2DM) patients, we designed a study to assess the association between SSBs and metabolic syndrome, a collection of cardiovascular risk factors, in these patients.MethodsA cross-sectional study was performed on T2DM adults (N = 157). Participants had no serious disease or insulin treatment. SSBs records were obtained from a validated food frequency questionnaire. Metabolic syndrome status was extracted from bioch...
Source: Journal of Diabetes and Metabolic Disorders - January 31, 2019 Category: Endocrinology Source Type: research

The use of conversation maps in the metabolic control of diabetes in Brazilians: a randomized clinical trial
ConclusionIt was observed that there was not statistical significant improvement of the metabolic control. However, it was possible to confirm that an educative intervention for SMBG at home presented a clinical significance, which in turn, resonates in a special way on the health of participants. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 26, 2019 Category: Endocrinology Source Type: research

Correction to: The basal to total insulin ratio in outpatients with diabetes on basal-bolus regimen
The article [The basal to total insulin ratio in outpatients with diabetes on basal-bolus regimen], written by [Elena Castellano, R. Attanasio, V. A. Giagulli, A. Boriano, M. Terzolo, E. Papini, E. Guastamacchia, S. Monti, A. Aglialoro, D. Agrimi, E. Ansaldi, A. C. Babini, A. Blatto, D. Brancato]. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 17, 2018 Category: Endocrinology Source Type: research

Life-style-induced metabolic derangement and epigenetic changes promote diabetes and oxidative stress leading to NASH and atherosclerosis severity
AbstractEnergy imbalance resulting from high calorie food intake and insufficient metabolic activity leads to increased body mass index (BMI) and sets the stage for metabolic derangement influencing lipid and carbohydrate metabolism and ultimately leading to insulin resistance, dyslipidemia, and type 2 diabetes. 70% of cardiovascular disease (CVD) deaths occur in patients with diabetes. Environment-induced physiological perturbations trigger epigenetic changes through chromatin modification and leads to type 2 diabetes and progression of nonalcoholic fatty liver disease (NAFLD) and CVD. Thus, in terms of disease progressio...
Source: Journal of Diabetes and Metabolic Disorders - November 29, 2018 Category: Endocrinology Source Type: research

Diets along with interval training regimes improves inflammatory & amp; anti-inflammatory condition in obesity with type 2 diabetes subjects
ConclusionsThese results demonstrated that HIIT along with low carbohydrate regimes improves overall cardiovascular parameters and reduce pro-inflammatory markers and increase anti-inflammatory markers in type 2 diabetic patients. Additionally, as with HIIT along with low carbohydrate, HIIT coupled with low fat would improve inflammation markers, though these effects were less significant. These findings suggest that HIIT along with low carbohydrate is a beneficial exercise and dietary strategy in T2D patients. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 28, 2018 Category: Endocrinology Source Type: research

Effect of sub-toxic chlorpyrifos on redox sensitive kinases and insulin signaling in rat L6 myotubes
ConclusionWe conclude that sub-toxic chlorpyrifos exposure induces oxidative stress in muscle cells activating redox sensitive kinases that impairs insulin signaling and thereby insulin-stimulated glucose uptake in muscle cells. This probably explains the biochemical basis of chlorpyrifos-induced insulin resistance state and diabetes mellitus. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 28, 2018 Category: Endocrinology Source Type: research

Behavioral interventions to improve self-management in Iranian adults with type 2 diabetes: a systematic review and meta-analysis
ConclusionIn line with other behavioral studies, our study shows that behavioral interventions improve self-management in Iranian adults with type 2 diabetes. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 27, 2018 Category: Endocrinology Source Type: research

Menopause and metabolic syndrome in the Middle East countries; a systematic review and meta-analysis study
ConclusionsMetS was highly prevalent as an alarming sign among menopaused women in the Middle East countries. Thus, it is an emergency requirement to promote healthy lifestyle. Also, early detection and treatment of women who reach menopause and are at great risk of developing MetS is necessary for prevention of diabetes and CVD in the region. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 27, 2018 Category: Endocrinology Source Type: research

The interaction of dyslipidaemia with glycaemia in an adult population study
ConclusionsDyslipidaemia occurs in the presence of insulin resistance. Dyslipidaemia predominated in the normoglycaemic state irrespective of statins use, indicating the need to manage dyslipidaemia prior to dysglycaemia. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 26, 2018 Category: Endocrinology Source Type: research

The effect of dietary fat on behavior in mice
ConclusionsOffspring diet, but not prenatal maternal diet, affected a wide range of behaviors in these mice. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 22, 2018 Category: Endocrinology Source Type: research

Incidence of hypoglycaemia in patients with type-2 diabetes taking multiple glucose lowering therapies during Ramadan: the PROFAST Ramadan Study
ConclusionDespite the tailored advice, there is a high incidence of hypoglycemia in people with T2DM taking multiple glucose lowering therapies whilst fasting during Ramadan. Guidelines should address the increased complexity in anti-diabetic medications in patients who fast during Ramadan. Healthcare providers should individualize the modifications in anti-diabetic medications during Ramadan. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 19, 2018 Category: Endocrinology Source Type: research

The potential of N-glycosylation profiles as biomarkers for monitoring the progression of Type II diabetes mellitus towards diabetic kidney disease
AbstractBackgroundOn a global scale, type II diabetes mellitus (T2DM) remain a major health problem and it is the driver for chronic kidney disease (CKD). Despite this association, we still do not have sufficient biomarkers to anticipate better outcomes. N-glycosylation profiles are robust biomarkers and can be used for early monitoring of the progression of T2DM towards CKD.MethodsIn this cross-sectional study, we recruited 241 T2DM patients from January to May 2016. Demographic and anthropometric data were collected, following which fasting blood samples were collected for clinical analyses. Renal function decline was de...
Source: Journal of Diabetes and Metabolic Disorders - November 17, 2018 Category: Endocrinology Source Type: research