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Effect of glucagon-like peptide-1 receptor agonist on insulin secretion index and serum Wnt5a protein in patients with new-onset type 2 diabetes mellitus
ConclusionOur results confirmed that GLP-1RA may improve HOMA- β in patients with type 2 diabetes by affecting the level of Wnt5a protein. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 3, 2023 Category: Endocrinology Source Type: research

A pre-clinical study to investigate the anti-diabetic potential of p-propoxybenzoic acid as a multi-target inhibitor in streptozotocin-nicotinamide induced type-2 diabetic rats
Conclusionp-PBA can be characterized as a multi-target inhibiting anti-diabetic agent which can be evaluated against diabetic complications. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 31, 2022 Category: Endocrinology Source Type: research

In silico docking based screening of constituents from Persian shallot as modulators of human glucokinase
ConclusionThese screened phytoconstituents may serve as promising hit molecules for further development of clinically beneficial and safe allosteric activators of the human GK enzyme. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 29, 2022 Category: Endocrinology Source Type: research

The stability of cardiometabolic risk factors clustering in children and adolescents: a 2-year longitudinal study
ConclusionThe higher the number of risk factors a child had at baseline, the higher the odds of presenting the same number of risk factors or more after two years of follow-up. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 23, 2022 Category: Endocrinology Source Type: research

Peroxisome proliferator-activated receptor γ Pro12 ala polymorphism and risk of cerebral stroke in type 2 diabetes mellitus egyptian patients
ConclusionA12 containing genotypes and A12 allele are not associated with IR, diabetes and risk of IS development, however, significant higher BMI were observed in A12 allele carriers in the studied patients with diabetes as well as those with IS. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 22, 2022 Category: Endocrinology Source Type: research

Prediction of hypercholesterolemia using machine learning techniques
ConclusionThe study shows that socioeconomic inequalities, unhealthy lifestyle, and metabolic syndrome (including obesity and hypertension) are significant predictors of hypercholesterolemia. Therefore controlling these factors is necessary to reduce the burden of hypercholesterolemia. Furthermore, machine learning algorithms such as random forest and gradient boosting can be employed for hypercholesterolemia screening and its timely diagnosis. Applying deep learning algorithms as well as techniques for handling the class overlap problem seems necessary to improve the performance of the models. (Source: Journal of Diabetes...
Source: Journal of Diabetes and Metabolic Disorders - December 22, 2022 Category: Endocrinology Source Type: research

HOMA-IR mean values in healthy individuals: a population-based study in iranian subjects
ConclusionsOur findings showed the mean value of 2.11  ± 0.99 HOMA-IR in the Iranian healthy population. Considering the large sample size in our study, more clinical investigations in terms of ethnicity should be done to provide a precise standardized HOMA-IR index in the Iranian population. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 22, 2022 Category: Endocrinology Source Type: research

Hypertonic saline solution 5% as an effective cost-beneficial alternative to normal saline for wound healing in patients with diabetic lower-extremity ulcers: a randomized controlled trial
ConclusionTreating diabetic foot ulcers with hypertonic saline solution may help improve wound healing. Therefore, rinsing with hypertonic saline is a cheap, safe, simple, and non-invasive treatment protocol for these patients. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 22, 2022 Category: Endocrinology Source Type: research

Dose-response relationship of photobiomodulation therapy and oxidative stress markers in healing dynamics of diabetic neuropathic ulcers in Wistar rats
Conclusion:Photobiomodulation therapy of dosages 4, 6, and 8  J/cm2 is effective and is a promising adjuvant modality in treating diabetic neuropathic ulcers. There was a strong dose-response relationship in the experimental groups treated with 4, 6 and 8  J/ cm2. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 22, 2022 Category: Endocrinology Source Type: research

Main drivers of diabetes pharmaceuticals expenditures: evidence from OECD countries and Iran
ConclusionPharmaceutical per capita expenditure is affected by several factors. These factors are not the same in various counties. Passing a judgment on drug utilization only based on pharmaceutical per capita expenditure cannot be perfect. Also, judging whether the per capita drug expenditure in one country is desirable without attention to the affecting factors and only relying on the value of utilized medicines is defective. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 22, 2022 Category: Endocrinology Source Type: research

Effects of eicosapentaenoic acid supplementation on heat shock protein 27, glycemic status and anthropometric indices in type 2 diabetes patients
ConclusionsWe found that EPA supplementation reduces HSP 27 serum level in T2DM patients. However, future large-scale trials are needed. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 22, 2022 Category: Endocrinology Source Type: research

Validation of standardized polyherbal formulation in the management of type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial
ConclusionIt can be concluded from the study that the advanced diabetic support formula (GP/PROD/2021/001) is a safer and more effective option as an adjuvant in the management of diabetes from newly diagnosed to chronic diabetic patients.Trial registrationCTRI/2022/01/039179 [Registered on: 05/01/2022] Trial Registered Prospectively. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 22, 2022 Category: Endocrinology Source Type: research

KADAM topical warm oxygen therapy device for diabetic foot ulcer-a novel approach
ConclusionTopical warm oxygen therapy serves as an adjunctive modality to facilitate diabetic foot ulcer healing in the clinical practice. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 21, 2022 Category: Endocrinology Source Type: research

Beneficial effects of 1,3 –1,6 β-glucans produced by Aureobasidium pullulans on non-esterified fatty acid levels in diabetic KKAy mice and their potential implications in metabolic dysregulation
ConclusionThese results, although modest, warrant further in-depth research into lipotoxicity and associated inflammatory cascades in both healthy and diseased subjects for the prevention and management of metabolic dysregulation and associated diseases such as non-alcoholic fatty liver disease (NAFLD). (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 11, 2022 Category: Endocrinology Source Type: research

Anacardium occidentale leaves extract and riboceine mitigate hyperglycemia through anti-oxidative effects and modulation of some selected genes associated with diabetes
ConclusionThe results obtained in this study demonstrate significant antidiabetic properties of ethanolic extract ofA. occidentale and riboceine. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 8, 2022 Category: Endocrinology Source Type: research