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Drug repurposing: Metformin ’s effect against liver tissue damage in diabetes and prostate cancer model
ConclusionThese highlights that the antidiabetic drug metformin can be repositioned for attenuating liver tissue damage associated with prostate cancer and diabetes. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 2, 2022 Category: Endocrinology Source Type: research

Future treatment of Diabetes – Tyrosine Kinase inhibitors
ConclusionTherefore, it is said that TKI drugs will be great potential for the treatment of Diabetes. This review summarizes the possible targets of TKIs and TKIs being a potential drug class in the management of Diabetes mellitus. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - December 1, 2022 Category: Endocrinology Source Type: research

The misuse of insulin by males with Type 1 Diabetes Mellitus for weight and/or shape control: a systematic scoping review
ConclusionDespite common preconceptions, this disordered eating behaviour appears to occur similarly in males and females. The findings shed light on areas for future research, including aetiology in males and the need for longitudinal and qualitative research. Clinical recommendations include being alert to the possibility of this behaviour in males with Type 1 Diabetes Mellitus and the need for health professionals to use open-ended questions to explore current and past deliberate restriction and/or omission of insulin among their patients. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 15, 2022 Category: Endocrinology Source Type: research

Using 17th century medication for modern diabetes management: Doctors ’ perceptions of self-medication practices – A qualitative study
ConclusionThese results suggest that doctors have limited strategies to implement to prevent self-medication practices among people with diabetes. Increasing knowledge amongst doctors about JAS medication effectiveness and thereby garnering greater trust in generic medications. In addition, efforts should be made to identify the best ways to integrate traditional and western medicine into patient-centered care delivery. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 12, 2022 Category: Endocrinology Source Type: research

The Iranian blood pressure measurement campaign, 2019: study protocol and preliminary results
ConclusionThe campaign was feasible with the objective to increase the awareness among the public and policymakers of the importance of tackling hypertension in Iran. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 11, 2022 Category: Endocrinology Source Type: research

Effect of using mobile phone communication on dietary management of Type 2 Diabetes Mellitus patients in Kenya
ConclusionRegular reminders on lifestyle and dietary behaviors using mobile phone communication improved adherence to dietary practices such as meal planning and frequency of meals in the management of T2DM. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 9, 2022 Category: Endocrinology Source Type: research

Adoption of IWGDF guidance on prevention and management of foot problems in diabetes for local use in Iran by ADAPTE methodology: a step toward best practice
ConclusionThe 2015 IWGDF guidance with 77 recommendations adopted for local use in different health care settings of Iran. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 8, 2022 Category: Endocrinology Source Type: research

Natural activators of AMPK signaling: potential role in the management of type-2 diabetes
AbstractAdenosine 5 ’-monophosphate-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase involved in the homeostasis of cellular energy. AMPK has developed as an appealing clinical target for the diagnosis of multiple metabolic diseases such as diabetes mellitus, obesity, inflammatio n, and cancer. Genetic and pharmacological studies indicate that AMPK is needed in response to glucose deficiency, dietary restriction, and increased physical activity for preserving glucose homeostasis. After activation, AMPK influences metabolic mechanisms contributing to enhanced ATP production, thus grow...
Source: Journal of Diabetes and Metabolic Disorders - November 8, 2022 Category: Endocrinology Source Type: research

Comparison of anxiety, stress, and social support levels of female patients with type 1 diabetes and mothers whose children have type 1 diabetes
ConclusionCaring for a child with T1DM was stressful and anxiety-provoking as having T1DM. Interventions including social support, may benefit mental health in mothers of diabetic children and women with T1DM. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 5, 2022 Category: Endocrinology Source Type: research

Chicoric acid ameliorates palmitate-induced sphingosine 1-phosphate signaling pathway in the PBMCs of patients with newly diagnosed type 2 diabetes
ConclusionThese data indicate that CA could be considered as a novel S1P signaling pathway inhibitor through down regulation of SPHK1 and S1PR1. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 5, 2022 Category: Endocrinology Source Type: research

Social determinants of health inequity in Iran: a narrative review
ConclusionIran, similar to large numbers of countries, face inequity at regional level in different SDH related issues. The COVID-19 pandemic showed that economic status and health are aligned. Sanctions superimposed on the COVID-19 pandemic cause harm to millions of innocent people. One of the main goals of health authorities is to reduce SDH inequity in order to achieve the goal of “health for all”. To tackle these inequities, prompt action is needed. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 5, 2022 Category: Endocrinology Source Type: research

Association between P300 parameters and cognitive function in people with diabetic neuropathy
ConclusionP300 latency and amplitude are associated with cognitive function and DTC of individuals with DPN. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 5, 2022 Category: Endocrinology Source Type: research

COVID-19 anti-vaccine attitude and hesitancy
AbstractHigh vaccination rates are required around the world to create herd immunity and terminate the current COVID-19 pandemic growth. With the steady rise in COVID-19 vaccine supplies, hesitancy and rejection to be vaccinated has become a problem worldwide for large vaccine coverage. Understanding the causes of vaccine avoidance or hesitancy can help to increase vaccination intentions in the general population. A number of factors contributed to increasing hesitancy. Some causes of COVID-19 vaccine hesitancy include anti-vaccine myths and confusing messages about some severe side effects of few vaccines, confusion over ...
Source: Journal of Diabetes and Metabolic Disorders - November 5, 2022 Category: Endocrinology Source Type: research

Pharmacological effect of Heritiera fomes on Long Evans rats against Postprandial Hyperglycemia and $${\left(\varvec{C}{\varvec{H}}_{2}\varvec{O}\right)}_{\varvec{n}}$$ adsorption in vitro
ConclusionsThe findings of this study provide evidence on probable mechanisms for the anti-diabetic characteristics ofH. fomes, and it is predicted that this plant will be studied further for the development of strong anti-hyperglycemic medicines. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 5, 2022 Category: Endocrinology Source Type: research

Diagnostic values of ischemia modified albumin in diabetes-related complications: a narrative review
ConclusionIMA levels are associated with DM complications and can be applied as a practical test for evaluating the risk and predicting the severity of DM complications. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 4, 2022 Category: Endocrinology Source Type: research