Mycophenolate mofetil hampers antibody responses to a broad range of vaccinations in kidney transplant recipients: results from a randomized controlled study.
To study the effect of mycophenolate mofetil (MMF) on various vaccination responses in kidney transplant recipients. (Source: Journal of Infection)
Source: Journal of Infection - March 1, 2024 Category: Infectious Diseases Authors: Z. Al Fatly, M.G.H. Betjes, W.A. Dik, R.A.M. Fouchier, M.E.J. Reinders, A.E. de Weerd Source Type: research

Current state of COVID-19 in children: 4 years on
Children have been disproportionately affected by the COVID-19 pandemic. Despite evidence of a very low risk of severe disease, children were subjected to extensive lockdown, restriction and mitigation measures, including school closures, to control the rapid spread of SARS-CoV-2 in most parts of the world. In this review we summarise the UK experience of COVID-19 in children four years into the largest and longest pandemic of this century. We address the risks of SARS-CoV-2 infection, immunity, transmission, severity and outcomes in children. (Source: Journal of Infection)
Source: Journal of Infection - March 1, 2024 Category: Infectious Diseases Authors: Annabel A. Powell, Alexander C. Dowell, Paul Moss, Shamez N Ladhani, the sKIDs Investigation Team Source Type: research

AZD1222 effectiveness against severe COVID-19 in individuals with comorbidity or frailty: the RAVEN cohort study
Despite being prioritized during initial COVID-19 vaccine rollout, vulnerable individuals at high risk of severe COVID-19 (hospitalization, intensive care unit admission, or death) remain underrepresented in vaccine effectiveness (VE) studies. The RAVEN cohort study (NCT05047822) assessed AZD1222 (ChAdOx1 nCov-19) two-dose primary series VE in vulnerable populations. (Source: Journal of Infection)
Source: Journal of Infection - February 29, 2024 Category: Infectious Diseases Authors: Wilhelmine Meeraus, Mark Joy, Mario Ouwens, Kathryn S Taylor, Sudhir Venkatesan, John Dennis, Trung N. Tran, Ashkan Dashtban, Xuejuan Fan, Robert Williams, Tamsin Morris, Lucy Carty, Debasish Kar, Uy Hoang, Michael Feher, Anna Forbes, Gavin Jamie, William Source Type: research

Lymphopenia is associated with broad host response aberrations in community-acquired pneumonia
Lymphopenia at hospital admission occurs in over one-third of patients with community-acquired pneumonia (CAP), yet its clinical relevance and pathophysiological implications remain underexplored. We evaluated outcomes and immune features of patients with lymphopenic CAP (L-CAP), a previously described immunophenotype characterized by admission lymphocyte count (Source: Journal of Infection)
Source: Journal of Infection - February 29, 2024 Category: Infectious Diseases Authors: Susanne E. Doeleman, Tom D.Y. Reijnders, Sebastiaan C.M. Joosten, Alex R. Schuurman, Tjitske S.R. van Engelen, Jan Verhoeff, Valentine L éopold, Xanthe Brands, Bastiaan W. Haak, Jan M. Prins, Maadrika M.N.P. Kanglie, Inge A.H. van den Berk, Daniël R. Fa Source Type: research

Intra-host genetic diversity of SARS-CoV-2 Omicron variants in children
Dear editor, (Source: Journal of Infection)
Source: Journal of Infection - February 29, 2024 Category: Infectious Diseases Authors: Pengcheng Liu, Jiehao Cai, He Tian, Jingjing Li, Lijuan Lu, Menghua Xu, Xunhua Zhu, Huaqing Zhong, Ran Jia, Xiaomin Fu, Xiangshi Wang, Yanling Ge, Yanfeng Zhu, Mei Zeng, Jin Xu Tags: Letter to the Editor Source Type: research

Ivermectin for COVID-19 in adults in the community (PRINCIPLE): an open, randomised, controlled, adaptive platform trial of short- and longer-term outcomes
Ivermectin for COVID-19 is unlikely to provide clinically meaningful improvement in recovery, hospital admissions, or longer-term outcomes. Further trials of ivermectin for SARS-Cov-2 infection in vaccinated community populations appear unwarranted. (Source: Journal of Infection)
Source: Journal of Infection - February 29, 2024 Category: Infectious Diseases Authors: Gail Hayward, Ly-Mee Yu, Paul Little, Oghenekome Gbinigie, Milensu Shanyinde, Victoria Harris, Jienchi Dorward, Benjamin R Saville, Nicholas Berry, Philip H Evans, Nicholas PB Thomas, Mahendra G Patel, Duncan Richards, Oliver Van Hecke, Michelle A Detry, Source Type: research

Identification of a newly emerging second-generation HIV-1 circulating recombinant form (CRF145_0755) among men who have sex with men in China
Dear Editor (Source: Journal of Infection)
Source: Journal of Infection - February 21, 2024 Category: Infectious Diseases Authors: Min Chen, Yanling Ma, Huichao Chen, Jie Dai, Lijuan Dong, Manhong Jia Source Type: research

Is paracetamol a missing piece of the severe acute hepatitis of unknown aetiology jigsaw?
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - February 19, 2024 Category: Infectious Diseases Authors: Pietro Vajro, Claudia Mandato, Bj örn Fischler Tags: Letter to the Editor Source Type: research

Bacteriophage Therapy and Current Delivery Strategies for Orthopedic Infections: A SCOPING Review
Interest in phages as adjunctive therapy to treat difficult infections has grown in the last decade. However, phage dosing and delivery for orthopedic infections have not been systematically summarized. (Source: Journal of Infection)
Source: Journal of Infection - February 17, 2024 Category: Infectious Diseases Authors: Jason Young, Sang Won Lee, Mohammad Javad Shariyate, Alexandria Cronin, John J. Wixted, Ara Nazarian, Christopher F. Rowley, Edward K. Rodriguez Source Type: research

Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): a phase 3, randomized, double-blind, placebo-controlled trial
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - February 15, 2024 Category: Infectious Diseases Authors: Maya Hites, Cl ément R. Massonnaud, Simon Jamard, François Goehringer, François Danion, Jean Reignier, Nathalie de Castro, Denis Garot, Eva Larranaga Lapique, Karine Lacombe, Violaine Tolsma, Emmanuel Faure, Denis Malvy, Thérèse Staub, Johan Courjon, Tags: Letter to the Editor Source Type: research

Molecular Insights into the Adaptive Evolution of SARS-CoV-2 Spike Protein
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has substantially damaged the global economy and human health. The spike (S) protein of coronaviruses plays a pivotal role in viral entry by binding to host cell receptors. Additionally, it acts as the primary target for neutralizing antibodies in those infected and is the central focus for currently utilized or researched vaccines. During the virus's adaptation to the human host, the S protein of SARS-CoV-2 has undergone significant evolution. (Source: Journal of Infection)
Source: Journal of Infection - February 15, 2024 Category: Infectious Diseases Authors: Zhuocheng Yao, Lin Zhang, Yuange Duan, Xiaolu Tang, Jian Lu Source Type: research

People Living with HIV who have poor immune status are a key population for SARS-CoV-2 prevention
In this Journal, Meredith Leston and colleagues reviewed the disparities in COVID-19 mortality amongst the immunosuppressed, and suggested People living with HIV (PLWH) (pooled OR:1.20, 95%CI:1.05-1.36) had just slightly higher risks than the immunocompetent people1. We further analyzed the expression levels of SARS-CoV-2 antibodies IgG and IgM in 184 PLWH after receiving the SARS-CoV-2 vaccine, as well as the influencing factors, in order to more meaningfully subdivide the COVID-19 prevention population. (Source: Journal of Infection)
Source: Journal of Infection - February 15, 2024 Category: Infectious Diseases Authors: Jie Zhou, Liuyan Lan, Sufang Ai, Jianyan Lin, Ningmei Liu, Yulan Xie, Ping Cui, Hao Liang, Li Ye, Jiegang Huang, Zhiman Xie Source Type: research

Introducing article numbering to Journal of Infection
Within the publishing industry, article numbering has emerged as an easy and efficient way to cite journal articles. Article numbering has already been successfully rolled out to Elsevier ’s multidisciplinary open access journal Heliyon, as well as more than 1600 other journals, and has been well received by the academic community. Based on that positive feedback, we are now pleased to introduce article numbering to Journal of Infection from the 5th of February 2024. (Source: Journal of Infection)
Source: Journal of Infection - February 14, 2024 Category: Infectious Diseases Tags: Publisher ’s Note Source Type: research

Antibiotics to eradicate Streptococcus pyogenes pharyngeal carriage in asymptomatic children and adults: a systematic review
Streptococcus pyogenes (S. pyogenes) is a Gram-positive bacteria which causes a spectrum of diseases ranging from asymptomatic infection to life-threatening sepsis. Studies report up to 2000 times greater risk of invasive S. pyogenes disease in close contacts of index cases within 30-days of symptom onset. Despite this, there is variability in the management of asymptomatic carriage of S. pyogenes and those at risk of secondary cases of invasive S. pyogenes infection. (Source: Journal of Infection)
Source: Journal of Infection - February 13, 2024 Category: Infectious Diseases Authors: Te-Yu Hung, Linny K. Phuong, Anneke Grobler, Steven Y.C. Tong, Pippin Freeth, Asika Pelenda, Katherine B Gibney, Andrew C Steer Tags: Review Source Type: research

Altered IgG4 Antibody Response to Repeated mRNA versus Recombinant Protein SARS-CoV-2 Vaccines
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - February 12, 2024 Category: Infectious Diseases Authors: Raj Kalkeri, Mingzhu Zhu, Shane Cloney-Clark, Joyce S. Plested, Anand Parekh, Drew Gorinson, Rongman Cai, Soham Mahato, Pradhipa Ramanathan, L. Carissa Aurelia, Kevin John Selva, Anthony M. Marchese, Louis Fries, Amy W. Chung, Lisa M. Dunkle Source Type: research