Editorial Board
(Source: Journal of Infection)
Source: Journal of Infection - September 22, 2021 Category: Infectious Diseases Source Type: research

Antibody titers and protection against a SARS-CoV-2 infection
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - September 20, 2021 Category: Infectious Diseases Authors: Chlo é Dimeglio, Fabrice Herin, Guillaume Martin-Blondel, Marcel Miedougé, Jacques Izopet Tags: Letter to the Editor Source Type: research

Clinical features of COVID-19 by SARS-CoV-2 Gamma variant: a prospective cohort study of vaccinated and unvaccinated healthcare workers
In this Journal, Gidari and colleagues showed that sera from BNT162b2 vaccinated humans had lower neutralization potency on the SARS-CoV-2 Gamma variant and that convalescent patients that had been infected by the Gamma variant were less protected from other SARS-CoV-2 strains.1 (Source: Journal of Infection)
Source: Journal of Infection - September 16, 2021 Category: Infectious Diseases Authors: Alessandra Luna-Muschi, Igor C. Borges, Elizabeth de Faria, Antonio S. Barboza, Fernando L. Maia, Mariana D. Leme, Ana Rubia Guedes, Maria Cassia Mendes-Correa, Esper G. Kallas, Alu ísio C. Segurado, Alberto J.S. Duarte, Carolina S. Lazari, Pamela S. And Tags: Letter to the editor Source Type: research

Risk factors associated with bloodstream infections among critically ill patients with COVID-19
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - September 16, 2021 Category: Infectious Diseases Authors: Tim McMillan, Conor Jones, Cavan J O'Connor, Daniel Nolan, Xin Hui Chan, Jayne Ellis, Clare Thakker, Katharina Kranzer, Neil RH Stone, Mervyn Singer, Andrew PR Wilson, Nishkantha Arulkumaran Source Type: research

Self-collected mid-nasal swabs and saliva specimens, compared with nasopharyngeal swabs, for SARS-CoV-2 detection in mild COVID-19 patients
The use of self-collected specimens for the screening of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gained interest as they may facilitate massive screening campaigns. Various authors have reported that mid-nasal swabs1,2 and saliva3 –6 are reliable specimens, alternative to nasopharyngeal swabs, to detect SARS-CoV-2 infections by RT-qPCR, irrespective of the age group tested.7 Despite drawing consistent conclusions, studies reported heterogeneous results regarding the performance of each type of sample, particularly sensitivi ty, which strongly depends on the viral load distribution of the ...
Source: Journal of Infection - September 16, 2021 Category: Infectious Diseases Authors: Andrea Alemany, Pere Millat-Martinez, Dan Ouchi, Marc Corbacho-Monn é, Antoni E. Bordoy, Cristina Esteban, Águeda Hernández, Cristina Casañ, Victoria Gonzalez, Gèlia Costes, Mar Capdevila-Jáuregui, Pamela Torrano-Soler, Alba San José, Jordi Ara, N Source Type: research

Predicting COVID-19 incidence in war-torn Afghanistan: A timely response is required!
We read with great interest the article entitled "A quick prediction tool for unfavourable outcome in COVID-19 inpatients: Development and internal validation" by Salto-Alejandre et al.1 Authors of this article forecast the outcomes of COVID-19. The upsurge in COVID-19 cases, along with health issues  in the war-torn country, stoked fears of a disaster amid a still-raging conflict. As a result, this paper will focus on the future prediction of COVID-19 cases in the war-torn country of Afghanistan, providing them with additional insight for taking necessary preventive measures. (Source: Journal of Infection)
Source: Journal of Infection - September 15, 2021 Category: Infectious Diseases Authors: Usman Ayub Awan, Muhammad Wasif Malik, Muhammad Imran Khan, Aamer Ali Khattak, Haroon Ahmed, Usman Hassan, Humera Qureshi, Muhammad Sohail Afzal Tags: Letter to the Editor Source Type: research

Letter in response to article in journal of infection: “The microbiology of chronic osteomyelitis: Changes over ten years”
We have read with interest the paper of Dudavera et al. about the microbiological etiology of chronic osteomyelitis (1). They report a lowered rate of methicillin-resistant Staphylococcus aureus (MRSA) infections in a cohort between 2013-2017 compared to 2001-2004 with a proportion of infections caused by multi-drug resistant bacteria of 15.2% and 17.2%. (Source: Journal of Infection)
Source: Journal of Infection - September 15, 2021 Category: Infectious Diseases Authors: Nike Walter, Susanne Baertl, Ulrike Engelstaedter, Martin Ehrenschwender, Florian Hitzenbichler, Volker Alt, Markus Rupp Source Type: research

Integrated Mobile Container PCR Laboratory (IMCPL): a novel strategy to reduce unnecessary rapid antigen testing
In this study, they used the PCR test to determine the false positive rate of the antigen test. The results showed that the total false positive rate of rapid antigen detection was as high as 46.28%. Andreas and colleagues concluded that “From a pure laboratory and diagnostic point of view it has to be concluded that the usage of an antigen testing strategy with a false detecting rate of about 50% is unacceptable.”1 (Source: Journal of Infection)
Source: Journal of Infection - September 15, 2021 Category: Infectious Diseases Authors: Ming Li, Jie Zhao, Hui Zhang, Jiang Liu, Xiangshi Fan, Xiaohui Bai, Zhiming Lu Tags: Letter to the Editor Source Type: research

Incident changes of rotavirus enteritis among children during the coronavirus disease-2019 pandemic in Hangzhou, China
In this report, the authors brought attention to sharp declines in measles cases in Pakistan during the COVID-19 pandemic and here we w ould like to present the decline in rotavirus enteritis among children during the COVID-19 pandemic in Hangzhou, China. (Source: Journal of Infection)
Source: Journal of Infection - September 15, 2021 Category: Infectious Diseases Authors: Chao Fang, Zheng Zhou, Jianping Li, Mingming Zhou Source Type: research

Mental health and physical symptoms of people quarantined during the COVID-19 outbreak
We read with great interest the letter by Fern ández-De-Las-Peñas and colleagues1 in Journal of Infection on the status of mental health and sleep in previously hospitalized COVID-19 patients. Evidence support that after hospital discharge for seven months, almost 50% of hospitalised survivors still have anxiety or depressive symptoms and/or p oor sleep quality. Meanwhile, Liu and colleagues2 thought the mental health of children quarantined would be negatively affected by COVID-19, which published in The Lancet Child& Adolescent Health. (Source: Journal of Infection)
Source: Journal of Infection - September 15, 2021 Category: Infectious Diseases Authors: Huan Chen, Xu Zhao, Li Li, Shiyan Yan, Xiaofei Shang, Xiuhui Li Source Type: research

Endogenous Candida endophthalmitis: has it been discerned from a cotton wool spot in the retina?
I read the paper by Seidelman et al with great interest and concern.1 The authors hypothesize that a variety of risk factors may predict the development of endophthalmitis in the setting of Candida septicemia with potential for guiding ophthalmologic screening. However, the data and interpretation presented demonstrate severe flaws that prohibitively limit their conclusions, including but not limited to inaccurate disease classification, selection bias, lack of control for confounding variables, lack of visual outcomes data, any details regarding changes in management based on ocular findings, lack of microbial confirmatio...
Source: Journal of Infection - September 15, 2021 Category: Infectious Diseases Authors: Mark P. Breazzano Source Type: research

14-year trends and resistance patterns of blood and cerebrospinal fluid cultures in children under three years old
Bacterial sepsis is a leading cause of morbidity and mortality in young infants accounting for approximately 6% of neonatal deaths worldwide, but its management is threatened by rising antimicrobial resistance (AMR). 1 2 Resistance in Gram-negative bacteria is particularly concerning, with increasing multi-drug resistance and evidence that poor empirical therapy choice can result in poor prognosis. 3 4 Improved surveillance is highlighted as one of the key recommendations to counter AMR in the World Health Organization's global action plan on antimicrobial resistance, and also in the 5-year antimicrobial resistance strateg...
Source: Journal of Infection - September 14, 2021 Category: Infectious Diseases Authors: Junko Takata, Dominic F Kelly, Manish Sadarangani, Katie Jeffery, Simon B Drysdale Source Type: research

Bamlanivimab improves hospitalization and mortality rates in patients with COVID-19: A systematic review and meta-analysis
The coronavirus disease 2019 (COVID-19) pandemic has spread globally and poses a serious threat to the world. As of August 9, 2021, there were over 200 million COVID-19 cases and 4 million deaths. The clinical manifestations of COVID-19 range from mild to severe, the incidence of illness and mortality is high in some vulnerable subgroup of patients. Until now, treatment option for patients to prevent progression to severe COVID-19 is limited. Although, vaccination  is considered as an effective method to stop the spread of the COVID-19 pandemic, the newly emerged SARS-CoV-2 variants have led to breakthrough infections...
Source: Journal of Infection - September 14, 2021 Category: Infectious Diseases Authors: Ling Zuo, Guangyu Ao, Yushu Wang, Ming Gao, Xin Qi Tags: Letter to the Editor Source Type: research

Mendelian randomization reveals potential causal candidates for COVID-19 in 123 blood metabolites
We read with interest the recently published letter in Journal of Infection by Dr. Yang et al., who conducted a quantitative meta-analysis of twenty-seven studies containing 146,364 cases and found a lack of association between dyslipidemia and COVID-19 mortality (1). However, Dr. Hilser et al. investigated the relationship between metabolic syndrome-related serum biomarkers and the severity of COVID-19 in UK Biobank and found that an increase of 10 mg/dl HDL-Cholesterol reduced the risk of suffering from COVID-19 by 13% (OR  = 0.87, 95% CI: 0.79–0.94, P = 1.2E-03) (2). (Source: Journal of Infection)
Source: Journal of Infection - September 13, 2021 Category: Infectious Diseases Authors: Shizheng Qiu, Donghua Wang, Yu Zhang, Yang Hu Tags: Letter to the Editor Source Type: research

Prognosis of unexpected positive intraoperative cultures in arthroplasty revision: a large multicenter cohort
Background. The positive-intraoperative-cultures-type prosthetic joint infection (PIOC-PJI) is considered when surgical cultures yield microorganisms in presumed aseptic arthroplasty revisions. Herein we assess the risk factors for failure in the largest cohort of PIOC-PJI patients reported to date.Methods. A retrospective, observational, multicenter study was performed during 2007-2017. Surgeries leading to diagnose PIOC-PJI included only one-stage procedures with either complete or partial prosthesis revision. (Source: Journal of Infection)
Source: Journal of Infection - September 9, 2021 Category: Infectious Diseases Authors: Mikel Manche ño-Losa, Jaime Lora-Tamayo, Marta Fernández-Sampedro, Dolors Rodríguez-Pardo, Ernesto Muñoz-Mahamud, Laura Soldevila, Mariona Palou, José María Barbero, María Dolores del Toro, José Antonio Iribarren, Beatriz Sobrino, Alicia Rico-Niet Tags: Original article Source Type: research

Clinical performance and accuracy of a qPCR-based SARS-CoV-2 mass-screening workflow for healthcare-worker surveillance using pooled self-sampled gargling solutions: a cross-sectional study
Healthcare workers (HCW) are on the frontlines of the current worldwide SARS-CoV-2 pandemic, placing themselves, their families and their patients at further risk of infection. Furthermore, their absence during periods of isolation for either suspected or proven infections places further strain on an already overburdened healthcare system. (Source: Journal of Infection)
Source: Journal of Infection - September 5, 2021 Category: Infectious Diseases Authors: Flaminia Olearo, Dominik N örz, Armin Hoffman, Moritz Grunwald, Kimani Gatzemeyer, Martin Christner, Anna Both, Cristina Elena Belmar Campos, Platon Braun, Gabriele Andersen, Susanne Pfefferle, Antonia Zapf, Martin Aepfelbacher, Johannes K.M. Knobloch, M Source Type: research

The high expression of SARS-CoV-2 cell receptors might lead to higher COVID-19 infection rates in cancer patients
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - September 2, 2021 Category: Infectious Diseases Authors: Shizheng Qiu, Yu Zhang, Donghua Wang, Yang Hu Source Type: research

Adopting fresh air ventilation may reduce the risk of airborne transmission of SARS-CoV-2 in COVID-19 unit
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - September 1, 2021 Category: Infectious Diseases Authors: Habibi Alkalamouni, Eveline Hitti, Hassan Zaraket Source Type: research

Dengue and Chikungunya seroprevalence in waste pickers from the largest Latin American open-air dump
Dear editor, (Source: Journal of Infection)
Source: Journal of Infection - August 30, 2021 Category: Infectious Diseases Authors: Évelin Mota Cassemiro, Daiani Cristina Cilião-Alves, Drielly Rodrigues Moura, Svetoslav Nanev Slavov, Tatyane de Souza Cardoso Quintão, James Alexander Scott, Carla Pintas Marques, Marcos Takashi Obara, Wildo Navegantes de Araújo, Vanessa Resende Nogu Tags: Letter to the Editor Source Type: research

Healthcare-associated COVID-19 in England: a national data linkage study
Healthcare-associated (nosocomial) transmission was a salient feature of SARS (severe acute respiratory syndrome) and MERS (Middle East respiratory syndrome) outbreaks, with 24% of SARS-CoV-1 infections and 36% of MERS-CoV infections among hospitalised cases (excluding healthcare workers) attributed to healthcare acquisition.1 Early in the COVID-19 pandemic, a single-centre study in Wuhan, China, reported that 57 (41%) of 138 COVID-19 cases were nosocomial, of whom 17 were patients already hospitalised for other reasons and 40 were healthcare workers. (Source: Journal of Infection)
Source: Journal of Infection - August 30, 2021 Category: Infectious Diseases Authors: Alex Bhattacharya, Simon M Collin, James Stimson, Simon Thelwall, Olisaeloka Nsonwu, Sarah Gerver, Julie Robotham, Mark Wilcox, Susan Hopkins, Russell Hope Source Type: research

SARS-CoV-2 variants with shortened incubation periods necessitate new definitions for nosocomial acquisition
To the Editors, (Source: Journal of Infection)
Source: Journal of Infection - August 30, 2021 Category: Infectious Diseases Authors: Luke B Snell, Ali R Awan, Themoula Charalampous, Adela Alcolea-Medina, Sam T Douthwaite, Jonathan D Edgeworth, Gaia Nebbia Source Type: research

Dengue and Chikungunya Seroprevalence  in waste pickers from the largest Latin American open-air dump
Dear editor, (Source: Journal of Infection)
Source: Journal of Infection - August 30, 2021 Category: Infectious Diseases Authors: Évelin Mota Cassemiro, Daiani Cristina Cilião-Alves, Drielly Rodrigues Moura, Svetoslav Nanev Slavov, Tatyane de Souza Cardoso Quintão, James A. Scott, Carla Pintas Marques, Marcos Takashi Obara, Wildo Navegantes de Araújo, Vanessa Resende Nogueira Cr Tags: LETTER TO THE EDITOR Source Type: research

On-treatment HBV RNA Dynamic Predicts Entecavir-induced HBeAg Seroconversion in Children with Chronic Hepatitis B
Despite preventive vaccination programs, significant numbers of children worldwide remain at risk of contracting hepatitis B virus (HBV) and developing chronic hepatitis B (CHB)1. Adults CHB patients have a 15 to 25% risk of dying from HBV-related liver disease, including liver cirrhosis and hepatocellular carcinoma (HCC)2. Instead during childhood and adolescence: Until reaching adulthood the risk of CHB patients developing cirrhosis or HCC is 3 to 5% and 0.01 to 0.03%, respectively3. Although host factors (e.g., sex, age, race, and family history) and viral factors (e.g., viral load, genotype, mutation, and co-infection)...
Source: Journal of Infection - August 30, 2021 Category: Infectious Diseases Authors: Yongbin Wu, Jian Wen, Guifang Tang, Jing Zhang, Jie Xin Source Type: research

Impact of the Alpha VOC on disease severity in SARS-CoV-2-positive adults in Sweden
Variants of concern (VOC) have rapidly become the dominating SARS-CoV-2 viruses worldwide (1, 2). Concerns have been raised that VOC may cause more severe disease than non-VOC (3). Cevik and Mishra (3) concluded that Alpha VOC (lineage B.1.1.7) positivity was associated with increased risk for hospitalisation in four of five, and for death in five of six community-based studies, but was not associated with increased mortality in 3 hospital-based studies. Two of these hospital-based studies (4, 5) also evaluated disease severity and did not find an association with Alpha VOC. (Source: Journal of Infection)
Source: Journal of Infection - August 30, 2021 Category: Infectious Diseases Authors: Kristoffer Str ålin, Daniel Bruce, Erik Wahlström, Sten Walther, Moa Rehn, AnnaSara Carnahan, Emmi Andersson, Anna M Bennet Bark, Håkan Hanberger Tags: Letter to the Editor Source Type: research

Staphylococcus argenteus transmission among healthy Royal Marines: a molecular epidemiology case-study
Staphylococcus argenteus is a newly identified staphylococcus species, previously known as S. aureus clonal complex 75 [1]. Globally, it is known to be a sporadic pathogen causing sepsis [2], skin and soft tissue infections [3] and bone infections [3,4]. Data on carriage and potential person-to-person transmission are scarce: two studies report carriage rates of 0.9% (5/563) and 3.4% (5/146) of S. argenteus in healthy individuals [5,6], while just one study has described familial transmission of S. (Source: Journal of Infection)
Source: Journal of Infection - August 29, 2021 Category: Infectious Diseases Authors: Elita Jauneikaite, Bruno Pichon, Mia Mosavie, Joanne L. Fallowfield, Trish Davey, Neil Thorpe, Andrew Nelstrop, Shiranee Sriskandan, Lucy E Lamb Source Type: research

Editorial Board
(Source: Journal of Infection)
Source: Journal of Infection - August 27, 2021 Category: Infectious Diseases Source Type: research

Dengue and Dementia Risk: A Nationwide Longitudinal Study
Dengue is an acute systemic disease and a mosquito-borne viral infection transmitted by Aedes aegypti and Aedes albopictus mosquitoes [1]. Dengue is widespread throughout tropical and sub-tropical urban regions [1]. The incidence of dengue has increased dramatically, according to the World Health Organization report in May 2015 [2], However, the actual incidence of dengue is still underreported. Each year, there are approximately 390 million newly diagnosed dengue infections, of which 96 million develop clinical manifestations with some level of severity [3]. (Source: Journal of Infection)
Source: Journal of Infection - August 26, 2021 Category: Infectious Diseases Authors: Che-Sheng Chu, Shih-Jen Tsai, Chih-Ming Cheng, Tung-Ping Su, Tzeng-Ji Chen, Ya-Mei Bai, Chih-Sung Liang, Mu-Hong Chen Source Type: research

A genome-wide cross-trait analysis highlights the shared genetic structure between COVID-19 and Alzheimer's disease
We read with interest the recently published research in Journal of Infection by Dr. Yang et al., who reported the higher mortality of COVID-19 patients with dementia compared with COVID-19 patients without dementia (effect estimate  = 1.84, 95% CI: 1.57–2.16) (1). Meanwhile, patients recovering from COVID-19 had a more severe burden of cognitive impairment, suggesting the potential risk of Alzheimer's disease (2). Although growing evidences indicate the potential genetic overlap between Alzheimer's disease and COVID-19, the genetic association degree and the shared genetic structure region between the two diseas...
Source: Journal of Infection - August 26, 2021 Category: Infectious Diseases Authors: Shizheng Qiu, Yang Hu, Liang Cheng Source Type: research

Why do clinicians treat, or not treat, a patient for sepsis? Using the Theoretical Domains Framework to elicit barriers and enablers to performing the Sepsis Six in UK hospitals
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - August 26, 2021 Category: Infectious Diseases Authors: Dr Guy Hooper, Dr Neil Roberts, Dr Fabiana Lorencatto, Dr Adam Pollard, Dr Michael Spivey, Dr Wendell Storr, Dr Deborah Webster, Mr Alan Eccles, Mr George Ramsay, Dr Jan Jansen, Dr Ruth Thomas, Dr Helen Bounds, Dr Michael Eddie, Dr Stephen Knight, Dr Robe Source Type: research

Are COVID-19 susceptibility genes related to lung cancer?
We read with great interest the recently published letter in Journal of Infection by Afshar et al., who suggested that the proportion of severe cases and mortality among cancer patients infected with COVID-19 were higher than those of COVID-19 patients without cancer, due to abnormal autoimmune function (1). Meanwhile, Liang et al. collected and analyzed 2007 cases from 575 hospitals in China who were diagnosed with COVID-19 and were admitted to hospital for treatment, and found that 1% of COVID-19 patients had a history of cancer, which was much higher than the incidence of cancer in the normal population (0.29%) (2). (So...
Source: Journal of Infection - August 23, 2021 Category: Infectious Diseases Authors: Shizheng Qiu, Yang Hu Source Type: research

Emergence of Q493R mutation in SARS-CoV-2 spike protein during bamlanivimab/etesevimab treatment and resistance to viral clearance
Data from clinical trials suggest that monoclonal antibody (mAb) treatments can prevent deaths and severe disease among people with mild to moderate COVID-19. Recently, a cocktail of two mAbs- bamlanivimab and etesevimab- was reported to cut the risk of hospitalization and death by 87% 1. The European Medicine Agency (EMA) recommends the use of this combination in patients who do not require supplemental oxygen, and who are at high risk of progression to severe disease 2. Since SARS-CoV-2 Spike protein is the target of antibody-based therapeutics, they all suffer from one major risk: mutational escape of the Spike protein3...
Source: Journal of Infection - August 23, 2021 Category: Infectious Diseases Authors: Aur élie Guigon, Emmanuel Faure, Chloé Lemaire, Marie-Charlotte Chopin, Claire Tinez, Ady Assaf, Mouna Lazrek, Didier Hober, Laurence Bocket, Ilka Engelmann, Enagnon Kazali Alidjinou Source Type: research

Antibiotic resistance genes in Bacillus cereus isolated from wild P ère David's deer (Elaphurus davidianus)
Antibiotics are the most commonly prescribed therapy to human and animals, however with a high proportion and misuse emergence the antibiotic resistance in animal husbandry. Antimicrobial resistance profile is highly concerned with humans and animal health globally1, 2. The natural environment provides a large library of drug-resistant genes for microorganisms. The antimicrobial resistance process is accelerated by the circulation of substances in nature (such as air and water) and biological activities (human activities and animal's abundance or insect's diversity) that may contribute to the dynamic evolution of bacterial...
Source: Journal of Infection - August 23, 2021 Category: Infectious Diseases Authors: Ying Li, Khalid Mehmood, Yung-Fu Chang, Rui Guo, Peng Shang, Hui Zhang Tags: Letter to the editor Source Type: research

Six-month interim analysis of ongoing immunogenicity surveillance of the mRNA-1273 vaccine in healthcare workers: A third dose is expected
Vaccines are currently one of the most effective weapons to fight the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and eradicate the enduring pandemic1. The health situation remains worrying. On August 7, the John Hopkins ’ University assessment reported that the number of confirmed cases exceeds 201.783.223, the number of deaths worldwide stands at 4.278.676 and the vaccine doses administered reached 4 370 877 6502. (Source: Journal of Infection)
Source: Journal of Infection - August 22, 2021 Category: Infectious Diseases Authors: Marie Tr é-Hardy, Roberto Cupaiolo, Alain Wilmet, Thomas Antoine-Moussiaux, Andrea Della Vecchia, Alexandra Horeanga, Emmanuelle Papleux, Marc Vekemans, Ingrid Beukinga, Laurent Blairon Tags: Research Article Source Type: research

Antibody formation against SARS-CoV-2 in imatinib-treated COVID-19 patients
The article by Gobbi and colleagues1 exemplifies the general interest in understanding the dynamics of immune response to SARS-CoV-2 vaccine, which is currently being widely investigated. However, the study of this response after COVID-19 infection should not be left aside, particularly in those patients who have been treated with drugs that may alter the normal functioning of the immune system. This is the case of imatinib, the principal BCR-Abl inhibitor for the treatment of chronic myeloid leukaemia (CML), which has been proposed as a potential treatment for SARS-CoV-2 infection, as it may exhibit both antiviral and imm...
Source: Journal of Infection - August 22, 2021 Category: Infectious Diseases Authors: Alejandro Morales-Ortega, Ana Isabel Farf án-Sedano, Aida Izquierdo-Martínez, Cristina Llarena-Barroso, Beatriz Jaenes-Barrios, Nieves Mesa-Plaza, María Toledano-Macías, Guillermo Soria Fernández-Llamazares, Laura Molina-Esteban, Jaime García de Ten Tags: Letter to the Editor Source Type: research

Long-lasting immune response to a mild course of PCR-confirmed SARS-CoV-2 infection: A cohort study
To the Editor – We read with great interest the paper by Wells et al. (2020).1 Wells et al. investigated seroprevalence of SARS-CoV-2 antibodies in a cohort of 431 non-hospitalized UK twins (median age = 48; 85% female), who systematically reported the presence or absence of COVID-19 symptoms on many occasi ons through time via an ad-hoc study app. Their results indicated that 51 of the 431 individuals (12%) were seropositive with IgG response to both N and S proteins 4-fold above the background of the assay. (Source: Journal of Infection)
Source: Journal of Infection - August 21, 2021 Category: Infectious Diseases Authors: Sabrina Kral, Chiara Banfi, Tobias Niedrist, Nazanin Sareban, Christian Guelly, Lisa Kriegl, Stefanie Schiffmann, Christoph Zurl, Markus Herrmann, Ivo Steinmetz, Peter Schlenke, Andrea Berghold, Robert Krause Tags: Letter to the Editor Source Type: research

Clinical efficacy and safety of high dose trivalent influenza vaccine in adults and immunosuppressed populations –a systematic review and meta-analysis
Influenza is associated with considerable morbidity and mortality, even more so in specific populations, including patients aged 65 years and older [1], children younger than 5 years old (especially those younger than 2 years) [2 –4], pregnant woman, patients with chronic illnesses [5], and immunocompromised patients [6]. The effectiveness of current treatment of influenza with neuraminidase inhibitors is debatable [7], emphasizing the importance of prevention of this infection. (Source: Journal of Infection)
Source: Journal of Infection - August 20, 2021 Category: Infectious Diseases Authors: Yaara Leibovici Weissman, Lisa Cooper, Neta Sternbach, Liat Ashkenazi-Hoffnung, Dafna Yahav Source Type: research

Cytokine levels in sputum, not serum, may be more helpful for indicating the damage in the lung and the prognosis of severe COVID-19 – A case series
To describe the relationship between the severity of lung damage and cytokine levels in sputum, bronchoalveolar lavage fluid (BALF), serum. (Source: Journal of Infection)
Source: Journal of Infection - August 19, 2021 Category: Infectious Diseases Authors: Changsong Wang, Kai Kang, Xiuwen Lan, Dongsheng Fei, Qian Wang, Xianyong Li, Yang Chong, Yan Gao, Huaiquan Wang, Xueting Li, Mingyan Zhao, Kaijiang Yu Tags: Letter to the Editor Source Type: research

Clinical, radiographic features and long-term outcomes of paradoxical cryptococcosis-associated immune reconstitution inflammatory syndrome secondary to the ventriculoperitoneal shunt
Paradoxical immune reactions in cryptococcal meningitis (CM), also termed as cryptococcal-immune reconstitution inflammatory syndrome (C-IRIS), occurs in 13% –30% of immunodeficiency individuals with CM receiving antifungal therapy and antiretroviral therapy(ART).1,2 However, in recent years, isolated cases and small case series of IRIS have also been reported in immunocompetent CM hosts with varying frequencies.3,4 IRIS manifestations include deterior ation of clinical manifestations and neuroimaging abnormalities, as well as changes in cerebrospinal fluid after clinical and/or microbial responses to anti-cryptococc...
Source: Journal of Infection - August 19, 2021 Category: Infectious Diseases Authors: Yu Yang, Min Li, Lijuan Yang, Qing Tian, Bing Qin Source Type: research

Evidence of the reduction of acute circulating communicable viruses during the SARS-CoV-2 pandemic in London.
To the Editor, (Source: Journal of Infection)
Source: Journal of Infection - August 19, 2021 Category: Infectious Diseases Authors: Alexandra Bramley, Tim Crocker-Buque, Judith Breuer, Tabitha W Mahungu Source Type: research

Cytokinelevels in sputum, not serum, may be more helpful 1 for indicating the damage in the lung and the prognosis of severe COVID-19 – A Case Series
To describe the relationship between the severity of lung damage and cytokine levels in sputum, bronchoalveolar lavage fluid (BALF), serum. (Source: Journal of Infection)
Source: Journal of Infection - August 19, 2021 Category: Infectious Diseases Authors: Changsong Wang, Kai Kang, Xiuwen Lan, Dongsheng Fei, Qian Wang, Xianyong Li, Yang Chong, Yan Gao, Huaiquan Wang, Xueting Li, Mingyan Zhao, Kaijiang Yu Source Type: research

The Delta SARS-CoV-2 variant has a higher viral load than the Beta and the historical variants in nasopharyngeal samples from newly diagnosed COVID-19
Dear editor, (Source: Journal of Infection)
Source: Journal of Infection - August 19, 2021 Category: Infectious Diseases Authors: Elisa Teyssou, H éloise Delagrèverie, Benoit Visseaux, Sidonie Lambert-Niclot, Ségolène Brichler, Valentine Ferre, Stéphane Marot, Aude Jary, Eve Todesco, Aurélie Schnuriger, Emna Ghidaoui, Basma Abdi, Sepideh Akhavan, Nadhira Houhou-Fidouh, Charlot Source Type: research

Influenza and Anosmia: important prediction factors for severity and death of COVID-19
To the editor (Source: Journal of Infection)
Source: Journal of Infection - August 18, 2021 Category: Infectious Diseases Authors: Yeon Seok You, Jong Seung Kim Source Type: research

False positive rapid antigen tests for SARS-CoV-2 in the real-world and their economic burden
Ladhani and coworkers reported in this journal that false positive SARS-CoV-2 assays may cause serious complications for elderly care homes (1). In their report they presented a number of such false-positive cases that had a significant impact on the care homes, including a temporary unnecessary isolation of vulnerable residents and a loss of workforce leading to reduced care provision. Ladhani and colleagues concluded that “repeated unnecessary interventions are also likely to be detrimental to the long-term mitigation strategy in care homes, have significant resource implications and impact on the wellbeing of resi...
Source: Journal of Infection - August 17, 2021 Category: Infectious Diseases Authors: Andreas Kretschmer, Annelene Kossow, Barbara Gr üne, Oliver Schildgen, Tim Mathes, Verena Schildgen Tags: Letter to the Editor Source Type: research

Genesis, Evolution and Host Species Distribution of influenza A (H10N3) Virus in China
A recent article by Wang in the Journal of Infection (1) confirmed the first case of human infection with H10N3 avian influenza virus (AIV) in Zhenjiang, Jiangsu Province, China, in April 2021. Transmission of H10 subtype AIVs from birds to humans is uncommon but has occurred in history. The first reported human infections with an H10 subtype influenza virus occurred in Egypt in 2004 (2). In subsequent surveillance, cross-species transmission of subtype H10 influenza virus has been detected occasionally. (Source: Journal of Infection)
Source: Journal of Infection - August 17, 2021 Category: Infectious Diseases Authors: Ruyi Gao, Huafen Zheng, Kaituo Liu, Zhuxing Ji, Miao Cai, Min Gu, Jiao Hu, Xiaowen Liu, Shunlin Hu, Xiaoquan Wang, Xiufan Liu Tags: Letter to the Editor Source Type: research

Effectiveness of maternal pertussis vaccination in protecting newborn: a matched case-control study
Pertussis remains an infection of global public health importance. Many countries with well-established vaccination programmes have reported a resurgence in pertussis, despite sustained high vaccine coverages [1]. (Source: Journal of Infection)
Source: Journal of Infection - August 15, 2021 Category: Infectious Diseases Authors: Pere Godoy, Manuel Garc ía-Cenoz, Cristina Rius, Carmen Muñoz-Almagro, Gloria Carmona, Miquel Alsedà, Mireia Jané, Maria-José Vidal, Raquel Rodríguez, Josep Álvarez, Neus Camps, Sofia Minguell, Mónica Carol, Maria-Rosa Sala, Jesús Castilla, Ànge Source Type: research

Post-SARS-CoV-2 vaccination specific antibody decrease — Thresholds for determining seroprevalence and seroneutralization differ
We would like to respond to the Letter to the Editor of Bene et al. discussing our articles on the evaluation of the serological response 3 months after BNT162b2 vaccination.(1-3) The authors pointed out that we used a “catchy label” when referring to the observe decline of antibody titers. The authors added that our analysis can be “in this touchy context, (be) interpreted as bad news” and (they) “would like to re-interpret these data in a more positive way by emphasizing the high antibody titers detect ed in this study”. (Source: Journal of Infection)
Source: Journal of Infection - August 15, 2021 Category: Infectious Diseases Authors: Jonathan Douxfils, Constant Gillot, Fran çois Mullier, Julien Favresse Tags: Letter to the Editor Source Type: research

Long-term impact of COVID-19 associated acute respiratory distress syndrome
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19) that emerged in Wuhan, China, and spread rapidly across the world, causing a pandemic in just a few weeks (1). Although most patients with COVID-19 will have a mild, self-limiting illness, up to 20% develop severe pneumonia and acute respiratory distress syndrome (ARDS) that can necessitate hospitalization, intensive care, and mechanical ventilation (2). (Source: Journal of Infection)
Source: Journal of Infection - August 13, 2021 Category: Infectious Diseases Authors: Judit Aranda, Isabel Oriol, Miguel Mart ín, Lucía Feria, Núria Vàzquez, Nicolás Rhyman, Estel Vall-Llosera, Natàlia Pallarés, Ana Coloma, Melani Pestaña, Jose Loureiro, Elena Güell, Beatriz Borjabad, Elena León, Elena Franz, Anna Domènech, Sara Source Type: research

Preserved C-reactive protein responses to blood stream infections following tocilizumab treatment for COVID-19
In this Journal, Rossotti and colleagues provided early data on tocilizumab utility in COVID-191, later confirmed in randomised studies2. Tocilizumab-mediated inhibition of IL-6 signalling can decrease CRP concentrations1, potentially confounding the diagnosis of bacterial co-infections in COVID-19 that occur more frequently following longer hospital stays and admissions to the intensive care unit (ICU)3 –5. (Source: Journal of Infection)
Source: Journal of Infection - August 13, 2021 Category: Infectious Diseases Authors: Emmanuel Q. Wey, Clare Bristow, Aarti Nandani, Bryan O'Farrell, Jay Pang, Marisa Lanzman, Shuang Yang, Soo Ho, Damien Mack, Michael Spiro, Indran Balakrishnan, Sanjay Bhagani, Gabriele Pollara Tags: Letter to the Editor Source Type: research

Emergence of SARS-CoV-2 Alpha (B.1.1.7) variant, infection rates, antibody seroconversion and seroprevalence rates in secondary school students and staff: active prospective surveillance, December 2020 to March 2021, England
: By March 2021, a third of secondary school students and staff had evidence of prior infection based on N-antibody seropositivity, and an additional third of staff had evidence of vaccine-induced immunity based on S-antibody seropositivity. (Source: Journal of Infection)
Source: Journal of Infection - August 13, 2021 Category: Infectious Diseases Authors: Shamez N. Ladhani, Georgina Ireland, Frances Baawuah, Joanne Beckmann, Ifeanyichukwu O Okike, Shazaad Ahmad, Joanna Garstang, Andrew J Brent, Bernadette Brent, Felicity Aiano, Zahin Amin-Chowdhury, Meaghan Kall, Ray Borrow, Ezra Linley, Maria Zambon, John Source Type: research

Influenza A/B and respiratory syncytial virus digital immunoassay evaluation in a paediatric emergency department
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - August 11, 2021 Category: Infectious Diseases Authors: Edward Moseley, Philip Williams, Peter Muir, Robin Marlow, Paul North Source Type: research