Integrated single-cell transcriptome and T cell receptor profiling reveals defects of T cell exhaustion in pulmonary tuberculosis

Tuberculosis-affected lungs with chronic inflammation harbor abundant immunosuppressive immune cells but the nature of such inflammation is unclear. Dysfunction in T cell exhaustion, while implicated in chronic inflammatory diseases, remains unexplored in tuberculosis. Given that immunotherapy targeting exhaustion checkpoints exacerbates tuberculosis, we speculate that T cell exhaustion is dysfunctional in tuberculosis. Using integrated single-cell RNA sequencing and T cell receptor profiling we reported defects in exhaustion responses within inflamed tuberculosis-affected lungs.

Source: Journal of Infection - April 18, 2024 Category: Infectious Diseases Authors: Zilu Wen, Lin Wang, Hui Ma, Leilei Li, Laiyi Wan, Lei Shi, Hongwei Li, Hui Chen, Wentao Hao, Shu Song, Qinghua Xue, Yutong Wei, Feng Li, Jianqing Xu, Shulin Zhang, Ka-Wing Wong, Yanzheng Song Tags: Bacteria and Bacterial Diseases Source Type: research