Nasal mucosal IgA levels against SARS-CoV-2 and seasonal coronaviruses are low in children but boosted by reinfection
Repeated coronavirus infections in childhood drive progressive maturation of systemic immune responses into adulthood. Analyses of immune responses in children have focused primarily upon systemic assessment but the importance of mucosal immunity is increasingly recognised. We studied virus-specific antibody responses in contemporaneous nasal swab and blood samples from 99 children (4-15 years) and 28 adults (22-56 years), all of whom had prior SARS-CoV-2 infection. Whilst mucosal IgA titres against Influenza and Respiratory Syncytial virus were comparable between children and adults, those against all coronaviruses, inclu...
Source: Journal of Infection - September 1, 2023 Category: Infectious Diseases Authors: Alexander C. Dowell, Gokhan Tut, Jusnara Begum, Rachel Bruton, Christopher Bentley, Megan Butler, Grace Uwenedi, Jianmin Zuo, Annabel A. Powell, Andrew J. Brent, Bernadette Brent, Frances Baawuah, Ifeanyichukwu Okike, Joanne Beckmann, Shazaad Ahmad, Felic Source Type: research
Robust generation of neutralising antibodies against omicron variants following bivalent mRNA booster vaccine in elderly people aged > 80 years
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - September 1, 2023 Category: Infectious Diseases Authors: Helen Parry, Rachel Bruton, Grace Uwenedi, Thomas Roberts, Panagiota Sylla, Jonathan Cook, Ahmed Elzaidi, May Lau, Tamsin Drury, Alexander Bray, Soumyajit Mallick, Katie Spencer, Christopher Bentley, Graham McIlroy, Sam Scott, Nicola Logan, Jianmin Zuo, B Tags: Letter to the Editor Source Type: research
Longitudinal analysis of neutralization in sera from HCWs receiving 2 doses of Omicron BA.4/5-adapted bivalent vaccine
Dear editor, (Source: Journal of Infection)
Source: Journal of Infection - August 31, 2023 Category: Infectious Diseases Authors: Masayuki Amano, Yasuko Ichikawa, Shota Matsumoto, Shuzo Matsushita, Shinya Shimada, Hiroaki Mitsuya Source Type: research
Differences caused by blood and secretion samples for the detection of Klebsiella pneumoniae using metagenomic next-generation sequencing: a comparative analysis
Dear Editors, (Source: Journal of Infection)
Source: Journal of Infection - August 29, 2023 Category: Infectious Diseases Authors: Weiming Yao, Shiyan Feng, Liuqing Yang, Yuanlong Lin, Mingxia Zhang, Kanru Cai, Li Xing, Ke Yuan, Hongzhou Lu, Fuxiang Wang Source Type: research
SARS-CoV-2 –specific antibody and T-cell immunity in convalescents after infection wave in Beijing in late 2022
To evaluate SARS-CoV-2 –specific antibody and T-cell responses in convalescents 5 months after infection wave in Beijing from December 2022 to January 2023 to prevent reinfection and severe disease. (Source: Journal of Infection)
Source: Journal of Infection - August 29, 2023 Category: Infectious Diseases Authors: Xuejiao Guan, Qi Huang, Mei Dong, Maozhong Li, Hui Xie, Xiaofeng Wei, Lu Kang, Xue Wang, Aihua Li, Qing Wang, Fang Huang, Quanyi Wang Source Type: research
Did the Black Death Give Birth to the Healthcare Hero?
“The entire world suffered…It was said that there never had been anything so fierce…[Other] plagues were local whereas this one involved the entire world. The victims in those plagues were treatable in some ways; here there was no cure.”1 (Source: Journal of Infection)
Source: Journal of Infection - August 25, 2023 Category: Infectious Diseases Authors: Shay Nair Sharma Tags: Letter to the Editor Source Type: research
Missing Subunits of Mpox Replication Complex: Possible Impact on Structural Organization
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - August 22, 2023 Category: Infectious Diseases Authors: Saathvik R Kannan, Athreya S Reddy, Dana M Burris, Siddappa N Byrareddy, Kamal Singh Source Type: research
Post-Covid-19 condition: A comprehensive analysis of the World Health Organisation definition
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - August 19, 2023 Category: Infectious Diseases Authors: Laure Carcaillon-Bentata, Tatjana T. Makovski, Caroline Alleaume, Valentina Decio, Nathalie Beltzer, Anne Gallay, Sarah Tebeka, Olivier Robineau, Jo ël Coste Tags: Letter to the Editor Source Type: research
Evaluation of the contribution of shotgun metagenomics in the microbiological diagnosis of liver abscesses
Shotgun metagenomics (SMg) sequencing has gained a considerable interest, as it enables the detection of any microorganisms through a single analysis. Due to the limitations of standard microbiological approaches, the microbial documentation of liver abscesses (LA), which is crucial for their medical management, can be difficult. Here we aimed to compare the performance of SMg with standard approaches for the microbiological documentation of LA. (Source: Journal of Infection)
Source: Journal of Infection - August 19, 2023 Category: Infectious Diseases Authors: Kimseng Hadrien, Rossi Geoffrey, Danjean Maxime, Jimenez-Araya Bryan, Chaligne Camille, Galy Adrien, Souhail B érénice, Bert Frédéric, Leflon Véronique, Fihman Vincent, Caillault Amandine, Demontant Vanessa, Seng Sarah, Trawinski Elisabeth, N’Debi Source Type: research
COVID-19 vaccine effectiveness against hospitalisation and death of people in clinical risk groups during the Delta variant period: English primary care network cohort study
In all clinical risk groups high levels of vaccine effectiveness against severe endpoints were seen. Reduced vaccine effectiveness was noted among the immunosuppressed group. (Source: Journal of Infection)
Source: Journal of Infection - August 12, 2023 Category: Infectious Diseases Authors: Heather J Whitaker, Ruby SM Tsang, Rachel Byford, Carole Aspden, Elizabeth Button, Praveen Sebastian Pillai, Gavin Jamie, Debasish Kar, John Williams, Mary Sinnathamby, Gemma Marsden, William H Elson, Meredith Leston, Sneha Anand, Cecilia Okusi, Xuejuan F Source Type: research
Determinants of Influenza A Infection Rate in Post-COVID-19 Era
Dear editor, (Source: Journal of Infection)
Source: Journal of Infection - August 9, 2023 Category: Infectious Diseases Authors: Isabell Wagenh äuser, Juliane Mees, Julia Reusch, Thiên-Trí Lâm, Alexandra Schubert-Unkmeir, Lukas B. Krone, Anna Frey, Oliver Kurzai, Stefan Frantz, Lars Dölken, Johannes Liese, Alexander Gabel, Nils Petri, Manuel Krone Tags: Letter to the Editor Source Type: research
Translating metagenomics into clinical practice for complex paediatric neurological presentations
Dear Editors, (Source: Journal of Infection)
Source: Journal of Infection - August 7, 2023 Category: Infectious Diseases Authors: Justin Penner, Jane Hassell, Julianne R Brown, Kshitij Mankad, Nathaniel Storey, Laura Atkinson, Nisha Ranganathan, Alexander Lennon, Jack C D Lee, Dimitrios Champsas, Angelika Kopec, Divya Shah, Cristina Venturini, Garth Dixon, Surjo De, James Hatcher, K Source Type: research
Publishers Note
The Publisher would like to note that the formatting of text to box 8 within article ‘UK Malaria Treatment Guidelines 2016’ within issue - Journal of Infection - Volume 72, Issue 6, June 2016, Pages 635-649 has been adjusted post publication for clarity. (Source: Journal of Infection)
Source: Journal of Infection - August 6, 2023 Category: Infectious Diseases Tags: Publisher's Note Source Type: research
Editorial Board
(Source: Journal of Infection)
Source: Journal of Infection - August 6, 2023 Category: Infectious Diseases Source Type: research
European candidaemia is characterised by notable differential epidemiology and susceptibility pattern; Results from the ECMM Candida III study
The objectives of this study were to assess Candida spp. distribution and antifungal resistance of candidaemia across Europe.Isolates were collected as part of the third ECMM Candida European multicentre observational study, conducted from 01-07-2018 to 31-03-2022. Each centre (maximum number/country determined by population size) included ~10 consecutive cases. Isolates were referred to central laboratories and identified by morphology and MALDI-TOF, supplemented by ITS-sequencing when needed. EUCAST MICs were determined for five antifungals. (Source: Journal of Infection)
Source: Journal of Infection - August 5, 2023 Category: Infectious Diseases Authors: Maiken Cavling Arendrup, Sevtap Arikan-Akdagli, Karin Meinike J ørgensen, Aleksandra Barac, Jörg Steinmann, Cristina Toscano, Valentina Arsic Arsenijevic, Assunta Sartor, Cornelia Lass Flörl, Axel Hamprecht, Tadeja Matos, Benedict R.S. Rogers, Inmacula Source Type: research
