Diagnostic accuracy of inflammatory markers in adults with suspected central nervous system infections
We aimed to determine diagnostic accuracy of inflammatory markers in plasma and cerebrospinal fluid for the diagnosis of central nervous system infections and specifically bacterial meningitis. (Source: Journal of Infection)
Source: Journal of Infection - February 4, 2024 Category: Infectious Diseases Authors: Sabine E. Olie, Steven L. Staal, Liora ter Horst, Ingeborg E. van Zeggeren, Wing K. Man, Michael W.T. Tanck, Diederik van de Beek, Matthijs C. Brouwer Source Type: research

Corrigendum to “Tick-borne encephalitis: Acute clinical manifestations and severity in 581 cases from Germany, 2018-2020” [J Infect 86 (2023) 369-375]
The authors regret that an extra affiliation was missed out during publication of this article. The affiliation relates to author Teresa M. Nygren. This affiliation is ‘Charité – Universitätsmedizin Berlin, Berlin, Germany'. (Source: Journal of Infection)
Source: Journal of Infection - February 2, 2024 Category: Infectious Diseases Authors: Teresa M. Nygren, Antonia Pilic, Merle M. B öhmer, Christiane Wagner-Wiening, Simone-Beatrice Went, Ole Wichmann, Wiebke Hellenbrand Source Type: research

IgG glycosylation associates with risk of progression from latent to active tuberculosis
Glycosylation motifs shape antibody structure, stability and antigen affinity and play an important role in antibody localization and function. Serum IgG glycosylation profiles are significantly altered in infectious diseases, including tuberculosis (TB), but have not been studied in the context of progression from latent to active TB. (Source: Journal of Infection)
Source: Journal of Infection - February 1, 2024 Category: Infectious Diseases Authors: Julie G Burel, Wenjun Wang, Manfred Wuhrer, Martin Dedicoat, Thomas E Fletcher, Adam F Cunningham, Matthew K O ’Shea Source Type: research

Pulmonary dysfunction severity may impact optimal dexamethasone dosing in patients with COVID-19
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - January 31, 2024 Category: Infectious Diseases Authors: Kuo-Chuan Hung, I-Wen Chen, Cheuk-Kwan Sun Tags: Letter to the Editor Source Type: research

Distinguishing community-acquired bacterial and viral meningitis: Microbes and biomarkers
Diagnostic tools to differentiate between community-acquired bacterial and viral meningitis are essential to target the potentially lifesaving antibiotic treatment to those at greatest risk and concurrently spare patients with viral meningitis from the disadvantages of antibiotics. In addition, excluding bacterial meningitis and thus decreasing antibiotic consumption would be important to help reduce antimicrobial resistance and healthcare expenses. The available diagnostic laboratory tests for differentiating bacterial and viral meningitis can be divided microbiological pathogen-focussed methods and biomarkers of the host...
Source: Journal of Infection - January 31, 2024 Category: Infectious Diseases Authors: Lauri Ivaska, Jethro Herberg, Manish Sadarangani Source Type: research

Disparities in COVID-19 Mortality Amongst the Immunosuppressed: A Systematic Review and Meta-analysis for Enhanced Disease Surveillance
Excess COVID-associated mortality among the immunosuppressed compared to immunocompetent was seen to vary significantly across subgroups. This novel means of subdivision has prospective benefit for targeting patient triage, shielding and vaccination policies during periods of high disease transmission. (Source: Journal of Infection)
Source: Journal of Infection - January 29, 2024 Category: Infectious Diseases Authors: Meredith Leston, Willam Elson, Jose M. Ord óñez-Mena, Debasish Kar, Heather Whitaker, Mark Joy, Nia Roberts, FD Richard Hobbs, Simon de Lusignan Source Type: research

Burden of child mortality from malaria in high endemic areas: results from the CHAMPS Network using minimally invasive tissue sampling
Malaria remains a significant cause of childhood mortality in the CHAMPS malaria-endemic sites. The high bacterial co-infection prevalence among malaria deaths underscores the potential benefits of antibiotics for severe malaria patients. Compared to non-malaria deaths, many of malaria-attributed deaths are preventable through accessible malaria control measures. (Source: Journal of Infection)
Source: Journal of Infection - January 28, 2024 Category: Infectious Diseases Authors: Ikechukwu U. Ogbuanu, Kephas Otieno, Rosauro Varo, Samba O. Sow, Julius Ojulong, Babatunde Duduyemi, Dickens Kowuor, Carrie Jo Cain, Emily A. Rogena, Dickens Onyango, Victor Akelo, Beth A. Tippett Barr, Feiko terKuile, Karen L. Kotloff, Milagritos D. Tapi Source Type: research

DNA mismatch repair in HIV-Associated Lymphoma: Lost in Translation?
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - January 28, 2024 Category: Infectious Diseases Authors: Yuanhui Jiang, Suling Chen, Muye Xia, Xuwen Xu, Jie Peng, Shaohang Cai Tags: Letter to the Editor Source Type: research

Less is more: uptake of recommended vaccines in a UK Travel Clinic
Letter (Source: Journal of Infection)
Source: Journal of Infection - January 25, 2024 Category: Infectious Diseases Authors: Thomas Harrison, Jacqueline Clark, Thomas C Darton Tags: Letter to the Editor Source Type: research

Longitudinal study of meningococcal carriage in adolescents and young adults in South Australia 2017-2020
This analysis investigated longitudinal changes in meningococcal carriage in adolescents in South Australia over 4 years. (Source: Journal of Infection)
Source: Journal of Infection - January 17, 2024 Category: Infectious Diseases Authors: Mark McMillan, Hassen Mohammed, Jana Bednarz, Lex E.X. Leong, Andrew Lawrence, Thomas R Sullivan, Martin C.J Maiden, Helen S Marshall Source Type: research

SARS-CoV-2 Delta and Omicron community transmission networks as added value to contact tracing
Calculations of SARS-CoV-2 transmission networks at a population level have been limited. Networks that estimate infections between individuals and whether this results in a mutation, can be a way to evaluate fitness of a mutational clone by how much it expands in number as well as determining the likelihood a transmission results in a new variant. (Source: Journal of Infection)
Source: Journal of Infection - January 17, 2024 Category: Infectious Diseases Authors: John M. Murray, Daniel D. Murray, Evelyne Schvoerer, Elma H. Akand Source Type: research

Emergence of a triple reassortment avian influenza virus (A/H5N6) from wild birds
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - January 17, 2024 Category: Infectious Diseases Authors: Yan-kun Ke, Xin-yu Han, Si-ru Lin, Han-guang Wu, Ying-xin Li, Rong-qi Liu, Ming Liao, Wei-xin Jia Source Type: research

Donor respiratory multidrug-resistant bacteria and lung transplantation outcomes
Respiratory culture screening is mandatory for all potential lung transplant donors. There is limited evidence on the significance of donor multidrug-resistant (MDR) bacteria on transplant outcomes. Establishing the safety of allografts colonized with MDR bacteria has implications for widening an already limited donor pool. (Source: Journal of Infection)
Source: Journal of Infection - January 15, 2024 Category: Infectious Diseases Authors: Rayid Abdulqawi, Rana Ahmed Saleh, Reem Mahmoud Alameer, Haifa Aldakhil, Khaled Manae AlKattan, Reem Saad Almaghrabi, Sahar Althawadi, Mahmoud Hashim, Waleed Saleh, Amani Hassan Yamani, Eid Abdullah Al-Mutairy Source Type: research

Stillbirths due to placental COVID infection associated with chronic histiocytic intervillositis do not recur in subsequent pregnancies
During the COVID-19 pandemic, when the SARS-CoV-2 B1.617.2 (Delta) variant was dominant, infected pregnant women had a 4-fold increased risk of stillbirth compared with non-infected women (2.70% vs. 0.63%)1. The placenta in these stillbirths showed COVID placentitis, a combination of SARS-CoV-2 within the syncytiotrophoblast and a triad of histological features: chronic histiocytic intervillositis, trophoblast necrosis, and massive perivillous fibrin deposition. COVID placentitis only occurred in a minority of women who tested positive for SARS-CoV-2 in pregnancy (~1.5%)2. (Source: Journal of Infection)
Source: Journal of Infection - January 11, 2024 Category: Infectious Diseases Authors: Emily F. Cornish, Lotte E. van der Meeren, Marie-Louise P. van der Hoorn, Sam Schoenmakers, Alexandre J. Vivanti, Alexandra Benachi, Melissa Whitten, Stephanie Hignett, Thomas McDonnell, David J. Williams Tags: Letter to the Editor Source Type: research

Novel small-molecule inhibitors of SARS-CoV-2 main protease with nanomolar antiviral potency
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - January 6, 2024 Category: Infectious Diseases Authors: Haoran Zhang, Kangping Zhou, Fei Peng, Zhao Gao, Guowei Song, Bing Hu, Sophia Chun, Junfeng Xiao, Mengfei Qian, Jin Wu, Kai Pan, Fan Gao, Meng Guo, Cheng Peng, Gang Zou, Jim Zhen Wu, Kun Cai, Yan Li Tags: Letter to the Editor Source Type: research