GSE264032 Heterogeneity of Immune Cells and Their Communications Unveiled by Transcriptome Profiling in Acute Inflammatory Lung Injury
Conclusions: This study has identified specific gene signatures and signaling pathways in animal models and human samples that facilitate the inter action between immune cells, which could be targeted therapeutically in ARDS patients of various etiologies. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Exome sequencing in extreme altitude mountaineers identifies pathogenic variants in RTEL1 and COL6A1 previously associated with respiratory failure
AbstractAdaptation of humans to challenging environmental conditions, such as extreme temperature, malnutrition, or hypoxia, is an interesting phenomenon for both basic and applied research. Identification of the genetic factors contributing to human adaptation to these conditions enhances our understanding of the underlying molecular and physiological mechanisms. In our study, we analyzed the exomes of 22 high altitude mountaineers to uncover genetic variants contributing to hypoxic adaptation. To our surprise, we identified two putative loss-of-function variants, rs1385101139 inRTEL1 and rs1002726737 inCOL6A1 in two extr...
Source: Physiological Reports - April 24, 2024 Category: Physiology Authors: Evgeniia M. Maksiutenko,
Valeriia Merkureva,
Yury A. Barbitoff,
Victoria V. Tsay,
Mikhail V. Aseev,
Andrey S. Glotov,
Oleg S. Glotov Tags: SHORT REPORT Source Type: research
Systematic Literature Review on the Incidence of Herpes Zoster in Populations at Increased Risk of Disease in the EU/EEA, Switzerland, and the UK
ConclusionsThe HZ incidence rate in Europe increased with age and varied across high-risk populations, with high rates for solid organ and stem cell transplants, cancer, and rheumatoid arthritis. Most studies were retrospective with methodological differences affecting generalizability and comparability. Future studies should stratify data by IC population, age, sex, severity, medication, and study timeframe. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 24, 2024 Category: Infectious Diseases Source Type: research
Outcome of Human Parainfluenza Virus infection in allogeneic stem cell transplantation recipients: possible impact of ribavirin therapy
ConclusionALC, corticosteroids, and fever increased the risk for progression to LRTD while ribavirin decreased the risk. However, mortality was associated with ALC and co-infections. This study supports further research of ribavirin therapy for hPIV in the allo-HSCT setting. (Source: Infection)
Source: Infection - April 24, 2024 Category: Infectious Diseases Source Type: research
Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure
AbstractThe progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as a cofactor for important proteins such as hemoglobin, myoglobin, oxidative respiratory chain, and DNA synthetase, in the myocardial energy metabolism process. In recent years, numerous studies have shown that HF is associated with iron dysmetabolism, and deficiencies in iron and overload of iron can both lead to the development of various myocarditis diseases, which ultimately progress to HF. Iron toxicity and iron metabolism may be key targets for the diagnosis, treatment, and pre...
Source: European Journal of Medical Research - April 24, 2024 Category: Research Source Type: research
Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts
Abnormal lipid metabolism has recently been reported as a crucial signature of idiopathic pulmonary fibrosis (IPF). However, the origin and biological function of the lipid and possible mechanisms of increased... (Source: Respiratory Research)
Source: Respiratory Research - April 24, 2024 Category: Respiratory Medicine Authors: Juntang Yang, Xin Pan, Min Xu, Yingge Li, Chenxi Liang, Lulu Liu, Zhongzheng Li, Lan Wang and Guoying Yu Tags: Research Source Type: research
Assessment of the impact of social deprivation, distance to hospital and time to diagnosis on survival in Idiopathic pulmonary fibrosis
The most deprived patients with IPF have more severe disease at presentation and worse outcomes. Living far from hospital was also associated with poor outcomes. This suggests inequalities in access to healthcare and requires consideration in delivering effective and equitable care to patients with IPF. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 24, 2024 Category: Respiratory Medicine Authors: Rashmi Shankar, Charaka M. Hadinnapola, Allan B. Clark, Huzaifa Adamali, Nazia Chaudhuri, Lisa G. Spencer, Andrew M. Wilson Tags: Original Research Source Type: research
Neural mechanisms of respiratory interoception
Respiratory interoception is one of the internal bodily systems that is comprised of different types of somatic and visceral sensations elicited by different patterns of afferent input and respiratory motor drive mediating multiple respiratory modalities. Respiratory interoception is a complex system, having multiple afferents grouped into afferent clusters and projecting into both discriminative and affective centers that are directly related to the behavioral assessment of breathing. The multi-afferent system provides a spectrum of input that result in the ability to interpret the different types of respiratory intercept...
Source: Autonomic Neuroscience: Basic and Clinical - April 24, 2024 Category: Neuroscience Authors: Pei-Ying Sarah Chan, Lu-Yuan Lee, Paul W. Davenport Tags: Review Article Source Type: research
Systematic Literature Review on the Incidence of Herpes Zoster in Populations at Increased Risk of Disease in the EU/EEA, Switzerland, and the UK
ConclusionsThe HZ incidence rate in Europe increased with age and varied across high-risk populations, with high rates for solid organ and stem cell transplants, cancer, and rheumatoid arthritis. Most studies were retrospective with methodological differences affecting generalizability and comparability. Future studies should stratify data by IC population, age, sex, severity, medication, and study timeframe. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 24, 2024 Category: Infectious Diseases Source Type: research
Impact of SARS-CoV-2 vaccines on Covid-19 incidence and mortality in the United States
ConclusionsAssociations between complete vaccination rates and COVID-19 incidence and mortality appeared to vary with shifts in the dominant variant, perhaps due to variations in vaccine efficacy by variant or to waning vaccine immunity over time. Vaccine boosters were associated with notable protection against Omicron disease and mortality. (Source: PLoS One)
Source: PLoS One - April 24, 2024 Category: Biomedical Science Authors: Fang Fang Source Type: research
Development of a risk prediction model for subsequent infection after colonization with carbapenem-resistant Enterobacterales: a retrospective cohort study
ConclusionsOur nomogram has a good predictive performance and could contribute to early identification of CRE carriers with a high-risk of subsequent infection, although external validation would be required. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - April 24, 2024 Category: Infectious Diseases Source Type: research
FEV1 and FVC as robust risk factors for cardiovascular disease and mortality: Insights from a large population study
Data is limited on influence of forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in a large adult population, including individuals with normal spirometry at baseline. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 24, 2024 Category: Respiratory Medicine Authors: Andreas Rydell, Christer Janson, Karin Lisspers, Yi-Ting Lin, Johan Ärnlöv Tags: Original Research Source Type: research
Use of Respiratory and Contact Precautions to Decrease the Spread of SARS-CoV-2 Infection Was Not Associated with a Decrease in Endometritis –Intra-Amniotic Infection
Conclusion The use of respiratory and contact precautions to limit the spread of SARS-CoV-2 was not associated with risk of endometritis/IAI.
Key Points
[...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - April 24, 2024 Category: Perinatology & Neonatology Authors: Roig, Jacqueline DeBolt, Chelsea A. Cabrera, Mariela Spiera, Emily Goldberger, Cody Bianco, Angela Stone, Joanne A. Factor, Stephanie H. Tags: Original Article Source Type: research
Treatment of malignant airway obstruction with Y-shape sigma stent loaded with I125 seeds installed via rigid bronchoscopy
To summarize and analyze the safety and efficacy of a Y-shape Sigma stent loaded with I125 in patients with inoperable malignant main airway obstruction. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - April 24, 2024 Category: Respiratory Medicine Authors: Chunlong Lin, Hesong Huang, Lixia Song, Xixi Zhao, Jialing Zeng, Lun Li, Qilong Ge, Rui Li and Zhiyuan Wu Tags: Research Source Type: research
Outcome of Human Parainfluenza Virus infection in allogeneic stem cell transplantation recipients: possible impact of ribavirin therapy
ConclusionALC, corticosteroids, and fever increased the risk for progression to LRTD while ribavirin decreased the risk. However, mortality was associated with ALC and co-infections. This study supports further research of ribavirin therapy for hPIV in the allo-HSCT setting. (Source: Infection)
Source: Infection - April 24, 2024 Category: Infectious Diseases Source Type: research
