Asthma Pathogenesis: Phenotypes, Therapies and Gaps. Summary of the Aspen Lung Conference 2023
This report summarizes the proceedings of the 2023 Aspen Lung Conference, which was organized to review the clinical and molecular heterogeneity of asthma and to better understand the impact of genetic, environmental, cellular, and molecular influences on disease susceptibility, heterogeneity, and severity. The goals of the conference were to review new information about asthma phenotypes, cellular processes, and cellular signatures underlying disease heterogeneity and treatment response. The report concludes with ongoing gaps in our understanding of asthma pathobiology and provides some recommendations for future research...
Source: Respiratory Care - April 18, 2024 Category: Respiratory Medicine Authors: Sunita Sharma Anthony N Gerber Monica Kraft Sally E Wenzel Source Type: research
Structural Lung Disease and Clinical Phenotype in Bronchiectasis Patients: The EMBARC CT Study
CONCLUSION: Patients with bronchiectasis have highly heterogeneous type and extent of structural lung abnormalities. Strong relationships between radiological disease and clinical features suggest CT analysis may be a useful tool for clinical phenotyping.PMID:38635862 | DOI:10.1164/rccm.202311-2109OC (Source: Respiratory Care)
Source: Respiratory Care - April 18, 2024 Category: Respiratory Medicine Authors: Angelina L P Pieters Tjeerd van der Veer Jennifer J Meerburg Eleni-Rosalina Andrinopoulou Menno M Vd Eerden Pierluigi Ciet Stefano Aliberti Pierre-Regis Burgel Megan L Crichton Amelia Shoemark Pieter C Goeminne Michal Shteinberg Michael R Loebinger Charle Source Type: research
Asthma patients' and physicians' perspectives on the burden and management of asthma: post-hoc analysis of APPaRENT 1 and 2 to assess predictors of treatment adherence
CONCLUSIONS: Results revealed an important disconnect between patient and physician treatment goals and treatment adherence, suggesting that strategies for improving patient adherence to maintenance medication are needed, focusing on younger patients with milder disease. High reliever use despite good adherence may indicate poor disease control. Personalised care considering patient characteristics alongside physician training in motivational communication and shared decision-making could improve patient management and outcomes.PMID:38636683 | DOI:10.1016/j.rmed.2024.107637 (Source: Respiratory Care)
Source: Respiratory Care - April 18, 2024 Category: Respiratory Medicine Authors: Giorgio Walter Canonica Christian Domingo Kim L Lavoie Amrit Kaliasethi Shireen Quli Khan Anurita Majumdar Sourabh Fulmali Source Type: research
Sputum colour as a simplified effective biomarker for clinical assessment of bronchiectasis
Eur Respir J. 2024 Apr 18;63(4):2400152. doi: 10.1183/13993003.00152-2024. Print 2024 Apr.NO ABSTRACTPMID:38636972 | DOI:10.1183/13993003.00152-2024 (Source: Respiratory Care)
Source: Respiratory Care - April 18, 2024 Category: Respiratory Medicine Authors: Rui-di Tang Jun-Qing Yue Wei-Jie Guan Source Type: research
JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice
In this study, a murine COVID-19 model was induced by nasal infection with mouse-adapted SARS-CoV-2 (MA10). MA10 infection induced body weight loss along with lung inflammation in mice four days after infection. Serum creatinine levels and the urinary albumin/creatinine ratio increased on day 4 after MA10 infection. Measurement of the urinary neutrophil gelatinase-associated lipocalin/creatinine ratio and hematoxylin and eosin staining revealed tubular damage in MA10-infected murine kidneys, indicating kidney injury in the murine COVID-19 model. Interferon (IFN)-γ and interleukin-6 upregulation in the sera of MA10-infecte...
Source: Am J Physiol Renal P... - April 18, 2024 Category: Urology & Nephrology Authors: Hibiki Sakai Hiroyasu Kamuro Nagisa Tokunoh Takeshi Izawa Shigeyuki Tamiya Ayaha Yamamoto Shota Tanaka Daisuke Okuzaki Chikako Ono Yoshiharu Matsuura Yoshiaki Okada Yasuo Yoshioka Yasushi Fujio Masanori Obana Source Type: research
Risk factors for progressing to critical illness in patients with hospital-acquired COVID-19
CONCLUSIONS: Among patients with hospital-acquired COVID-19, preexisting respiratory disease, preexisting cardiovascular disease, immunocompromised status, and higher clinical frailty scale and SOFA scores at baseline were risk factors for progression to critical illness. Patients with these risk factors must be prioritized and appropriately isolated or treated in a timely manner, especially in pandemic settings.PMID:38632896 | DOI:10.3904/kjim.2023.347 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 18, 2024 Category: Internal Medicine Authors: Kyung-Eui Lee Jinwoo Lee Sang-Min Lee Hong Yeul Lee Source Type: research
Removal of airway foreign body using flexible bronchoscopy in children
CONCLUSION: AFB removal using a flexible bronchoscope is an efficient and safe procedure when performed by an experienced team. The recent use of LMA has facilitated the use of a larger bronchofiberscope and the insertion of multiple tools that can reach distal airways.PMID:38637247 | DOI:10.1016/j.arcped.2024.01.008 (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - April 18, 2024 Category: Pediatrics Authors: Sabrine Louhaichi Nouha Boubaker Besma Hamdi Ella Nemsi Sonia Ouerghi Taher Mestiri Adel Marghli Jamel Ammar Agn ès Hamzaoui Source Type: research
Persistent and symptomatic periodic breathing beyond the neonatal period in full-term infants: A case series
CONCLUSION: This study presents cases of persistent and symptomatic PB after 1 month of life in infants born at term. The interesting finding was the presence of obstructive sleep apnea syndrome and/or central apnea syndrome in the majority of children, along with GER.PMID:38637248 | DOI:10.1016/j.arcped.2024.01.007 (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - April 18, 2024 Category: Pediatrics Authors: Oc éane Cheyrou-Lagrèze Eglantine Hullo Jessica Taytard Lisa Giovannini-Chami Patricia Franco Iulia-Cristina Ioan Laurianne Coutier Source Type: research
Association of coagulation function with the risk of in-hospital mortality in patients with severe acute respiratory distress syndrome
CONCLUSION: Poor coagulation function was associated with increased risk of in-hospital mortality in ARDS patients. The findings implied that clinicians should regularly detect the levels of coagulation-associated biomarkers for the management of ARDS patients.PMID:38636652 | DOI:10.1016/j.amjms.2024.04.012 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 18, 2024 Category: General Medicine Authors: Jie Li Gang Pan Source Type: research
40 years neonatology : An academic life
CONCLUSION: As we look ahead it is imperative to build upon the progress made, harnessing the power of science and technology to further improve the survival and quality of life for preterm infants in Austria and worldwide. At the same time, neonatology must continue to prioritize ethical reflection and education, fostering a culture of integrity, interdisciplinary collaboration, and the development of guidelines and protocols that uphold ethical standards while addressing the evolving needs and complexities of neonatal medicine.PMID:38634910 | DOI:10.1007/s00508-024-02360-2 (Source: Wiener Klinische Wochenschrift)
Source: Wiener Klinische Wochenschrift - April 18, 2024 Category: General Medicine Authors: Arnold Pollak Source Type: research
Molecular characterization of equine herpes viruses type 1 and 4 among Arabian horse populations in Egypt during the period between 2021 and 2022
CONCLUSION: The current investigation showed that molecular methods are appropriate assays for an efficient and accurate diagnosis of EHVs. Furthermore, it supports earlier research findings about the prevalence of EHV-1 and 4 in Arabian horse populations in Egypt.PMID:38633187 | PMC:PMC11018441 | DOI:10.5455/OVJ.2024.v14.i1.48 (Source: Herpes)
Source: Herpes - April 18, 2024 Category: Infectious Diseases Authors: Ahmed A H Ali Fatma Abdallah Omayma A Shemies Gamilat Kotb Maged R Nafea Source Type: research
Bronchiectasis not due to cystic fibrosis
Med Clin (Barc). 2024 Apr 17:S0025-7753(24)00145-3. doi: 10.1016/j.medcli.2024.01.023. Online ahead of print.ABSTRACTBronchiectasis is a clinical-radiological condition composed of irreversible bronchial dilation due to inflammation and infection of the airways, which causes respiratory symptoms, usually productive cough and infectious exacerbations. Bronchiectasis can have multiple causes, both pulmonary and extrapulmonary, and its clinical presentation is very heterogenous. Its prevalence is unknown, although up to 35-50% of severe COPD and 25% of severe asthma present them, so their underdiagnosis is evident. Chronic ba...
Source: Medicina Clinica - April 18, 2024 Category: General Medicine Authors: Rosa Gir ón Rafael Golpe Miguel Ángel Martínez-García Source Type: research
Urinary Metabolomic Profiles Uncover Metabolic Pathways in Children with Asthma
Conclusions: This study suggests that there are significant metabolic differences in the urine of asthmatic children and healthy controls, and alpha-linolenic acid metabolic pathways may be involved in the pathogenesis of asthma.PMID:38634666 | DOI:10.1080/02770903.2024.2338865 (Source: Journal of Asthma)
Source: Journal of Asthma - April 18, 2024 Category: Respiratory Medicine Authors: Sainan Jiang Yiting Zhou Jianlong Gao Siyi Jin Genli Pan Yuan Jiang Source Type: research
Heat shock protein 71 restricts mutation of porcine reproductive and respiratory syndrome virus nsp2 in vitro
In this study, the binding of PRRSV nsp2 to HSP71 protein was detected by using the IP/MS technique. And the inhibitory effect of HSP71 on nsp2 antagonistic activity was validated by measuring NF-kB luciferase reporter. According to stress from inhibitory effects, the amino acid variation profile of PRRSV nsp2 under HSP71 stress was further analyzed using second-generation sequencing. Surprisingly, the results indicated that HSP71 pressure limits the random mutations of PRRSV nsp2 and maintains the dominant PRRSV strain within the population. Mutant strain showed weaker antagonistic activity and replication capability in c...
Source: Comparative immunology, microbiology and infectious diseases. - April 18, 2024 Category: Allergy & Immunology Authors: Fengyu Xie Lei Kang Mengli Chen Tong Zhang Zongjie Li Donghua Shao Beibei Li Jianchao Wei Yafeng Qiu Manxiang Li Zhiyong Ma Ke Liu Source Type: research
Clinical utilization of airway inflammatory biomarkers in the prediction and monitoring of clinical outcomes in patients with chronic obstructive pulmonary disease
Expert Rev Mol Diagn. 2024 Apr 18. doi: 10.1080/14737159.2024.2344777. Online ahead of print.ABSTRACTINTRODUCTION: Chronic obstructive pulmonary disease (COPD) accounts for 545 million people living with chronic respiratory disorders and is the third leading cause of morbidity and mortality around the world. COPD is a progressive disease, characterized by episodes of acute worsening of symptoms such as cough, dyspnea, and sputum production.AREAS COVERED: Airway inflammation is a prominent feature of COPD. Chronic airway inflammation results in airway structural remodeling and emphysema. Persistent airway inflammation is a ...
Source: Expert Review of Molecular Diagnostics - April 18, 2024 Category: Laboratory Medicine Authors: Dina Yehia Clarus Leung Don D Sin Source Type: research
