Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
The influenza landscape and vaccination coverage in older adults during the SARS-Cov-2 pandemic: data from Several European Countries and Israel
Expert Rev Respir Med. 2024 Apr 23. doi: 10.1080/17476348.2024.2340470. Online ahead of print.ABSTRACTINTRODUCTION: The Raise Awareness of Influenza Strategies in Europe (RAISE) group gathered information about the healthcare burden of influenza (hospitalizations, intensive care unit [ICU] admissions, and excess deaths), surveillance systems, and the vaccine coverage rate (VCR) in older adults in 18 European countries and Israel.AREAS COVERED: Published medical literature and official medical documentation on the influenza disease burden in the participating countries were reviewed from 2010/11 until the 2022/23 influenza ...
Source: Expert Review of Respiratory Medicine - April 23, 2024 Category: Respiratory Medicine Authors: George Kassianos Jean-Marie Cohen Rok Civljak Nadav Davidovitch Oana Falup Pecurariu Filipe Froes Andrei Galev Inga Ivaskeviciene Kadri K õivumägi Zuzana Kristufkova Ernest Kuchar Jan Kyncl Helena C Maltezou Milo š Marković Aneta Nitsch-Osuch Raul Ort Source Type: research
An Unwanted but Long-Known Company: Post-Viral Symptoms in the Context of Past Pandemics in Switzerland (and Beyond)
Conclusion: In the next pandemic, it should not be surprising that post-viral conditions will again play a role, and pandemic plans should reflect this.PMID:38651133 | PMC:PMC11033310 | DOI:10.3389/phrs.2024.1606966 (Source: Public Health Reviews)
Source: Public Health Reviews - April 23, 2024 Category: International Medicine & Public Health Authors: Kaspar Staub Tala Ballouz Milo Puhan Source Type: research
Characterization of Ceftriaxone-Resistant < em > Haemophilus influenzae < /em > Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | DOI:10.3346/jkms.2024.39.e136 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 23, 2024 Category: Biomedical Science Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research
Rhinovirus infection presenting with symptomatic hyponatremia —Atypical presentation of a common infection
Key Clinical MessageRhinovirus infection has the potential to exhibit unconventional symptoms like symptomatic hyponatremia. Health care professionals should remain vigilant about this potential complication, especially in cases with uncommon presentations. Timely identification and effective management of hyponatremia can mitigate potential complications and enhance patient prognosis.AbstractThe syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a prominent contributor to low sodium levels. Various factors can contribute to hyponatremia, affecting the diagnosis and treatment of the condition. Of note, ...
Source: Clinical Case Reports - April 23, 2024 Category: General Medicine Authors: Koutaibah Obaid,
Mohamad Talal Basrak,
Bisher Sawaf,
Hiba Habib,
Mohammed Alkhatib,
Anas A. Ashour,
Mhd Baraa Habib Tags: CASE REPORT Source Type: research
Survival and safety analysis of COVID ‐19 vaccine in Chinese patients with non‐small cell lung cancer
ConclusionsCOVID-19 vaccination is safe for Chinese NSCLC patients actively receiving different antitumor treatments without increasing the incidence of adverse reactions, and vaccination does not affect cancer patient survival. (Source: Cancer Medicine)
Source: Cancer Medicine - April 23, 2024 Category: Cancer & Oncology Authors: Wei Xu,
Jing Zhao,
Fang Luan,
Zhizhao Zhang,
Lei Liu,
Hui Zhao,
Bin Feng,
Guobin Fu Tags: RESEARCH ARTICLE Source Type: research
Establishing breath as a biomarker platform —take home messages from the Breath Biopsy Conference 2023
The annual Breath Biopsy Conference hosted by Owlstone Medical gathers together the leading experts, early career researchers, and physicians working with breath as a biomarker platform for clinical purposes. The current topics in breath research are discussed and presented, and an overarching topical theme is identified and discussed as part of an expert panel to close the conference. The profiling of normal breath composition and the establishment of standards for analyzing breath compared to background signal were two important topics that were major focuses of this conference, as well as important innovative progress t...
Source: Journal of Breath Research - April 23, 2024 Category: Respiratory Medicine Authors: Hsuan Chou, Lucy Godbeer and Madeleine L Ball Source Type: research
Cystic fibrosis newborn screening in Switzerland – evaluation and scenarios for improvement after 11 years of follow-up
Newborn bloodspot screening (NBS) for cystic fibrosis (CF) has become an essential component of early CF diagnosis in many countries [1,2]. The main goal of NBS programmes is to detect infants with a treatable disease early, to initiate treatment, prevent symptoms, and decrease mortality [3]. While CF-NBS programmes have benefits for children with CF, it is important to be aware of possible harmful effects. Every follow-up test, such as a second IRT measurement or sweat test, due to a false-positive CF-NBS result causes distress for the family and burdens the health-care system [4 –6]. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 23, 2024 Category: Respiratory Medicine Authors: ESL Pedersen, CM de Jong Carmen, M Jurca, DO Berger, J Sanz, SHM Sluka, M Poms, MR Baumgartner, N Regamey, CE Kuehni, J Barben, CS Rueegg, Swiss Cystic Fibrosis Newborn Screening Group Tags: Original Article Source Type: research
Changes in urinary glutathione sulfonamide (GSA) levels between admission and discharge of patients with cystic fibrosis
Data from the Australian Early Respiratory Surveillance Team for Cystic Fibrosis (AREST CF) program suggests that pulmonary inflammation, infection, and structural disease can be present not only in the absence of clinical symptoms, but in patients as young as 3 months of age [1,2]. Furthermore, acute pulmonary exacerbations, particularly those requiring hospitalisation, are significantly correlated with loss of lung function and adverse lung health outcomes [3,4]. Published data suggest that exaggerated neutrophilic inflammation is a primary driver of early CF lung disease progression [1,2,5 –7]. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 23, 2024 Category: Respiratory Medicine Authors: Tamara L Blake, Peter D Sly, Isabella Andersen, Claire E Wainwright, David W Reid, Scott C Bell, Briana R Smith, Anthony J Kettle, Nina Dickerhof Tags: Short Communication Source Type: research
Pandemic planning and its relevance to surgeons
This article will briefly discuss pandemic planning and it's relevance to surgeons. It will cover principally the UK response to the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) although will compare and contrast other diseases, and reference more general principles of major incident planning. Areas that individual surgeons and departments can, and should, influence are discussed. (Source: Surgery (Medicine Publishing))
Source: Surgery (Medicine Publishing) - April 23, 2024 Category: Surgery Authors: Ian Nesbitt Tags: Surgery for major incidents Source Type: research
Case study observational research: inflammatory cytokines in the bronchial epithelial lining fluid of COVID-19 patients with acute hypoxemic respiratory failure
In this study, the concentrations of inflammatory cytokines were measured in the bronchial epithelial lining fluid (ELF) and plasma in patients with acute hypoxemic respiratory failure (AHRF) secondary to seve... (Source: Critical Care)
Source: Critical Care - April 23, 2024 Category: Intensive Care Authors: Kazuki Sudo, Mao Kinoshita, Ken Kawaguchi, Kohsuke Kushimoto, Ryogo Yoshii, Keita Inoue, Masaki Yamasaki, Tasuku Matsuyama, Kunihiko Kooguchi, Yasuo Takashima, Masami Tanaka, Kazumichi Matsumoto, Kei Tashiro, Tohru Inaba, Bon Ohta and Teiji Sawa Tags: Brief Report Source Type: research
Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome
In acute respiratory distress syndrome (ARDS), respiratory drive often differs among patients with similar clinical characteristics. Readily observable factors like acid –base state, oxygenation, mechanics, and... (Source: Critical Care)
Source: Critical Care - April 23, 2024 Category: Intensive Care Authors: Elias Baedorf-Kassis, Michael Murn, Amy L. Dzierba, Alexis L. Serra, Ivan Garcia, Emily Minus, Clarissa Padilla, Todd Sarge, Valerie M. Goodspeed, Michael A. Matthay, Michelle N. Gong, Deborah Cook, Stephen H. Loring, Daniel Talmor and Jeremy R. Beitler Tags: Research Source Type: research
Veno-venous extracorporeal membrane oxygenation for covid-19 in postpartum patients: 1-year outcome
During the pandemic, a significant number of patients with severe COVID-19 pneumonia required intensive care. Among these, peripartum women were particularly susceptible to severe respiratory symptoms. This complex pathophysiology involves mechanical and hormonal pathways, including the presence of lung restriction 1, modulation of the immune system by pregnancy 2, and increased oxygen demand 3. Additionally, a high level of vaccine hesitancy in this population meant that most pregnant women were not vaccinated during the COVID-19 pandemic 4. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - April 23, 2024 Category: Anesthesiology Authors: Alexandra P álfi, Éva Zöllei, Zoltán Varga, László B. Tomozi, Domonkos Schulcz, Gábor Bari, Ferenc Peták, Fruzsina Kun-Szabó, Kristóf Baráth, László Rudas, Ádám L. Balogh, Barna Babik Tags: Case Report Source Type: research
The Association between Sickle Cell Disease and Postpartum Severe Maternal Morbidity
Conclusion SCD is significantly associated with an increased risk of SMM during the delivery admission and through 42 days' postdischarge. Active crisis at delivery further increases the risk of SMM.
Key Points
[...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - April 23, 2024 Category: Perinatology & Neonatology Authors: Poliektov, Natalie E. Vuncannon, Danielle M. Ha, Thoa K. Lindsay, Michael K. Chandrasekaran, Suchitra Tags: Original Article Source Type: research
Identification and experimental validation of PYCARD as a crucial PANoptosis-related gene for immune response and inflammation in COPD
AbstractChronic inflammatory and immune responses play key roles in the development and progression of chronic obstructive pulmonary disease (COPD). PANoptosis, as a unique inflammatory cell death modality, is involved in the pathogenesis of many inflammatory diseases. We aim to identify critical PANoptosis-related biomarkers and explore their potential effects on respiratory tract diseases and immune infiltration landscapes in COPD. Total microarray data consisting of peripheral blood and lung tissue datasets associated with COPD were obtained from the GEO database. PANoptosis-associated genes in COPD were identified by i...
Source: Apoptosis - April 23, 2024 Category: Molecular Biology Source Type: research
