SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells
Serine peptidase inhibitor, clade B, member 10 (SERPINB10) contributes to allergic inflammation in asthma. However, its role in the T-helper type 2 (Th2) response of allergic asthma is not known. The goal of t... (Source: Respiratory Research)
Source: Respiratory Research - June 14, 2021 Category: Respiratory Medicine Authors: Yuqing Mo, Ling Ye, Hui Cai, Guiping Zhu, Jian Wang, Mengchan Zhu, Xixi Song, Chengyu Yang and Meiling Jin Tags: Research Source Type: research

Circulating miRNA expression in asthmatics is age-related and associated with clinical asthma parameters, respiratory function and systemic inflammation
The course of asthma may differ between elderly asthmatics (EA) and non-elderly asthmatics (nEA), which may be partially associated with an age-dependent aberrant immune response. The aim of the study was to d... (Source: Respiratory Research)
Source: Respiratory Research - June 10, 2021 Category: Respiratory Medicine Authors: Aleksandra Wardzy ńska, Małgorzata Pawełczyk, Joanna Rywaniak, Joanna Makowska, Joanna Jamroz-Brzeska and Marek L. Kowalski Tags: Research Source Type: research

A risk-predictive model for invasive pulmonary aspergillosis in patients with acute exacerbation of chronic obstructive pulmonary disease
Invasive pulmonary aspergillosis (IPA) is increasingly reported in chronic obstructive pulmonary disease (COPD) patients. These patients often have poor clinical outcomes. Early recognition of IPA in COPD is a... (Source: Respiratory Research)
Source: Respiratory Research - June 9, 2021 Category: Respiratory Medicine Authors: Yu Gu, Xianping Ye, Yuxiu Liu, Yu Wang, Kunlu Shen, Jinjin Zhong, Bilin Chen and Xin Su Tags: Research Source Type: research

Heparin-binding protein in lower airway samples as a biomarker for pneumonia
Ventilator-associated pneumonia (VAP) is difficult to diagnose using clinical criteria and no biomarkers have yet been proved to be sufficiently accurate. The use of the neutrophil-derived Heparin-binding prot... (Source: Respiratory Research)
Source: Respiratory Research - June 8, 2021 Category: Respiratory Medicine Authors: Magnus Paulsson, Louise Thelaus, Kristian Riesbeck, Ingemar Qvarfordt, Margaretha E. Smith, Anders Lind én and Adam Linder Tags: Letter to the Editor Source Type: research

Idiopathic pulmonary fibrosis and diabetes mellitus: a meta-analysis and systematic review
Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial lung disease, of which the etiology has been poorly understood. Several studies have focused on the relationship between IPF and diabetes m... (Source: Respiratory Research)
Source: Respiratory Research - June 8, 2021 Category: Respiratory Medicine Authors: Le Bai, Li Zhang, Tingyu Pan, Wei Wang, Dian Wang, Cassidy Turner, Xianmei Zhou and Hailang He Tags: Research Source Type: research

Mepolizumab improves clinical outcomes in patients with severe asthma and comorbid conditions
Comorbidities can complicate the management of severe asthma; therefore, the presence of comorbid conditions or traits often need to be considered when considering treatment options for patients with severe as... (Source: Respiratory Research)
Source: Respiratory Research - June 7, 2021 Category: Respiratory Medicine Authors: Peter G. Gibson, Charlene M. Prazma, Geoffrey L. Chupp, Eric S. Bradford, Mark Forshag, Stephen A. Mallett, Steve W. Yancey, Steven G. Smith and Elisabeth H. Bel Tags: Research Source Type: research

Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis
Patients with chronic obstructive pulmonary disease (COPD) frequently suffer from chronic bronchitis (CB) and display steroid-resistant inflammation with increased sputum neutrophils and macrophages. Recently,... (Source: Respiratory Research)
Source: Respiratory Research - June 7, 2021 Category: Respiratory Medicine Authors: Kristina Andelid, Karolina Öst, Anders Andersson, Esha Mohamed, Zala Jevnikar, Lowie E. G. W. Vanfleteren and Melker Göransson Tags: Research Source Type: research

Ameliorative effects of eosinophil deficiency on immune response, endoplasmic reticulum stress, apoptosis, and autophagy in fungus-induced allergic lung inflammation
Respiratory fungal exposure is known to be associated with various allergic pulmonary disorders. Eosinophils have been implicated in tissue homeostasis of allergic inflammation as both destructive effector cel... (Source: Respiratory Research)
Source: Respiratory Research - June 7, 2021 Category: Respiratory Medicine Authors: Sijiao Wang, Zhilong Jiang, Liyang Li, Jun Zhang, Cuiping Zhang and Changzhou Shao Tags: Research Source Type: research

Patients ’ treatment limitations as predictive factor for mortality in COVID-19: results from hospitalized patients of a hotspot region for SARS-CoV-2 infections
In hospitalized patients with SARS-CoV-2 infection, outcomes markedly differ between locations, regions and countries. One possible cause for these variations in outcomes could be differences in patient treatm... (Source: Respiratory Research)
Source: Respiratory Research - June 4, 2021 Category: Respiratory Medicine Authors: Stephan Budweiser, Şevki Baş, Rudolf A. Jörres, Sebastian Engelhardt, Stefan von Delius, Katharina Lenherr, Jens Deerberg-Wittram and Andreas Bauer Tags: Research Source Type: research

A novel miRNA biomarker panel associated with mortality in pediatric patients with ARDS
We identified a novel microRNA biomarker panel consisting of 6 microRNAs predicting mortality in pediatric acute respiratory distress syndrome patients. Each of the identified mRNA have potential mechanistic i... (Source: Respiratory Research)
Source: Respiratory Research - June 4, 2021 Category: Respiratory Medicine Authors: Lisa K. Lee, Mansoureh Eghbali and Anil Sapru Tags: Letter to the Editor Source Type: research

Intralymphatic immunotherapy with tyrosine-adsorbed allergens: a double-blind, placebo-controlled trial
In this study, we evaluated the... (Source: Respiratory Research)
Source: Respiratory Research - June 4, 2021 Category: Respiratory Medicine Authors: Hye Jung Park, Sae-Hoon Kim, Yoo Seob Shin, Chul Hwan Park, Eun-Suk Cho, Seung Joon Choi, So Hyun Park, Joo Hyun Jung, Il Gyu Kang, Myoung Seok Lee, Dae Woo Kim, Sang Min Lee, Min-Suk Yang and Sang Pyo Lee Tags: Research Source Type: research

Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma
Extracellular DNA (e-DNA) and neutrophil extracellular traps (NETs) are linked to asthmatics airway inflammation. However, data demonstrating the characterization of airway inflammation associated with excessi... (Source: Respiratory Research)
Source: Respiratory Research - June 3, 2021 Category: Respiratory Medicine Authors: Mustafa Abdo, Mohib Uddin, Torsten Goldmann, Sebastian Marwitz, Thomas Bahmer, Olaf Holz, Anne-Marie Kirsten, Frederik Trinkmann, Erika von Mutius, Matthias Kopp, Gesine Hansen, Klaus F. Rabe, Henrik Watz and Frauke Pedersen Tags: Research Source Type: research

The TBAg/PHA ratio in T-SPOT.TB assay has high prospective value in the diagnosis of active tuberculosis: a multicenter study in China
The positive rate of pathogenic examination about tuberculosis is low. It is still difficult to achieve early diagnosis for some TB patients. The value of Interferon-gamma release assays (IGRA) in the diagnosi... (Source: Respiratory Research)
Source: Respiratory Research - June 1, 2021 Category: Respiratory Medicine Authors: Yidian Liu, Lan Yao, Feng Wang, Ziyong Sun, Yaoju Tan and Wei Sha Tags: Research Source Type: research

Less airway inflammation and goblet cell metaplasia in an IL-33-induced asthma model of leptin-deficient obese mice
Obesity-associated asthma is a phenotype of severe asthma. Late-onset, non-eosinophilic and female-dominant phenotype is highly symptomatic and difficult to treat. Leptin, an adipokine, exerts an immunomodulat... (Source: Respiratory Research)
Source: Respiratory Research - June 1, 2021 Category: Respiratory Medicine Authors: Atsushi Kurokawa, Mitsuko Kondo, Ken Arimura, Shigeru Ashino and Etsuko Tagaya Tags: Research Source Type: research

Dysregulation of COVID-19 related gene expression in the COPD lung
Chronic obstructive pulmonary disease (COPD) patients are at increased risk of poor outcome from Coronavirus disease (COVID-19). Early data suggest elevated Severe Acute Respiratory Syndrome Coronavirus 2 (SAR... (Source: Respiratory Research)
Source: Respiratory Research - May 29, 2021 Category: Respiratory Medicine Authors: Alastair Watson, Lisa Öberg, Bastian Angermann, C. Mirella Spalluto, Michael Hühn, Hannah Burke, Doriana Cellura, Anna Freeman, Daniel Muthas, Damla Etal, Graham Belfield, Fredrik Karlsson, Karl Nordström, Kris Ostridge, Karl J. Staples and Tom Wilkins Tags: Research Source Type: research

Real-life cost-effectiveness of benralizumab in patients with severe asthma
Availability of clinically effective and cost-effective treatments for severe asthma would be beneficial to patients and national healthcare systems. The aim of this study was to evaluate clinical outcomes and... (Source: Respiratory Research)
Source: Respiratory Research - May 27, 2021 Category: Respiratory Medicine Authors: A. Padilla-Galo, A. J. Garc ía-Ruiz, R. Ch. Levy Abitbol, C. Olveira, F. Rivas-Ruiz, N. García-Agua Soler, M. Pérez Morales, B. Valencia Azcona, B. Tortajada-Goitia, I. Moya-Carmona and A. Levy-Naon Tags: Research Source Type: research

Effects of diabetes on the development of radiation pneumonitis
Radiation pneumonia (RP) is a common adverse reaction to radiation therapy in patients with chest tumors. Recent studies have shown that diabetes mellitus (DM), which can cause systemic multisystem damage, spe... (Source: Respiratory Research)
Source: Respiratory Research - May 24, 2021 Category: Respiratory Medicine Authors: Guangtong Dong, Yuxiao Li, Qiyao Zhao, Bing Pang, Xin Qi, Junping Wei and Wei Hou Tags: Review Source Type: research

Nonlinear relationship between visceral adiposity index and lung function: a population-based study
As one of the critical indicators of obesity, the interaction between visceral fat content and lung disease is the focus of current research. However, the exact relationship between Visceral adipose index (VAI... (Source: Respiratory Research)
Source: Respiratory Research - May 24, 2021 Category: Respiratory Medicine Authors: Yide Wang, Zheng Li and Fengsen Li Tags: Research Source Type: research

Estimates of epidemiology, mortality and disease burden associated with progressive fibrosing interstitial lung disease in France (the PROGRESS study)
There is a paucity of data on the epidemiology, survival estimates and healthcare resource utilisation and associated costs of patients with progressive fibrosing interstitial lung disease (PF-ILD) in France. ... (Source: Respiratory Research)
Source: Respiratory Research - May 24, 2021 Category: Respiratory Medicine Authors: Mouhamad Nasser, Sophie Larrieu, Loic Boussel, Salim Si-Mohamed, Fabienne Bazin, S ébastien Marque, Jacques Massol, Françoise Thivolet-Bejui, Lara Chalabreysse, Delphine Maucort-Boulch, Eric Hachulla, Stéphane Jouneau, Katell Le Lay and Vincent Cottin Tags: Research Source Type: research

ROR γt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma
ROR γt is a transcription factor that enables elaboration of Th17-associated cytokines (including IL-17 and IL-22) and is proposed as a pharmacological target for severe asthma. (Source: Respiratory Research)
Source: Respiratory Research - May 22, 2021 Category: Respiratory Medicine Authors: David Lamb, Dorothy De Sousa, Karsten Quast, Katrin Fundel-Clemens, Jonas S. Erjef ält, Caroline Sandén, Hans Jürgen Hoffmann, Marc Kästle, Ramona Schmid, Kevin Menden and Denis Delic Tags: Research Source Type: research

Mechanical ventilation enhances Acinetobacter baumannii-induced lung injury through JNK pathways
Patients in intensive care units (ICUs) often received broad-spectrum antibiotic treatment and Acinetobacter baumannii (A.b.) and Pseudomonas aeruginosa (P.a.) were the most common pathogens causing ventilator-as... (Source: Respiratory Research)
Source: Respiratory Research - May 22, 2021 Category: Respiratory Medicine Authors: Tzyy-Bin Tsay, Wan-Hsuan Chang, Ching-Mei Hsu and Lee-Wei Chen Tags: Research Source Type: research

Use of capnography for prediction of obstruction severity in non-intubated COPD and asthma patients
Capnography waveform contains essential information regarding physiological characteristics of the airway and thus indicative of the level of airway obstruction. Our aim was to develop a capnography-based, poi... (Source: Respiratory Research)
Source: Respiratory Research - May 21, 2021 Category: Respiratory Medicine Authors: Barak Pertzov, Michal Ronen, Dror Rosengarten, Dorit Shitenberg, Moshe Heching, Yael Shostak and Mordechai R. Kramer Tags: Research Source Type: research

Effect of different corticosteroid regimes for hospitalised patients with exacerbated COPD: pooled analysis of individual participant data from the REDUCE and CORTICO-COP trials
Systemic corticosteroid administration for severe acute exacerbations of COPD (AECOPD) reduces the duration of hospital stays. Corticosteroid-sparing regimens have showed non-inferiority to higher accumulated ... (Source: Respiratory Research)
Source: Respiratory Research - May 21, 2021 Category: Respiratory Medicine Authors: Pradeesh Sivapalan, Jonas Rutishauser, Charlotte Suppli Ulrik, J örg D. Leuppi, Lars Pedersen, Beat Mueller, Josefin Eklöf, Tor Biering-Sørensen, Vibeke Gottlieb, Karin Armbruster, Julie Janner, Mia Moberg, Therese S. Lapperre, Thyge L. Nielsen, Andrea Tags: Research Source Type: research

Effects of bilateral lung transplantation on cardiac autonomic modulation and cardiorespiratory coupling: a prospective study
Although cardiac autonomic modulation has been studied in several respiratory diseases, the evidence is limited on lung transplantation, particularly on its acute and chronic effects. Thus, we aimed to evaluat... (Source: Respiratory Research)
Source: Respiratory Research - May 21, 2021 Category: Respiratory Medicine Authors: E. Tobaldini, G. D. Rodrigues, G. Mantoan, A. Monti, G. Coti Zelati, Ludovico Furlan, P. Tarsia, L. C. Morlacchi, V. Rossetti, I. Righi, L. Rosso, M. Nosotti, P. P. S. Soares, N. Montano, S. Aliberti and F. Blasi Tags: Research Source Type: research

Risk factors for persistent abnormality on chest radiographs at 12-weeks post hospitalisation with PCR confirmed COVID-19
The long-term consequences of COVID-19 remain unclear. There is concern a proportion of patients will progress to develop pulmonary fibrosis. We aimed to assess the temporal change in CXR infiltrates in a coho... (Source: Respiratory Research)
Source: Respiratory Research - May 21, 2021 Category: Respiratory Medicine Authors: T. J. M. Wallis, E. Heiden, J. Horno, B. Welham, H. Burke, A. Freeman, L. Dexter, A. Fazleen, A. Kong, C. McQuitty, M. Watson, S. Poole, N. J. Brendish, T. W. Clark, T. M. A. Wilkinson, M. G. Jones & hellip; Tags: Research Source Type: research

Acute exacerbation of fibrotic hypersensitivity pneumonitis: incidence and outcomes
Patients with fibrotic hypersensitivity pneumonitis (HP) show variable clinical courses, and some experience rapid deterioration (RD), including acute exacerbation (AE). However, little is known about AE in fi... (Source: Respiratory Research)
Source: Respiratory Research - May 20, 2021 Category: Respiratory Medicine Authors: Jieun Kang, Yeon Joo Kim, Jooae Choe, Eun Jin Chae and Jin Woo Song Tags: Research Source Type: research

The modification effect of temperature on the relationship between air pollutants and daily incidence of influenza in Ningbo, China
Although exposure to air pollution has been linked to many health issues, few studies have quantified the modification effect of temperature on the relationship between air pollutants and daily incidence of in... (Source: Respiratory Research)
Source: Respiratory Research - May 20, 2021 Category: Respiratory Medicine Authors: Rui Zhang, Yujie Meng, Hejia Song, Ran Niu, Yu Wang, Yonghong Li and Songwang Wang Tags: Research Source Type: research

An updated overview of e-cigarette impact on human health
The electronic cigarette (e-cigarette), for many considered as a safe alternative to conventional cigarettes, has revolutionised the tobacco industry in the last decades. In e-cigarettes, tobacco combustion is re... (Source: Respiratory Research)
Source: Respiratory Research - May 18, 2021 Category: Respiratory Medicine Authors: Patrice Marques, Laura Piqueras and Maria-Jesus Sanz Tags: Review Source Type: research

Loss of IL-33 enhances elastase-induced and cigarette smoke extract-induced emphysema in mice
IL-33, which is known to induce type 2 immune responses via group 2 innate lymphoid cells, has been reported to contribute to neutrophilic airway inflammation in chronic obstructive pulmonary disease. However,... (Source: Respiratory Research)
Source: Respiratory Research - May 15, 2021 Category: Respiratory Medicine Authors: Daisuke Morichika, Akihiko Taniguchi, Naohiro Oda, Utako Fujii, Satoru Senoo, Junko Itano, Arihiko Kanehiro, Yoshiaki Kitaguchi, Masanori Yasuo, Masayuki Hanaoka, Takashi Satoh, Shizuo Akira, Katsuyuki Kiura, Yoshinobu Maeda and Nobuaki Miyahara Tags: Research Source Type: research

Association of endothelial activation assessed through endothelin-I precursor peptide measurement with mortality in COVID-19 patients: an observational analysis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has been linked to thrombotic complications and endothelial dysfunction. We assessed the prognostic implications of endothelial a... (Source: Respiratory Research)
Source: Respiratory Research - May 13, 2021 Category: Respiratory Medicine Authors: Claudia Gregoriano, Dominik Damm, Alexander Kutz, Daniel Koch, Selina Wolfisberg, Sebastian Haubitz, Anna Conen, Luca Bernasconi, Angelika Hammerer-Lercher, Christoph A. Fux, Beat Mueller and Philipp Schuetz Tags: Research Source Type: research

Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial
To investigate whether the administration of hydrogen/oxygen mixture was superior to oxygen in improving symptoms in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). (Source: Respiratory Research)
Source: Respiratory Research - May 13, 2021 Category: Respiratory Medicine Authors: Ze-Guang Zheng, Wu-Zhuang Sun, Jie-Ying Hu, Zhi-Jun Jie, Jin-Fu Xu, Jie Cao, Yuan-Lin Song, Chang-Hui Wang, Jing Wang, Hui Zhao, Zhong-Liang Guo and Nan-Shan Zhong Tags: Research Source Type: research

Characteristics and treatable traits of patients with chronic obstructive pulmonary disease (COPD) with and without paid employment
Patients with COPD are vulnerable to workforce detachment. Better knowledge of features associated with paid work loss might be of help to design and select appropriate interventions. (Source: Respiratory Research)
Source: Respiratory Research - May 12, 2021 Category: Respiratory Medicine Authors: Peter A. Jacobsen, Alex J. van ’t Hul, Remco S. Djamin, Jeanine C. Antons, Marianne de Man, Ulla Møller Weinreich, Martijn A. Spruit and Daisy J. A. Janssen Tags: Research Source Type: research

Relationship between long non-coding RNA PCAT-1 expression and gefitinib resistance in non-small-cell lung cancer cells
Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, has been used as first-line treatment for advanced non-small-cell lung cancer (NSCLC). However, during treatment, cancer cells often de... (Source: Respiratory Research)
Source: Respiratory Research - May 12, 2021 Category: Respiratory Medicine Authors: Shaojia Wang, Chao Liu, Qing Lei, Zhengwei Wu, Xiangshuai Miao, Debing Zhu, Xu Yang, Na Li, Mingwei Tang, Yan Chen and Weiwei Wang Tags: Research Source Type: research

Osimertinib alone as second-line treatment for brain metastases (BM) control may be more limited than for non-BM in advanced NSCLC patients with an acquired EGFR T790M mutation
This study was designed to investigate the difference between brain metastases (BM) and non-brain metastases (non-BM) treated by osimertinib in advanced patients with an acquired EGFR T790M mutation after obta... (Source: Respiratory Research)
Source: Respiratory Research - May 11, 2021 Category: Respiratory Medicine Authors: Changhui Li, Wei Nie, Jingdong Guo, Anning Xiong, Hua Zhong, Tianqing Chu, Runbo Zhong, Jianlin Xu, Jun Lu, Xiaoxuan Zheng, Bo Zhang, Yinchen Shen, Feng Pan, Baohui Han and Xueyan Zhang Tags: Research Source Type: research

Lung function trajectories in children with post-prematurity respiratory disease: identifying risk factors for abnormal growth
This study aims to describ... (Source: Respiratory Research)
Source: Respiratory Research - May 10, 2021 Category: Respiratory Medicine Authors: Jonathan C. Levin, Catherine A. Sheils, Jonathan M. Gaffin, Craig P. Hersh, Lawrence M. Rhein and Lystra P. Hayden Tags: Research Source Type: research

Benefit of switching to mepolizumab from omalizumab in severe eosinophilic asthma based on patient characteristics
The objective of this analysis was to assess the ... (Source: Respiratory Research)
Source: Respiratory Research - May 10, 2021 Category: Respiratory Medicine Authors: Mark C. Liu, Bradley Chipps, Xavier Munoz, Gilles Devouassoux, Miguel Bergna, Steven G. Smith, Robert G. Price, Dmitry V. Galkin, Jay Azmi, Dalal Mouneimne, Frank C. Albers and Kenneth R. Chapman Tags: Research Source Type: research

Effect of mesenchymal stromal cell infusions on lung function in COPD patients with high CRP levels
We previously reported a Phase 1/2 randomized placebo-controlled trial of systemic administration of bone marrow-derived allogeneic MSCs (remestemcel-L) in COPD. While safety profile was good, no functional ef... (Source: Respiratory Research)
Source: Respiratory Research - May 8, 2021 Category: Respiratory Medicine Authors: Daniel J. Weiss, Karen Segal, Richard Casaburi, Jack Hayes and Donald Tashkin Tags: Research Source Type: research

Surfactant protein D and bronchopulmonary dysplasia: a new way to approach an old problem
Surfactant protein D (SP-D) is a collectin protein synthesized by alveolar type II cells in the lungs. SP-D participates in the innate immune defense of the lungs by helping to clear infectious pathogens and m... (Source: Respiratory Research)
Source: Respiratory Research - May 8, 2021 Category: Respiratory Medicine Authors: Raquel Arroyo and Paul S. Kingma Tags: Review Source Type: research

Weight gain from early to middle adulthood increases the risk of incident asthma later in life in the United States: a retrospective cohort study
This study aimed to investigate the association between weight change from early to middle ad... (Source: Respiratory Research)
Source: Respiratory Research - May 5, 2021 Category: Respiratory Medicine Authors: Tao Wang, Yunping Zhou, Nan Kong, Jianzhong Zhang, Guo Cheng and Yuxin Zheng Tags: Research Source Type: research

Increased monocyte count and red cell distribution width as prognostic biomarkers in patients with Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis (IPF) represents a chronic lung disease with unpredictable course. (Source: Respiratory Research)
Source: Respiratory Research - May 5, 2021 Category: Respiratory Medicine Authors: Theodoros Karampitsakos, Sebastiano Torrisi, Katerina Antoniou, Effrosyni Manali, Ioanna Korbila, Ourania Papaioannou, Fotios Sampsonas, Matthaios Katsaras, Eirini Vasarmidi, Despoina Papakosta, Kalliopi Domvri, Eva Fouka, Ioannis Organtzis, Zoe Daniil, I Tags: Research Source Type: research

FASE-CPHG Study: identification of asthma phenotypes in the French Severe Asthma Study using cluster analysis
The objective of this study was to describe asthma phenotypes using a cluster analysis in severe asthmatics recruited in a rea... (Source: Respiratory Research)
Source: Respiratory Research - May 4, 2021 Category: Respiratory Medicine Authors: Chantal Raherison-Semjen, Eric Parrat, C écilia Nocent-Eijnani, Gilles Mangiapan, Anne Prudhomme, Jean-Philippe Oster, Corinne Aperre de Vecchi, Cyril Maurer, Didier Debieuvre and Laurent Portel Tags: Research Source Type: research

Plasma markers in pulmonary hypertension subgroups correlate with patient survival
Recent studies have provided evidence for an important contribution of the immune system in the pathophysiology of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH... (Source: Respiratory Research)
Source: Respiratory Research - May 4, 2021 Category: Respiratory Medicine Authors: T. Koudstaal, D. van Uden, J. A. C. van Hulst, P. Heukels, I. M. Bergen, L. W. Geenen, V. J. M. Baggen, A. E. van den Bosch, L. M. van den Toorn, P. P. Chandoesing, M. Kool, E. Boersma, R. W. Hendriks and K. A. Boomars Tags: Research Source Type: research

Whole-body vibration training versus conventional balance training in patients with severe COPD —a randomized, controlled trial
Whole-body vibration training (WBV) performed on a vibration platform can significantly improve physical performance in patients with chronic obstructive pulmonary disease. It has been suggested that an import... (Source: Respiratory Research)
Source: Respiratory Research - May 4, 2021 Category: Respiratory Medicine Authors: Rainer Gloeckl, Tessa Schneeberger, Daniela Leitl, Tobias Reinold, Christoph Nell, Inga Jarosch, Klaus Kenn and Andreas R. Koczulla Tags: Research Source Type: research

The alveolar epithelial cells are involved in pulmonary vascular remodeling and constriction of hypoxic pulmonary hypertension
Hypoxic pulmonary hypertension (HPH) is a common type of pulmonary hypertension and characterized by pulmonary vascular remodeling and constriction. Alveolar epithelial cells (AECs) primarily sense alveolar hy... (Source: Respiratory Research)
Source: Respiratory Research - May 4, 2021 Category: Respiratory Medicine Authors: Yanxia Wang, Xiaoming Li, Wen Niu, Jian Chen, Bo Zhang, Xiumin Zhang, Yingmei Wang, Shaokang Dang and Zhichao Li Tags: Research Source Type: research

Comparative outcomes in patients receiving pirfenidone or nintedanib for idiopathic pulmonary fibrosis
Real-world data regarding outcomes of idiopathic pulmonary fibrosis (IPF) are scarce, outside of registries. In France, pirfenidone and nintedanib are only reimbursed for documented IPF, with similar reimburse... (Source: Respiratory Research)
Source: Respiratory Research - May 4, 2021 Category: Respiratory Medicine Authors: Manon Belhassen, Faustine Dalon, Ma ëva Nolin and Eric Van Ganse Tags: Research Source Type: research

Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease
Nutritional immunity is the sequestration of bioavailable trace metals such as iron, zinc and copper by the host to limit pathogenicity by invading microorganisms. As one of the most conserved activities of th... (Source: Respiratory Research)
Source: Respiratory Research - April 29, 2021 Category: Respiratory Medicine Authors: Claire Healy, Natalia Munoz-Wolf, Jann é Strydom, Lynne Faherty, Niamh C. Williams, Sarah Kenny, Seamas C. Donnelly and Suzanne M. Cloonan Tags: Review Source Type: research

Effect of ambient fine particulates (PM2.5) on hospital admissions for respiratory and cardiovascular diseases in Wuhan, China
Positive associations between ambient PM2.5 and cardiorespiratory disease have been well demonstrated during the past decade. However, few studies have examined the adverse effects of PM2.5 based on an entire pop... (Source: Respiratory Research)
Source: Respiratory Research - April 28, 2021 Category: Respiratory Medicine Authors: Zhan Ren, Xingyuan Liu, Tianyu Liu, Dieyi Chen, Kuizhuang Jiao, Xiaodie Wang, Jingdong Suo, Haomin Yang, Jingling Liao and Lu Ma Tags: Research Source Type: research

Tropomyosin 2.1 collaborates with fibronectin to promote TGF- β1-induced contraction of human lung fibroblasts
Many lung diseases are characterized by fibrosis, leading to impaired tissue patency and reduced lung function. Development of fibrotic tissue depends on two-way interaction between the cells and the extra-cel... (Source: Respiratory Research)
Source: Respiratory Research - April 28, 2021 Category: Respiratory Medicine Authors: Peta Bradbury, Cassandra P. Nader, Aylin Cidem, Sandra Rutting, Dianne Sylvester, Patrick He, Maria C. Rezcallah, Geraldine M. O ’Neill and Alaina J. Ammit Tags: Research Source Type: research

InforMing the PAthway of COPD Treatment (IMPACT) trial: fibrinogen levels predict risk of moderate or severe exacerbations
Fibrinogen is the first qualified prognostic/predictive biomarker for exacerbations in patients with chronic obstructive pulmonary disease (COPD). The IMPACT trial investigated fluticasone furoate/umeclidinium... (Source: Respiratory Research)
Source: Respiratory Research - April 28, 2021 Category: Respiratory Medicine Authors: Dave Singh, Gerard J. Criner, Mark T. Dransfield, David M. G. Halpin, MeiLan K. Han, Peter Lange, Sally Lettis, David A. Lipson, David Mannino, Neil Martin, Fernando J. Martinez, Bruce E. Miller, Robert Wise, Chang-Qing Zhu and David Lomas Tags: Research Source Type: research

Prediction of successful de-cannulation of tracheostomised patients in medical intensive care units
Limited data are available on practical predictors of successful de-cannulation among the patients who undergo tracheostomies. We evaluated factors associated with failed de-cannulations to develop a predictio... (Source: Respiratory Research)
Source: Respiratory Research - April 28, 2021 Category: Respiratory Medicine Authors: Chul Park, Ryoung-Eun Ko, Jinhee Jung, Soo Jin Na and Kyeongman Jeon Tags: Research Source Type: research