αAzithromycin has enhanced effects on lung fibroblasts from idiopathic pulmonary fibrosis (IPF) patients compared to controls
Idiopathic pulmonary fibrosis (IPF) is a chronic fatal lung disease without a cure and new drug strategies are urgently needed. Differences in behavior between diseased and healthy cells are well known and dru... (Source: Respiratory Research)
Source: Respiratory Research - January 15, 2020 Category: Respiratory Medicine Authors: Kristina Krempaska, Sandra Barnowski, Jacopo Gavini, Nina Hobi, Simone Ebener, Cedric Simillion, Andrea Stokes, Ronja Schliep, Lars Knudsen, Thomas K. Geiser and Manuela Funke-Chambour Tags: Research Source Type: research

Fluid intake-related association between urine output and mortality in acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS), a complex response to various insults, has a high mortality rate. As pulmonary edema resulting from increased vascular permeability is a hallmark of ARDS, management... (Source: Respiratory Research)
Source: Respiratory Research - January 14, 2020 Category: Respiratory Medicine Authors: Yanfei Shen, Guolong Cai, Shangzhong Chen, Caibao Hu and Jing Yan Tags: Research Source Type: research

A comparison of tiotropium, long-acting β2-agonists and leukotriene receptor antagonists on lung function and exacerbations in paediatric patients with asthma
Diagnosing and treating asthma in paediatric patients remains challenging, with many children and adolescents remaining uncontrolled despite treatment. Selecting the most appropriate pharmacological treatment ... (Source: Respiratory Research)
Source: Respiratory Research - January 13, 2020 Category: Respiratory Medicine Authors: Christian Vogelberg, Stanley Goldstein, LeRoy Graham, Alan Kaplan, Alberto de la Hoz and Eckard Hamelmann Tags: Research Source Type: research

Extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of Korean organ transplantation registry (KOTRY) data
The objective of thi... (Source: Respiratory Research)
Source: Respiratory Research - January 13, 2020 Category: Respiratory Medicine Authors: Ryoung-Eun Ko, Jin Gu Lee, Song Yee Kim, Young Tae Kim, Sun Mi Choi, Do Hyung Kim, Woo Hyun Cho, Seung-Il Park, Kyung-Wook Jo, Hong Kwan Kim, Hyo Chae Paik and Kyeongman Jeon Tags: Research Source Type: research

Reduced airway levels of fatty-acid binding protein 4 in COPD: relationship with airway infection and disease severity
For still unclear reasons, chronic airway infection often occurs in patients with Chronic Obstructive Pulmonary Disease (COPD), particularly in those with more severe airflow limitation. Fatty-acid binding pro... (Source: Respiratory Research)
Source: Respiratory Research - January 13, 2020 Category: Respiratory Medicine Authors: L ídia Perea, Ana Rodrigo-Troyano, Elisabet Cantó, Marisol Domínguez-Álvarez, Jordi Giner, Ferran Sanchez-Reus, Judit Villar-García, Sara Quero, Marian García-Núñez, Alicia Marín, Eduard Monsó, Rosa Faner, Alvar Agustí, Silvia Vidal and Oriol S Tags: Research Source Type: research

ZDHXB-101 (3 ′,5-Diallyl-2, 4′-dihydroxy-[1,1′-biphen-yl]-3,5′-dicarbaldehyde) protects against airway remodeling and hyperresponsiveness via inhibiting both the activation of the mitogen-activated protein kinase and the signal transducer and activator of transcription-3 signaling pathways
Airway remodeling consists of the structural changes of airway walls, which is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of c... (Source: Respiratory Research)
Source: Respiratory Research - January 13, 2020 Category: Respiratory Medicine Authors: Jun-xia Jiang, Hui-juan Shen, Yan Guan, Yong-liang Jia, Jian Shen, Qi Liu, Qiang-min Xie and Xiao-feng Yan Tags: Research Source Type: research

Neuromuscular blocking agents for acute respiratory distress syndrome: an updated meta-analysis of randomized controlled trials
The aim of this study is investigating the benefits and harms of neuromuscular blocking agents (NMBAs) in patients with acute respiratory distress syndrome (ARDS). (Source: Respiratory Research)
Source: Respiratory Research - January 13, 2020 Category: Respiratory Medicine Authors: Zhongjun Zheng, Libing Jiang, Song Zhang, Christophe Guervilly, Mao Zhang, Xia Feng and Jianbo Ding Tags: Research Source Type: research

Impact of diffusing lung capacity before and after neoadjuvant concurrent chemoradiation on postoperative pulmonary complications among patients with stage IIIA/N2 non-small-cell lung cancer
This study aims to evaluate the impact of diffusing capacity of the lung for carbon monoxide (DLco) before and after neoadjuvant concurrent chemoradiotherapy (CCRT) on postoperative pulmonary complication (PPC... (Source: Respiratory Research)
Source: Respiratory Research - January 10, 2020 Category: Respiratory Medicine Authors: Sumin Shin, Yong Soo Choi, Jae Jun Jung, Yunjoo Im, Sun Hye Shin, Danbee Kang, Jong Ho Cho, Hong Kwan Kim, Jhingook Kim, Jae Ill Zo, Young Mog Shim, Keunchil Park, Myung-Ju Ahn, Yong Chan Ahn, Genehee Lee, Juhee Cho & hellip; Tags: Research Source Type: research

Construction of asthma related competing endogenous RNA network revealed novel long non-coding RNAs and potential new drugs
Asthma is a heterogeneous disease characterized by chronic airway inflammation. Long non-coding RNA can act as competing endogenous RNA to mRNA, and play significant role in many diseases. However, there is li... (Source: Respiratory Research)
Source: Respiratory Research - January 10, 2020 Category: Respiratory Medicine Authors: Yifang Liao, Ping Li, Yanxia Wang, Hong Chen, Shangwei Ning and Dongju Su Tags: Research Source Type: research

The stability of blood Eosinophils in chronic obstructive pulmonary disease
Blood eosinophils are a predictive biomarker of inhaled corticosteroid response in chronic obstructive pulmonary disease (COPD). We investigated blood eosinophil stability over 1  year using the Global Initiati... (Source: Respiratory Research)
Source: Respiratory Research - January 10, 2020 Category: Respiratory Medicine Authors: Gabriella H. Long, Thomas Southworth, Umme Kolsum, Gavin C. Donaldson, Jadwiga A. Wedzicha, Christopher E. Brightling and Dave Singh Tags: Letter to the Editor Source Type: research

Lung-protective ventilation worsens ventilator-induced diaphragm atrophy and weakness
Lung –protective ventilation (LPV) has been found to minimize the risk of ventilator–induced lung injury (VILI). However, whether LPV is able to diminish ventilator–induced diaphragm dysfunction (VIDD) remains ... (Source: Respiratory Research)
Source: Respiratory Research - January 10, 2020 Category: Respiratory Medicine Authors: Xian-Long Zhou, Xiao-Jun Wei, Shao-Ping Li, Hao-Li Ma and Yan Zhao Tags: Research Source Type: research

Reduced risk of clinically important deteriorations by ICS in COPD is eosinophil dependent: a pooled post-hoc analysis
We examined the performance and utility of CID in assessing the... (Source: Respiratory Research)
Source: Respiratory Research - January 10, 2020 Category: Respiratory Medicine Authors: Mona Bafadhel, Dave Singh, Christine Jenkins, Stefan Peterson, Thomas Bengtsson, Peter Wessman and Malin Fager ås Tags: Research Source Type: research

Comorbidities and survival in patients with chronic hypersensitivity pneumonitis
Chronic Hypersensitivity Pneumonitis (cHP) is a fibrotic interstitial lung disease (ILD) resulting from repeated exposure to an offending antigen. Prognostication in cHP remains challenging, and the relationsh... (Source: Respiratory Research)
Source: Respiratory Research - January 9, 2020 Category: Respiratory Medicine Authors: Julia W älscher, Benjamin Gross, Julie Morisset, Kerri A. Johannson, Martina Vasakova, Jacques Bruhwyler and Michael Kreuter Tags: Research Source Type: research

SOD2 ameliorates pulmonary hypertension in a murine model of sleep apnea via suppressing expression of NLRP3 in CD11b+ cells
High prevalence of obstructive sleep apnea (OSA) in the pulmonary hypertension (PH) population suggests that chronic intermittent hypoxia (CIH) is an important pathogenic factor of PH. However, the exact mecha... (Source: Respiratory Research)
Source: Respiratory Research - January 8, 2020 Category: Respiratory Medicine Authors: Cuiping Fu, Shengyu Hao, Zilong Liu, Liang Xie, Xu Wu, Xiaodan Wu and Shanqun Li Tags: Research Source Type: research

Characteristic chest CT findings for progressive cavities in Mycobacterium avium complex pulmonary disease: a retrospective cohort study
This study was ... (Source: Respiratory Research)
Source: Respiratory Research - January 8, 2020 Category: Respiratory Medicine Authors: Yohei Oshitani, Seigo Kitada, Ryuya Edahiro, Kazuyuki Tsujino, Hiroyuki Kagawa, Kenji Yoshimura, Keisuke Miki, Mari Miki and Hiroshi Kida Tags: Research Source Type: research

The European MultiPartner IPF registry (EMPIRE): validating long-term prognostic factors in idiopathic pulmonary fibrosis
Several registries of idiopathic pulmonary fibrosis (IPF) have been established to better understand its natural history, though their size and duration of follow-up are limited. Here, we describe the large Eu... (Source: Respiratory Research)
Source: Respiratory Research - January 8, 2020 Category: Respiratory Medicine Authors: Tanja Tran, Martina Šterclová, Nesrin Mogulkoc, Katarzyna Lewandowska, Veronika Müller, Marta Hájková, Mordechai R. Kramer, Dragana Jovanović, Jasna Tekavec-Trkanjec, Michael Studnicka, Natalia Stoeva, Karel Hejduk, Ladislav Dušek, Samy Suissa and Tags: Research Source Type: research

Porcine versus bovine surfactant therapy for RDS in preterm neonates: pragmatic meta-analysis and review of physiopathological plausibility of the effects on extra-pulmonary outcomes
While porcine seems to be superior to bovine surfactants in terms of respiratory outcomes, it is unclear if a surfactant can improve extra-pulmonary outcomes in preterm neonates with respiratory distress syndr... (Source: Respiratory Research)
Source: Respiratory Research - January 7, 2020 Category: Respiratory Medicine Authors: Silvia Foligno and Daniele De Luca Tags: Research Source Type: research

Use of antibiotics and asthma medication for acute lower respiratory tract infections in people with and without asthma: retrospective cohort study
Antibiotics are overused in patients with acute lower respiratory tract infections (ALRTIs), but less is known about their use in patients with asthma, or the use of asthma medication for ALRTI in patients wit... (Source: Respiratory Research)
Source: Respiratory Research - January 6, 2020 Category: Respiratory Medicine Authors: Rachel Denholm, Esther T. van der Werf and Alastair D. Hay Tags: Research Source Type: research

Risk factors for exacerbations and pneumonia in patients with chronic obstructive pulmonary disease: a pooled analysis
Patients with chronic obstructive pulmonary disease (COPD) are at risk of exacerbations and pneumonia; how the risk factors interact is unclear. (Source: Respiratory Research)
Source: Respiratory Research - January 6, 2020 Category: Respiratory Medicine Authors: Benjamin F. Hartley, Neil C. Barnes, Sally Lettis, Chris H. Compton, Alberto Papi and Paul Jones Tags: Research Source Type: research

Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis
Serum chitotriosidase is a promising biomarker that has shown high specificity and sensitivity in patients with sarcoidosis. The aim of this study was to investigate correlations between serum chitotriosidase,... (Source: Respiratory Research)
Source: Respiratory Research - January 6, 2020 Category: Respiratory Medicine Authors: David Bennett, Paolo Cameli, Nicola Lanzarone, Loredana Carobene, Nicola Bianchi, Annalisa Fui, Luigi Rizzi, Laura Bergantini, Giuseppe Cillis, D ’ Alessandro Miriana, Maria Antonietta Mazzei, Rosa Metella Refini, Piersante Sestini, Elena Bargagli and P Tags: Research Source Type: research

Ongoing challenges in pulmonary fibrosis and insights from the nintedanib clinical programme
The approvals of nintedanib and pirfenidone changed the treatment paradigm in idiopathic pulmonary fibrosis (IPF), and increased our understanding of the underlying disease mechanisms. Nonetheless, many challe... (Source: Respiratory Research)
Source: Respiratory Research - January 6, 2020 Category: Respiratory Medicine Authors: Claudia Valenzuela, Sebastiano Emanuele Torrisi, Nicolas Kahn, Manuel Quaresma, Susanne Stowasser and Michael Kreuter Tags: Review Source Type: research

The impact of palliative care on quality of life, anxiety, and depression in idiopathic pulmonary fibrosis: a randomized controlled pilot study
Idiopathic pulmonary fibrosis (IPF) is a fatal disease that results in poor quality of life due to progressive respiratory symptoms, anxiety, and depression. Palliative care improves quality of life and surviv... (Source: Respiratory Research)
Source: Respiratory Research - January 3, 2020 Category: Respiratory Medicine Authors: Katherine Janssen, Drew Rosielle, Qi Wang and Hyun Joo Kim Tags: Research Source Type: research

Blood eosinophil count, a marker of inhaled corticosteroid effectiveness in preventing COPD exacerbations in post-hoc RCT and observational studies: systematic review and meta-analysis
Blood eosinophil count has been proposed as a predictor of response to inhaled corticosteroid (ICS) in the prevention of acute exacerbations of COPD. An optimal threshold of blood eosinophil count for prescrib... (Source: Respiratory Research)
Source: Respiratory Research - January 3, 2020 Category: Respiratory Medicine Authors: Timothy H. Harries, Victoria Rowland, Christopher J. Corrigan, Iain J. Marshall, Lucy McDonnell, Vibhore Prasad, Peter Schofield, David Armstrong and Patrick White Tags: Research Source Type: research

Therapeutic effect of subcutaneous injection of low dose recombinant human granulocyte-macrophage colony-stimulating factor on pulmonary alveolar proteinosis
To observe the efficacy of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) for pulmonary alveolar proteinosis (PAP). (Source: Respiratory Research)
Source: Respiratory Research - January 2, 2020 Category: Respiratory Medicine Authors: Fen Zhang, Dong Weng, Yiliang Su, Chengsheng Yin, Li Shen, Yuan Zhang, Ying Zhou, Qiuhong Li, Yang Hu and Huiping Li Tags: Research Source Type: research

TBX2-positive cells represent a multi-potent mesenchymal progenitor pool in the developing lung
In the embryonic mammalian lung, mesenchymal cells act both as a signaling center for epithelial proliferation, differentiation and morphogenesis as well as a source for a multitude of differentiated cell type... (Source: Respiratory Research)
Source: Respiratory Research - December 23, 2019 Category: Respiratory Medicine Authors: Irina Wojahn, Timo H. L üdtke, Vincent M. Christoffels, Mark-Oliver Trowe and Andreas Kispert Tags: Research Source Type: research

Neurally adjusted ventilatory assist mitigates ventilator-induced diaphragm injury in rabbits
Ventilator-induced diaphragmatic dysfunction is a serious complication associated with higher ICU mortality, prolonged mechanical ventilation, and unsuccessful withdrawal from mechanical ventilation. Although ... (Source: Respiratory Research)
Source: Respiratory Research - December 23, 2019 Category: Respiratory Medicine Authors: Tatsutoshi Shimatani, Nobuaki Shime, Tomohiko Nakamura, Shinichiro Ohshimo, Justin Hotz and Robinder G. Khemani Tags: Research Source Type: research

Gene therapy-emulating small molecule treatments in cystic fibrosis airway epithelial cells and patients
Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated... (Source: Respiratory Research)
Source: Respiratory Research - December 21, 2019 Category: Respiratory Medicine Authors: Q. Yang, A. R. Soltis, G. Sukumar, X. Zhang, H. Caohuy, J. Freedy, C. L. Dalgard, M. D. Wilkerson, H. B. Pollard and B. S. Pollard Tags: Research Source Type: research

The socioeconomic burden of chronic lung disease in low-resource settings across the globe – an observational FRESH AIR study
Low-resource settings are disproportionally burdened by chronic lung disease due to early childhood disadvantages and indoor/outdoor air pollution. However, data on the socioeconomic impact of respiratory dise... (Source: Respiratory Research)
Source: Respiratory Research - December 21, 2019 Category: Respiratory Medicine Authors: Evelyn A. Brakema, Aizhamal Tabyshova, Rianne M. J. J. van der Kleij, Talant Sooronbaev, Christos Lionis, Marilena Anastasaki, Pham Le An, Luan Than Nguyen, Bruce Kirenga, Simon Walusimbi, Maarten J. Postma, Niels H. Chavannes and Job F. M. van Boven Tags: Research Source Type: research

The effectiveness of Reslizumab in severe asthma treatment: a real-world experience
Increased numbers of blood and sputum eosinophils are associated with higher exacerbation frequency and increased asthma severity. In clinical trials, targeting Interleukin-5 has been shown to be a useful ther... (Source: Respiratory Research)
Source: Respiratory Research - December 20, 2019 Category: Respiratory Medicine Authors: H. Ibrahim, R. O ’Sullivan, D. Casey, J. Murphy, J. MacSharry, B. J. Plant and D. M. Murphy Tags: Letter to the Editor Source Type: research

Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study
Although allergic asthma is a complex area with many interacting factors involved, the ‘hygiene hypothesis’ proposes that a lack of exposure to infection during childhood may polarise the immune system towards... (Source: Respiratory Research)
Source: Respiratory Research - December 19, 2019 Category: Respiratory Medicine Authors: Brian R. Leaker, Dave Singh, Sam Lindgren, Gun Almqvist, Leif Eriksson, Barbara Young and Brian O ’Connor Tags: Research Source Type: research

Electronic cigarette vapour increases virulence and inflammatory potential of respiratory pathogens
Bacteria have been extensively implicated in the development of smoking related diseases, such as COPD, by either direct infection or bacteria-mediated inflammation. In response to the health risks associated ... (Source: Respiratory Research)
Source: Respiratory Research - December 18, 2019 Category: Respiratory Medicine Authors: Deirdre F. Gilpin, Katie-Ann McGown, Kevin Gallagher, Jose Bengoechea, Amy Dumigan, Gisli Einarsson, J. Stuart Elborn and Michael M. Tunney Tags: Research Source Type: research

Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice
β2 receptor agonists induce airway smooth muscle relaxation by increasing intracellular cAMP production. PKA is the traditional downstream signaling pathway of cAMP. Exchange protein directly activated by cAMP (.... (Source: Respiratory Research)
Source: Respiratory Research - December 18, 2019 Category: Respiratory Medicine Authors: Yi-fei Chen, Ge Huang, Yi-min Wang, Ming Cheng, Fang-fang Zhu, Jin-nan Zhong and Ya-dong Gao Tags: Research Source Type: research

Clinical characteristics and treatment outcomes of patients with macrolide-resistant Mycobacterium avium complex pulmonary disease: a systematic review and meta-analysis
Macrolide is a key drug in the treatment of Mycobacterium avium complex pulmonary disease (MAC-PD). Macrolide-resistant MAC is gaining importance, but there are little data in clinical characteristics and treatme... (Source: Respiratory Research)
Source: Respiratory Research - December 18, 2019 Category: Respiratory Medicine Authors: Youngmok Park, Eun Hye Lee, Inkyung Jung, Goeun Park and Young Ae Kang Tags: Research Source Type: research

Prognostic differences among patients with idiopathic interstitial pneumonias with acute exacerbation of varying pathogenesis: a retrospective study
Acute exacerbation of chronic fibrosing idiopathic interstitial pneumonias (AE-IIPs) is associated with a high mortality rate. In 2016, an international working group proposed a revised diagnostic criteria for... (Source: Respiratory Research)
Source: Respiratory Research - December 18, 2019 Category: Respiratory Medicine Authors: Motoyasu Kato, Tomoko Yamada, Shunichi Kataoka, Yuta Arai, Keita Miura, Yusuke Ochi, Hiroaki Ihara, Ryo Koyama, Shinichi Sasaki and Kazuhisa Takahashi Tags: Research Source Type: research

The clinical impact of drug-induced hepatotoxicity on anti-tuberculosis therapy: a case control study
There are limited data available on whether drug-induced hepatotoxicity (DIH) affects the clinical outcomes of tuberculosis (TB) treatment. We explored the effects of DIH on the clinical course and outcomes of... (Source: Respiratory Research)
Source: Respiratory Research - December 16, 2019 Category: Respiratory Medicine Authors: Jin Hwa Song, Seo-Young Yoon, Tae Yun Park, Eun Young Heo, Deog Kyeom Kim, Hee Soon Chung and Jung-Kyu Lee Tags: Research Source Type: research

Comparative analyses of long non-coding RNA profiles in vivo in cystic fibrosis lung airway and parenchyma tissues
Recent advances in the functional analyses of endogenous non-coding RNA (ncRNA) molecules, including long non-coding RNAs (LncRNAs), have provided a new perspective on the crucial roles of RNA in gene regulati... (Source: Respiratory Research)
Source: Respiratory Research - December 16, 2019 Category: Respiratory Medicine Authors: Parameet Kumar, Chaitali Sen, Kathryn Peters, Raymond A. Frizzell and Roopa Biswas Tags: Research Source Type: research

Upregulation of MUC5AC by VEGF in human primary bronchial epithelial cells: implications for asthma
Airway mucus hypersecretion is an important pathophysiological feature in asthma. Mucins are glycoproteins that are mainly responsible for the viscoelastic property of mucus, and MUC5AC is a major mucin glycop... (Source: Respiratory Research)
Source: Respiratory Research - December 12, 2019 Category: Respiratory Medicine Authors: Sung-Ho Kim, Qing-Mei Pei, Ping Jiang, Juan Liu, Rong-Fei Sun, Xue-Jiao Qian and Jiang-Bo Liu Tags: Research Source Type: research

Threshold of the upper airway cross-section for hypopnea onset during sleep and its identification under waking condition
There is currently no method that can predict whether or under what condition hypopnea, even obstructive sleep apnea (OSA), will occur during sleep for individuals based on credible parameters measured under w... (Source: Respiratory Research)
Source: Respiratory Research - December 11, 2019 Category: Respiratory Medicine Authors: Hongyi Lin, Cunting Wang, Han Zhang, Huahui Xiong, Zheng Li, Xiaoqing Huang, Changjin Ji, Junfang Xian and Yaqi Huang Tags: Research Source Type: research

Targeted regulation of fibroblast state by CRISPR-mediated CEBPA expression
Fibroblasts regulate tissue homeostasis and the balance between tissue repair and fibrosis. CCAAT/enhancer-binding protein alpha (CEBPA) is a key transcription factor that regulates adipogenesis. CEBPA has bee... (Source: Respiratory Research)
Source: Respiratory Research - December 11, 2019 Category: Respiratory Medicine Authors: Wei Liu, Jeffrey A. Meridew, Aja Aravamudhan, Giovanni Ligresti, Daniel J. Tschumperlin and Qi Tan Tags: Research Source Type: research

Serum bilirubin level is associated with exercise capacity and quality of life in chronic obstructive pulmonary disease
Bilirubin has antioxidant properties against chronic respiratory diseases. However, previous studies are limited by acquisition of serum bilirubin level at one time point and its analysis with clinical paramet... (Source: Respiratory Research)
Source: Respiratory Research - December 9, 2019 Category: Respiratory Medicine Authors: Ah Young Leem, Young Sam Kim, Ji-Hyun Lee, Tae-Hyung Kim, Ha Yan Kim, Yeon Mok Oh, Sang Do Lee and Ji Ye Jung Tags: Research Source Type: research

Impaired training-induced angiogenesis process with loss of pericyte-endothelium interactions is associated with an abnormal capillary remodelling in the skeletal muscle of COPD patients
Chronic obstructive pulmonary disease (COPD) is associated with exercise intolerance and limits the functional gains in response to exercise training in patients compared to sedentary healthy subjects (SHS). T... (Source: Respiratory Research)
Source: Respiratory Research - December 5, 2019 Category: Respiratory Medicine Authors: L éo Blervaque, Emilie Passerieux, Pascal Pomiès, Matthias Catteau, Nelly Héraud, Marine Blaquière, François Bughin, Bronia Ayoub, Nicolas Molinari, Jean-Paul Cristol, Antonia Perez-Martin, Jacques Mercier, Maurice Hayot and Fares Gouzi Tags: Research Source Type: research

Determination of rheology and surface tension of airway surface liquid: a review of clinical relevance and measurement techniques
By airway surface liquid, we mean a thin fluid continuum consisting of the airway lining layer and the alveolar lining layer, which not only serves as a protective barrier against foreign particles but also co... (Source: Respiratory Research)
Source: Respiratory Research - December 4, 2019 Category: Respiratory Medicine Authors: Zhenglong Chen, Ming Zhong, Yuzhou Luo, Linhong Deng, Zhaoyan Hu and Yuanlin Song Tags: Review Source Type: research

Primary immunodeficiency-related bronchiectasis in adults: comparison with bronchiectasis of other etiologies in a French reference center
Bronchiectasis is a heterogeneous disease depending on etiology. It represents the most frequent non-infectious pulmonary complication of primary immunodeficiencies (PID). We investigated whether bronchiectasi... (Source: Respiratory Research)
Source: Respiratory Research - December 4, 2019 Category: Respiratory Medicine Authors: H élène Goussault, Hélène Salvator, Emilie Catherinot, Marie-Laure Chabi, Colas Tcherakian, Alexandre Chabrol, Morgane Didier, Elisabeth Rivaud, Alain Fischer, Felipe Suarez, Olivier Hermine, Fanny Lanternier, Olivier Lortholary, Nizar Mahlaoui, Phili Tags: Research Source Type: research

Excessive daytime sleepiness, metabolic syndrome, and obstructive sleep apnea: two independent large cross-sectional studies and one interventional study
This study was performed to assess the association between MetS and EDS in two independent large-scal... (Source: Respiratory Research)
Source: Respiratory Research - December 4, 2019 Category: Respiratory Medicine Authors: Xinyi Li, Hengye Huang, Huajun Xu, Yue Shi, Yingjun Qian, Jianyin Zou, Hongliang Yi, Jian Guan and Shankai Yin Tags: Research Source Type: research

Inhaled corticosteroids and FEV1 decline in chronic obstructive pulmonary disease: a systematic review
Rate of FEV1 decline in COPD is heterogeneous and the extent to which inhaled corticosteroids (ICS) influence the rate of decline is unclear. The majority of previous reviews have investigated specific ICS and no... (Source: Respiratory Research)
Source: Respiratory Research - December 4, 2019 Category: Respiratory Medicine Authors: Hannah R. Whittaker, Debbie Jarvis, Mohamed R. Sheikh, Steven J. Kiddle and Jennifer K. Quint Tags: Review Source Type: research

Mortality risk and causes of death in patients with non-cystic fibrosis bronchiectasis
All-cause mortality risk and causes of death in bronchiectasis patients have not been fully investigated. The aim of this study was to compare the mortality risk and causes of death between individuals with br... (Source: Respiratory Research)
Source: Respiratory Research - December 3, 2019 Category: Respiratory Medicine Authors: Sooim Sin, Seo Young Yun, Jee Min Kim, Chang Min Park, Jaeyoung Cho, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Sang-Min Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han and Chang-Hoon Lee Tags: Research Source Type: research

Dysbiosis of lower respiratory tract microbiome are associated with inflammation and microbial function variety
Lower respiratory tract (LRT) microbiome has been reported to associate with pulmonary diseases. Unregulated inflammation is an underlying cause of variable lung diseases. The lung microbiome may play an impor... (Source: Respiratory Research)
Source: Respiratory Research - December 3, 2019 Category: Respiratory Medicine Authors: Kang-jie Li, Zi-long Chen, Yao Huang, Rui Zhang, Xiao-qian Luan, Ting-ting Lei and Ling Chen Tags: Research Source Type: research

Does a tailored intervention to promote adherence in patients with chronic lung disease affect exacerbations? A randomized controlled trial
This study aimed to investigate the impact of an acoustic reminder and support... (Source: Respiratory Research)
Source: Respiratory Research - December 3, 2019 Category: Respiratory Medicine Authors: Claudia Gregoriano, Thomas Dieterle, Anna-Lisa Breitenstein, Selina D ürr, Amanda Baum, Stéphanie Giezendanner, Sabrina Maier, Anne Leuppi-Taegtmeyer, Isabelle Arnet, Kurt E. Hersberger and Jörg D. Leuppi Tags: Research Source Type: research

DNA methylation is associated with lung function in never smokers
Active smoking is the main risk factor for COPD. Here, epigenetic mechanisms may play a role, since cigarette smoking is associated with differential DNA methylation in whole blood. So far, it is unclear wheth... (Source: Respiratory Research)
Source: Respiratory Research - December 2, 2019 Category: Respiratory Medicine Authors: Maaike de Vries, Ivana Nedeljkovic, Diana A. van der Plaat, Alexandra Zhernakova, Lies Lahousse, Guy G. Brusselle, Najaf Amin, Cornelia M. van Duijn, Judith M. Vonk and H. Marike Boezen Tags: Research Source Type: research

Relationship between diffusion capacity and small airway abnormality in COPDGene
Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is u... (Source: Respiratory Research)
Source: Respiratory Research - December 2, 2019 Category: Respiratory Medicine Authors: Rachel N. Criner, Charles R. Hatt, Craig J. Galb án, Ella A. Kazerooni, David A. Lynch, Meredith C. McCormack, Richard Casaburi, Neil R. MacIntyre, Barry J. Make, Fernando J. Martinez, Wassim W. Labaki, Jeffrey L. Curtis and Mei Lan K. Han Tags: Letter to the Editor Source Type: research