Smoking-associated increase in mucins 1 and 4 in human airways
Smoking-related chronic obstructive pulmonary disease (COPD) is associated with dysregulated production of mucus. Mucins (MUC) are important both for mucus secretion and epithelial defense. We have examined th... (Source: Respiratory Research)
Source: Respiratory Research - September 18, 2020 Category: Respiratory Medicine Authors: Heta Merikallio, Riitta Kaarteenaho, Sara Lind én, Médea Padra, Reza Karimi, Chuan-Xing Li, Elisa Lappi-Blanco, Åsa M. Wheelock and Magnus C. Sköld Tags: Research Source Type: research

Influence of obesity on remodeling of lung tissue and organization of extracellular matrix after blunt thorax trauma
Previously, it has been shown that obesity is a risk factor for recovery, regeneration, and tissue repair after blunt trauma and can affect the rate of muscle recovery and collagen deposition after trauma. To ... (Source: Respiratory Research)
Source: Respiratory Research - September 17, 2020 Category: Respiratory Medicine Authors: Pengfei Xu, Fabian G ärtner, Adrian Gihring, Congxing Liu, Timo Burster, Martin Wabitsch, Uwe Knippschild and Stephan Paschke Tags: Research Source Type: research

Blood eosinophils as a biomarker of future COPD exacerbation risk: pooled data from 11 clinical trials
Chronic obstructive pulmonary disease (COPD) is characterised by progressive airflow limitation and chronic inflammation. Predicting exacerbations of COPD, which contribute to disease progression, is important... (Source: Respiratory Research)
Source: Respiratory Research - September 17, 2020 Category: Respiratory Medicine Authors: Dave Singh, Jadwiga A. Wedzicha, Salman Siddiqui, Alberto de la Hoz, Wenqiong Xue, Helgo Magnussen, Marc Miravitlles, James D. Chalmers and Peter M. A. Calverley Tags: Research Source Type: research

LINC01503/miR-342-3p facilitates malignancy in non-small-cell lung cancer cells via regulating LASP1
Non-small cell lung cancer (NSCLC) is one of the major types of lung cancer, which is a prevalent human disease all over the world. LncRNA LINC01503 is a super-enhancer-driven long non-coding RNA that is dysre... (Source: Respiratory Research)
Source: Respiratory Research - September 16, 2020 Category: Respiratory Medicine Authors: Qiming Shen, Yanbin Sun and Shun Xu Tags: Research Source Type: research

Pneumothorax in COVID-19 disease- incidence and clinical characteristics
Spontaneous pneumothorax is an uncommon complication of COVID-19 viral pneumonia. The exact incidence and risk factors are still unknown. Herein we review the incidence and outcomes of pneumothorax in over 300... (Source: Respiratory Research)
Source: Respiratory Research - September 16, 2020 Category: Respiratory Medicine Authors: Massa Zantah, Eduardo Dominguez Castillo, Ryan Townsend, Fusun Dikengil and Gerard J. Criner Tags: Research Source Type: research

Pentraxin 3 promotes airway inflammation in experimental asthma
Pentraxin 3 (PTX3) regulates multiple aspects of innate immunity and tissue inflammation. Recently, it has been reported that PTX3 deficiency enhances interleukin (IL)-17A –dominant pulmonary inflammation in an... (Source: Respiratory Research)
Source: Respiratory Research - September 16, 2020 Category: Respiratory Medicine Authors: Pengfei Gao, Kun Tang, Yanjiao Lu, Zhenli Huang, Shanshan Wang, Meijia Wang, Jianmiao Wang, Jianping Zhao and Jungang Xie Tags: Research Source Type: research

Presence of heat shock protein 47-positive fibroblasts in cancer stroma is associated with increased risk of postoperative recurrence in patients with lung cancer
Heat shock protein 47 (HSP47), a collagen-binding protein, has a specific role in the intracellular processing of procollagen production. HSP47 expression is associated with cancer growth and metastasis in sev... (Source: Respiratory Research)
Source: Respiratory Research - September 14, 2020 Category: Respiratory Medicine Authors: Takuto Miyamura, Noriho Sakamoto, Kaori Ishida, Tomoyuki Kakugawa, Hirokazu Taniguchi, Yoshiko Akiyama, Daisuke Okuno, Atsuko Hara, Takashi Kido, Hiroshi Ishimoto, Takuro Miyazaki, Keitaro Matsumoto, Tomoshi Tsuchiya, Hiroyuki Yamaguchi, Taiga Miyazaki, Y Tags: Research Source Type: research

Azithromycin ameliorates sulfur dioxide-induced airway epithelial damage and inflammatory responses
The airway epithelium (AE) forms the first line of defence against harmful particles and pathogens. Barrier failure of the airway epithelium contributes to exacerbations of a range of lung diseases that are co... (Source: Respiratory Research)
Source: Respiratory Research - September 10, 2020 Category: Respiratory Medicine Authors: Jon Petur Joelsson, Jennifer A. Kricker, Ari J. Arason, Snaevar Sigurdsson, Bryndis Valdimarsdottir, Fridrik Runar Gardarsson, Clive P. Page, Fredrik Lehmann, Thorarinn Gudjonsson and Saevar Ingthorsson Tags: Research Source Type: research

Navafenterol (AZD8871) in patients with COPD: a randomized, double-blind, phase I study evaluating safety and pharmacodynamics of single doses of this novel, inhaled, long-acting, dual-pharmacology bronchodilator
Navafenterol (AZD8871) is a dual-pharmacology muscarinic antagonist β2−agonist (MABA) molecule in development for the treatment of chronic obstructive pulmonary disease (COPD). The pharmacodynamics, safety and to... (Source: Respiratory Research)
Source: Respiratory Research - September 9, 2020 Category: Respiratory Medicine Authors: Dave Singh, Victor Balaguer, Carol Astbury, Ulrika W ählby-Hamrén, Eulalia Jimenez, Beatriz Seoane, Cristina Villarroel, Alejhandra Lei, Ajay Aggarwal and Ioannis Psallidas Tags: Research Source Type: research

Navafenterol (AZD8871) in patients with mild asthma: a randomised placebo-controlled phase I study evaluating the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending doses of this novel inhaled long-acting dual-pharmacology bronchodilator
Navafenterol (AZD8871) is an inhaled long-acting dual-pharmacology muscarinic antagonist/ β2-adrenoceptor agonist (MABA) in development for the treatment of obstructive airways diseases. The safety, tolerability, ... (Source: Respiratory Research)
Source: Respiratory Research - September 9, 2020 Category: Respiratory Medicine Authors: Eulalia Jimenez, Carol Astbury, Muna Albayaty, Ulrika W ählby-Hamrén, Beatriz Seoane, Cristina Villarroel, Helena Pujol, Maria Jesus Bermejo, Ajay Aggarwal and Ioannis Psallidas Tags: Research Source Type: research

Navafenterol (AZD8871) in healthy volunteers: safety, tolerability and pharmacokinetics of multiple ascending doses of this novel inhaled, long-acting, dual-pharmacology bronchodilator, in two phase I, randomised, single-blind, placebo-controlled studies
Navafenterol (AZD8871) is a novel, long-acting, dual-pharmacology (muscarinic receptor antagonist and β2−adrenoceptor agonist) molecule in development for chronic obstructive pulmonary disease and asthma. (Source: Respiratory Research)
Source: Respiratory Research - September 9, 2020 Category: Respiratory Medicine Authors: Victor Balaguer, Muna Albayaty, Eulalia Jimenez, Ulrika W ählby-Hamrén, Carol Astbury, Beatriz Seoane, Marie-Pierre Malice, Alejhandra Lei, Ajay Aggarwal and Ioannis Psallidas Tags: Research Source Type: research

Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis
Ferroptosis is a new type of nonapoptotic cell death model that was closely related to reactive oxygen species (ROS) accumulation. Seawater drowning-induced acute lung injury (ALI) which is caused by severe ox... (Source: Respiratory Research)
Source: Respiratory Research - September 9, 2020 Category: Respiratory Medicine Authors: Yu-bao Qiu, Bin-bin Wan, Gang Liu, Ya-xian Wu, Dan Chen, Mu-dan Lu, Jun-liang Chen, Ren-qiang Yu, Dao-zhen Chen and Qing-feng Pang Tags: Research Source Type: research

Usefulness of surgical lung biopsies after cryobiopsies when pathological results are inconclusive or show a pattern suggestive of a nonspecific interstitial pneumonia
Although increasing data supports the use of transbronchial lung cryobiopsies (TBLCs) for the diagnosis of diffuse parenchymal lung diseases (DPLDs), its role as an alternative to surgical lung biopsy (SLB) is... (Source: Respiratory Research)
Source: Respiratory Research - September 4, 2020 Category: Respiratory Medicine Authors: Benjamin Bondue, Dimitri Leduc, Antoine Froidure, Thierry Pieters, Olivier Taton, Vincent Heinen, Patrick Alexander, Delphine Hoton, Florence Dome and Myriam Remmelink Tags: Research Source Type: research

Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model
Emphysema is a crucial pathological characteristic of chronic obstructive pulmonary disease (COPD). Oxidative stress, apoptosis and epigenetic mechanisms contribute to the pathogenesis of emphysema. However, a... (Source: Respiratory Research)
Source: Respiratory Research - September 3, 2020 Category: Respiratory Medicine Authors: Huihui Zeng, Tiao Li, Xue He, Shan Cai, Hong Luo, Ping Chen and Yan Chen Tags: Research Source Type: research

Effect of maternal sleep, physical activity and screen time during pregnancy on the risk of childhood respiratory allergies: a sex-specific study
Early life exposure in the uterus had a long-term effect on children ’s health. As the prevalence of allergies is increasing with a remarkable sex difference, very few studies have traced back to their early or... (Source: Respiratory Research)
Source: Respiratory Research - September 3, 2020 Category: Respiratory Medicine Authors: Yiting Chen, Jiajun Lyu, Yuanqing Xia, Jianzhen Zhu, Shilu Tong, Yong Ying, Jiajie Qu and Shenghui Li Tags: Research Source Type: research

Value of metalloproteinases in predicting COPD in heavy urban smokers
Emphysema in asymptomatic heavy smokers can be detected during CT-scan screening for lung cancer. Metalloproteinases (MMPs) have been found to play a role in the pathogenesis of chronic obstructive pulmonary d... (Source: Respiratory Research)
Source: Respiratory Research - September 2, 2020 Category: Respiratory Medicine Authors: Jun-Chieh J. Tsay, Yingjie Hu, Judith D. Goldberg, Bin Wang, Soumya Vijayalekshmy, Ting-An Yie, Katrina Bantis, Daniel H. Sterman and William N. Rom Tags: Research Source Type: research

AKT2 drives cancer progression and is negatively modulated by miR-124 in human lung adenocarcinoma
AKT2 is highly expressed in many human cancers, including non-small cell lung cancer (NSCLC). Accumulating evidence has also revealed that AKT2 can promote NSCLC cell proliferation and metastasis. However, the... (Source: Respiratory Research)
Source: Respiratory Research - September 1, 2020 Category: Respiratory Medicine Authors: Ting Liu, Jianjie Zhu, Wenwen Du, Weiwei Ning, Yang Zhang, Yuanyuan Zeng, Zeyi Liu and Jian-An Huang Tags: Research Source Type: research

A retrospective analysis of usefulness of impulse oscillometry system in the treatment of asthma
Bronchial asthma (BA) has different phenotypes, and it requires a clinically effective subtype classification system. The impulse oscillometry system (IOS) is an emerging technique device used in respiratory f... (Source: Respiratory Research)
Source: Respiratory Research - August 31, 2020 Category: Respiratory Medicine Authors: Hiroyuki Sugawara, Atsushi Saito, Saori Yokoyama, Kazunori Tsunematsu, Hirofumi Chiba and Hiroki Takahashi Tags: Research Source Type: research

From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses
Within two decades, there have emerged three highly pathogenic and deadly human coronaviruses, namely SARS-CoV, MERS-CoV and SARS-CoV-2. The economic burden and health threats caused by these coronaviruses are... (Source: Respiratory Research)
Source: Respiratory Research - August 27, 2020 Category: Respiratory Medicine Authors: Zhixing Zhu, Xihua Lian, Xiaoshan Su, Weijing Wu, Giuseppe A. Marraro and Yiming Zeng Tags: Review Source Type: research

Maternal and infant outcomes in sarcoidosis pregnancy: a Swedish population-based cohort study of first births
It is unclear whether sarcoidosis, a multisystem inflammatory disease, is associated with adverse pregnancy outcomes. We aimed to assess the risk of adverse maternal and infant outcomes in sarcoidosis pregnanc... (Source: Respiratory Research)
Source: Respiratory Research - August 27, 2020 Category: Respiratory Medicine Authors: Laura K öcher, Marios Rossides, Katarina Remaeus, Johan Grunewald, Anders Eklund, Susanna Kullberg and Elizabeth V. Arkema Tags: Research Source Type: research

CXCR4+ cells are increased in lung tissue of patients with idiopathic pulmonary fibrosis
CXCR4, a transmembrane-receptor located on epithelial cells that is activated by CXCL12, may have a role in IPF via migration of CXCR4+ fibrocytes to the lung. However, its expression has not been fully character... (Source: Respiratory Research)
Source: Respiratory Research - August 26, 2020 Category: Respiratory Medicine Authors: Jade Jaffar, Kate Griffiths, Sara Oveissi, Mubing Duan, Michael Foley, Ian Glaspole, Karen Symons, Louise Organ and Glen Westall Tags: Research Source Type: research

Flagellin shifts 3D bronchospheres towards mucus hyperproduction
Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are associated with acute and chronic bacterial infections of the lung. Excessive differentiation of basal cells to mucus-producing goblet ... (Source: Respiratory Research)
Source: Respiratory Research - August 26, 2020 Category: Respiratory Medicine Authors: Richard F. Sprott, Felix Ritzmann, Frank Langer, Yiwen Yao, Christian Herr, Yvonne Kohl, Thomas Tschernig, Robert Bals and Christoph Beisswenger Tags: Letter to the Editor Source Type: research

The effects of anti-inflammatory agents as host-directed adjunct treatment of tuberculosis in humans: a systematic review and meta-analysis
The potential role of adjunctive anti-inflammatory therapy to enhance tuberculosis (TB) treatment has recently received increasing interest. There is, therefore, a need to broadly examine current host-directed... (Source: Respiratory Research)
Source: Respiratory Research - August 26, 2020 Category: Respiratory Medicine Authors: Frank Ekow Atta Hayford, Robin Claire Dolman, Renee Blaauw, Arista Nienaber, Cornelius Mattheus Smuts, Linda Malan and Cristian Ricci Tags: Review Source Type: research

Laryngopharyngeal reflux in chronic obstructive pulmonary disease - a multi-centre study
Reflux of gastric content has been associated with recurrent exacerbations of chronic obstructive pulmonary disease (COPD). We aimed to assess the prevalence of laryngopharyngeal reflux (LPR) in COPD and if LP... (Source: Respiratory Research)
Source: Respiratory Research - August 21, 2020 Category: Respiratory Medicine Authors: Julia Sanchez, Desiree M. Schumann, Meropi Karakioulaki, Eleni Papakonstantinou, Frank Rassouli, Matthias Frasnelli, Martin Brutsche, Michael Tamm and Daiana Stolz Tags: Letter to the Editor Source Type: research

Cluster analysis in 975 patients with current cough identifies a phenotype with several cough triggers, many background disorders, and low quality of life
Recognition of disorder phenotypes may help to estimate prognosis and to guide the clinical management. Current cough management guidelines classify patients according to the duration of the cough episode. How... (Source: Respiratory Research)
Source: Respiratory Research - August 20, 2020 Category: Respiratory Medicine Authors: Heikki O. Koskela, Tuomas A. Selander and Anne M. L ätti Tags: Research Source Type: research

An authoritative algorithm most appropriate for the prediction of pulmonary embolism in patients with AECOPD
Contemporarily authoritative algorithms for the prediction of acute pulmonary embolism (PE) comprise the Standard algorithm, the Age-adjusted algorithm, the YEARS algorithm, the PERC algorithm, and the PEGeD a... (Source: Respiratory Research)
Source: Respiratory Research - August 18, 2020 Category: Respiratory Medicine Authors: Wei Xiong, He Du, Mei Xu, Wei Ding, Jinyuan Sun, Fengfeng Han and Xuejun Guo Tags: Research Source Type: research

Fortified whey beverage for improving muscle mass in chronic obstructive pulmonary disease: a single-blind, randomized clinical trial
This study was conducted to investigate the efficacy of daily consumption... (Source: Respiratory Research)
Source: Respiratory Research - August 17, 2020 Category: Respiratory Medicine Authors: Afsane Ahmadi, Mohammad Hassan Eftekhari, Zohreh Mazloom, Masoom Masoompour, Mohammad Fararooei, Mohammad Hadi Eskandari, Samrad Mehrabi, Alireza Bedeltavana, Mandana Famouri, Morteza Zare, Nasrin Nasimi and Zahra Sohrabi Tags: Research Source Type: research

Outcome measures for airway clearance techniques in children with chronic obstructive lung diseases: a systematic review
Airway clearance techniques (ACTs) are an important aspect of the treatment of children with chronic obstructive lung diseases. Unfortunately, a sound evidence base is lacking and airway clearance strategies a... (Source: Respiratory Research)
Source: Respiratory Research - August 17, 2020 Category: Respiratory Medicine Authors: Eline Lauwers, Kris Ides, Kim Van Hoorenbeeck and Stijn Verhulst Tags: Review Source Type: research

HGF alleviates septic endothelial injury by inhibiting pyroptosis via the mTOR signalling pathway
Endothelial injury is one of the predominant pathophysiological characteristics of sepsis and is the major cause of sepsis-induced multiple organ failure. Endothelial pyroptosis is a fatal mechanism of endothe... (Source: Respiratory Research)
Source: Respiratory Research - August 14, 2020 Category: Respiratory Medicine Authors: Fei Peng, Wei Chang, Qin Sun, Xinyi Xu, Jianfeng Xie, Haibo Qiu and Yi Yang Tags: Research Source Type: research

Correction to: Oxidative stress and Nrf2 expression in peripheral blood mononuclear cells derived from COPD patients: an observational longitudinal study
An amendment to this paper has been published and can be accessed via the original article. (Source: Respiratory Research)
Source: Respiratory Research - August 12, 2020 Category: Respiratory Medicine Authors: A. M. Fratta Pasini, C. Stranieri, M. Ferrari, U. Garbin, L. Cazzoletti, C. Mozzini, F. Spelta, D. Peserico and L. Cominacini Tags: Correction Source Type: research

Chronic oral corticosteroids use and persistent eosinophilia in severe asthmatics from the Belgian severe asthma registry
Severe asthma (SA) may require frequent courses or chronic use of oral corticosteroids (OCS), inducing many known side effects and complications. Therefore, it is important to identify risk factors of chronic ... (Source: Respiratory Research)
Source: Respiratory Research - August 12, 2020 Category: Respiratory Medicine Authors: S. Graff, S. Vanwynsberghe, G. Brusselle, S. Hanon, C. Sohy, L. J. Dupont, R. Peche, A. Michils, C. Pilette, G. Joos, R. E. Louis and F. N. Schleich Tags: Research Source Type: research

FGL1 regulates acquired resistance to Gefitinib by inhibiting apoptosis in non-small cell lung cancer
This study investigated the role of fibrinogen-like protein 1 (FGL1) in regulating gefitinib resistance of PC9/GR non-small cell lung cancer (NSCLC). (Source: Respiratory Research)
Source: Respiratory Research - August 10, 2020 Category: Respiratory Medicine Authors: Cuilan Sun, Weiwei Gao, Jiatao Liu, Hao Cheng and Jiqing Hao Tags: Research Source Type: research

Functional glutamate transporters are expressed in the carotid chemoreceptor
The carotid body (CB) plays a critical role in cyclic intermittent hypoxia (CIH)-induced chemosensitivity; however, the underlying mechanism remains uncertain. We have demonstrated the presence of multiple ino... (Source: Respiratory Research)
Source: Respiratory Research - August 8, 2020 Category: Respiratory Medicine Authors: Chaohong Li, Lu Huang, Xianglei Jia, Baosheng Zhao, Lingyun Chen and Yuzhen Liu Tags: Research Source Type: research

A comparison of four different models of acute respiratory distress syndrome in sheep
Acute respiratory distress syndrome (ARDS) can have various causes. The study objective was to investigate whether different pathophysiologic models of ARDS would show different respiratory, cardiovascular and... (Source: Respiratory Research)
Source: Respiratory Research - August 8, 2020 Category: Respiratory Medicine Authors: Monique Engel, Relana M. E. Nowacki, Elly M. Jonker, Daan Ophelders, Maria Nikiforou, Nico Kloosterboer, Luc J. I. Zimmermann, Dick A. van Waardenburg and Boris W. Kramer Tags: Research Source Type: research

Impact of gastroesophageal reflux on longitudinal lung function and quantitative computed tomography in the COPDGene cohort
Gastroesophageal reflux disease (GERD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and has been associated with increased risk of acute exacerbations, hospitalization, emergency roo... (Source: Respiratory Research)
Source: Respiratory Research - August 3, 2020 Category: Respiratory Medicine Authors: Arianne K. Baldomero, Chris H. Wendt, Ashley Petersen, Nathaniel T. Gaeckle, MeiLan K. Han and Ken M. Kunisaki Tags: Research Source Type: research

Pregnancy-associated plasma protein A – a new indicator of pulmonary vascular remodeling in chronic thromboembolic pulmonary hypertension?
In chronic thromboembolic pulmonary hypertension (CTEPH) impaired pulmonary hemodynamics lead to right heart failure. Natriuretic peptides reflect hemodynamic disease severity. Pregnancy-associated plasma prot... (Source: Respiratory Research)
Source: Respiratory Research - August 3, 2020 Category: Respiratory Medicine Authors: Steffen D. Kriechbaum, Felix Rudolph, Christoph B. Wiedenroth, Lisa Mielzarek, Moritz Haas, Stefan Guth, Christian W. Hamm, Eckhard Mayer, Christoph Liebetrau and Till Keller Tags: Letter to the Editor Source Type: research

Endotrophin, an extracellular hormone, in combination with neoepitope markers of von Willebrand factor improves prediction of mortality in the ECLIPSE COPD cohort
Lung epithelial damage, activation of the wound healing cascade, and remodeling of the extracellular matrix (ECM) play a major role in chronic obstructive pulmonary disease (COPD). The pro-peptide of type VI c... (Source: Respiratory Research)
Source: Respiratory Research - July 30, 2020 Category: Respiratory Medicine Authors: Sarah R. R ønnow, Lasse L. Langholm, Morten A. Karsdal, Tina Manon-Jensen, Ruth Tal-Singer, Bruce E. Miller, Jørgen Vestbo, Diana J. Leeming and Jannie M. B. Sand Tags: Letter to the Editor Source Type: research

Tiotropium in chronic obstructive pulmonary disease – a review of clinical development
Bronchodilators are the mainstay of pharmacological treatment in chronic obstructive pulmonary disease (COPD), and long-acting muscarinic antagonist (LAMA) monotherapy is recommended as initial treatment for G... (Source: Respiratory Research)
Source: Respiratory Research - July 29, 2020 Category: Respiratory Medicine Authors: Antonio Anzueto and Marc Miravitlles Tags: Review Source Type: research

Cell-specific expression of lung disease risk-related genes in the human small airway epithelium
The human small airway epithelium (SAE) plays a central role in the early events in the pathogenesis of most inherited and acquired lung disorders. Little is known about the molecular phenotypes of the specifi... (Source: Respiratory Research)
Source: Respiratory Research - July 29, 2020 Category: Respiratory Medicine Authors: Wu-lin Zuo, Mahboubeh R. Rostami, Shushila A. Shenoy, Michelle G. LeBlanc, Jacqueline Salit, Yael Strulovici-Barel, Sarah L. O ’Beirne, Robert J. Kaner, Philip L. Leopold, Jason G. Mezey, Juergen Schymeinsky, Karsten Quast, Sudha Visvanathan, Jay S. Fin Tags: Research Source Type: research

Association between cytokine profiles and lung injury in COVID-19 pneumonia
Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investiga... (Source: Respiratory Research)
Source: Respiratory Research - July 29, 2020 Category: Respiratory Medicine Authors: Li-Da Chen, Zhen-Yu Zhang, Xiao-Jie Wei, Yu-Qing Cai, Weng-Zhen Yao, Ming-Hui Wang, Qiu-Fen Huang and Xiao-Bin Zhang Tags: Research Source Type: research

The pathophysiology of ‘happy’ hypoxemia in COVID-19
The novel coronavirus disease 2019 (COVID-19) pandemic is a global crisis, challenging healthcare systems worldwide. Many patients present with a remarkable disconnect in rest between profound hypoxemia yet wi... (Source: Respiratory Research)
Source: Respiratory Research - July 28, 2020 Category: Respiratory Medicine Authors: Sebastiaan Dhont, Eric Derom, Eva Van Braeckel, Pieter Depuydt and Bart N. Lambrecht Tags: Review Source Type: research

Palliation of chronic breathlessness with morphine in patients with fibrotic interstitial lung disease – a randomised placebo-controlled trial
Patients suffering from fibrotic interstitial lung diseases (fILD) have a poor prognosis and a high symptom burden. Palliative treatment includes relief of symptoms such as breathlessness. There is no evidence... (Source: Respiratory Research)
Source: Respiratory Research - July 23, 2020 Category: Respiratory Medicine Authors: Sissel Kronborg-White, Charlotte Uggerh øj Andersen, Charlotte Kohberg, Ole Hilberg and Elisabeth Bendstrup Tags: Research Source Type: research

Patient expectations, experiences and satisfaction with nintedanib and pirfenidone in idiopathic pulmonary fibrosis: a quantitative study
Two antifibrotic drugs, nintedanib and pirfenidone, are available for treatment of idiopathic pulmonary fibrosis (IPF). Although efficacy and adverse events have been well studied, little is known about patien... (Source: Respiratory Research)
Source: Respiratory Research - July 23, 2020 Category: Respiratory Medicine Authors: C. C. Moor, R. L. M. Mostard, J. C. Grutters, P. Bresser, J. G. J. V. Aerts, C. D. Dirksen, M. L. Kimman and M. S. Wijsenbeek Tags: Research Source Type: research

The need for a holistic approach for SSc-ILD – achievements and ambiguity in a devastating disease
Systemic sclerosis (SSc) is a multi-organ autoimmune disease with complex interactions between immune-mediated inflammatory processes and vascular pathology leading to small vessel obliteration, promoting unco... (Source: Respiratory Research)
Source: Respiratory Research - July 23, 2020 Category: Respiratory Medicine Authors: Anna-Maria Hoffmann-Vold, Yannick Allanore, Elisabeth Bendstrup, Cosimo Bruni, Oliver Distler, Toby M. Maher, Marlies Wijsenbeek and Michael Kreuter Tags: Review Source Type: research

Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19
Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. (Source: Respiratory Research)
Source: Respiratory Research - July 22, 2020 Category: Respiratory Medicine Authors: Xiaofan Lu, Liyun Jiang, Taige Chen, Yang Wang, Bing Zhang, Yizhou Hong, Jun Wang and Fangrong Yan Tags: Letter to the Editor Source Type: research

LPS aggravates lung inflammation induced by RSV by promoting the ERK-MMP-12 signaling pathway in mice
RSV can lead to persistent airway inflammation and airway hyperresponsiveness (AHR), and is intimately associated with childhood recurrent wheezing and asthma, but the underlying mechanisms remain unclear. Lip... (Source: Respiratory Research)
Source: Respiratory Research - July 21, 2020 Category: Respiratory Medicine Authors: Shenglin Chen, Jun Xie, Keting Zhao, Luo Ren, Yu Deng, Xiaohong Xie, Shiyi Chen, Hongmei Xu, Xiaoru Long and Enmei Liu Tags: Research Source Type: research

Cold-inducible RNA-binding protein might determine the severity and the presences of major/minor criteria for severe community-acquired pneumonia and best predicted mortality
Severity of community-acquired pneumonia (CAP) depends on microbial pathogenicity, load and virulence, and immune responses. The Infectious Disease Society of America and the American Thoracic Society (IDSA/AT... (Source: Respiratory Research)
Source: Respiratory Research - July 20, 2020 Category: Respiratory Medicine Authors: Qi Guo, Wei-dong Song, Hai-yan Li, Ming Li, Xiao-ke Chen, Hui Liu, Hong-lin Peng, Hai-qiong Yu, Nian Liu, Zhong-dong L ü, Li-hua Liang, Qing-zhou Zhao and Mei Jiang Tags: Research Source Type: research

Investigation of occurrence patterns of respiratory syncytial virus A and B in infected-patients from Cheonan, Korea
Respiratory infections caused by viruses affect the lower respiratory tract; these infections are severe in patients with underlying diseases and can even lead to death. Respiratory syncytial virus (RSV), one ... (Source: Respiratory Research)
Source: Respiratory Research - July 18, 2020 Category: Respiratory Medicine Authors: Ga-Yeon Kim, Insoo Rheem, You Hyun Joung and Jae Kyung Kim Tags: Research Source Type: research

The SPLUNC1- βENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia
Cystic fibrosis (CF) patients are extremely vulnerable to Burkholderia cepacia complex (Bcc) infections. However, the underlying etiology is poorly understood. We tested the hypothesis that short palate lung and ... (Source: Respiratory Research)
Source: Respiratory Research - July 17, 2020 Category: Respiratory Medicine Authors: Saira Ahmad, Christine Seul Ki Kim and Robert Tarran Tags: Research Source Type: research

The association between pulmonary embolism and the cancer-related genomic alterations in patients with NSCLC
To date, the association between the acute pulmonary embolism (PE) and the currently existing cancer-related genomic alterations in patients with non-small cell lung cancer (NSCLC) has been understudied. We re... (Source: Respiratory Research)
Source: Respiratory Research - July 16, 2020 Category: Respiratory Medicine Authors: Wei Xiong, He Du, Wei Ding, Jinyuan Sun, Mei Xu and Xuejun Guo Tags: Letter to the Editor Source Type: research