Risk factors of in-hospital mortality and discriminating capacity of NIVO score in exacerbations of COPD requiring noninvasive ventilation
CONCLUSION: Our findings identified predictors of mortality in patients with AECOPD receiving NIV, providing useful information to identify severe patients and guide the management of AECOPD. The NIVO score showed an acceptable predictive value for AECOPD receiving NIV in Chinese patients, and additional studies are needed to develop and validate predictive scores based on specific populations.PMID:38652928 | DOI:10.1177/14799731241249474 (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - April 23, 2024 Category: Respiratory Medicine Authors: Jiarui Zhang Qun Yi Chen Zhou Yuanming Luo Hailong Wei Huiqing Ge Huiguo Liu Jianchu Zhang Xianhua Li Xiufang Xie Pinhua Pan Mengqiu Yi Lina Cheng Hui Zhou Liang Liu Adila Aili Yu Liu Lige Peng Jiaqi Pu Haixia Zhou MAGNET AECOPD Registry Investigators Source Type: research
Survey of Ventilator Waveform Interpretation Among ICU Professionals
CONCLUSIONS: Slightly over half respondents correctly identified ≥ 60% of waveforms demonstrating patient-ventilator discordance. High performance was associated with ≥ 10 years of ICU working experience, RT profession, graduate degree, working in a teaching hospital, and prior ventilator waveforms training. Some discordances were poorly recognized across all groups of surveyed professionals.PMID:38653558 | DOI:10.4187/respcare.11677 (Source: Respiratory Care)
Source: Respiratory Care - April 23, 2024 Category: Respiratory Medicine Authors: Ping Liu Shan Lyu Eduardo Mireles-Cabodevila Andrew G Miller Fai A Albuainain Miguel Ibarra-Estrada Jie Li Source Type: research
Risk factors of in-hospital mortality and discriminating capacity of NIVO score in exacerbations of COPD requiring noninvasive ventilation
CONCLUSION: Our findings identified predictors of mortality in patients with AECOPD receiving NIV, providing useful information to identify severe patients and guide the management of AECOPD. The NIVO score showed an acceptable predictive value for AECOPD receiving NIV in Chinese patients, and additional studies are needed to develop and validate predictive scores based on specific populations.PMID:38652928 | DOI:10.1177/14799731241249474 (Source: Respiratory Care)
Source: Respiratory Care - April 23, 2024 Category: Respiratory Medicine Authors: Jiarui Zhang Qun Yi Chen Zhou Yuanming Luo Hailong Wei Huiqing Ge Huiguo Liu Jianchu Zhang Xianhua Li Xiufang Xie Pinhua Pan Mengqiu Yi Lina Cheng Hui Zhou Liang Liu Adila Aili Yu Liu Lige Peng Jiaqi Pu Haixia Zhou MAGNET AECOPD Registry Investigators Source Type: research
Positive Airway Pressure and Metabolic Markers in Children With Obstructive Sleep Apnea
CONCLUSIONS: Although evidence on effects of PAP on metabolic markers in children with OSA is encouraging, available literature is limited. Longitudinal studies are still required to further assess the long-term influence of PAP on metabolic and inflammatory markers, particularly in children with obesity.PMID:38653555 | DOI:10.4187/respcare.11679 (Source: Respiratory Care)
Source: Respiratory Care - April 23, 2024 Category: Respiratory Medicine Authors: Christopher A Gerdung Daniel B Ofosu Sara Rodriguez-Lopez Stefan Palkowski Diana Keto-Lambert Meng Lin Maria L Castro-Codesal Source Type: research
Using the ROX Index to Predict Treatment Outcome for High-Flow Nasal Cannula and/or Noninvasive Ventilation in Patients With COPD Exacerbations
CONCLUSIONS: The ROX index applied to adults with COPD exacerbations treated with HFNC and/or NIV required higher scores to achieve similar prediction of low risk of treatment failure when compared to subjects with hypoxemic respiratory failure/pneumonia. ROX scores < 4.88 did not accurately predict intubation or death.PMID:38653556 | DOI:10.4187/respcare.11544 (Source: Respiratory Care)
Source: Respiratory Care - April 23, 2024 Category: Respiratory Medicine Authors: Brett Z Schaeffer Sarina A Fazio Jacqueline C Stocking Jason Y Adams Anna Liu Hugh B Black Richart W Harper Irene Cortes-Puch Timothy E Albertson Brooks T Kuhn Source Type: research
Human Airway and Alveolar Organoids from Bronchoalveolar Lavage Fluid
Am J Respir Crit Care Med. 2024 Apr 23. doi: 10.1164/rccm.202310-1831LE. Online ahead of print.NO ABSTRACTPMID:38652140 | DOI:10.1164/rccm.202310-1831LE (Source: Respiratory Care)
Source: Respiratory Care - April 23, 2024 Category: Respiratory Medicine Authors: Monica Yun Liu Belinda Chen Mehdi Borji Carolina Garcia de Alba Rivas Antonella F M Dost Aaron L Moye Nusrath Movval Abdulla Margherita Paschini Stuart D Rollins Ruobing Wang Lynn M Schnapp Hassan A Khalil Catherine J Wu Nirmal S Sharma Carla F Kim Source Type: research
The Top 100 Cited Articles Focusing on Acute Lung Injury and ARDS: Bibliometric and Visualization Analyses
CONCLUSIONS: This study provides a historical perspective on the scientific advancements in ALI/ARDS research, highlighting the need for further investigation and development in specific areas within the field. Bibliometric analyses reveal that the United States is the predominant force in the field of ALI/ARDS, contributing significantly to its development. Through an examination of highly cited papers on ALI/ARDS, we have identified global research trends, assessed the quality of studies, and identified hot topics in the field of ALI/ARDS.PMID:38653557 | DOI:10.4187/respcare.11616 (Source: Respiratory Care)
Source: Respiratory Care - April 23, 2024 Category: Respiratory Medicine Authors: Xinyue Song Zixin Luo Duoqin Huang Li Xiao Kang Zou Source Type: research
Modifiable risk factors that may be addressed in routine care to prevent progression to and extension of multimorbidity in people with COPD: a systematic literature review
BMJ Open Respir Res. 2024 Apr 22;11(1):e002272. doi: 10.1136/bmjresp-2023-002272.ABSTRACTChronic obstructive pulmonary disease (COPD) is a multisystem disease, and many patients have multiple conditions. We explored multimorbidity patterns that might inform intervention planning to reduce health-care costs while preserving quality of life for patients. Literature searches up to February 2022 revealed 4419 clinical observational and comparative studies of risk factors for multimorbidity in people with COPD, pulmonary emphysema, or chronic bronchitis at baseline. Of these, 29 met the inclusion criteria for this review. Eight...
Source: Respiratory Care - April 23, 2024 Category: Respiratory Medicine Authors: Andi Orlowski Jack Ettinger Alex Bottle Sally Snow Rachel Ashton Jennifer K Quint Source Type: research
The influenza landscape and vaccination coverage in older adults during the SARS-Cov-2 pandemic: data from Several European Countries and Israel
Expert Rev Respir Med. 2024 Apr 23. doi: 10.1080/17476348.2024.2340470. Online ahead of print.ABSTRACTINTRODUCTION: The Raise Awareness of Influenza Strategies in Europe (RAISE) group gathered information about the healthcare burden of influenza (hospitalizations, intensive care unit [ICU] admissions, and excess deaths), surveillance systems, and the vaccine coverage rate (VCR) in older adults in 18 European countries and Israel.AREAS COVERED: Published medical literature and official medical documentation on the influenza disease burden in the participating countries were reviewed from 2010/11 until the 2022/23 influenza ...
Source: Respiratory Care - April 23, 2024 Category: Respiratory Medicine Authors: George Kassianos Jean-Marie Cohen Rok Civljak Nadav Davidovitch Oana Falup Pecurariu Filipe Froes Andrei Galev Inga Ivaskeviciene Kadri K õivumägi Zuzana Kristufkova Ernest Kuchar Jan Kyncl Helena C Maltezou Milo š Marković Aneta Nitsch-Osuch Raul Ort Source Type: research
Changes in Physiological Traits, Gene Expression and Phytochemical Profile of Mentha piperita in Response to Elicitor
The objective of this research is to investigate the expression of essential genes in the menthol pathway of Mentha piperita, including Pulegone reductase (Pr), Menthofuran synthase (Mfs), and limonene synthase (Ls) using qPCR, physiological analysis and essential oil composition in response to methyl jasmonate (MeJA) (0.5 mM) elicitation. Physiological analysis showed that 0.5 mM MeJA triggers defensive responsiveness in Mentha piperita by increasing superoxide dismutase (SOD) and Peroxidase (POD) enzymes activity. The highest transcript levels of Pr and Mfs genes were observed during 8 and 12 h after treatment respective...
Source: Biochemical Genetics - April 23, 2024 Category: Genetics & Stem Cells Authors: Soheila Afkar Ghasem Karimzadeh Source Type: research
Characterization of Ceftriaxone-Resistant < em > Haemophilus influenzae < /em > Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | DOI:10.3346/jkms.2024.39.e136 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 23, 2024 Category: General Medicine Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research
ISGylation by HERCs facilitates STING activation
Cell Rep. 2024 Apr 21;43(5):114135. doi: 10.1016/j.celrep.2024.114135. Online ahead of print.ABSTRACTOptimal activation of stimulator of interferon genes (STING) protein is crucial for host defenses against pathogens and avoiding detrimental effects. Various post-translational modifications control STING activity. However, the function of interferon (IFN)-stimulated gene (ISG) 15 modification (ISGylation) in controlling STING stability and activation is unclear. Here, we show that the E3 ISGylation ligases HECT domain- and RCC1-like domain-containing proteins (HERCs; HERC5 in humans and HERC6 in mice) facilitate STING acti...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Ying Qin Min Wang Xintong Meng Mengge Wang Haojia Jiang Yanjie Gao Jingxin Li Chunyuan Zhao Chaofeng Han Wei Zhao Xuexing Zheng Source Type: research
Buprenorphine Affects the Initiation and Severity of Interleukin Induced Acute Pancreatitis in Mice
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 23. doi: 10.1152/ajpgi.00083.2024. Online ahead of print.ABSTRACTAcute pancreatitis (AP) is a common disease with no targeted therapy and has varied outcomes ranging from spontaneous resolution to being lethal. While typically painful, AP can also be painless. Various agents, including opioids are used for pain control in AP; the risks, and benefits of which are often debated. Since experimental AP in mice is used to study the efficacy of potential therapies, we studied the effect of a commonly used opioid buprenorphine on the initiation and progression of AP. For this we a...
Source: Am J Physiol Gastroi... - April 23, 2024 Category: Gastroenterology Authors: Sarah Jahangir Biswajit Khatua Nabil Smichi Prasad Rajalingamgari Anoop Narayana Pillai Megan J Summers Bryce McFayden Sergiy Kostenko Naomi M Gades Vijay P Singh Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
