Strategies to Reduce the Burden of Respiratory Syncytial Virus Infections in Children in Portugal: Results from the Focus Group RSV Think Tank
Acta Med Port. 2024 Apr 1;37(4):243-246. doi: 10.20344/amp.20620. Epub 2024 Apr 1.NO ABSTRACTPMID:38631056 | DOI:10.20344/amp.20620 (Source: Acta Medica Portuguesa)
Source: Acta Medica Portuguesa - April 17, 2024 Category: General Medicine Authors: Manuel Ferreira-Magalh ães Teresa Bandeira Eduardo Costa Paula Guerra Hugo Lopes Maria Ros ário Martins Ricardo Mexia Teresa Tom é Eduarda Silva Ana Rita Dias Source Type: research
Hydrangea serrata extract attenuates PM-exacerbated airway inflammation in the CARAS model by modulating the IL-33/ST2/NF- κB signaling pathway
This study was conducted to investigate the efficacy of Hydrangea serrata extract (HSE) in airway inflammation in a mouse model of CARAS exacerbated by PM. In the CARAS mouse model worsened by PM, the airway inflammation improvement effect of HSE was evaluated by analyzing allergic nasal symptoms, changes in inflammatory cells, OVA-specific immunoglobulin (Ig) levels, cytokines, mast cell activation, and histopathological findings of both nasal mucosa and lung tissue. HSE effectively reduced OVA-specific IgE and IgG1 and inhibited the production of T helper type 2 (Th2)-related cytokines such as IL-4 and IL-5. Importantly,...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 17, 2024 Category: Drugs & Pharmacology Authors: Juan Jin Thi Van Nguyen Yuna Jiang Zhen Nan Yu Chang Ho Song So-Young Lee Hee Soon Shin Ok Hee Chai Source Type: research
Mitochondrial reactive oxygen species impact human fibroblast responses to protracted γ-ray exposures
Conclusion: These results implicate mtROS production in fibroblast responses to protracted radiation exposure, and suggest potentially protective effects of mitochondrial-targeted antioxidants against radiogenic tissue injury in vivo.PMID:38631047 | DOI:10.1080/09553002.2024.2338518 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - April 17, 2024 Category: Radiology Authors: Luke A Whitcomb Xu Cao Dilip Thomas Claudia Wiese Alissa S Pessin Robert Zhang Joseph C Wu Michael M Weil Adam J Chicco Source Type: research
Competencies for proficiency in basic point-of-care ultrasound in anesthesiology: national expert recommendations using Delphi methodology
CONCLUSION: Through national expert consensus, this study identified POCUS competencies suitable for curriculum development and assessment in perioperative anesthesiology. Next steps include designing and piloting a POCUS curriculum and assessment tool(s) based upon these nationally defined competencies.PMID:38632162 | DOI:10.1007/s12630-024-02746-w (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - April 17, 2024 Category: Anesthesiology Authors: Glenio B Mizubuti Sarah Maxwell Sergiy Shatenko Heather Braund Rachel Phelan Anthony M-H Ho Nancy Dalgarno Hailey Hobbs Adam Szulewski Faizal Haji Ramiro Arellano and the Canadian Anesthesiology POCUS Consortium Source Type: research
Cost-effectiveness of high-dose influenza vaccination in the Netherlands: Incorporating the impact on both respiratory and cardiovascular hospitalizations
CONCLUSIONS: Implementing HD-QIV for adults aged 60 and over within the existing influenza vaccination campaign is highly cost effective. HD-QIV may support alleviating potential capacity issues in Dutch hospitals in the winter respiratory season.PMID:38631948 | DOI:10.1016/j.vaccine.2024.04.040 (Source: Vaccine)
Source: Vaccine - April 17, 2024 Category: Allergy & Immunology Authors: Simon van der Pol Florian Zeevat Maarten J Postma Cornelis Boersma Source Type: research
Modulation of mitochondrial function by extracellular acidosis in tumor cells and normal fibroblasts: Role of signaling pathways
Neoplasia. 2024 Apr 16;52:100999. doi: 10.1016/j.neo.2024.100999. Online ahead of print.ABSTRACTIn many tumors pronounced extracellular acidosis resulting from glycolytic metabolism is found. Since several environmental stress factors affect the mitochondrial activity the aim of the study was to analyze the impact of acidosis on cellular oxygen consumption and which signaling pathways may be involved in the regulation. In two tumor cell lines and normal fibroblasts cellular oxygen consumption rate (OCR) and mitochondrial function were measured after 3 h at pH 6.6. Besides the activation of ERK1/2, p38 and PI3K signaling in...
Source: Neoplasia - April 17, 2024 Category: Cancer & Oncology Authors: Carmen Degitz Sarah Reime Christina-Marie Baumbach Mandy Rauschner Oliver Thews Source Type: research
Opioids-Induced Long QT Syndrome: A Challenge to Cardiac Health
Cardiovasc Toxicol. 2024 Apr 17. doi: 10.1007/s12012-024-09853-6. Online ahead of print.ABSTRACTThe challenge posed by opioid overdose has become a significant concern for health systems due to the complexities associated with drug prohibition, widespread clinical use, and potential abuse. In response, healthcare professionals have primarily concentrated on mitigating the hallucinogenic and respiratory depressant consequences of opioid overdose to minimize associated risks. However, it is crucial to acknowledge that most opioids possess the capacity to prolong the QT interval, particularly in cases of overdose, thereby pot...
Source: Cardiovascular Toxicology - April 17, 2024 Category: Cardiology Authors: Jiale Hu Yongfei Song Xiaoyan Huang Chongrong Li Xiaojun Jin Lichao Cen Chuanjin Zhang Beilei Ding Jiangfang Lian Source Type: research
< em > Sphingobium cyanobacteriorum < /em > sp. nov., isolated from fresh water
Int J Syst Evol Microbiol. 2024 Apr;74(4). doi: 10.1099/ijsem.0.006339.ABSTRACTA novel Gram-stain-negative, yellow-pigmented, short rod-shaped bacterial strain, HBC34T, was isolated from a freshwater sample collected from Daechung Reservoir, Republic of Korea. The results of 16S rRNA gene sequence analysis indicated that HBC34T was affiliated with the genus Sphingobium and shared the highest sequence similarity to the type strains of Sphingobium vermicomposti (98.01 %), Sphingobium psychrophilum (97.87 %) and Sphingobium rhizovicinum (97.59 %). The average nucleotide identity (ANI) and digital DNA-DNA hybridisation (dDDH) ...
Source: International Journal of Systematic and Evolutionary Microbiology - April 17, 2024 Category: Microbiology Authors: Ve Van Le So-Ra Ko Min-Seong Kim Mingyeong Kang Seonah Jeong Chi-Yong Ahn Source Type: research
Two novel Fe(III)-reducing bacteria, Geothrix campi sp. nov. and Geothrix mesophila sp. nov., isolated from paddy soils
Antonie Van Leeuwenhoek. 2024 Apr 17;117(1):68. doi: 10.1007/s10482-024-01967-9.ABSTRACTIn this research, two novel Fe(III)-reducing bacteria, SG10T and SG198T of genus Geothrix, were isolated from the rice field of Fujian Agriculture and Forestry University in Fuzhou, Fujian Province, China. Strains SG10T and SG198T were strictly anaerobic, rod-shaped and Gram-stain-negative. The two novel strains exhibited iron reduction ability, utilizing various single organic acid as the elector donor and Fe(III) as a terminal electron acceptor. Strains SG10T and SG198T showed the highest 16S rRNA sequences similarities to the type st...
Source: Antonie van Leeuwenhoek - April 17, 2024 Category: Microbiology Authors: Shuang Han Shang Yang Rong Tang Cheng-Jie Xie Xing Liu Guo-Hong Liu Shun-Gui Zhou Source Type: research
Predicting Antibiotic Tolerance in hvKP and cKP Respiratory Infections Through Biofilm Formation Analysis and Its Resistance Implications
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - April 17, 2024 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
The effects of photobiomodulation on the improvement of sperm parameters: A review study
In this study, a comprehensive analysis of the existing literature, specifically examining the mechanisms of action of PBM has been presented. Our objective was to enhance knowledge in the field of laser light therapy in order to promote the usage of irradiation in clinical settings in a more effective way. Within the realm of reproductive science, the utilization of PBM has been employed to enhance the metabolic processes, motility, and viability of spermatozoa. This is attributed to its advantageous effects on mitochondria, resulting in the activation of the mitochondrial respiratory chain and subsequent synthesis of ATP...
Source: Photochemistry and Photobiology - April 17, 2024 Category: Science Authors: Ali Parvin,
Gisou Erabi,
Mohammad Reza Saboohi Tasooji,
Sonia Sadeghpour,
Hassan Mellatyar,
Sahar Rezaei Arablouydareh,
Leila Navapour,
Mortaza Taheri‐Anganeh,
Hojat Ghasemnejad‐Berenji Tags: INVITED REVIEW Source Type: research
GSE261920 Human long noncoding RNA, VILMIR, is induced by major respiratory viral infections and modulates the host interferon response
Contributors : Kristen John ; Ian Huntress ; Ethan Smith ; Hsuan Chou ; Tammy S Tollison ; Sergio Covarrubias ; Elisa Crisci ; Susan Carpenter ; Xinxia PengSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensLong noncoding RNAs (lncRNAs) are a newer class of noncoding transcripts identified as key regulators of biological processes. Here we aimed to identify novel lncRNA targets that play critical roles in major human respiratory viral infections by systematically mining large-scale transcriptomic datasets. Using bulk RNA-sequencing (RNA-seq) analysis, we identified a previous...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
GSE263867 Heterogeneity of immune cells and their communications unveiled by transcriptome profiling in acute inflammatory lung injury
Conclusion: This study has identified specific gene signatures and signaling pathways in animal models and human samples that facilitate the interaction between immune cells, which could be targeted therapeutically in ARDS patients of various etiologies. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE240656 Multi-center Korean cohort study based on RNA-sequencing data targeting COPD patients
This study confirmed gene expression differences in non-coding RNA in COPD patients according to the degree of airflow limitation through RNA-Seq transcriptome analysis. These results may provide valuable predictive resources for future COPD research. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE250043 Identification of a chromatin-bound ERR α interactome network in mouse liver [ChIP-Seq]
ConclusionsOur work unveils a repertoire of previously unknown transcriptional partners of ERR α comprised of chromatin modifiers and transcription factors thus advancing our knowledge of how ERRα regulates metabolic transcriptional programs. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
