Tuberculous abdominal cocoon mimicking peritoneal carcinomatosis
ConclusionPreoperative diagnosis of tuberculous abdominal cocoon is a true challenge. Early diagnostic peritoneal biopsy should be recommended and surgery is usually unnecessary if definitive diagnosis can be made. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - June 19, 2019 Category: Infectious Diseases Source Type: research

Mortality related to Verona Integron-encoded Metallo- β-lactamase-positive Pseudomonas aeruginosa : assessment by a novel clinical tool
ConclusionUsing our assessment tool, infections with VIM-PA were shown to have an important influence on mortality in our complex and severely ill patients. The tool may be used for other (resistant) bacteria as well but this needs further exploration. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - June 19, 2019 Category: Infectious Diseases Source Type: research

Control of MSSA and MRSA in the United States: protocols, policies, risk adjustment and excuses
AbstractData released by the U.S. Centers for Disease Control and Prevention (CDC) on March 5, 2019 showed thatStaph aureus infections are a major problem in the United States, with 119,000 infections and almost 20,000 deaths in 2017. Rates of decline for hospital-onset MRSA have slowed since 2012 and the United States is not on track for meeting the 2015  U.S. Dept. of Health and Human Services’ goal of a 50% reduction by 2020. There is a need for improved standards for control of dangerous pathogens. Currently, the World Health Organization’s recommendation of preoperatively screening patients for...
Source: Antimicrobial Resistance and Infection Control - June 19, 2019 Category: Infectious Diseases Source Type: research

Distribution of quinolone resistance gene ( qnr ) in ESBL- producing Escherichia coli and Klebsiella spp. in Lom é, Togo
ConclusionThis study identified quinolone resistance (qnr) gene inESBL-producingE. coli andKlebsiella spp. in Togo. These finding which suggest a possible resistance to quinolone are of high interest for better management of patients and control of antimicrobial resistance in Togo. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - June 18, 2019 Category: Infectious Diseases Source Type: research

Evaluation of an in vitro model with a novel statistical approach to measure differences in bacterial survival of extended-spectrum β -lactamase-producing Escherichia coli on an inanimate surface
ConclusionsWe found a difference in survival probability betweenE. coli ST10 and ST131, with a higher proportion of viable bacteria remaining after 7  h for ST131, particularly in sheep blood. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - June 18, 2019 Category: Infectious Diseases Source Type: research

Access-related infections in two haemodialysis units: results of a nine-year intervention and surveillance program
AbstractBackgroundAccess-related infections are a major cause of morbidity and mortality in haemodialysis patients. Our goal was to decrease the rate of these infections by implementing an intervention and surveillance program.MethodsThis intervention took place in two haemodialysis units (Units A and B) and was a joint effort by the haemodialysis staff and the unit for infection prevention and control. It included reviewing the work methods and work space, observations on compliance with standard precautions and handling of the vascular access, creating a checklist and a designated kit for handling the vascular access and...
Source: Antimicrobial Resistance and Infection Control - June 18, 2019 Category: Infectious Diseases Source Type: research

The role of patients and healthcare workers Staphylococcus aureus nasal colonization in occurrence of surgical site infection among patients admitted in two centers in Tanzania
ConclusionA significant proportion of patients acquiredS. aureus during hospitalization. The finding of more than 90% ofS. aureus SSI to be of endogenous source underscores the need of improving infection prevention and control measures including screening and decolonization of high risk patients. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - June 17, 2019 Category: Infectious Diseases Source Type: research

Potential of innovations in hygiene management – a managerial perspective
ConclusionsHospital managers are open to innovative hygiene interventions. In particular, they welcome the active involvement of patients and their relatives in infection prevention. Therefore, financial and institutional barriers, such as insufficient funding of hygiene management, must be overcome. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - June 14, 2019 Category: Infectious Diseases Source Type: research

Bacteriology of community acquired pneumonia in adult patients at Felege Hiwot Referral Hospital, Northwest Ethiopia: a cross-sectional study
ConclusionsThe study showed high prevalence of mono- and multi-drug resistant isolates in the study area. Therefore, regular surveillance of the type of isolates and their AMR patterns should be considered. Interventions for reducing community acquired pneumonia should be integrated with lifestyle factors related to household and alcohol use. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - June 14, 2019 Category: Infectious Diseases Source Type: research

Antimicrobial susceptibility against metronidazole and carbapenem in clinical anaerobic isolates from Pakistan
ConclusionThe rising trend of metronidazole resistance and emergence of carbapenem resistance in anaerobic bacteria is alarming. Continued surveillance with strengthening of laboratory capacity regarding anaerobic susceptibility testing is urgently needed in Pakistan. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - June 14, 2019 Category: Infectious Diseases Source Type: research

Extended-spectrum β-lactamase, plasmid-mediated AmpC β-lactamase, fluoroquinolone resistance, and decreased susceptibility to carbapenems in Enterobacteriaceae : fecal carriage rates and associated risk factors in the community of Northern Cyprus
ConclusionThe study indicates that resistantEnterobacteriaceae isolates are carried by humans in the community. To prevent further spread of resistance, rational use of antibiotics should be encouraged, and antibiotic resistance should be carefully monitored in Northern Cyprus. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - June 10, 2019 Category: Infectious Diseases Source Type: research

Bacterial colonization of handheld devices in a tertiary care setting: a hygiene intervention study
ConclusionOur results indicate that a twice daily disinfection can still substantially reduce bacterial colonization of in-hospital tablet computers used in a high-resource and high hygiene setting. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - June 6, 2019 Category: Infectious Diseases Source Type: research

Trends in antimicrobial resistance in Israel, 2014 –2017
AbstractWe analyzed Israeli national data on antimicrobial susceptibility from bloodstream isolates collected between 2014 and 2017 and compared resistance proportions with those of Europe. The incidence of bloodstream infection (BSI) caused by most antibiotic-resistant organisms remained unchanged or decreased. An exception was increased incidence of BSI caused by third-generation cephalosporin-resistantEscherichia coli. Overall, resistance proportions were similar to those observed in southern Europe, with the exception of a lower proportion of carbapenem-resistantKlebsiella pneumoniae in Israel. (Source: Antimicrobial R...
Source: Antimicrobial Resistance and Infection Control - June 4, 2019 Category: Infectious Diseases Source Type: research

A multifaceted hand hygiene improvement program on the intensive care units of the National Referral Hospital of Indonesia in Jakarta
AbstractBackgroundHand hygiene (HH) is considered to be the single most effective measure in preventing healthcare-associated infections. However, HH compliance rates among nurses and doctors in hospitals are often very low. Few studies have addressed HH compliance in Indonesia, performed interventions to increase HH compliance, and none have had long-term follow-up. We, therefore, addressed this issue by performing long-term follow-up after a multifaceted intervention in the intensive care unit (ICU) setting.MethodsThis was an observational, prospective, before-and-after intervention study (May –September 2014, Febr...
Source: Antimicrobial Resistance and Infection Control - June 3, 2019 Category: Infectious Diseases Source Type: research

CA-MRSA and HA-MRSA coexist in community and hospital settings in Uganda
ConclusionThe MRSA carriage rate in children in eastern Uganda is high (5.7%) and comparable to estimates for Mulago Hospital in Kampala city. Importantly, HA-MRSA (mainly ofspa type t037) and CA-MRSA (mainly ofspa type t064) coexist in children in the community in eastern Uganda, and due to high proportion of MDR detected, outpatient treatment of MRSA infection in eastern Uganda might be difficult. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - June 3, 2019 Category: Infectious Diseases Source Type: research

Gender-related risk factors for surgical site infections. Results from 10  years of surveillance in Germany
ConclusionsSSI-rates differ by sex for certain procedures. When examining underlying risk factors, differences between male and female patients can be demonstrated. Our analysis considered a limited number of parameters, which were not sufficient to fully explain the observed differences. Further studies are required to obtain a more comprehensive understanding of the topic and to include gender-specific aspects into future SSI-prevention strategies. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - June 3, 2019 Category: Infectious Diseases Source Type: research

Effectiveness over time of a multimodal intervention to improve compliance with standard hygiene precautions in an intensive care unit of a large teaching hospital
In this study, we evaluated the ability over time of a multimodal intervention to improve HCWs compliance with standard hygiene precautions.MethodsTrend analysis of direct observations of compliance with HH guidelines and proper glove or gown use was conducted in the medical/surgical intensive care unit (ICU) of Umberto I Teaching Hospital of Sapienza University of Rome. The study consisted of two phases: a six-month baseline phase and a 12-month post-intervention phase. The multimodal intervention was based on the World Health Organization strategy and included education and training of HCWs, together with performance fee...
Source: Antimicrobial Resistance and Infection Control - May 31, 2019 Category: Infectious Diseases Source Type: research

Implementation of a surgical unit-based safety programme in African hospitals: a multicentre qualitative study
ConclusionsParticipating hospitals benefitted from the SUSP programme structures (e.g. surveillance, hospital networks, formation of multidisciplinary teams) and adaptive tools (e.g. learning from defects, executive rounds guide) to change perceptions around patient safety and improve behaviours to prevent SSI. The combination of technical and adaptive elements represents a promising approach to facilitate the introduction of evidence-based best practices and to improve safety culture through local team engagement in resource-limited settings. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 30, 2019 Category: Infectious Diseases Source Type: research

Epidemiology and risk factors of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci infections in Zhejiang China from 2015 to 2017
ConclusionsThe detection rates of MRSA and VRE stayed at moderate and low levels during the three year period of this study, while local dissemination was found in MRSA and VRE isolates. Sustained surveillance is necessary to prevent the spread or clonal dissemination of drug-resistant strains in Zhejiang China. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 30, 2019 Category: Infectious Diseases Source Type: research

Epidemiology, species distribution, antifungal susceptibility and mortality risk factors of candidemia among critically ill patients: a retrospective study from 2011 to 2017 in a teaching hospital in China
ConclusionsCandida albicans was the most frequently isolated fungal species. Most isolates were susceptible to the antifungal agents. The worst GCS score, P/F ratio, and MAP within three days after admission were independent risk factors for mortality due to candidemia in critically ill patients. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 29, 2019 Category: Infectious Diseases Source Type: research

Airborne fungal spores and invasive aspergillosis in hematologic units in a tertiary hospital during construction: a prospective cohort study
ConclusionsAirborne fungal spore levels tended to be higher during the period with heavier construction works involving demolition and excavation, during which the incidence of IA was significantly higher as well. We recommend monitoring airborne fungal spore levels during construction periods in hospitals with immunocompromised patients. Subsequently, the effect of airborne fungal spore level monitoring in reducing hospital-acquired IA should be evaluated. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 29, 2019 Category: Infectious Diseases Source Type: research

Implementation research for the prevention of antimicrobial resistance and healthcare-associated infections; 2017 Geneva infection prevention and control (IPC)-think tank (part 1)
ConclusionsExperts of the 2017 Geneva Think Tank on IPC and AMS, CDC, and WHO agreed that sustained efforts on implementation of IPC and AMS strategies are required at international, country, and hospital management levels, to provide an adequate multimodal framework that addresses (not exclusively) leadership, resources, education and training for implementing IPC and AMS. Future strategies can build on this agreement to make strategies on IPC and AMS more effective. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 28, 2019 Category: Infectious Diseases Source Type: research

Antimicrobial resistance trends in bloodstream infections at a large teaching hospital in China: a 20-year surveillance study (1998-2017)
ConclusionsBSIs caused by CRK. pneumoniae clearly posed a severe challenge to infection control and treatment of ICU and non-ICU patients in this retrospective study, while MRSA was an issue for non-ICU patients. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 28, 2019 Category: Infectious Diseases Source Type: research

Clinical outcomes in patients admitted to a hospitalist service exposed to an antimicrobial stewardship program – a retrospective matched cohort study
ConclusionsIn this retrospective cohort study, patient admissions in which PAF recommendations were accepted had better clinical outcomes than matched historical controls managed in the absence of this AS service. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 24, 2019 Category: Infectious Diseases Source Type: research

Control of Acinetobacter baumannii outbreak in the neonatal intensive care unit in Latvia: whole-genome sequencing powered investigation and closure of the ward
ConclusionThe HAI surveillance system successfully detected and facilitated the control of theA.baumannii outbreak. Whole-genome sequencing was found to be a useful method for differentiation of phenotypically identicalA.baumannii strains from the intrahospital outbreak. Only multi-modal infection control program, including closure, temporary relocation, and renovation of the ward, restricted the outbreak. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 22, 2019 Category: Infectious Diseases Source Type: research

Effectiveness of an edutainment video teaching standard precautions – a randomized controlled evaluation study
AbstractBackgroundStandard precautions are essential to prevent pathogen transmission and nosocomial infections. We assessed learning effect (primary outcome) and satisfaction (secondary outcome) of watching a 5-min humorous “edutainment (=education and entertainment) video” on Standard Precautions compared to reading a written standard operating procedure (SOP) or receiving no intervention.MethodsThis randomized controlled trial was executed at the University Hospital Zurich, Switzerland, a tertiary care centre with a state-of-the-art infection prevention programme. Healthcare providers (HCPs) of different med...
Source: Antimicrobial Resistance and Infection Control - May 22, 2019 Category: Infectious Diseases Source Type: research

Distribution of bla CTX  − M , bla TEM , bla SHV and bla OXA genes in Extended-spectrum- β -lactamase-producing Clinical isolates: A three-year multi-center study from Lahore, Pakistan
ConclusionPrevalence of ESBL-producing isolates has increased 1.13 folds during study years. Isolates had high prevalence of ESBL-encodingblaCTXM  − 15 gene and narrow spectrumblaOXA  − 1 andblaTEM  − 1B were also prevalent. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 22, 2019 Category: Infectious Diseases Source Type: research

Technology for the prevention of antimicrobial resistance and healthcare-associated infections; 2017 Geneva IPC-Think Tank (Part 2)
ConclusionsThe four domains of technological innovation contribute to the prevention of HAI and AMR at different levels. Microbiome research may offer innovative concepts for future prevention, whole genome sequencing could detect new modes of transmission and become an additional tool for effective public health epidemiology, antimicrobial surfaces might help to decrease the environment as source of transmission but continue to raise more questions than answers, and technological innovation may have a role in improving surveillance approaches and supporting best practice in hand hygiene. (Source: Antimicrobial Resistance ...
Source: Antimicrobial Resistance and Infection Control - May 22, 2019 Category: Infectious Diseases Source Type: research

Patterns in the longitudinal oropharyngeal microbiome evolution related to ventilator-associated pneumonia
ConclusionsIn acutely-ill patients who developed enterobacterial VAP the causative pathogen gained access to the oropharynx early after starting mechanical ventilation and outgrew the commensal members of the microbiome. Whether a specific pattern of the oropharyngeal microbiome between days three to five of mechanical ventilation may predict VAP enterobacterial VAP has to be evaluated in further studies. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 22, 2019 Category: Infectious Diseases Source Type: research

“Enhanced acquisition of antibiotic-resistant intestinal E. coli during the first year of life assessed in a prospective cohort study”
ConclusionOne third of healthy Thai neonates harboured antibiotic-resistantE. coli in meconium. The proportion of resistantE. coli increased during the first year of life almost reaching the value in adults. We hypothesize that enhancement of infection control measures and cautious use of antibiotics may help to control further increase of resistance. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 20, 2019 Category: Infectious Diseases Source Type: research

Derivation and validation of a simple score to predict the presence of bacteria requiring carbapenem treatment in ICU-acquired bloodstream infection and pneumonia: CarbaSCORE
ConclusionsThe CarbaSCORE is a simple and efficient score for predicting the presence of bacteria requiring carbapenem treatment. Further studies are needed to test this score before it can be used in practice. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 20, 2019 Category: Infectious Diseases Source Type: research

Lymphocytic choriomeningitis virus meningitis after needlestick injury: a case report
ConclusionsThis is the first case report of a PCR-documented LCMV meningitis, coupled with seroconversion, following needlestick injury. It highlights the importance of infection prevention practices that comprise particularly well established safety precaution protocols in research laboratories handling this pathogenic virus, because exposure to even a small amount of LCMV can lead to a severe, life-threatening infection. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 20, 2019 Category: Infectious Diseases Source Type: research

Antibiotics versus biofilm: an emerging battleground in microbial communities
AbstractBiofilm is a complex structure of microbiome having different bacterial colonies or single type of cells in a group; adhere to the surface. These cells are embedded in extracellular polymeric substances, a matrix which is generally composed of eDNA, proteins and polysaccharides, showed high resistance to antibiotics. It is one of the major causes of infection persistence especially in nosocomial settings through indwelling devices. Quorum sensing plays an important role in regulating the biofilm formation. There are many approaches being used to control infections by suppressing its formation but CRISPR-CAS (gene e...
Source: Antimicrobial Resistance and Infection Control - May 16, 2019 Category: Infectious Diseases Source Type: research

Operating room technician trainees teach medical students - an inter-professional peer teaching approach for infection prevention strategies in the operation room
ConclusionsUndergraduate inter-professional teaching among ORTT and MDS in infection prevention and control proved feasible with high educational quality. Inducing early mutual understanding between professional groups might improve professional collaboration and patient safety. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 14, 2019 Category: Infectious Diseases Source Type: research

Broadening the infection prevention and control network globally; 2017 Geneva IPC-think tank (part 3)
ConclusionsThe working group determined that international organisations should take the lead in creating new networks, which will in turn attract academia and other stakeholders to join. At the same time, they should invest in bringing existing IPC and AMR networks under one umbrella. Transmission of multidrug-resistant microorganisms in hospitals and in the community threatens the success of antimicrobial stewardship programmes, and thus, research and development in IPC should be addressed as an enhanced global priority. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 10, 2019 Category: Infectious Diseases Source Type: research

A national survey on the implementation of key infection prevention and control structures in German hospitals: results from 736 hospitals conducting the WHO Infection Prevention and Control Assessment Framework (IPCAF)
ConclusionsIPC key aspects in general are well established in Germany. Potentials for improvement were identified particularly with regard to workload and staffing. Insufficient implementation of multimodal strategies was found to be another relevant deficit. Our survey represents a successful attempt at promoting the IPCAF and encouraging hospitals to utilize WHO tools for self-assessment. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 8, 2019 Category: Infectious Diseases Source Type: research

Network meta-analysis and pharmacoeconomic evaluation of antibiotics for the treatment of patients infected with complicated skin and soft structure infection and hospital-acquired or ventilator-associated penumonia
ConclusionIn these clinical trials, considering efficacy, safety, and cost-effectivenes, linezolid and tedizolid showed their superiority in MRSA cSSSI; while linezolid might be recommended to treat MRSA pneumonia. Although vancomycin was not cost-effective in pharmacoeconomic evaluation, it is still the first-line treatment for MRSA infection in the clinical practice. This study might provide new insights of therapeutic choices for patients with MRSA infections whilst awaiting the arrival of higher quality evidence. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 6, 2019 Category: Infectious Diseases Source Type: research

Risk factors for surgical site infection after craniotomy: a prospective cohort study
AbstractBackgroundAlthough surgical site infection after craniotomy (SSI-CRAN) is a serious complication, risk factors for its development have not been well defined. We aim to identify the risk factors for developing SSI-CRAN in a large prospective cohort of adult patients undergoing craniotomy.MethodsA series of consecutive patients who underwent craniotomy at a university hospital from January 2013 to December 2015 were prospectively assessed. Demographic, epidemiological, surgical, clinical and microbiological data were collected. Patients were followed up in an active post-discharge surveillance programm e for up to o...
Source: Antimicrobial Resistance and Infection Control - May 2, 2019 Category: Infectious Diseases Source Type: research

Overprescribing antibiotics for asymptomatic bacteriuria in older adults: a case series review of admissions in two UK hospitals
AbstractBackgroundOverdiagnosis and overtreatment of urinary tract infection (UTI) with antibiotics is a concern. In older adults, diagnosis of UTI using near-patient urine tests (reagent strip tests, dipsticks) is advised against because the age-related increase in asymptomatic bacteriuria can cause false-positive results. Instead, UTI diagnosis should be based on a full clinical assessment. Previous research lacks systematic information on urine dipstick use in hospitals. The aim of this study was to examine the use of urine dipstick tests and microbiology among older adult hospital admissions in relation to recommended ...
Source: Antimicrobial Resistance and Infection Control - May 2, 2019 Category: Infectious Diseases Source Type: research

Scrutinizing the drug resistance mechanism of multi- and extensively-drug resistant Mycobacterium tuberculosis: mutations versus efflux pumps
ConclusionsOur results clearly showed that efflux systems, besides spontaneous mutations, play a role in the development of INH/RIF resistance. In addition, although VP was effective in reducing the expression of some efflux pumps, it was not very successful at the phenotypic level. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - May 2, 2019 Category: Infectious Diseases Source Type: research

A retrospective analysis of Pseudomonas aeruginosa bloodstream infections: prevalence, risk factors, and outcome in carbapenem-susceptible and -non-susceptible infections
ConclusionIncreased incidence of CnSPA BSIs was observed during the study period, with higher mortality seen in patients with these infections. Respiratory disease and exposure to carbapenems were independent risk factors for development of CnSPA BSIs. Appropriate definitive therapy reduced mortality rates. BLBLIs were as effective as carbapenems as a treatment for PA BSIs. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - April 25, 2019 Category: Infectious Diseases Source Type: research

Assessment of knowledge and attitude trends towards antimicrobial resistance (AMR) among the community members, pharmacists/pharmacy owners and physicians in district Sialkot, Pakistan
ConclusionOur study will provide effective assessment and potential insights in designing tri-faceted interventions for rationalizing antibiotics consumption thus controlling the development and dissemination of AMR. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - April 24, 2019 Category: Infectious Diseases Source Type: research

In vitro polymyxin activity against clinical multidrug-resistant fungi
Conclusioncolistin could be proposed, in clinical practice, in association with other antifungals, to treat life-threatening fungal infections caused by MDR yeasts or moulds. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - April 24, 2019 Category: Infectious Diseases Source Type: research

The species distribution, antimicrobial resistance and risk factors for poor outcome of coagulase-negative staphylococci bacteraemia in China
ConclusionStaphylococcus hominis andStaphylococcus epidermidis were the most common species in CoNS bacteraemia. All CoNS had high multi-drug resistance, but gentamicin and rifampicin had a relatively lower resistance and could be considered as alternative antibiotics for anti-CoNS bacteraemia in addition to vancomycin and linezolid. Additionally, patients with chronic renal failure or chronic liver failure have a higher 30-day mortality after the onset of CoNS bacteraemia. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - April 24, 2019 Category: Infectious Diseases Source Type: research

“Clean care for all-it’s in your hands”: the May 5th, 2019 World Health Organization SAVE LIVES: Clean Your Hands campaign
(Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - April 17, 2019 Category: Infectious Diseases Source Type: research

The association between adherence to national antibiotic guidelines and mortality, readmission and length of stay in hospital inpatients: results from a Norwegian multicentre, observational cohort study
ConclusionsAdhering to antibiotic guidelines when treating infections in hospital inpatients was associated with favourable patient outcomes in terms of mortality and LOS. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - April 15, 2019 Category: Infectious Diseases Source Type: research

Doxycycline-encapsulated solid lipid nanoparticles as promising tool against Brucella melitensis enclosed in macrophage: a pharmacodynamics study on J774A.1 cell line
ConclusionsSince the DOX-SLN showed better effects onB. melitensis enclosed in macrophages than the free doxycycline, it is recommended to use it for treating brucellosis and preventing relapse. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - April 3, 2019 Category: Infectious Diseases Source Type: research

Shifting trends and age distribution of ESKAPEEc resistance in bloodstream infection, Southwest China, 2012 –2017
ConclusionsOngoing burden of ESKAPEEc in BSIs and increasing trend of imipenem resistance inE. coli andK. pneumoniae call for continued surveillance. Carbapenems are still active against Gram-negative ESKAPEEc, except forA. baumannii and vancomycin or linezolid is still effective against Gram-positive ESKAPEEc. Carbapenem-resistantK. pneumoniae in children and carbapenem-resistantA. baumannii in adults necessitate effective antimicrobial strategies in consideration of age stratification. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - March 29, 2019 Category: Infectious Diseases Source Type: research

Community pharmacy staff ’s response to symptoms of common infections: a pseudo-patient study
ConclusionsIllegal and inappropriate dispensing of antibiotics was evident in the participating community pharmacies. This may be a public health threat to Sri Lanka and beyond. Strategies to improve the appropriate dispensing practice of antibiotics among community pharmacies should be considered seriously. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - March 29, 2019 Category: Infectious Diseases Source Type: research

Molecular characterization of class 1, 2 and 3 integrons in clinical multi-drug resistant Klebsiella pneumoniae isolates
ConclusionsThe finding of present study revealed a high prevalence of integrons especially class 1 among MDRK. pneumoniae isolates from nosocomial infections in Kashan, which led to rapid extension of MDR strains. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - March 29, 2019 Category: Infectious Diseases Source Type: research