Transcriptome-Wide Association Study of Idiopathic Pulmonary Fibrosis Survival Identifies < em > PTPN9 < /em > and < em > SNRPB2 < /em >
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202310-1741LE. Online ahead of print.NO ABSTRACTPMID:38626378 | DOI:10.1164/rccm.202310-1741LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Xiaowei Hu John S Kim Aabida Saferali Yong Huang Shwu-Fan Ma Grace C Bingham Catherine A Bonham Carlos Flores Peter Castaldi Craig P Hersh Michael H Cho Imre Noth Ani Manichaikul IPF Survival GWAS Consortium Source Type: research
Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD
CONCLUSIONS: A novel multi-layer network analysis is able to identify clinically relevant COPD patient communities. Patients with similarly low FEV1 and emphysema can have molecularly distinct small airways and immune response patterns, indicating that different endotypes can lead to similar clinical presentation.PMID:38626356 | DOI:10.1164/rccm.202303-0500OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Nuria Olvera Jon S ánchez-Valle Iker N úñez-Carpintero Joselyn Rojas-Quintero Guillaume Noell Sandra Casas-Recasens Alen Faiz Philip Hansbro Angela Guirao Rosalba Lepore Davide Cirillo Alvar Agust í Francesca Polverino Alfonso Valencia Rosa Faner Source Type: research
Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis
CONCLUSIONS: WFDC2 dysfunction defines a novel molecular etiology of bronchiectasis characterized by the deficiency of a secreted component of the airways. A commercially available blood test combined with genetic testing allows its diagnosis. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38626355 | DOI:10.1164/rccm.202308-1370OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Gerard W Dougherty Lawrence E Ostrowski Tabea N öthe-Menchen Johanna Raidt Andre Schramm Heike Olbrich Weining Yin Patrick R Sears Hong Dang Amanda J Smith Achim G Beule Rim Hjeij Niels Rutjies Eric G Haarman Saskia M Maas Thomas W Ferkol Peadar G Noone Source Type: research
Autoimmunity Against Surfactant Protein B Is Associated with Pneumonitis During Checkpoint Blockade
CONCLUSIONS: Our data suggest that the co-occurrence of surfactant protein-B-specific immunoglobulin G autoantibodies and CD4+ T cells is associated with the development of pneumonitis during ICI therapy. Pre-treatment levels of these antibodies may represent a potential biomarker for elevated risk of developing pneumonitis and on-treatment levels may provide a diagnostic aid.PMID:38626354 | DOI:10.1164/rccm.202311-2136OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Nina Wyss Fiamma Berner Vincent Walter Ann-Kristin Jochum Mette T Purde Marie-Therese Abdou Tobias Sinnberg Kathrin Hofmeister Oltin T Pop Omar Hasan Ali Jens Bauer Hung-Wei Cheng Mechthild L ütge Niklas Kl ümper Stefan Diem Zeynep Kosaloglu-Yalcin Yizh Source Type: research
Plastic Bronchitis Related to Idiopathic Lymphatic Regurgitation
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202307-1246IM. Online ahead of print.NO ABSTRACTPMID:38625076 | DOI:10.1164/rccm.202307-1246IM (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Jiarui He Jun Li Huaping Dai Source Type: research
Quantitative CT in IPF: Is It Time to Act?
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202403-0659ED. Online ahead of print.NO ABSTRACTPMID:38625082 | DOI:10.1164/rccm.202403-0659ED (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Lucio Calandriello Source Type: research
Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome
CONCLUSION: The study findings suggest that portal hypertension-induced loss of BMP-9 signaling contributes to HPS development.PMID:38626313 | DOI:10.1164/rccm.202307-1289OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 16, 2024 Category: Respiratory Medicine Authors: Fabien Robert Marie-Caroline Certain Audrey Baron Rapha ël Thuillet L éa Duhaut Mina Ottaviani Mustapha Kamel Chelgham Corinne Normand Nihel Berrebeh Nicolas Ricard Valerie Furlan Agn ès Desroches-Castan Emmanuel Gonzales Emmanuel Jacquemin Olivier Sit Source Type: research
Robust multishot diffusion-weighted imaging of the abdomen with region-based shot rejection
CONCLUSION: Region-based shot rejection is a linear reconstruction that improves the motion robustness of multi-shot DWI and requires no sequence modifications.PMID:38623901 | DOI:10.1002/mrm.30102 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - April 16, 2024 Category: Radiology Authors: Philip K Lee Xuetong Zhou Brian A Hargreaves Source Type: research
Cytotoxicity, anti-inflammatory effect, and acute oral toxicity of a novel Attalea phalerata kernel oil-loaded nanocapsules
Biomed Pharmacother. 2024 Apr 15;174:116308. doi: 10.1016/j.biopha.2024.116308. Online ahead of print.ABSTRACTThe kernel oil of the Attalea phalerata Mart. Ex Spreng (Acurí) is traditionally used in several Latin American countries to treat respiratory problems, inflammation, and fever. However, it cannot be found on the literature any attend to use this oil in pharmaceutical formulation. In this paper, it was developed Acurí oil-loaded nanocapsules, and it was evaluated the cytotoxicity against cancer cells, the antinflammatory activity and the oral acute toxicity in rats. Acurí oil contains lauric acid as the predomin...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 16, 2024 Category: Drugs & Pharmacology Authors: Bianca Rodrigues Ac ácio Ariadna Lafourcade Prada Serafim Florentino Neto Giovana Bicudo Gomes Renata Trentin Perdomo Carlos Eduardo Domingues Nazario Eduardo Sobieski Neto Marco Ant ónio Utrera Martines Danielle Ayr Tavares de Almeida Arquimedes Gaspar Source Type: research
A new era of targeting cystic fibrosis with non-viral delivery of genomic medicines
Adv Drug Deliv Rev. 2024 Apr 14:115305. doi: 10.1016/j.addr.2024.115305. Online ahead of print.ABSTRACTCystic fibrosis (CF) is a complex genetic respiratory disorder that necessitates innovative gene delivery strategies to address the mutations in the gene. This review delves into the promises and challenges of non-viral gene delivery for CF therapy and explores strategies to overcome these hurdles. Several emerging technologies and nucleic acid cargos for CF gene therapy are discussed. Novel formulation approaches including lipid and polymeric nanoparticles promise enhanced delivery through the CF mucus barrier, augmentin...
Source: Advanced Drug Delivery Reviews - April 16, 2024 Category: Drugs & Pharmacology Authors: Namratha Turuvekere Vittala Murthy Kseniia Vlasova Jonas Renner Antony Jozic Gaurav Sahay Source Type: research
Alleviatory Role of < em > Panax Notoginseng < /em > Saponins in Modulating Inflammation and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease: mechanisms and Implications
This study delves into the therapeutic potential and mechanistic underpinnings of Panax notoginseng Saponins (PNS) in alleviating inflammation and pulmonary vascular remodeling in a COPD rat model. Symmap and ETCM databases provided Panax notoginseng-related target genes, and the CTD and DisGeNET databases provided COPD-related genes. Intersection genes were subjected to protein-protein interaction analysis and pathway enrichment to identify downstream pathways. A COPD rat model was established, with groups receiving varying doses of PNS and a Roxithromycin control. The pathological changes in lung tissue and vasculature w...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 16, 2024 Category: Respiratory Medicine Authors: Yanan Hu Qiuyang Fan Bo Qiao Ou Xu Bijun Lv Niping Han Xiaomei Zhang Source Type: research
Differential changes in expression of inflammatory mRNA and protein after oleic acid-induced acute lung injury
Conclusions: The change of proinflammatory cytokines IFN-γ and IL-6 expression is different comparing mRNA and plasma proteins at oleic acid-induced ARDS compared to baseline. The migration of cells to the lung may be the cause for this discrepancy.PMID:38625585 | DOI:10.1080/01902148.2024.2341099 (Source: Experimental Lung Research)
Source: Experimental Lung Research - April 16, 2024 Category: Respiratory Medicine Authors: Regina Golding Rudolf K Braun Lorenzo Miller Michael Lasarev Timothy A Hacker Allison C Rodgers Ava Staehler Marlowe W Eldridge Awni Al-Subu Source Type: research
Top studies of 2023 relevant to primary care: From the PEER team
CONCLUSION: Research published in 2023 yielded several high-quality articles with topics relevant to primary care, including cardiovascular care, irritable bowel syndrome, care of the elderly, and acne management.PMID:38626998 | DOI:10.46747/cfp.7004245 (Source: Pain Physician)
Source: Pain Physician - April 16, 2024 Category: Anesthesiology Authors: Betsy S Thomas Danielle Perry Samantha S Moe Ricky D Turgeon Jen Potter Émélie Braschi Nicholas Dugr é Jessica E M Kirkwood G Michael Allan Source Type: research
Adult Cancer Patients' Perceptions of Factors That Influence Hospital Admissions
CONCLUSIONS: These findings highlight opportunities for clinical nurse specialists to target these vulnerable patients and provide expert consultation to address potential barriers and gaps in utilization of appropriate supportive services that may reduce unplanned hospital admissions.PMID:38625801 | DOI:10.1097/NUR.0000000000000816 (Source: Pain Physician)
Source: Pain Physician - April 16, 2024 Category: Anesthesiology Authors: Patricia I Geddie Victoria W Loerzel Source Type: research
Novel utilization and quantification of Xsight diaphragm tracking for respiratory motion compensation in Cyberknife Synchrony treatment of liver tumors
CONCLUSION: The diaphragm has the potential to serve as an alternative to gold fiducial markers for detecting liver tumors in close proximity or within it. We also found that we needed to reduce the motion amplitude and train the respiration of the patients during liver radiotherapy, as well as control and evaluate their breathing.PMID:38622894 | DOI:10.1002/acm2.14341 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - April 16, 2024 Category: Physics Authors: Jianping Zhang Lin Wang Chenyu Xie Zhiyu Yang Benhua Xu Xiaobo Li Source Type: research
