Effect of the Mitochondrial Transaminase (GOT2) on Membrane Potential Sensitive Respiration in Mitochondria of Differentiated C2C12 Muscle Cells
Am J Physiol Cell Physiol. 2024 Apr 22. doi: 10.1152/ajpcell.00576.2023. Online ahead of print.ABSTRACTWe previously showed that the transaminase inhibitor, aminooxyacetic acid, reduced respiration energized at complex II (succinate dehydrogenase, SDH) in mitochondria isolated from mouse hindlimb muscle. The effect required a reduction in membrane potential with resultant accumulation of oxaloacetate (OAA), a potent inhibitor of SDH. To specifically assess the effect of the mitochondrial transaminase, glutamic oxaloacetic transaminase (GOT2) on complex II respiration and to determine the effect in intact cells as well as i...
Source: American Journal of Physiology. Cell Physiology - April 22, 2024 Category: Cytology Authors: Ritu Som Brian D Fink Liping Yu William I Sivitz Source Type: research
Effect of the Mitochondrial Transaminase (GOT2) on Membrane Potential Sensitive Respiration in Mitochondria of Differentiated C2C12 Muscle Cells
Am J Physiol Cell Physiol. 2024 Apr 22. doi: 10.1152/ajpcell.00576.2023. Online ahead of print.ABSTRACTWe previously showed that the transaminase inhibitor, aminooxyacetic acid, reduced respiration energized at complex II (succinate dehydrogenase, SDH) in mitochondria isolated from mouse hindlimb muscle. The effect required a reduction in membrane potential with resultant accumulation of oxaloacetate (OAA), a potent inhibitor of SDH. To specifically assess the effect of the mitochondrial transaminase, glutamic oxaloacetic transaminase (GOT2) on complex II respiration and to determine the effect in intact cells as well as i...
Source: Am J Physiol Cell Ph... - April 22, 2024 Category: Cytology Authors: Ritu Som Brian D Fink Liping Yu William I Sivitz Source Type: research
Bronchial Thermoplasty Improves Ventilation Heterogeneity Measured by Functional Respiratory Imaging in Severe Asthma
(Source: Journal of Asthma and Allergy)
Source: Journal of Asthma and Allergy - April 22, 2024 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Lower airway microbiota compositions differ between influenza, COVID-19 and bacteria-related acute respiratory distress syndromes
Acute respiratory distress syndrome (ARDS) is responsible for 400,000 deaths annually worldwide. Few improvements have been made despite five decades of research, partially because ARDS is a highly heterogeneo... (Source: Critical Care)
Source: Critical Care - April 22, 2024 Category: Intensive Care Authors: S ébastien Imbert, Mathilde Revers, Raphaël Enaud, Arthur Orieux, Adrian Camino, Alexandre Massri, Laurent Villeneuve, Cédric Carrié, Laurent Petit, Alexandre Boyer, Patrick Berger, Didier Gruson, Laurence Delhaes and Renaud Prével Tags: Brief Report Source Type: research
A pulmonary artery was embolized in a patient with an occluded pulmonary vein to manage massive hemoptysis
Stenosis and obliteration of the pulmonary vein can be developed by multiple diseases and might cause hemoptysis. Traditional therapy including surgical procedure and conservative treatments might be inappropr... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - April 22, 2024 Category: Respiratory Medicine Authors: Dongping Xia, Wenhao Cao and Yi Hu Tags: Case Report Source Type: research
Lung cancer in older patients with granulomatosis with polyangiitis: a report of three cases
Granulomatosis with polyangiitis (GPA) is characterized by necrotizing granulomatous inflammation with necrotizing vasculitis predominantly affecting small to medium vessels. The survival rates have drasticall... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - April 22, 2024 Category: Respiratory Medicine Authors: Malgorzata Potentas-Policewicz, Malgorzata Szolkowska, Katarzyna Blasinska, Dariusz Gawryluk, Malgorzata Sobiecka and Justyna Fijolek Tags: Case Report Source Type: research
Abnormal expression of LCA and CD43 in SCLC: a rare case report and brief literature review
To present an unusual case of abnormal LCA expression and CD43 in SCLC and to review the reported literature to avoid potential diagnostic pitfalls. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - April 22, 2024 Category: Respiratory Medicine Authors: Zhe Cai, Linwei Zuo, Fangfang Hu, Huiyan You, Xiangtong Lu, Shousheng Liao, Fanrong Liu, Lixiang Li and Wenyong Huang Tags: Case Report Source Type: research
CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus
ConclusionsData from the combined cohort suggest that rilematovir has a small but favorable antiviral effect of indeterminate clinical relevance compared with placebo, as well as a favorable safety profile. Safe and effective therapeutic options for RSV in infants and young children remain an unmet need.Clinical Trial RegistrationEudraCT Number: 2016-003642-93; ClinicalTrials.gov Identifier: NCT03656510. First posted date: 4 September, 2018. (Source: Pediatric Drugs)
Source: Pediatric Drugs - April 22, 2024 Category: Pediatrics Source Type: research
Toupet fundoplication to prevent progression of scleroderma-associated interstitial lung damage: a study protocol
ConclusionsThe expected reduction of reflux burden in SSc patients selected for Toupet fundoplication may improve GERD symptoms/complications, pulmonary function, and quality of life, and may be associated with a reduced risk for lung transplant. (Source: European Surgery)
Source: European Surgery - April 22, 2024 Category: Surgery Source Type: research
Diagnostic utility of capnography in emergency department triage for screening acidemia: a pilot study
ConclusionsCapnography is a quantitative method of screening acidemia in patients and can be implemented feasibly in Emergency Department triage as an adjunct to vital signs. While it was shown to have only modest ability to predict acidemia, triage capnography has wide generalizability to screen other life-threatening disease processes such as sepsis or can serve as an early indicator of clinical deterioration. (Source: International Journal of Emergency Medicine)
Source: International Journal of Emergency Medicine - April 22, 2024 Category: Emergency Medicine Source Type: research
Educational video demonstrating collapsibility of the upper airway during sleep improves initial acceptance of CPAP in patients with severe obstructive sleep apnea: a retrospective study
Journal of Clinical Sleep Medicine, Ahead of Print. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - April 22, 2024 Category: Sleep Medicine Authors: Charikleia Tselepi
Georgios Tsirves
Konstantinos Exarhos
Christos Chronis
Christos Kyriakopoulos
Konstantinos Tatsis
Konstantinos Kostikas
Athanasios Konstantinidis
1Sleep Disorders Unit, Department of Respiratory Medicine, University Hospital of Ioannina Source Type: research
Evaluating the impact of automatic positive airway pressure therapy on cardiovascular risk index and vascular behavior in patients with obstructive sleep apnea: a study on heterogeneity in the therapeutic response
Journal of Clinical Sleep Medicine, Ahead of Print. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - April 22, 2024 Category: Sleep Medicine Authors: Wenjun Zhu
Lin Xiang
Linna Cao
Yaping Tian
Wenjun Li
Lirong He
1Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China
2Department of Respiratory and Sleep Medicine, Peking University P Source Type: research
Estimating the incidence of COVID-19, influenza and respiratory syncytial virus infection in three regions of Queensland, Australia, winter 2022: findings from a novel longitudinal testing-based sentinel surveillance programme
Conclusion
This testing-based surveillance programme could estimate disease trends and be a useful tool in settings where testing is less common or accessible. Difficulties with recruitment meant the study was underpowered. The frontline sentinel nature of workplaces meant participants were not representative of the general population but were high-risk groups providing early warning of disease. (Source: BMJ Open)
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: May, F., Ginige, S., Firman, E., Li, Y. S., Soonarane, Y. K., Smoll, N., Hunter, I., Pery, B., Macfarlane, B., Bladen, T., Allen, T., Green, T., Walker, J., Slinko, V., Stickley, M., Khandaker, G., Anuradha, S., Wattiaux, A. Tags: Open access, Public health, COVID-19 Source Type: research
Carrageenan maintains the contractile phenotype of vascular smooth muscle cells by increasing macromolecular crowding in vitro
ConclusionsThe in vitro study showed that VSMCs can maintain the contractile phenotype by sensing changes in the crowding of the culture environment, which can be maintained by adding CR.Graphical Abstract (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 22, 2024 Category: Research Source Type: research
Comparison between high-flow nasal oxygen (HFNO) alternated with non-invasive ventilation (NIV) and HFNO and NIV alone in patients with COVID-19: a retrospective cohort study
ConclusionsIn patients with COVID-19, NIV alternating with HFNO was associated with a higher rate of IMV independent of the presence of comorbidities, chest CT score and SpO2/FiO2.Trial registration ClinicalTrials.gov identifier: NCT05579080. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 22, 2024 Category: Research Source Type: research
