A mouse model of progressive lung fibrosis with cutaneous involvement induced by a combination of oropharyngeal and osmotic minipump bleomycin delivery
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00408.2023. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) with interstitial lung disease (SSc-ILD) lacks curative pharmacological treatments, thus necessitating effective animal models for candidate drug discovery. Existing Bleomycin (BLM)-induced SSc-ILD mouse models feature spatially limited pulmonary fibrosis, spontaneously resolving after 28 days. Here, we present an alternative BLM administration approach in female C57BL/6 mice, combining oropharyngeal aspiration (OA) and subcutaneous mini-pump delivery (pump) of BLM to induce a sustained a...
Source: Am J Physiol Lung Ce... - April 23, 2024 Category: Respiratory Medicine Authors: Andrea Grandi Erica Ferrini Matteo Zoboli Davide Buseghin Francesca Pennati Zahra Khalajzeyqami Roberta Ciccimarra Gino Villetti Franco Fabio Stellari Source Type: research
Hypoxic perfusion of pulmonary arterial vasa vasorum increases pulmonary arterial pressure
In conclusion, the results of the current study prove that hypoxic perfusion of the vasa vasorum of the PA directly increases PAP in an ex situ lung perfusion setup suggesting that PA vasa vasorum function and wall ischemia may contribute to the development of PH.PMID:38651234 | DOI:10.1152/ajplung.00346.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 23, 2024 Category: Respiratory Medicine Authors: Emma L Heise Jawad Salman Karolin S Webs Klaus H öffler Christina Brandenberger Dietmar B öthig Christian M ühlfeld Axel Haverich Source Type: research
A Novel DNase Assay Reveals Low DNase Activity in Severe Asthma
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 23. doi: 10.1152/ajplung.00081.2024. Online ahead of print.ABSTRACTSecreted deoxyribonucleases (DNases), such as DNase-1 and DNase-IL3, degrade extracellular DNA, and endogenous DNases have roles in resolving airway inflammation and guarding against autoimmune responses to nucleotides. Subsets of patients with asthma have high airway DNA levels, but information about DNase activity in health and in asthma is lacking. To characterize DNase activity in health and in asthma, we developed a novel kinetic assay using a Taqman probe sequence that is quickly cleaved by DNase-I to produ...
Source: Am J Physiol Lung Ce... - April 23, 2024 Category: Respiratory Medicine Authors: Annabelle R Charbit Maude A Liegeois Wilfred W Raymond Suzy A A Comhair Mats W Johansson Annette T Hastie Eugene R Bleecker Merritt Fajt Mario Castro Kaharu Sumino Serpil C Erzurum Elliot Israel Nizar N Jarjour David T Mauger Wendy C Moore Sally E Wenzel Source Type: research
Characterization of Ceftriaxone-Resistant < em > Haemophilus influenzae < /em > Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | DOI:10.3346/jkms.2024.39.e136 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 23, 2024 Category: General Medicine Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research
Real-time imaging of decompression gas bubble growth in the spinal cord of live rats
CONCLUSION: We have shown the direct observation of decompression gas bubble formation in real time by MRI in live, anesthetized rats.PMID:38651172 | DOI:10.1002/mrm.30128 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - April 23, 2024 Category: Radiology Authors: Roman Alvarado Ulrich M Scheven Jens-Christian Meiners Source Type: research
Human Airway and Alveolar Organoids from Bronchoalveolar Lavage Fluid
Am J Respir Crit Care Med. 2024 Apr 23. doi: 10.1164/rccm.202310-1831LE. Online ahead of print.NO ABSTRACTPMID:38652140 | DOI:10.1164/rccm.202310-1831LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 23, 2024 Category: Respiratory Medicine Authors: Monica Yun Liu Belinda Chen Mehdi Borji Carolina Garcia de Alba Rivas Antonella F M Dost Aaron L Moye Nusrath Movval Abdulla Margherita Paschini Stuart D Rollins Ruobing Wang Lynn M Schnapp Hassan A Khalil Catherine J Wu Nirmal S Sharma Carla F Kim Source Type: research
Risk factors of in-hospital mortality and discriminating capacity of NIVO score in exacerbations of COPD requiring noninvasive ventilation
CONCLUSION: Our findings identified predictors of mortality in patients with AECOPD receiving NIV, providing useful information to identify severe patients and guide the management of AECOPD. The NIVO score showed an acceptable predictive value for AECOPD receiving NIV in Chinese patients, and additional studies are needed to develop and validate predictive scores based on specific populations.PMID:38652928 | PMC:PMC11041537 | DOI:10.1177/14799731241249474 (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - April 23, 2024 Category: Respiratory Medicine Authors: Jiarui Zhang Qun Yi Chen Zhou Yuanming Luo Hailong Wei Huiqing Ge Huiguo Liu Jianchu Zhang Xianhua Li Xiufang Xie Pinhua Pan Mengqiu Yi Lina Cheng Hui Zhou Liang Liu Adila Aili Yu Liu Lige Peng Jiaqi Pu Haixia Zhou MAGNET AECOPD Registry Investigators Source Type: research
ISGylation by HERCs facilitates STING activation
Cell Rep. 2024 Apr 21;43(5):114135. doi: 10.1016/j.celrep.2024.114135. Online ahead of print.ABSTRACTOptimal activation of stimulator of interferon genes (STING) protein is crucial for host defenses against pathogens and avoiding detrimental effects. Various post-translational modifications control STING activity. However, the function of interferon (IFN)-stimulated gene (ISG) 15 modification (ISGylation) in controlling STING stability and activation is unclear. Here, we show that the E3 ISGylation ligases HECT domain- and RCC1-like domain-containing proteins (HERCs; HERC5 in humans and HERC6 in mice) facilitate STING acti...
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Ying Qin Min Wang Xintong Meng Mengge Wang Haojia Jiang Yanjie Gao Jingxin Li Chunyuan Zhao Chaofeng Han Wei Zhao Xuexing Zheng Source Type: research
Case Report: Obstetric and COVID-19-Related Morbidity and Mortality in Three Patients with Sickle Hemoglobinopathy
We describe the maternal and neonatal outcomes of three patients with COVID-19 and SCD (including two with hemoglobin SC disease and one with hemoglobin SS disease), with complications including the demise of a mother and a newborn. Vaso-occlusive crisis was the more common presentation. Two patients required ventilatory support. Although previous reports have shown similar clinical sequelae in pregnant and nonpregnant patients with SCD and COVID-19, maternal and neonatal deaths remain possible.PMID:38653217 | DOI:10.4269/ajtmh.23-0761 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - April 23, 2024 Category: Infectious Diseases Authors: Shanea Gibson Tiffany Hunter Nadine Johnson Source Type: research
Adverse events in biologics for severe asthma
CONCLUSION: Biologics for severe asthma are recent drugs with a favorable safety profile, but with little real-life experience, justifying increased vigilance by prescribing physicians.PMID:38653607 | DOI:10.1016/j.rmr.2024.04.001 (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - April 23, 2024 Category: Respiratory Medicine Authors: G Dargentolle M Georges G Beltramo C Poisson P Bonniaud Source Type: research
Buprenorphine Affects the Initiation and Severity of Interleukin Induced Acute Pancreatitis in Mice
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 23. doi: 10.1152/ajpgi.00083.2024. Online ahead of print.ABSTRACTAcute pancreatitis (AP) is a common disease with no targeted therapy and has varied outcomes ranging from spontaneous resolution to being lethal. While typically painful, AP can also be painless. Various agents, including opioids are used for pain control in AP; the risks, and benefits of which are often debated. Since experimental AP in mice is used to study the efficacy of potential therapies, we studied the effect of a commonly used opioid buprenorphine on the initiation and progression of AP. For this we a...
Source: Am J Physiol Gastroi... - April 23, 2024 Category: Gastroenterology Authors: Sarah Jahangir Biswajit Khatua Nabil Smichi Prasad Rajalingamgari Anoop Narayana Pillai Megan J Summers Bryce McFayden Sergiy Kostenko Naomi M Gades Vijay P Singh Source Type: research
The influenza landscape and vaccination coverage in older adults during the SARS-Cov-2 pandemic: data from Several European Countries and Israel
Expert Rev Respir Med. 2024 Apr 23. doi: 10.1080/17476348.2024.2340470. Online ahead of print.ABSTRACTINTRODUCTION: The Raise Awareness of Influenza Strategies in Europe (RAISE) group gathered information about the healthcare burden of influenza (hospitalizations, intensive care unit [ICU] admissions, and excess deaths), surveillance systems, and the vaccine coverage rate (VCR) in older adults in 18 European countries and Israel.AREAS COVERED: Published medical literature and official medical documentation on the influenza disease burden in the participating countries were reviewed from 2010/11 until the 2022/23 influenza ...
Source: Expert Review of Respiratory Medicine - April 23, 2024 Category: Respiratory Medicine Authors: George Kassianos Jean-Marie Cohen Rok Civljak Nadav Davidovitch Oana Falup Pecurariu Filipe Froes Andrei Galev Inga Ivaskeviciene Kadri K õivumägi Zuzana Kristufkova Ernest Kuchar Jan Kyncl Helena C Maltezou Milo š Marković Aneta Nitsch-Osuch Raul Ort Source Type: research
An Unwanted but Long-Known Company: Post-Viral Symptoms in the Context of Past Pandemics in Switzerland (and Beyond)
Conclusion: In the next pandemic, it should not be surprising that post-viral conditions will again play a role, and pandemic plans should reflect this.PMID:38651133 | PMC:PMC11033310 | DOI:10.3389/phrs.2024.1606966 (Source: Public Health Reviews)
Source: Public Health Reviews - April 23, 2024 Category: International Medicine & Public Health Authors: Kaspar Staub Tala Ballouz Milo Puhan Source Type: research
RIP1 kinase inactivation protects against LPS-induced acute respiratory distress syndrome in mice
This study enhances our understanding of the therapeutic potential of RIPK1 kinase modulation in ARDS, providing insights for the pathogenesis of ARDS.PMID:38652970 | DOI:10.1016/j.intimp.2024.112060 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Emmauel Mago Xunan Zhao Weigao Zhang Qianchao Shao Peiqi Li Shuxian Huang Xinyu Ding Hu Liu Tingzhe Sun Fei He Dan Weng Source Type: research
The immunostimulatory roles of gold nanoparticles in immunization and vaccination against Brucella abortus antigens
Int Immunopharmacol. 2024 Apr 22;133:112121. doi: 10.1016/j.intimp.2024.112121. Online ahead of print.ABSTRACTOne effective antigen carrier proposed for use in immunization and vaccination is gold nanoparticles. Prior work has shown that gold nanoparticles themselves have adjuvant properties. Currently, gold nanoparticles are used to design new diagnostic tests and vaccines against viral, bacterial, and parasitic infections. We investigated the use of gold nanoparticles as immunomodulators in immunization and vaccination with an antigen isolated from Brucella abortus. Gold nanoparticles with a diameter of 15 nm were synthe...
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Sergey A Staroverov Roman D Vyrshchikov Vladimir A Bogatyrev Lev A Dykman Source Type: research
