Acute exacerbations of chronic respiratory disease: Progress and opportunities.
PMID: 32195599 [PubMed - as supplied by publisher] (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - January 1, 2020 Category: Respiratory Medicine Authors: Osadnik CR Tags: Chron Respir Dis Source Type: research

Physical exercise during acute exacerbations of chronic obstructive pulmonary disease: Australian physiotherapy practice.
This study evaluated Australian physiotherapy practice and clinical perspectives regarding exercise and physical activity for patients with AECOPD. A national survey of 123 Australian public hospitals was conducted from 2016 to 2017 using a purpose-designed survey measuring self-reported physical exercise prescription, objective measure use, referral patterns and factors influencing service delivery. The response rate was 72% (88 hospitals; 176 physiotherapists). Most physiotherapists (92%) prescribed physical exercise frequently for patients with AECOPD and perceived their role to be important (81%). The most commonly pre...
Source: Chronic Respiratory Disease - January 1, 2020 Category: Respiratory Medicine Authors: DeGaris JS, Osadnik CR Tags: Chron Respir Dis Source Type: research

Monocyte count and the risk for acute exacerbation of fibrosing interstitial lung disease: A retrospective cohort study.
Abstract Recent studies have suggested that an increased peripheral monocyte count predicts a poor outcome in fibrosing interstitial lung disease (ILD). However, the association between an increased monocyte count and acute exacerbations (AEs) of fibrosing ILD remains to be elucidated. Our retrospective cohort study aimed to assess the impact of peripheral monocyte count on AEs of fibrosing ILD. We analyzed the electronic medical records of 122 consecutive patients with fibrosing ILD and no prior history of an AE, who were treated with anti-fibrotic agents from August 2015 to December 2018. We determined their per...
Source: Chronic Respiratory Disease - January 1, 2020 Category: Respiratory Medicine Authors: Kawamura K, Ichikado K, Anan K, Yasuda Y, Sekido Y, Suga M, Ichiyasu H, Sakagami T Tags: Chron Respir Dis Source Type: research

Nutritional supplementation during pulmonary rehabilitation in COPD: Do not expect an elixir of life but keep the hunger for more robust evidence.
PMID: 32090606 [PubMed - in process] (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - January 1, 2020 Category: Respiratory Medicine Authors: van den Borst B Tags: Chron Respir Dis Source Type: research

Nutritional supplementation during pulmonary rehabilitation in COPD: A systematic review.
The objective was to report and summarise the current evidence supporting the use of nutritional supplementation to improve outcomes during PR in stable COPD patients. A systematic search was conducted up to 7 August 2019 (registration number CRD42018089142). The preferred reporting items for systematic reviews and meta-analyses guidelines were used. Six databases were included: Medical Literature Analysis and Retrieval System Online or MEDLARS Online, Allied and Complementary Medicine Database, the Cochrane Database of Systematic Reviews, Excerpta Medica dataBASE, Cumulative Index of Nursing and Allied Health Literature a...
Source: Chronic Respiratory Disease - January 1, 2020 Category: Respiratory Medicine Authors: Aldhahir AM, Rajeh AMA, Aldabayan YS, Drammeh S, Subbu V, Alqahtani JS, Hurst JR, Mandal S Tags: Chron Respir Dis Source Type: research

Use of 3-D navigation to target the site of autologous blood installation for lung volume reduction in bullous emphysema.
We present the use of three-dimensional navigation to instill autologous blood into emphysematous bullae for BLVR. A 62-year-old man presented with increasing dyspnea, due to emphysema with a conglomerate of giant bullae with two particularly large bullae. Surgical treatment was refused, so bronchoscopic autologous blood instillation into the bronchial segment leading to the large bullae was attempted, but was unsuccessful; blood failed to penetrate into the bullous cavity. Dyspnea worsened over the following year. We therefore performed another bronchoscopy and punctured a large bulla with a needle and created a tunnel fr...
Source: Chronic Respiratory Disease - January 1, 2020 Category: Respiratory Medicine Authors: Hetzel J, Boeckeler M, Lewis RA, Horger M, Haentschel M Tags: Chron Respir Dis Source Type: research

Reviewer's List.
Authors: PMID: 32031419 [PubMed - in process] (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - January 1, 2020 Category: Respiratory Medicine Tags: Chron Respir Dis Source Type: research

Device use errors with soft mist inhalers: A global systematic literature review and meta-analysis.
Abstract Inhaled bronchodilators are the cornerstone of treatment for chronic obstructive pulmonary disease (COPD). Soft mist inhalers (SMIs) are devices that deliver bronchodilators. Although correct device use is paramount to successful medication delivery, patient errors are common. This global systematic literature review and meta-analysis examined device use errors with SMIs among patients with obstructive lung diseases. PubMed, EMBASE, PsycINFO, Cochrane, and Google Scholar were searched to identify studies published between 2010 and 2019 that met the following inclusion criteria: (a) English language; (b) a...
Source: Chronic Respiratory Disease - January 1, 2020 Category: Respiratory Medicine Authors: Navaie M, Dembek C, Cho-Reyes S, Yeh K, Celli BR Tags: Chron Respir Dis Source Type: research

Hospitalization rates among patients with cystic fibrosis using pancreatic enzyme replacement therapy.
Abstract We investigated the relationship between self-reported adherence to pancreatic enzyme replacement therapy (PERT), nutritional status, and all-cause hospitalization in cystic fibrosis (CF) patients with a record of PERT use. Association of self-reported annual PERT use rate (adherence) with annual hospital admission rate (HAR) and annual total hospital nights (THNs) were analyzed for 5301 children (2000-2012) and 13,989 adults (2000-2013) from the CF Foundation Patient Registry. Multivariate linear regression was used to determine the association of HAR and THN with mean annual PERT use rate, cumulative PE...
Source: Chronic Respiratory Disease - January 1, 2020 Category: Respiratory Medicine Authors: Trapnell BC, Chen S, Khurmi R, Bodhani A, Kapoor M, Haupt M Tags: Chron Respir Dis Source Type: research

Models of care across the continuum of exacerbations for patients with chronic obstructive pulmonary disease.
Abstract Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with significant morbidity and mortality, and treatments require a multidisciplinary approach to address patient needs. This review considers different models of care across the continuum of exacerbations (1) chronic care and self-management interventions with the action plan, (2) domiciliary care for severe exacerbation and the impact on readmission prevention and (3) the discharge care bundle for management beyond the acute exacerbation episode. Self-management strategies include written action plans and coaching with patient a...
Source: Chronic Respiratory Disease - January 1, 2020 Category: Respiratory Medicine Authors: Bourbeau J, Echevarria C Tags: Chron Respir Dis Source Type: research

Interventional lifestyle and self-management trials: A double-edged sword. Is it time to mandate formal data and safety monitoring?
PMID: 31903772 [PubMed - in process] (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - January 1, 2020 Category: Respiratory Medicine Authors: Greening NJ, Ward TJ Tags: Chron Respir Dis Source Type: research

Pragmatic randomised controlled trial of a personalised intervention for carers of people requiring home oxygen therapy.
Abstract We used a pragmatic randomised controlled trial to evaluate a behavioural change strategy targeting carers of chronically hypoxaemic patients using long-term home oxygen therapy. Intervention group carers participated in personalised educational sessions focusing on motivating carers to take actions to assist patients. All patients received usual care. Effectiveness was measured through a composite event of patient survival to hospitalisation, residential care admission or death to 12 months. Secondary outcomes at baseline, 3, 6 and 12 months included carer and patient emotional and physical well-being. N...
Source: Chronic Respiratory Disease - January 1, 2020 Category: Respiratory Medicine Authors: Frith P, Sladek R, Woodman R, Effing T, Bradley S, van Asten S, Jones T, Hnin K, Luszcz M, Cafarella P, Eckermann S, Rowett D, Phillips PA Tags: Chron Respir Dis Source Type: research

Why do people with chronic obstructive pulmonary disease repeat pulmonary rehabilitation? Perspectives of patients and health professionals.
In conclusion, patients with COPD reported many symptomatic benefits from repeating pulmonary rehabilitation and gained confidence from a supervised program. There was no agreement between health professionals regarding the optimal time to repeat pulmonary rehabilitation. PMID: 30789015 [PubMed - in process] (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - January 1, 2019 Category: Respiratory Medicine Authors: Storey S, Erbas B, Holland AE Tags: Chron Respir Dis Source Type: research

Inter-day test-retest reliability and feasibility of isokinetic, isometric, and isotonic measurements to assess quadriceps endurance in people with chronic obstructive pulmonary disease: A multicenter study.
In conclusion, isokinetic, isometric, and isotonic measurements of quadriceps endurance were feasible to a similar extent and presented low-to-very high relative reliability. Absolute reliability seems to favor isokinetic total work measurements. PMID: 30789016 [PubMed - in process] (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - January 1, 2019 Category: Respiratory Medicine Authors: Frykholm E, Géphine S, Saey D, van Hees H, Lemson A, Klijn P, Maltais F, Nyberg A Tags: Chron Respir Dis Source Type: research

Physical activity in COPD: Minimal clinically important difference for medical events.
The objective is to provide an anchor-based estimate of the MCID for daily step count. PA was promoted in persons with COPD using a pedometer (Omron HJ-720ITC) alone or a pedometer plus interactive website for 3 months. Participants wore the pedometer daily and received phone calls monthly to ascertain medical events. Medical events were counted when a participant self-reported that he/she had (1) worsening of breathing, (2) change to breathing medications, (3) medical care from an emergency room for any reason, or (4) hospitalization for any reason. Generalized linear regression models assessed daily step count as change ...
Source: Chronic Respiratory Disease - January 1, 2019 Category: Respiratory Medicine Authors: Teylan M, Kantorowski A, Homsy D, Kadri R, Richardson C, Moy M Tags: Chron Respir Dis Source Type: research

Correct use and ease of use of a placebo dry powder inhaler in subjects with asthma and chronic obstructive pulmonary disease.
Abstract Correct use and ease of use of a placebo dry powder inhaler was evaluated in two single-arm, United States-multicenter, phase-IV studies in adults with asthma ( n = 259) or chronic obstructive pulmonary disease (COPD; n = 278) who were receiving maintenance inhaler therapy. Subjects demonstrating correct placebo inhaler use within three attempts at screening were instructed to take once-daily inhalations from the inhaler for 28 ± 2 days (continuing usual maintenance), followed by randomization to complete one of two versions of an ease-of-use questionnaire and reassessment for correct inhaler use. ...
Source: Chronic Respiratory Disease - January 1, 2019 Category: Respiratory Medicine Authors: Feldman GJ, Galkin DV, Patel P, Collison KA, Sharma R Tags: Chron Respir Dis Source Type: research

Balance assessment in people with COPD: An evidence-based guide.
Abstract Balance problems and an increased rate and risk of falls are common in people with chronic obstructive pulmonary disease (COPD). Although a balance assessment is now recommended by clinical practice guidelines for pulmonary rehabilitation, specific tests have yet to be suggested. The purpose of this review is to provide an evidence-based synthesis of balance measurement in older adults and in people with COPD, to guide practice in this area. An overview of best practices for assessing balance and fall risk in older adults is provided along with a practical synthesis of evidence to date on common balance m...
Source: Chronic Respiratory Disease - January 1, 2019 Category: Respiratory Medicine Authors: Beauchamp MK Tags: Chron Respir Dis Source Type: research

Functional status measures for the COPD patient: A practical categorization.
The objective of this study is to review available functional status measures (FSMs) validated for use in the chronic obstructive pulmonary disease (COPD) population and categorizing the measures by their commonalities to formulate a framework that supports clinicians in the selection and application of FSMs. A literature review identifying valid and reliable measures of functional status for people with COPD was undertaken. Measures were thematically analyzed and categorized to develop a framework for clinical application. A variety of measures of activity levels exist, with 35 included in this review. Thematic categoriza...
Source: Chronic Respiratory Disease - January 1, 2019 Category: Respiratory Medicine Authors: Lareau SC, Blackstock FC Tags: Chron Respir Dis Source Type: research

How health literacy and patient activation play their own unique role in self-management of chronic obstructive pulmonary disease (COPD)?
This article describes how HL, PA and their determinants intersect and diverge and how these concepts might inform the development of self-management interventions. The concepts of HL and PA contribute to self-management interventions in different ways. HL includes the skills and confidence required for self-management while PA focuses more on motivation and ability to take action. In this light, communication of concepts on HL and PA needs to be more widely understood by academics, researchers and policy experts as each of them plays a unique role in promoting self-management for long-term conditions such as chronic obstr...
Source: Chronic Respiratory Disease - January 1, 2019 Category: Respiratory Medicine Authors: Yadav UN, Hosseinzadeh H, Lloyd J, Harris MF Tags: Chron Respir Dis Source Type: research

Recommendations for services for people living with chronic breathlessness in advanced disease: Results of a transparent expert consultation.
Abstract Chronic breathlessness is highly distressing for people with advanced disease and their informal carers, yet health services for this group remain highly heterogeneous. We aimed to generate evidence-based stakeholder-endorsed recommendations for practice, policy and research concerning services for people with advanced disease and chronic breathlessness. We used transparent expert consultation, comprising modified nominal group technique during a stakeholder workshop, and an online consensus survey. Stakeholders, representing multiple specialities and professions, and patient/carers were invited to partic...
Source: Chronic Respiratory Disease - January 1, 2019 Category: Respiratory Medicine Authors: Brighton LJ, Tunnard I, Farquhar M, Booth S, Miller S, Yi D, Gao W, Bajwah S, Man WD, Reilly CC, Ogden M, Bailey S, Ewart C, Higginson IJ, Maddocks M Tags: Chron Respir Dis Source Type: research

Effectiveness of early rehabilitation on patients with chronic obstructive lung disease and acute respiratory failure in intensive care units: A case-control study.
We examined the effect of early rehabilitation on the outcomes of COPD patients requiring mechanical ventilation (MV) in the ICU. This retrospective, observational, case-control study was conducted in a medical center with a 19-bed ICU. The records of all 105 ICU patients with COPD and ARF who required MV from January to December 2011 were examined. The outcomes (MV duration, rates of successful weaning and survival, lengths of ICU and hospital stays, and medical costs) were recorded and analyzed. During the study period, 35 patients with COPD underwent early rehabilitation in the ICU and 70 demographically and clinically ...
Source: Chronic Respiratory Disease - January 1, 2019 Category: Respiratory Medicine Authors: Chou W, Lai CC, Cheng KC, Yuan KS, Chen CM, Cheng AC Tags: Chron Respir Dis Source Type: research

Unravelling the mystery of the 'minimum important difference' using practical outcome measures in chronic respiratory disease.
We describe the various ways in which an MID can be calculated via anchor- and distribution-based methods, looking at practical examples and considering the importance of understanding how an MID was derived when seeking to apply it to a particular situation. The terms MID and MCID are challenging and often used interchangeably. However, we propose all MIDs are described as such, but they could be qualified by a suffix: MIDS (MID - Statistical), MID-C (MID - Clinical outcome), MID-P (MID - Patient determined). However, this type of classification would only work if accepted and adopted. In the meantime, we advise clinician...
Source: Chronic Respiratory Disease - January 1, 2019 Category: Respiratory Medicine Authors: Houchen-Wolloff L, Evans RA Tags: Chron Respir Dis Source Type: research

Clinical outcomes of theophylline use as add-on therapy in patients with chronic obstructive pulmonary disease: A propensity score matching analysis.
Abstract To examine clinical outcomes of theophylline use in patients with chronic obstructive pulmonary disease (COPD) receiving inhaled corticosteroids (ICS) and long-acting beta-2 agonists (LABA). Electronic data from five hospitals located in Northern Thailand between January 2011 and December 2015 were retrospectively collected. Propensity score (PS) matching (2:1 ratio) technique was used to minimize confounding factors. The primary outcome was overall exacerbations. Secondary outcomes were exacerbation not leading to hospital admission, hospitalization for exacerbation, hospitalization for pneumonia, and al...
Source: Chronic Respiratory Disease - December 20, 2018 Category: Respiratory Medicine Authors: Wilairat P, Kengkla K, Thayawiwat C, Phlaisaithong P, Somboonmee S, Saokaew S Tags: Chron Respir Dis Source Type: research

Low income as a determinant of exercise capacity in COPD.
Abstract Exercise capacity (EC) is a critical outcome in chronic obstructive lung disease (chronic obstructive pulmonary disease (COPD)). It measures the impact of the disease and the effect of specific interventions like pulmonary rehabilitation (PR). EC determines COPD prognosis and is associated with health-care utilization and quality of life. Field walking tests and cardiopulmonary exercise test (CPET) are two ways to measure EC. The 6-minute walking test (6MWT) is the commonest and easiest field test. CPET has the advantage of assessing maximal aerobic capacity. Determinants of EC include age, gender, breath...
Source: Chronic Respiratory Disease - November 21, 2018 Category: Respiratory Medicine Authors: Porta AS, Lam N, Novotny P, Benzo R, NETT Research Group Tags: Chron Respir Dis Source Type: research

Early readmission and mortality in acute exacerbation of chronic obstructive pulmonary disease with community-acquired pneumonia.
Abstract Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are important causes of hospital admission and mortality. Pneumonia is a major contributor to hospitalization for AECOPD and has a close relationship with poor outcomes. We performed a prospective cohort study to evaluate the prognosis of AECOPD patients with or without community-acquired pneumonia (CAP) who hospitalized from January 2012 to December 2015. We investigated mortality and readmission rates within 6 months after the first admission between two groups and analyzed the difference of survival rate according to readmission dura...
Source: Chronic Respiratory Disease - November 17, 2018 Category: Respiratory Medicine Authors: Shin B, Kim SH, Yong SJ, Lee WY, Park S, Lee SJ, Lee SJ, Lee MK Tags: Chron Respir Dis Source Type: research

The effect of comorbidity severity on pulmonary rehabilitation outcomes in chronic obstructive pulmonary disease patients.
uml;oğlu B Abstract CLINICAL TRIAL NUMBER:: NCT03319108. PMID: 30428708 [PubMed - in process] (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - November 17, 2018 Category: Respiratory Medicine Authors: Naz I, Sahin H, Varol Y, Kömürcüoğlu B Tags: Chron Respir Dis Source Type: research

Pain in patients with chronic obstructive pulmonary disease indicated for post-acute pulmonary rehabilitation.
Abstract Pain is a significant problem in stable chronic obstructive pulmonary disease (COPD) and is associated with other symptoms, worse health status and lower functional status. Not much is known about pain in unstable disease. The primary aim of the present study is to investigate prevalence, characteristics and relationships of pain in patients with COPD hospitalized for an acute exacerbation (AECOPD) and indicated for post-acute pulmonary rehabilitation (PR). This cross-sectional observational study included 149 patients (mean age 70.8 (±7.9) years, 49% male, mean forced expiratory volume in one seco...
Source: Chronic Respiratory Disease - November 17, 2018 Category: Respiratory Medicine Authors: van Dam van Isselt EF, Groenewegen-Sipkema KH, van Eijk M, Chavannes NH, Achterberg WP Tags: Chron Respir Dis Source Type: research

Cluster analysis identifying patients with COPD at high risk of 2-year all-cause mortality.
The objective of the article is to identify clusters of patients with COPD according to factors known to be associated with mortality and to verify whether clusters' assignment is associated with 2-year mortality. Patients ( n = 141) were evaluated by bioelectrical impedance, maximal inspiratory pressure (MIP), one-repetition maximum test of the quadriceps femoris (1RMQF) and BODE index (body mass index; airflow obstruction (spirometry); dyspnea (modified Medical Research Council scale); and exercise capacity (6-minute walk test (6MWT) distance). Vital status was retrospectively checked 2 years after the assessments, and t...
Source: Chronic Respiratory Disease - November 17, 2018 Category: Respiratory Medicine Authors: Rodrigues A, Camillo CA, Furlanetto KC, Paes T, Morita AA, Spositon T, Donaria L, Ribeiro M, Probst VS, Hernandes NA, Pitta F Tags: Chron Respir Dis Source Type: research

Differences in clinical features of acute exacerbation between connective tissue disease-associated interstitial pneumonia and idiopathic pulmonary fibrosis.
Abstract Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a devastating condition that frequently occurs in the advanced stage of IPF. However, the clinical features in AE of connective tissue disease-associated interstitial pneumonia (AE-CTD-IP) have not been well-established. The aim of this study was to clarify the clinical features of AE-CTD-IP and to compare them with those of AE-IPF. Fifteen AE-CTD-IP patients and 48 AE-IPF patients who were diagnosed and treated at our hospital were retrospectively studied. Compared with AE-IPF patients, AE-CTD-IP patients had a significantly higher %FVC (med...
Source: Chronic Respiratory Disease - October 31, 2018 Category: Respiratory Medicine Authors: Enomoto N, Oyama Y, Enomoto Y, Yasui H, Karayama M, Kono M, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Inui N, Nakamura Y, Suda T Tags: Chron Respir Dis Source Type: research

Patient measures for respiratory patients.
PMID: 30354395 [PubMed - as supplied by publisher] (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - October 24, 2018 Category: Respiratory Medicine Authors: Lareau SC Tags: Chron Respir Dis Source Type: research

Development of a core outcome set for trials investigating the long-term management of bronchiectasis.
This study has achieved consensus on 18 outcomes that should be measured in trials of interventions for bronchiectasis. Selection of the highest ranked outcomes may represent a pragmatic means for comparison. Further research is required to condense the number of outcomes selected and to determine its relevance to interventions. PMID: 30278785 [PubMed - as supplied by publisher] (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - October 3, 2018 Category: Respiratory Medicine Authors: Spargo M, Ryan C, Downey D, Hughes C Tags: Chron Respir Dis Source Type: research

COPD patients in need of palliative care: Identification after hospitalization through the surprise question.
Abstract Currently, few patients suffering from chronic obstructive pulmonary disease (COPD) who might benefit from a palliative care approach are referred to a palliative care team. Tools to identify patients eligible for a palliative care approach have been found to be difficult to apply in daily practice. Therefore, there is need for a simple and easily applicable tool to identify those patients who would benefit from referral to a palliative care team. The aim of this study was to determine if the surprise question (SQ) "Would I be surprised if this patient dies within 12 months?" in a subset of rece...
Source: Chronic Respiratory Disease - September 16, 2018 Category: Respiratory Medicine Authors: Noppe D, Veen HI', Mooren K Tags: Chron Respir Dis Source Type: research

Testosterone replacement therapy and hospitalization rates in men with COPD.
The objective of the study was to assess whether TRT reduced the risk of respiratory hospitalizations in middle-aged and older men with COPD. We conducted two retrospective cohort studies. First, using the Clinformatics Data Mart-a database of one of the largest commercially insured populations in the United States-we examined 450 men, aged 40-63 years, with COPD who initiated TRT between 2005 and 2014. Second, using the national 5% Medicare database, we examined 253 men, aged ≥66 years, with COPD who initiated TRT between 2008 and 2013. We used difference-in-differences (DID) statistical modeling to compare pre- versus...
Source: Chronic Respiratory Disease - September 11, 2018 Category: Respiratory Medicine Authors: Baillargeon J, Urban RJ, Zhang W, Zaiden MF, Javed Z, Sheffield-Moore M, Kuo YF, Sharma G Tags: Chron Respir Dis Source Type: research

Azithromycin or erythromycin? Macrolides for non-cystic fibrosis bronchiectasis in adults: A systematic review and adjusted indirect treatment comparison.
Abstract Non-cystic fibrosis (non-CF) bronchiectasis is a condition characterized by an airway inflammatory response to bacterial pathogens. Frequent exacerbations have a major influence on the quality of life. Macrolide antibiotics have not only antibacterial but also immune-regulation effects. It is proved that macrolides have a benefit in preventing exacerbations. However, it is still uncertain whether azithromycin or erythromycin is more effective and safe. The purpose of this study was to answer the following question: Which kind of macrolide antibiotic is more effective and safe in preventing non-CF bronchie...
Source: Chronic Respiratory Disease - August 12, 2018 Category: Respiratory Medicine Authors: Li W, Qin Z, Gao J, Jiang Z, Chai Y, Guan L, Chen Y Tags: Chron Respir Dis Source Type: research

Flow and airway pressure analysis for detecting ineffective effort during mechanical ventilation in neuromuscular patients.
The objective of this study is to validate IE detection during expiration using pressure and flow signals, with respiratory effort detection by esophageal pressure (Pes) measurement as the reference, in patients with neuromuscular diseases (NMDs). We included 10 patients diagnosed with chronic respiratory failure related to NMD. Twenty-eight 5-minute recordings of daytime ventilation were studied for IE detection. Standard formulas were used to calculate sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of IE detection using pressure and flow signals compared to Pes measurement....
Source: Chronic Respiratory Disease - July 31, 2018 Category: Respiratory Medicine Authors: Ciorba C, Gonzalez-Bermejo J, Salva MQ, Annane D, Orlikowski D, Lofaso F, Prigent H Tags: Chron Respir Dis Source Type: research

Inhaler usability of a pressurized metered dose inhaler and a soft mist inhaler in patients with COPD: A simulated-use study.
The objective of this study was to evaluate task performance and handling errors with soft mist inhalers (SMIs) or pressurized metered-dose inhalers (pMDIs) among patients with chronic obstructive pulmonary disease (COPD) experienced with, but not recently trained in, using these devices. This exploratory, noninterventional, simulated-use study (D5970R00004) assessed handling/usability of SMIs and pMDIs in inhaler-experienced patients with COPD (40-78 years; diagnosis ≥6 months). Patients received a device and instruction-for-use leaflet but no training and were recorded while performing tasks required for checking the ...
Source: Chronic Respiratory Disease - January 1, 2018 Category: Respiratory Medicine Authors: Ding B, Siddiqui S, DePietro M, Petersson G, Martin UJ Tags: Chron Respir Dis Source Type: research

Variation in treatment strategies for the eradication of Pseudomonas aeruginosa in primary ciliary dyskinesia across European centers.
Abstract Primary ciliary dyskinesia (PCD) is a rare disease causing motile cilia dysfunction, recurrent airway infection, and bronchiectasis. Airway infection management strategies are borrowed from cystic fibrosis. The aim of this study is to describe the management of airway infection with Pseudomonas aeruginosa ( PA) in children and adults with PCD across European centers. An online survey questionnaire was sent electronically using SurveyMonkey® to 55 PCD centers in 36 European countries. Fifty-two responded from 43 centers in 26 countries, a response rate of 70%. Most (89%) countries did not have written ...
Source: Chronic Respiratory Disease - January 1, 2018 Category: Respiratory Medicine Authors: Crowley S, Holgersen MG, Nielsen KG Tags: Chron Respir Dis Source Type: research

Health-related quality of life, treatment adherence and psychosocial support in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension.
ouml;m B Abstract Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) share similar quality of life impairment. The aim of the present study was to investigate health-related quality of life (HRQoL) and its relation to the perception of treatment and psychosocial support among PAH and CTEPH patients. All adult PAH or CTEPH patients in the Swedish Pulmonary Arterial Hypertension Register were invited to participate in a national cohort survey. The survey included the EuroQol 5-dimensions (EQ-5D) instrument that measures an individual's HRQoL; the Beliefs about Medicines Q...
Source: Chronic Respiratory Disease - January 1, 2018 Category: Respiratory Medicine Authors: Ivarsson B, Hesselstrand R, Rådegran G, Kjellström B Tags: Chron Respir Dis Source Type: research

The influence of South Asian ethnicity on the incremental shuttle walk test in UK adults.
The objective of this study was to compare incremental shuttle walking test (ISWT) performance between South Asian and Caucasian British adults, identify predictors of ISWT distance and produce ethnicity-specific reference equations. Data from a mixed gender sample aged 40-75 years from Leicestershire, United Kingdom, were selected for analyses. Analysis of covariance determined differences in ISWT performance between South Asian and Caucasian British ethnic groups. Linear regressions identified predictors of ISWT distance, which determined the reference equations. In total, 144 participants took part in the study (79 Sout...
Source: Chronic Respiratory Disease - January 1, 2018 Category: Respiratory Medicine Authors: Orme M, Sherar L, Morgan M, Steiner M, Esliger D, Kingsnorth A, Singh S Tags: Chron Respir Dis Source Type: research

Comparison of procalcitonin, C-reactive protein, white blood cell count and clinical status in diagnosing pneumonia in patients hospitalized with acute exacerbations of COPD: A prospective observational study.
rg A Abstract Lower respiratory tract infection is the most common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). The aim of the present study was to compare the accuracy of procalcitonin (PCT), C-reactive protein (CRP) and white blood cell count (WBC) as single diagnostic tests and in combination with clinical signs and symptoms to diagnose pneumonia in patients hospitalized with AECOPD. This was a prospective, single centre observational study. Patients with spirometry-confirmed COPD who were hospitalized due to AECOPD were consecutively recruited at the hospital's Emergency Unit...
Source: Chronic Respiratory Disease - January 1, 2018 Category: Respiratory Medicine Authors: Titova E, Christensen A, Henriksen AH, Sigurd S, Åsberg A Tags: Chron Respir Dis Source Type: research

Relationship of spirometric, body plethysmographic, and diffusing capacity parameters to emphysema scores derived from CT scans.
RA Abstract Phenotyping of chronic obstructive pulmonary disease (COPD) with computed tomography (CT) is used to distinguish between emphysema- and airway-dominated type. The phenotype is reflected in correlations with lung function measures. Among these, the relative value of body plethysmography has not been quantified. We addressed this question using CT scans retrospectively collected from clinical routine in a large COPD cohort. Three hundred and thirty five patients with baseline data of the German COPD cohort COPD and Systemic Consequences-Comorbidities Network were included. CT scans were primarily evalua...
Source: Chronic Respiratory Disease - January 1, 2018 Category: Respiratory Medicine Authors: Kahnert K, Jobst B, Biertz F, Biederer J, Watz H, Huber RM, Behr J, Grenier PA, Alter P, Vogelmeier CF, Kauczor HU, Jörres RA Tags: Chron Respir Dis Source Type: research

Depression is a major determinant of both disease-specific and generic health-related quality of life in people with severe COPD.
This article investigates predictors of the disease-specific and generic health-related quality of life (HRQL) in patients with severe COPD. This multicentre prospective cross-sectional study enrolled 80 patients with severe COPD. At enrolment, all patients completed a disease-specific instrument, the St George's Respiratory Questionnaire (SGRQ), and a generic instrument, the Short Form 36 Health Survey Questionnaire (SF-36). The data were analyzed by Pearson's correlation and multiple linear regression. The mean age of the patients was 66 ± 8 years; 93% were males. The SGRQ and SF-36 scores were not influenced by a...
Source: Chronic Respiratory Disease - January 1, 2018 Category: Respiratory Medicine Authors: Jang SM, Kim KU, Na HJ, Song SE, Lee SH, Lee H, Kim YS, Lee MK, Park HK Tags: Chron Respir Dis Source Type: research

Feasibility study to assess the effect of a brief mindfulness intervention for patients with chronic obstructive pulmonary disease: A randomized controlled trial.
This study aimed to assess whether a 10-minute mindfulness intervention reduces distress and breathlessness, improves mood and increases mindfulness among hospital inpatients following acute exacerbation of COPD.Fifty patients were recruited following an acute admission. The immediate effects of a 10-minute mindfulness-based body scan were compared with a control intervention. Participants were randomized to receive either a mindfulness-based body scan ( n = 24) or a control condition ( n = 26) via a 10-minute audio recording. Participants completed a self-assessment survey, including the Borg scale for breathlessness, Phi...
Source: Chronic Respiratory Disease - January 1, 2018 Category: Respiratory Medicine Authors: Perkins-Porras L, Riaz M, Okekunle A, Zhelezna S, Chakravorty I, Ussher M Tags: Chron Respir Dis Source Type: research

Chronic bronchitis: High prevalence in never smokers and underdiagnosis- A population-based study in Colombia.
The objective of the article was to establish the prevalence, underdiagnosis, and risk factors of chronic bronchitis (CB) in a general population in five Colombian cities. Cross-sectional study using a probabilistic sampling technique in five Colombian cities was adopted. The CB definition was "cough and expectoration for three or more months per year for at least two consecutive years." Underdiagnosis was considered in subjects with clinical definition without previous medical diagnosis. Univariate χ2 or Student's t-test and logistic regression analysis were used. The study included 5539 subjects. The preval...
Source: Chronic Respiratory Disease - January 1, 2018 Category: Respiratory Medicine Authors: Gonzalez-Garcia M, Caballero A, Jaramillo C, Torres-Duque CA Tags: Chron Respir Dis Source Type: research

Why are COPD patients unable to complete the outpatient pulmonary rehabilitation program?
This study aims to compare demographic and clinical characteristics of chronic obstructive pulmonary disease (COPD) patients who complete and fail to complete outpatient pulmonary rehabilitation (PR) program and to determine the reasons for not completing the program. Patients with COPD referred to the PR program were divided into two groups: Those who completed the program were classified as group 1 and those who did not complete were classified as group 2, and their data were compared. Patients who failed to complete the program were contacted through phone and asked why they ceased their participation in the program. In...
Source: Chronic Respiratory Disease - January 1, 2018 Category: Respiratory Medicine Authors: Sahin H, Naz I Tags: Chron Respir Dis Source Type: research

Prospective risk of osteoporotic fractures in patients with advanced chronic obstructive pulmonary disease.
Abstract Despite the high prevalence of osteoporosis in chronic obstructive pulmonary disease (COPD) patients, the fracture risk prediction tools are not routinely undertaken in the management of COPD. We quantified fracture risk using a validated risk prediction tool (Fracture Risk Assessment (FRAX®)) and determined potential bone-protection treatment needs in patients with advanced COPD. The 10-year probability of major osteoporotic or hip fracture was calculated using the FRAX tool in a cohort of patients attending a hospital complex COPD service. Patients were identified to be at low, intermediate and high...
Source: Chronic Respiratory Disease - January 1, 2018 Category: Respiratory Medicine Authors: Gupta A, Greening NJ, Evans RA, Samuels A, Toms N, Steiner MC Tags: Chron Respir Dis Source Type: research

How resources determine pulmonary rehabilitation programs: A survey among Belgian chest physicians.
The objective of this study is to assess how PR is organized in specialized care centres in Belgium and to identify which barriers may exist according to respiratory physicians. A telephone and online survey was developed by a Belgian expert panel and distributed among all active Belgian chest physicians ( n = 492). Data were obtained from 200 respondents (40%). Seventy-five percentage of the chest physicians had direct access to an ambulatory rehabilitation program in their hospital. Most of these programs are organized bi or triweekly for an average period of 3-6 months. Programs focus strongly on chronic obstructive pul...
Source: Chronic Respiratory Disease - January 1, 2018 Category: Respiratory Medicine Authors: Janssens W, Corhay JL, Bogaerts P, Derom E, Frusch N, Dang DN, Kibanda J, Ruttens D, Thyrion L, Troosters T, Marchand E Tags: Chron Respir Dis Source Type: research

Adherence to long-term oxygen therapy in patients with chronic obstructive pulmonary disease.
Abstract Long-term oxygen therapy (LTOT) has beneficial effects on survival in patients with chronic obstructive pulmonary disease (COPD) and severe hypoxemia at rest. Two landmark trials suggested that these benefits depend on the time of exposure to oxygen. Patients are usually prescribed LTOT for at least 15-18 hours/day. The primary objective of this study was to determine the average daily exposure to supplemental oxygen in patients with severely hypoxemic COPD who were newly prescribed LTOT and the proportion of patients who were adherent to their prescription. The secondary objective was to identify predict...
Source: Chronic Respiratory Disease - January 1, 2018 Category: Respiratory Medicine Authors: Gauthier A, Bernard S, Bernard E, Simard S, Maltais F, Lacasse Y Tags: Chron Respir Dis Source Type: research

Asthma knowledge, care, and outcome during pregnancy: The QAKCOP study.
Abstract Asthma is the most common chronic medical condition affecting pregnancy. Optimizing asthma management in pregnancy is paramount for the well-being of both the mother and the baby. The primary objectives of this study were to assess patient's knowledge about asthma, the level of asthma care, and fetal and maternal outcomes among pregnant asthmatic women in this wealthy country with tremendous improvement in maternal and fetal health care. The secondary objective was to identify barriers to asthma control. This was a cross-sectional, face-to-face, prospective study of 80 pregnant women with physician-diagno...
Source: Chronic Respiratory Disease - January 1, 2018 Category: Respiratory Medicine Authors: Ibrahim WH, Rasul F, Ahmad M, Bajwa AS, Alamlih LI, El Arabi AM, Dauleh MM, Abubeker IY, Khan MU, Ibrahim TS, Ibrahim AA Tags: Chron Respir Dis Source Type: research

Comparative analysis of the psychometric parameters of two quality-of-life questionnaires, the SGRQ and CAT, in the assessment of patients with COPD exacerbations during hospitalization: A multicenter study.
jas-Babot N Abstract The aim of this study was to assess health-related quality of life (HRQL) in patients with chronic obstructive pulmonary disease (COPD) and to discuss the different tools available for its assessment. The most widely used assessments are the St. George respiratory questionnaire (SGRQ) and the COPD assessment test (CAT) questionnaire. Both have a different difficulty in exam completion, calculation, and scoring. No studies exist that analyze the validity and internal consistency of using both questionnaires on patients admitted to the hospital for a COPD exacerbation. A multicenter, cross-secti...
Source: Chronic Respiratory Disease - January 1, 2018 Category: Respiratory Medicine Authors: Folch Ayora A, Macia-Soler L, Orts-Cortés MI, Hernández C, Seijas-Babot N Tags: Chron Respir Dis Source Type: research